Sequential CT studies of 24 children with infantile spasms on ACTH therapy / Masatoshi ITO in Developmental Medicine & Child Neurology, 25-4 (August 1983)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 25-4 (August 1983) . - p.475-480 Titre : Sequential CT studies of 24 children with infantile spasms on ACTH therapy Type de document : Texte imprimé et/ou numérique Auteurs : Masatoshi ITO, Auteur ; Tastuo TAKAO, Auteur ; Takehiko OKUNA, Auteur ; Haruki MIKAWA, Auteur Année de publication : 1983 Article en page(s) : p.475-480 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Sequential CT studies were performed in 24 patients with infantile spasms, before, during and after ACTH therapy, in order to analyze the relationship between the dose of ACTH and changes in CT scan findings. In six cases CT scans did not return to their original state after ACTH therapy. Two illustrative cases are reported. There was a good correlation between the total dose of ACTH and the percentage decrease of brain parenchyma. It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Sequential CT studies of 24 children with infantile spasms on ACTH therapy [Texte imprimé et/ou numérique] / Masatoshi ITO, Auteur ; Tastuo TAKAO, Auteur ; Takehiko OKUNA, Auteur ; Haruki MIKAWA, Auteur . - 1983 . - p.475-480. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 25-4 (August 1983) . - p.475-480 Index. décimale : PER Périodiques Résumé : Sequential CT studies were performed in 24 patients with infantile spasms, before, during and after ACTH therapy, in order to analyze the relationship between the dose of ACTH and changes in CT scan findings. In six cases CT scans did not return to their original state after ACTH therapy. Two illustrative cases are reported. There was a good correlation between the total dose of ACTH and the percentage decrease of brain parenchyma. It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

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