Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Peter D. GLUCKMAN |
Documents disponibles écrits par cet auteur (5)
Faire une suggestion Affiner la recherche
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes / Li CHEN in Development and Psychopathology, 27-1 (February 2015)
[article]
Titre : Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes Type de document : Texte imprimé et/ou numérique Auteurs : Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F. P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur Article en page(s) : p.137-150 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257
in Development and Psychopathology > 27-1 (February 2015) . - p.137-150[article] Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes [Texte imprimé et/ou numérique] / Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F. P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur . - p.137-150.
Langues : Anglais (eng)
in Development and Psychopathology > 27-1 (February 2015) . - p.137-150
Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways / Jessica P. UY in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)
[article]
Titre : Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways Type de document : Texte imprimé et/ou numérique Auteurs : Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit B.F.P. BROECKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur Article en page(s) : p.426-436 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493
in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436[article] Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways [Texte imprimé et/ou numérique] / Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit B.F.P. BROECKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur . - p.426-436.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436
Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 Is the Cure Worse than the Disease? Caveats in the Move from Laboratory to Clinic / Peter D. GLUCKMAN in Developmental Medicine & Child Neurology, 34-11 (November 1992)
[article]
Titre : Is the Cure Worse than the Disease? Caveats in the Move from Laboratory to Clinic Type de document : Texte imprimé et/ou numérique Auteurs : Peter D. GLUCKMAN, Auteur ; Christopher E. WILLIAMS, Auteur Année de publication : 1992 Article en page(s) : p.1015-1018 Langues : Anglais (eng) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=138
in Developmental Medicine & Child Neurology > 34-11 (November 1992) . - p.1015-1018[article] Is the Cure Worse than the Disease? Caveats in the Move from Laboratory to Clinic [Texte imprimé et/ou numérique] / Peter D. GLUCKMAN, Auteur ; Christopher E. WILLIAMS, Auteur . - 1992 . - p.1015-1018.
Langues : Anglais (eng)
in Developmental Medicine & Child Neurology > 34-11 (November 1992) . - p.1015-1018
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=138 Neonatal hypopituitarism: a neurological perspective / J.M. COSTELLO in Developmental Medicine & Child Neurology, 30-2 (April 1988)
[article]
Titre : Neonatal hypopituitarism: a neurological perspective Type de document : Texte imprimé et/ou numérique Auteurs : J.M. COSTELLO, Auteur ; Peter D. GLUCKMAN, Auteur Année de publication : 1988 Article en page(s) : p.190-199 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Hypopituitarisme néonatal: perspective neurologique
Douze patients présentaient durant la période néonatale, des signes évoquant un hypopituitarisme mais le diagnostic ne fut porté que fois dés ce moment. Les caractéristiques craniofaciales, oculaires et neurologiques étaient typiques. L'hypoplasie optique était présente dans six cas, des fontanelles antérieures et postérieures trop larges dans quatre cas, des sutures larges dans quatre cas, un pont nasal déprimé dans trois cas, une paralysie faciale dans trois cas et un nourrisson avait un faciès asymétrique, pleurant. Des crises comitiales survinrent chez trois patients à la période néonatale et huit ultérieurement. L'hyper bilirubinémie existait dans les douze cas, l'hypoglycémie dans 11 cas et un micropénis existait chez cinq des sept garçons. Cette étude suggère que l'incidence de l'hypopituitarisme néonatal a pu s'accroitre.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=774
in Developmental Medicine & Child Neurology > 30-2 (April 1988) . - p.190-199[article] Neonatal hypopituitarism: a neurological perspective [Texte imprimé et/ou numérique] / J.M. COSTELLO, Auteur ; Peter D. GLUCKMAN, Auteur . - 1988 . - p.190-199.
Langues : Anglais (eng)
in Developmental Medicine & Child Neurology > 30-2 (April 1988) . - p.190-199
Index. décimale : PER Périodiques Résumé : Hypopituitarisme néonatal: perspective neurologique
Douze patients présentaient durant la période néonatale, des signes évoquant un hypopituitarisme mais le diagnostic ne fut porté que fois dés ce moment. Les caractéristiques craniofaciales, oculaires et neurologiques étaient typiques. L'hypoplasie optique était présente dans six cas, des fontanelles antérieures et postérieures trop larges dans quatre cas, des sutures larges dans quatre cas, un pont nasal déprimé dans trois cas, une paralysie faciale dans trois cas et un nourrisson avait un faciès asymétrique, pleurant. Des crises comitiales survinrent chez trois patients à la période néonatale et huit ultérieurement. L'hyper bilirubinémie existait dans les douze cas, l'hypoglycémie dans 11 cas et un micropénis existait chez cinq des sept garçons. Cette étude suggère que l'incidence de l'hypopituitarisme néonatal a pu s'accroitre.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=774 When and Why Do Brain Cells Die? / Peter D. GLUCKMAN in Developmental Medicine & Child Neurology, 34-11 (November 1992)
[article]
Titre : When and Why Do Brain Cells Die? Type de document : Texte imprimé et/ou numérique Auteurs : Peter D. GLUCKMAN, Auteur ; Christopher E. WILLIAMS, Auteur Année de publication : 1992 Article en page(s) : p.1010.1014 Langues : Anglais (eng) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=138
in Developmental Medicine & Child Neurology > 34-11 (November 1992) . - p.1010.1014[article] When and Why Do Brain Cells Die? [Texte imprimé et/ou numérique] / Peter D. GLUCKMAN, Auteur ; Christopher E. WILLIAMS, Auteur . - 1992 . - p.1010.1014.
Langues : Anglais (eng)
in Developmental Medicine & Child Neurology > 34-11 (November 1992) . - p.1010.1014
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=138