Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways / Jessica P. UY in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436 Titre : Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways Type de document : texte imprimé Auteurs : Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur Article en page(s) : p.426-436 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways [texte imprimé] / Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur . - p.426-436. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436 Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Nucleus accumbens volume mediates the association between prenatal adversity and attention problems in youth / Chase ANTONACCI in Development and Psychopathology, 38-1 (February 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-1 (February 2026) . - p.117-129 Titre : Nucleus accumbens volume mediates the association between prenatal adversity and attention problems in youth Type de document : texte imprimé Auteurs : Chase ANTONACCI, Auteur ; Jessica L. BUTHMANN, Auteur ; Lauren R. BORCHERS, Auteur ; Marielle V. FORTIER, Auteur ; Yap Seng CHONG, Auteur ; Peter GLUCKMAN, Auteur ; Johan ERIKSSON, Auteur ; Helen Y. CHEN, Auteur ; Evelyn LAW, Auteur ; Michael J. MEANEY, Auteur ; Ai Peng TAN, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.117-129 Langues : Anglais (eng) Mots-clés : adversity attention maternal mental health nucleus accumbens perinatal Index. décimale : PER Périodiques Résumé : Exposure to adversity during the perinatal period has been associated with cognitive difficulties in children. Given the role of the nucleus accumbens (NAcc) in attention and impulsivity, we examined whether NAcc volume at age six mediates the relations between pre- and postnatal adversity and subsequent attention problems in offspring. 306 pregnant women were recruited as part of the Growing Up in Singapore Towards Healthy Outcomes Study. Psychosocial stress was assessed during pregnancy and across the first 5 years postpartum. At six years of age, children underwent structural MRI and, at age seven years, mothers reported on their children’s attention problems. Separate factor analyses conducted on measures of pre- and postnatal adversity each yielded two latent factors: maternal mental health and socioeconomic status. Both pre- and postnatal maternal mental health predicted children’s attention difficulties. Further, NAcc volume mediated the relation between prenatal, but not postnatal, maternal mental health and children’s attention problems. These findings suggest that the NAcc is particularly vulnerable to prenatal maternal mental health challenges and contributes to offspring attention problems. Characterizing the temporal sensitivity of neurobiological structures to adversity will help to elucidate mechanisms linking environmental exposures and behavior, facilitating the development of neuroscience-informed interventions for childhood difficulties. En ligne : https://dx.doi.org/10.1017/S0954579425000240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Nucleus accumbens volume mediates the association between prenatal adversity and attention problems in youth [texte imprimé] / Chase ANTONACCI, Auteur ; Jessica L. BUTHMANN, Auteur ; Lauren R. BORCHERS, Auteur ; Marielle V. FORTIER, Auteur ; Yap Seng CHONG, Auteur ; Peter GLUCKMAN, Auteur ; Johan ERIKSSON, Auteur ; Helen Y. CHEN, Auteur ; Evelyn LAW, Auteur ; Michael J. MEANEY, Auteur ; Ai Peng TAN, Auteur ; Ian H. GOTLIB, Auteur . - p.117-129. Langues : Anglais (eng) in Development and Psychopathology > 38-1 (February 2026) . - p.117-129 Mots-clés : adversity attention maternal mental health nucleus accumbens perinatal Index. décimale : PER Périodiques Résumé : Exposure to adversity during the perinatal period has been associated with cognitive difficulties in children. Given the role of the nucleus accumbens (NAcc) in attention and impulsivity, we examined whether NAcc volume at age six mediates the relations between pre- and postnatal adversity and subsequent attention problems in offspring. 306 pregnant women were recruited as part of the Growing Up in Singapore Towards Healthy Outcomes Study. Psychosocial stress was assessed during pregnancy and across the first 5 years postpartum. At six years of age, children underwent structural MRI and, at age seven years, mothers reported on their children’s attention problems. Separate factor analyses conducted on measures of pre- and postnatal adversity each yielded two latent factors: maternal mental health and socioeconomic status. Both pre- and postnatal maternal mental health predicted children’s attention difficulties. Further, NAcc volume mediated the relation between prenatal, but not postnatal, maternal mental health and children’s attention problems. These findings suggest that the NAcc is particularly vulnerable to prenatal maternal mental health challenges and contributes to offspring attention problems. Characterizing the temporal sensitivity of neurobiological structures to adversity will help to elucidate mechanisms linking environmental exposures and behavior, facilitating the development of neuroscience-informed interventions for childhood difficulties. En ligne : https://dx.doi.org/10.1017/S0954579425000240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

Subregion-specific thalamocortical functional connectivity, executive function, and social behavior in children with autism spectrum disorders / Jasmine Si Min CHUAH ; Aisleen M.A. MANAHAN ; Shi Yu CHAN ; Zhen Ming NGOH ; Pei HUANG ; Ai Peng TAN in Autism Research, 18-1 (January 2025)  

Public ISBD [article]  inAutism Research > 18-1 (January 2025) . - p.70-82 Titre : Subregion-specific thalamocortical functional connectivity, executive function, and social behavior in children with autism spectrum disorders : Autism Research Type de document : texte imprimé Auteurs : Jasmine Si Min CHUAH, Auteur ; Aisleen M.A. MANAHAN, Auteur ; Shi Yu CHAN, Auteur ; Zhen Ming NGOH, Auteur ; Pei HUANG, Auteur ; Ai Peng TAN, Auteur Article en page(s) : p.70-82 Langues : Anglais (eng) Mots-clés : autism spectrum disorders (ASDs)  children  executive function  resting-state functional connectivity (RSFC)  social behavior  thalamocortical connectivity Index. décimale : PER Périodiques Résumé : Abstract The thalamus has extensive cortical connections and is an integrative hub for cognitive functions governing social behavior. This study examined (1) associations between thalamocortical resting-state functional connectivity (RSFC) and social behavior in children and (2) how various executive function (EF) subdomains mediate the association between thalamocortical RSFC and social behavior. Children from the autism brain imaging data exchange (ABIDE) initiative with neuroimaging, behavioral, and demographic data were included in our study (age < 14, ASD; n 207, typically developing; n 259). Thalamocortical RSFC was examined for associations with social communication and interaction (SCI) scores (SRS; social responsiveness scale) using Spearman's rank-order correlation, first in ASD children and then in typically developing children. This was followed by a more granular analysis at the thalamic subregion level. We then examined the mediating roles of eight EF subdomains in ASD children (n 139). Right thalamus-default mode network (DMN) RSFC was significantly associated with SCI scores in ASD children (? 0.23, pFDR 0.012), primarily driven by the medial (? 0.22, pFDR 0.013), ventral (? 0.17, pFDR 0.036), and intralaminar (? 0.17, pFDR 0.036) thalamic subregions. Cognitive flexibility (ACME 0.13, punc 0.016) and emotional control (ACME 0.08, punc 0.020) significantly mediated the association between right thalamus-DMN RSFC and SCI scores. This study provided novel insights into the association between thalamocortical RSFC and social behavior in ASD children at the thalamic subregion level, providing higher levels of precision in brain-behavior mapping. Cognitive flexibility and emotion regulation were highlighted as potential targets to ameliorate the downstream effects of altered thalamocortical connectivity to improve social outcomes in ASD children. En ligne : https://doi.org/10.1002/aur.3280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Subregion-specific thalamocortical functional connectivity, executive function, and social behavior in children with autism spectrum disorders : Autism Research [texte imprimé] / Jasmine Si Min CHUAH, Auteur ; Aisleen M.A. MANAHAN, Auteur ; Shi Yu CHAN, Auteur ; Zhen Ming NGOH, Auteur ; Pei HUANG, Auteur ; Ai Peng TAN, Auteur . - p.70-82. Langues : Anglais (eng) in Autism Research > 18-1 (January 2025) . - p.70-82 Mots-clés : autism spectrum disorders (ASDs)  children  executive function  resting-state functional connectivity (RSFC)  social behavior  thalamocortical connectivity Index. décimale : PER Périodiques Résumé : Abstract The thalamus has extensive cortical connections and is an integrative hub for cognitive functions governing social behavior. This study examined (1) associations between thalamocortical resting-state functional connectivity (RSFC) and social behavior in children and (2) how various executive function (EF) subdomains mediate the association between thalamocortical RSFC and social behavior. Children from the autism brain imaging data exchange (ABIDE) initiative with neuroimaging, behavioral, and demographic data were included in our study (age < 14, ASD; n 207, typically developing; n 259). Thalamocortical RSFC was examined for associations with social communication and interaction (SCI) scores (SRS; social responsiveness scale) using Spearman's rank-order correlation, first in ASD children and then in typically developing children. This was followed by a more granular analysis at the thalamic subregion level. We then examined the mediating roles of eight EF subdomains in ASD children (n 139). Right thalamus-default mode network (DMN) RSFC was significantly associated with SCI scores in ASD children (? 0.23, pFDR 0.012), primarily driven by the medial (? 0.22, pFDR 0.013), ventral (? 0.17, pFDR 0.036), and intralaminar (? 0.17, pFDR 0.036) thalamic subregions. Cognitive flexibility (ACME 0.13, punc 0.016) and emotional control (ACME 0.08, punc 0.020) significantly mediated the association between right thalamus-DMN RSFC and SCI scores. This study provided novel insights into the association between thalamocortical RSFC and social behavior in ASD children at the thalamic subregion level, providing higher levels of precision in brain-behavior mapping. Cognitive flexibility and emotion regulation were highlighted as potential targets to ameliorate the downstream effects of altered thalamocortical connectivity to improve social outcomes in ASD children. En ligne : https://doi.org/10.1002/aur.3280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

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