Clinical utility of the standardized observation tool Autism Behavior Coding System for early intervention research in autism spectrum disorder / Marianne NOTTER ; Olga LAZARI ; Klaus SCHMECK ; Evelyn HERBRECHT in Autism Research, 16-12 (December 2023)  

Public ISBD [article]  inAutism Research > 16-12 (December 2023) . - p.2415-2431 Titre : Clinical utility of the standardized observation tool Autism Behavior Coding System for early intervention research in autism spectrum disorder Type de document : texte imprimé Auteurs : Marianne NOTTER, Auteur ; Olga LAZARI, Auteur ; Klaus SCHMECK, Auteur ; Evelyn HERBRECHT, Auteur Article en page(s) : p.2415-2431 Index. décimale : PER Périodiques Résumé : Abstract The Autism Behavior Coding System (ABCS) was developed to help evaluating the effectiveness of early intensive interventions in children with autism spectrum disorder (ASD). The video-based ABCS assesses eight core autistic behavioral variables during therapist-child interaction using standardized quantitative criteria, four behaviors according to their frequency of occurrence, four according to their duration. The present study focuses (1) on the correspondence of ABCS scores with scores on two standard clinical instruments (the ADOS-2 and an ASD-adaptation of the Children's Global Assessment Scale, DD-CGAS), (2) on the sensitivity to change of ABCS scores by the end of an intensive 18 days intervention period (EIP) and (c) on the predictability of short- and longer-term changes in social and repetitive behaviors from ABCS scores at baseline and EIP. Data from 51 children (42 M, 9 F; median age 45 months) followed over 1 year were available. There were significant correlations at baseline between several ABCS scores and ADOS-2 as well as DD-CGAS scores. Correlations at EIP between some ABCS and DD-CGAS scores were highly significant. Four ABCS scores reflected significant changes from baseline to EIP. Several baseline ABCS scores were predictive of DD-CGAS and ADOS-2 scores at EIP and Year 1. However, associations between ABCS score changes from baseline to EIP and the clinical scale changes by Year 1 were not significant. It is concluded that several ABCS scores have adequate clinical validity and sensitivity to change. The short-term changes in ABCS scores and their relationship to longer-term clinical changes need further study. En ligne : https://doi.org/10.1002/aur.3047 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Clinical utility of the standardized observation tool Autism Behavior Coding System for early intervention research in autism spectrum disorder [texte imprimé] / Marianne NOTTER, Auteur ; Olga LAZARI, Auteur ; Klaus SCHMECK, Auteur ; Evelyn HERBRECHT, Auteur . - p.2415-2431. in Autism Research > 16-12 (December 2023) . - p.2415-2431 Index. décimale : PER Périodiques Résumé : Abstract The Autism Behavior Coding System (ABCS) was developed to help evaluating the effectiveness of early intensive interventions in children with autism spectrum disorder (ASD). The video-based ABCS assesses eight core autistic behavioral variables during therapist-child interaction using standardized quantitative criteria, four behaviors according to their frequency of occurrence, four according to their duration. The present study focuses (1) on the correspondence of ABCS scores with scores on two standard clinical instruments (the ADOS-2 and an ASD-adaptation of the Children's Global Assessment Scale, DD-CGAS), (2) on the sensitivity to change of ABCS scores by the end of an intensive 18 days intervention period (EIP) and (c) on the predictability of short- and longer-term changes in social and repetitive behaviors from ABCS scores at baseline and EIP. Data from 51 children (42 M, 9 F; median age 45 months) followed over 1 year were available. There were significant correlations at baseline between several ABCS scores and ADOS-2 as well as DD-CGAS scores. Correlations at EIP between some ABCS and DD-CGAS scores were highly significant. Four ABCS scores reflected significant changes from baseline to EIP. Several baseline ABCS scores were predictive of DD-CGAS and ADOS-2 scores at EIP and Year 1. However, associations between ABCS score changes from baseline to EIP and the clinical scale changes by Year 1 were not significant. It is concluded that several ABCS scores have adequate clinical validity and sensitivity to change. The short-term changes in ABCS scores and their relationship to longer-term clinical changes need further study. En ligne : https://doi.org/10.1002/aur.3047 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Empathy deficits, callous-unemotional traits and structural underpinnings in autism spectrum disorder and conduct disorder youth / Antonia TKALCEC in Autism Research, 16-10 (October 2023)  

Public ISBD [article]  inAutism Research > 16-10 (October 2023) . - p.1946-1962 Titre : Empathy deficits, callous-unemotional traits and structural underpinnings in autism spectrum disorder and conduct disorder youth Type de document : texte imprimé Auteurs : Antonia TKALCEC, Auteur ; Maria BIERLEIN, Auteur ; Gudrun SEEGER-SCHNEIDER, Auteur ; Susanne WALITZA, Auteur ; Bettina JENNY, Auteur ; Willeke M. MENKS, Auteur ; Lynn V. FELHBAUM, Auteur ; Reka BORBAS, Auteur ; David M. COLE, Auteur ; Nora RASCHLE, Auteur ; Evelyn HERBRECHT, Auteur ; Christina STADLER, Auteur ; Ana I. CUBILLO, Auteur Article en page(s) : p.1946-1962 Index. décimale : PER Périodiques Résumé : Abstract Distinct empathy deficits are often described in patients with conduct disorder (CD) and autism spectrum disorder (ASD) yet their neural underpinnings and the influence of comorbid Callous-Unemotional (CU) traits are unclear. This study compares the cognitive (CE) and affective empathy (AE) abilities of youth with CD and ASD, their potential neuroanatomical correlates, and the influence of CU traits on empathy. Adolescents and parents/caregivers completed empathy questionnaires (N 148 adolescents, mean age 15.16 years) and T1 weighted images were obtained from a subsample (N 130). Group differences in empathy and the influence of CU traits were investigated using Bayesian analyses and Voxel-Based Morphometry with Threshold-Free Cluster Enhancement focusing on regions involved in AE (insula, amygdala, inferior frontal gyrus and cingulate cortex) and CE processes (ventromedial prefrontal cortex, temporoparietal junction, superior temporal gyrus, and precuneus). The ASD group showed lower parent-reported AE and CE scores and lower self-reported CE scores while the CD group showed lower parent-reported CE scores than controls. When accounting for the influence of CU traits no AE deficits in ASD and CE deficits in CD were found, but CE deficits in ASD remained. Across all participants, CU traits were negatively associated with gray matter volumes in anterior cingulate which extends into the mid cingulate, ventromedial prefrontal cortex, and precuneus. Thus, although co-occurring CU traits have been linked to global empathy deficits in reports and underlying brain structures, its influence on empathy aspects might be disorder-specific. Investigating the subdimensions of empathy may therefore help to identify disorder-specific empathy deficits. En ligne : https://doi.org/10.1002/aur.2993 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Empathy deficits, callous-unemotional traits and structural underpinnings in autism spectrum disorder and conduct disorder youth [texte imprimé] / Antonia TKALCEC, Auteur ; Maria BIERLEIN, Auteur ; Gudrun SEEGER-SCHNEIDER, Auteur ; Susanne WALITZA, Auteur ; Bettina JENNY, Auteur ; Willeke M. MENKS, Auteur ; Lynn V. FELHBAUM, Auteur ; Reka BORBAS, Auteur ; David M. COLE, Auteur ; Nora RASCHLE, Auteur ; Evelyn HERBRECHT, Auteur ; Christina STADLER, Auteur ; Ana I. CUBILLO, Auteur . - p.1946-1962. in Autism Research > 16-10 (October 2023) . - p.1946-1962 Index. décimale : PER Périodiques Résumé : Abstract Distinct empathy deficits are often described in patients with conduct disorder (CD) and autism spectrum disorder (ASD) yet their neural underpinnings and the influence of comorbid Callous-Unemotional (CU) traits are unclear. This study compares the cognitive (CE) and affective empathy (AE) abilities of youth with CD and ASD, their potential neuroanatomical correlates, and the influence of CU traits on empathy. Adolescents and parents/caregivers completed empathy questionnaires (N 148 adolescents, mean age 15.16 years) and T1 weighted images were obtained from a subsample (N 130). Group differences in empathy and the influence of CU traits were investigated using Bayesian analyses and Voxel-Based Morphometry with Threshold-Free Cluster Enhancement focusing on regions involved in AE (insula, amygdala, inferior frontal gyrus and cingulate cortex) and CE processes (ventromedial prefrontal cortex, temporoparietal junction, superior temporal gyrus, and precuneus). The ASD group showed lower parent-reported AE and CE scores and lower self-reported CE scores while the CD group showed lower parent-reported CE scores than controls. When accounting for the influence of CU traits no AE deficits in ASD and CE deficits in CD were found, but CE deficits in ASD remained. Across all participants, CU traits were negatively associated with gray matter volumes in anterior cingulate which extends into the mid cingulate, ventromedial prefrontal cortex, and precuneus. Thus, although co-occurring CU traits have been linked to global empathy deficits in reports and underlying brain structures, its influence on empathy aspects might be disorder-specific. Investigating the subdimensions of empathy may therefore help to identify disorder-specific empathy deficits. En ligne : https://doi.org/10.1002/aur.2993 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Gaze behavior, facial emotion processing, and neural underpinnings: A comparison of adolescents with autism spectrum disorder and conduct disorder / Antonia TKALCEC in Journal of Child Psychology and Psychiatry, 66-11 (November 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-11 (November 2025) . - p.1664-1674 Titre : Gaze behavior, facial emotion processing, and neural underpinnings: A comparison of adolescents with autism spectrum disorder and conduct disorder Type de document : texte imprimé Auteurs : Antonia TKALCEC, Auteur ; Alessandro BALDASSARRI, Auteur ; Alex JUNGHANS, Auteur ; Vithusan SOMASUNDARAM, Auteur ; Willeke M. MENKS, Auteur ; Lynn V. FEHLBAUM, Auteur ; Reka BORBAS, Auteur ; Nora RASCHLE, Auteur ; Gudrun SEEGER-SCHNEIDER, Auteur ; Bettina JENNY, Auteur ; Susanne WALITZA, Auteur ; David M. COLE, Auteur ; Philipp STERZER, Auteur ; Francesco SANTINI, Auteur ; Evelyn HERBRECHT, Auteur ; Ana CUBILLO, Auteur ; Christina STADLER, Auteur Article en page(s) : p.1664-1674 Langues : Anglais (eng) Mots-clés : Conduct disorder  autism spectrum disorders  emotion processing  eye gaze  brain activation Index. décimale : PER Périodiques Résumé : Background Facial emotion processing deficits and atypical eye gaze are often described in individuals with autism spectrum disorder (ASD) and those with conduct disorder (CD) and high callous unemotional (CU) traits. Yet, the underlying neural mechanisms of these deficits are still unclear. The aim of this study was to investigate if eye gaze can partially account for the differences in brain activation in youth with ASD, with CD, and typically developing youth (TD). Methods In total, 105 adolescent participants (NCD?=?39, NASD?=?27, NTD?=?39; mean age?=?15.59?years) underwent a brain functional imaging session including eye tracking during an implicit emotion processing task while parents/caregivers completed questionnaires. Group differences in gaze behavior (number of fixations to the eye and mouth regions) for different facial expressions (neutral, fearful, angry) presented in the task were investigated using Bayesian analyses. Full-factorial models were used to investigate group differences in brain activation with and without including gaze behavior parameters and focusing on brain regions underlying facial emotion processing (insula, amygdala, and medial prefrontal cortex). Results Youth with ASD showed increased fixations on the mouth compared to TD and CD groups. CD participants with high CU traits tended to show fewer fixations to the eye region compared to TD for all emotions. Brain imaging results show higher right anterior insula activation in the ASD compared with the CD group when angry faces were presented. The inclusion of gaze behavior parameters in the model reduced the size of that cluster. Conclusions Differences in insula activation may be partially explained by gaze behavior. This implies an important role of gaze behavior in facial emotion processing, which should be considered for future brain imaging studies. In addition, our results suggest that targeting gaze behavior in interventions might be potentially beneficial for disorders showing impairments associated with the processing of emotional faces. The relation between eye gaze, CU traits, and neural function in different diagnoses needs further clarification in larger samples. En ligne : https://doi.org/10.1111/jcpp.14172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Gaze behavior, facial emotion processing, and neural underpinnings: A comparison of adolescents with autism spectrum disorder and conduct disorder [texte imprimé] / Antonia TKALCEC, Auteur ; Alessandro BALDASSARRI, Auteur ; Alex JUNGHANS, Auteur ; Vithusan SOMASUNDARAM, Auteur ; Willeke M. MENKS, Auteur ; Lynn V. FEHLBAUM, Auteur ; Reka BORBAS, Auteur ; Nora RASCHLE, Auteur ; Gudrun SEEGER-SCHNEIDER, Auteur ; Bettina JENNY, Auteur ; Susanne WALITZA, Auteur ; David M. COLE, Auteur ; Philipp STERZER, Auteur ; Francesco SANTINI, Auteur ; Evelyn HERBRECHT, Auteur ; Ana CUBILLO, Auteur ; Christina STADLER, Auteur . - p.1664-1674. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-11 (November 2025) . - p.1664-1674 Mots-clés : Conduct disorder  autism spectrum disorders  emotion processing  eye gaze  brain activation Index. décimale : PER Périodiques Résumé : Background Facial emotion processing deficits and atypical eye gaze are often described in individuals with autism spectrum disorder (ASD) and those with conduct disorder (CD) and high callous unemotional (CU) traits. Yet, the underlying neural mechanisms of these deficits are still unclear. The aim of this study was to investigate if eye gaze can partially account for the differences in brain activation in youth with ASD, with CD, and typically developing youth (TD). Methods In total, 105 adolescent participants (NCD?=?39, NASD?=?27, NTD?=?39; mean age?=?15.59?years) underwent a brain functional imaging session including eye tracking during an implicit emotion processing task while parents/caregivers completed questionnaires. Group differences in gaze behavior (number of fixations to the eye and mouth regions) for different facial expressions (neutral, fearful, angry) presented in the task were investigated using Bayesian analyses. Full-factorial models were used to investigate group differences in brain activation with and without including gaze behavior parameters and focusing on brain regions underlying facial emotion processing (insula, amygdala, and medial prefrontal cortex). Results Youth with ASD showed increased fixations on the mouth compared to TD and CD groups. CD participants with high CU traits tended to show fewer fixations to the eye region compared to TD for all emotions. Brain imaging results show higher right anterior insula activation in the ASD compared with the CD group when angry faces were presented. The inclusion of gaze behavior parameters in the model reduced the size of that cluster. Conclusions Differences in insula activation may be partially explained by gaze behavior. This implies an important role of gaze behavior in facial emotion processing, which should be considered for future brain imaging studies. In addition, our results suggest that targeting gaze behavior in interventions might be potentially beneficial for disorders showing impairments associated with the processing of emotional faces. The relation between eye gaze, CU traits, and neural function in different diagnoses needs further clarification in larger samples. En ligne : https://doi.org/10.1111/jcpp.14172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Interprétation de situations sociales dans le Syndrome d’Asperger / Anca-Maria SAV in Bulletin Scientifique de l'arapi (Le), 25 (Printemps 2010)

Public ISBD [article]  inBulletin Scientifique de l'arapi (Le) > 25 (Printemps 2010) . - p.85-88 Titre : Interprétation de situations sociales dans le Syndrome d’Asperger Type de document : texte imprimé Auteurs : Anca-Maria SAV, Auteur ; Marion LEBOYER, Auteur ; Tiziana ZALLA, Auteur ; Sabrina AHADE, Auteur ; Nadia SACHS, Auteur ; Celina PAREDES, Auteur ; Evelyn HERBRECHT, Auteur ; Michèle MONTREUIL, Auteur Année de publication : 2010 Article en page(s) : p.85-88 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=107 [article] Interprétation de situations sociales dans le Syndrome d’Asperger [texte imprimé] / Anca-Maria SAV, Auteur ; Marion LEBOYER, Auteur ; Tiziana ZALLA, Auteur ; Sabrina AHADE, Auteur ; Nadia SACHS, Auteur ; Celina PAREDES, Auteur ; Evelyn HERBRECHT, Auteur ; Michèle MONTREUIL, Auteur . - 2010 . - p.85-88. Langues : Français (fre) in Bulletin Scientifique de l'arapi (Le) > 25 (Printemps 2010) . - p.85-88 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=107

Process research in early intensive intervention in autism spectrum disorder: Sensitivity to change of the autism behavior coding system / Evelyn HERBRECHT in Autism Research, 12-12 (December)  

Public ISBD [article]  inAutism Research > 12-12 (December) . - p.1817-1828 Titre : Process research in early intensive intervention in autism spectrum disorder: Sensitivity to change of the autism behavior coding system Type de document : texte imprimé Auteurs : Evelyn HERBRECHT, Auteur ; Olga LAZARI, Auteur ; Marianne NOTTER, Auteur ; Klaus SCHMECK, Auteur ; René SPIEGEL, Auteur Année de publication : 2019 Article en page(s) : p.1817-1828 Langues : Anglais (eng) Mots-clés : Abcs  autism spectrum disorder  early intensive intervention  process research  sensitivity to change Index. décimale : PER Périodiques Résumé : The development of sensitive measures to capture changes in core autism symptoms is crucial in early intervention research. The study examines the sensitivity to change of the Autism Behavior Coding System (ABCS), a video-based instrument to assess core autism symptoms during therapist-child interaction. Video sequences of 40 young children treated in the Fruhintervention bei Autistischen Storungen center were analyzed with regard to the question of whether short-term changes during an 18 day period of early intervention could be captured, and whether these results are reflected in an independent clinical assessment (Developmental Disorders-Child-Global Assessment Scale [DD-C-GAS]). ABCS results showed statistically significant improvements on behavioral domains such as "expression of wishes" and "social cooperative behavior" (P < 0.01), less pronounced on "eye contact." Improvements on the DD-C-GAS were highly significant on all subdomains. Both scales showed high correlations within their subdomains, yet no significant correlations between the changes in both instruments' scores were found. An additional analysis between the DD-C-GAS scores at day 18 and the changes in the ABCS scores showed statistically significant associations in the expected direction between the changes in the variable "eye contact" and all DD-C-GAS subdomains. The correspondence of the two levels of assessment is low, but the specifics of this relationship deserve further study. The ABCS may prove useful in addition to standard assessment tools, especially in early intervention research settings, as it allows reliable analysis of core behavioral elements in young children with autism. Autism Res 2019, 12: 1817-1828. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: The study examined the sensitivity of an autism-specific video coding system (ABCS) in assessing changes after an 18 day period of intensive early intervention. Video sequences of therapist-child-interaction of 40 young children with autism spectrum disorder (ASD) were analyzed. Children's behavior improved in expression of wishes, social cooperativity and eye contact. A therapist-based global assessment scale also showed important improvement after 18 days, yet both assessment instruments showed weak correlations between their respective changes. We showed that the ABCS may prove useful in capturing short-term changes in autism-related behaviors, especially in early intervention research. En ligne : http://dx.doi.org/10.1002/aur.2188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413 [article] Process research in early intensive intervention in autism spectrum disorder: Sensitivity to change of the autism behavior coding system [texte imprimé] / Evelyn HERBRECHT, Auteur ; Olga LAZARI, Auteur ; Marianne NOTTER, Auteur ; Klaus SCHMECK, Auteur ; René SPIEGEL, Auteur . - 2019 . - p.1817-1828. Langues : Anglais (eng) in Autism Research > 12-12 (December) . - p.1817-1828 Mots-clés : Abcs  autism spectrum disorder  early intensive intervention  process research  sensitivity to change Index. décimale : PER Périodiques Résumé : The development of sensitive measures to capture changes in core autism symptoms is crucial in early intervention research. The study examines the sensitivity to change of the Autism Behavior Coding System (ABCS), a video-based instrument to assess core autism symptoms during therapist-child interaction. Video sequences of 40 young children treated in the Fruhintervention bei Autistischen Storungen center were analyzed with regard to the question of whether short-term changes during an 18 day period of early intervention could be captured, and whether these results are reflected in an independent clinical assessment (Developmental Disorders-Child-Global Assessment Scale [DD-C-GAS]). ABCS results showed statistically significant improvements on behavioral domains such as "expression of wishes" and "social cooperative behavior" (P < 0.01), less pronounced on "eye contact." Improvements on the DD-C-GAS were highly significant on all subdomains. Both scales showed high correlations within their subdomains, yet no significant correlations between the changes in both instruments' scores were found. An additional analysis between the DD-C-GAS scores at day 18 and the changes in the ABCS scores showed statistically significant associations in the expected direction between the changes in the variable "eye contact" and all DD-C-GAS subdomains. The correspondence of the two levels of assessment is low, but the specifics of this relationship deserve further study. The ABCS may prove useful in addition to standard assessment tools, especially in early intervention research settings, as it allows reliable analysis of core behavioral elements in young children with autism. Autism Res 2019, 12: 1817-1828. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: The study examined the sensitivity of an autism-specific video coding system (ABCS) in assessing changes after an 18 day period of intensive early intervention. Video sequences of therapist-child-interaction of 40 young children with autism spectrum disorder (ASD) were analyzed. Children's behavior improved in expression of wishes, social cooperativity and eye contact. A therapist-based global assessment scale also showed important improvement after 18 days, yet both assessment instruments showed weak correlations between their respective changes. We showed that the ABCS may prove useful in capturing short-term changes in autism-related behaviors, especially in early intervention research. En ligne : http://dx.doi.org/10.1002/aur.2188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413

A randomized cross-over trial investigating the neurocognitive effects of acute exercise on face recognition in children with autism spectrum disorder / Sebastian LUDYGA in Autism Research, 16-8 (August 2023)  

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