Association between urinary toxic and essential metals exposure and autism in children / Josefa CANALS-SANS ; Paula MORALES-HIDALGO ; Victoria ARIJA in Research in Autism, 125 (July 2025)  

Public ISBD [article]  inResearch in Autism > 125 (July 2025) . - p.202616 Titre : Association between urinary toxic and essential metals exposure and autism in children Type de document : Texte imprimé et/ou numérique Auteurs : Josefa CANALS-SANS, Auteur ; Paula MORALES-HIDALGO, Auteur ; Victoria ARIJA, Auteur Article en page(s) : p.202616 Langues : Anglais (eng) Mots-clés : Heavy metals  Autism  Neurodevelopment conditions  Children Index. décimale : PER Périodiques Résumé : Autism has a multifactorial origin, with genetic factors playing a significant role, while various environmental factors, including early exposure to toxic or essential metals, have been associated with an increased likelihood in children. The current study analysed the association between 15 different essential and heavy metals and autism among Spanish school children. Urine samples from a total of 108 children (autism group: N = 42; non-autism group: N = 66) between the ages of 5-16 years were analysed. Logistic regressions, adjusted for sex, age, BMI, SES, and diet quality, were performed using a categorical comparison of metal concentrations in quartiles, with the first quartile as a reference. Significant associations were found in the fourth quartile for copper (Cu) (aOR 9.45; CI: 1.89-48.02), third quartile for lead (Pb) (aOR 5.59; CI 1.36-22.94) and in the 75th percentile for manganese (Mn) (aOR 12.50; CI 3.27-47.72). Furthermore, Mn exposure was associated with more pronounced differences in social cognition, as measured by the Social Responsiveness Scale-2nd edition (? = 22.04, p = .038). However, no significant associations were found with other essential or heavy metals. This study provides significant insights into the association between metal exposure and autism in school-aged children, emphasising the need for further research to better understand and mitigate the impact of environmental influences on children?s health and development. En ligne : https://doi.org/10.1016/j.reia.2025.202616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559 [article] Association between urinary toxic and essential metals exposure and autism in children [Texte imprimé et/ou numérique] / Josefa CANALS-SANS, Auteur ; Paula MORALES-HIDALGO, Auteur ; Victoria ARIJA, Auteur . - p.202616. Langues : Anglais (eng) in Research in Autism > 125 (July 2025) . - p.202616 Mots-clés : Heavy metals  Autism  Neurodevelopment conditions  Children Index. décimale : PER Périodiques Résumé : Autism has a multifactorial origin, with genetic factors playing a significant role, while various environmental factors, including early exposure to toxic or essential metals, have been associated with an increased likelihood in children. The current study analysed the association between 15 different essential and heavy metals and autism among Spanish school children. Urine samples from a total of 108 children (autism group: N = 42; non-autism group: N = 66) between the ages of 5-16 years were analysed. Logistic regressions, adjusted for sex, age, BMI, SES, and diet quality, were performed using a categorical comparison of metal concentrations in quartiles, with the first quartile as a reference. Significant associations were found in the fourth quartile for copper (Cu) (aOR 9.45; CI: 1.89-48.02), third quartile for lead (Pb) (aOR 5.59; CI 1.36-22.94) and in the 75th percentile for manganese (Mn) (aOR 12.50; CI 3.27-47.72). Furthermore, Mn exposure was associated with more pronounced differences in social cognition, as measured by the Social Responsiveness Scale-2nd edition (? = 22.04, p = .038). However, no significant associations were found with other essential or heavy metals. This study provides significant insights into the association between metal exposure and autism in school-aged children, emphasising the need for further research to better understand and mitigate the impact of environmental influences on children?s health and development. En ligne : https://doi.org/10.1016/j.reia.2025.202616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559

Nutrient intake and adequacy in children with autism spectrum disorder: EPINED epidemiological study / Victoria ARIJA in Autism, 27-2 (February 2023)  

Public ISBD [article]  inAutism > 27-2 (February 2023) . - p.371-388 Titre : Nutrient intake and adequacy in children with autism spectrum disorder: EPINED epidemiological study Type de document : Texte imprimé et/ou numérique Auteurs : Victoria ARIJA, Auteur ; Patricia ESTEBAN-FIGUEROLA, Auteur ; Paula MORALES-HIDALGO, Auteur ; Cristina JARDI, Auteur ; Josefa CANALS-SANS, Auteur Article en page(s) : p.371-388 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  mineral  nutrition/feeding  preschool children  primary school children  vitamin Index. décimale : PER Périodiques Résumé : This article assesses nutritional intake and adequacy in children with autism spectrum disorder (ASD), subdiagnostic autistic symptoms and children with typical development (TD). In total, 77 children diagnosed with ASD, 40 with subdiagnostic autistic symptoms and 333 children with TD were assessed. A validated food frequency questionnaire was used. Very few nutritional differences were found between ASD and TD groups. Preschool children with ASD and subdiagnostic autistic symptoms had slightly lower intake of monounsaturated fatty acids (MUFA), vitamin D and vitamin B12, and primary school children with ASD and subdiagnostic autistic symptoms had slightly higher intake of protein, cholesterol, thiamine and niacin, and a higher percentage of obesity than children with TD. All samples had an unbalanced energy intake (high in added sugars, fats and saturated fatty acids (SFAs); extremely inadequate intake (80% “100%) of vitamins D and E; high intake (50% “80%) of fibre, b-carotene (except preschool children with TD), calcium (except preschool children) and magnesium). The fact that differences between diagnoses are scarce may be related to the low level of ASD severity in this school sample. En ligne : http://dx.doi.org/10.1177/13623613221098237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Nutrient intake and adequacy in children with autism spectrum disorder: EPINED epidemiological study [Texte imprimé et/ou numérique] / Victoria ARIJA, Auteur ; Patricia ESTEBAN-FIGUEROLA, Auteur ; Paula MORALES-HIDALGO, Auteur ; Cristina JARDI, Auteur ; Josefa CANALS-SANS, Auteur . - p.371-388. Langues : Anglais (eng) in Autism > 27-2 (February 2023) . - p.371-388 Mots-clés : autism spectrum disorder  mineral  nutrition/feeding  preschool children  primary school children  vitamin Index. décimale : PER Périodiques Résumé : This article assesses nutritional intake and adequacy in children with autism spectrum disorder (ASD), subdiagnostic autistic symptoms and children with typical development (TD). In total, 77 children diagnosed with ASD, 40 with subdiagnostic autistic symptoms and 333 children with TD were assessed. A validated food frequency questionnaire was used. Very few nutritional differences were found between ASD and TD groups. Preschool children with ASD and subdiagnostic autistic symptoms had slightly lower intake of monounsaturated fatty acids (MUFA), vitamin D and vitamin B12, and primary school children with ASD and subdiagnostic autistic symptoms had slightly higher intake of protein, cholesterol, thiamine and niacin, and a higher percentage of obesity than children with TD. All samples had an unbalanced energy intake (high in added sugars, fats and saturated fatty acids (SFAs); extremely inadequate intake (80% “100%) of vitamins D and E; high intake (50% “80%) of fibre, b-carotene (except preschool children with TD), calcium (except preschool children) and magnesium). The fact that differences between diagnoses are scarce may be related to the low level of ASD severity in this school sample. En ligne : http://dx.doi.org/10.1177/13623613221098237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

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