Beyond Gaze: Affective Synchrony and Sensory-Linked Interactional Profiles as Early Markers of Autism Risk / Lan LIN in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70209 Titre : Beyond Gaze: Affective Synchrony and Sensory-Linked Interactional Profiles as Early Markers of Autism Risk Type de document : texte imprimé Auteurs : Lan LIN, Auteur ; Qian LI, Auteur ; Zenghe YUE, Auteur ; Yaxin DAI, Auteur ; Haozhen CHEN, Auteur ; Yuheng CHEN, Auteur ; Jinyi ZHU, Auteur ; Yazhu HAN, Auteur ; Shengjian YIN, Auteur ; Luyang GUAN, Auteur ; Xiaoyan KE, Auteur Article en page(s) : e70209 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  early identification  high-risk infants  interpersonal affect synchrony  mutual gaze  parent–child interaction  sensory processing Index. décimale : PER Périodiques Résumé : ABSTRACT Identifying early markers for autism spectrum disorder (ASD) is a clinical priority. This study investigated interpersonal affect synchrony (IAS) as a measure of interactional quality in a longitudinal cohort of 90 high-risk infants. We aimed to disentangle its contribution from mutual gaze and identify data-driven social interaction profiles linked to sensory traits. Parent-infant interactions were recorded at 6?18?months; IAS was quantified using Cross-Recurrence Quantification Analysis, and ASD outcomes were determined at 18?24?months. Infants later diagnosed with ASD (n?=?25) showed significantly lower IAS (F(1,84)?=?5.89, p FDR?=?0.023) and synchrony stability (F(1,84)?=?5.37, p FDR?=?0.023) than non-diagnosed infants (n?=?65), yet the groups did not differ in mutual gaze (p?=?0.200). Logistic regression analysis further showed that IAS (OR?=?0.561, p FDR?=?0.038) and synchrony stability (OR?=?0.013, p FDR?=?0.038) both significantly predict clinical outcome. K-means clustering revealed three profiles: ?High Gaze-High Synchrony,? ?Mid Gaze-Low Synchrony,? and ?Low Gaze-High Synchrony.? The ?Mid Gaze-Low Synchrony? profile was significantly associated with a later ASD diagnosis (p adj?=?0.031), while the ?Low Gaze-High Synchrony? profile was linked to higher sensation-seeking traits (p adj?=?0.028). The quality of parent-infant affective connection is a more robust early marker for ASD than the quantity of mutual gaze. These findings reveal critical heterogeneity, identifying a high-risk ?gaze without engagement? pattern and a potential adaptive pathway to synchrony, underscoring the need for individualized strategies in early screening and intervention. En ligne : https://doi.org/10.1002/aur.70209 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Beyond Gaze: Affective Synchrony and Sensory-Linked Interactional Profiles as Early Markers of Autism Risk [texte imprimé] / Lan LIN, Auteur ; Qian LI, Auteur ; Zenghe YUE, Auteur ; Yaxin DAI, Auteur ; Haozhen CHEN, Auteur ; Yuheng CHEN, Auteur ; Jinyi ZHU, Auteur ; Yazhu HAN, Auteur ; Shengjian YIN, Auteur ; Luyang GUAN, Auteur ; Xiaoyan KE, Auteur . - e70209. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70209 Mots-clés : autism spectrum disorder  early identification  high-risk infants  interpersonal affect synchrony  mutual gaze  parent–child interaction  sensory processing Index. décimale : PER Périodiques Résumé : ABSTRACT Identifying early markers for autism spectrum disorder (ASD) is a clinical priority. This study investigated interpersonal affect synchrony (IAS) as a measure of interactional quality in a longitudinal cohort of 90 high-risk infants. We aimed to disentangle its contribution from mutual gaze and identify data-driven social interaction profiles linked to sensory traits. Parent-infant interactions were recorded at 6?18?months; IAS was quantified using Cross-Recurrence Quantification Analysis, and ASD outcomes were determined at 18?24?months. Infants later diagnosed with ASD (n?=?25) showed significantly lower IAS (F(1,84)?=?5.89, p FDR?=?0.023) and synchrony stability (F(1,84)?=?5.37, p FDR?=?0.023) than non-diagnosed infants (n?=?65), yet the groups did not differ in mutual gaze (p?=?0.200). Logistic regression analysis further showed that IAS (OR?=?0.561, p FDR?=?0.038) and synchrony stability (OR?=?0.013, p FDR?=?0.038) both significantly predict clinical outcome. K-means clustering revealed three profiles: ?High Gaze-High Synchrony,? ?Mid Gaze-Low Synchrony,? and ?Low Gaze-High Synchrony.? The ?Mid Gaze-Low Synchrony? profile was significantly associated with a later ASD diagnosis (p adj?=?0.031), while the ?Low Gaze-High Synchrony? profile was linked to higher sensation-seeking traits (p adj?=?0.028). The quality of parent-infant affective connection is a more robust early marker for ASD than the quantity of mutual gaze. These findings reveal critical heterogeneity, identifying a high-risk ?gaze without engagement? pattern and a potential adaptive pathway to synchrony, underscoring the need for individualized strategies in early screening and intervention. En ligne : https://doi.org/10.1002/aur.70209 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Cross-Cultural Generalizability of the First Year Inventory for Early ASD Screening in China / Qingyao ZHU ; Tianshu GAO ; Kaiyan GAN ; Fei WANG ; Luyang GUAN ; Xiaoyan KE in Journal of Autism and Developmental Disorders, 55-7 (July 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-7 (July 2025) . - p.2480-2491 Titre : Cross-Cultural Generalizability of the First Year Inventory for Early ASD Screening in China Type de document : texte imprimé Auteurs : Qingyao ZHU, Auteur ; Tianshu GAO, Auteur ; Kaiyan GAN, Auteur ; Fei WANG, Auteur ; Luyang GUAN, Auteur ; Xiaoyan KE, Auteur Article en page(s) : p.2480-2491 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The First Year Inventory (FYI) is a parent report screening measure, aimed at identifying the risk of autism spectrum disorder (ASD) in 12-month-old infants. This study aimed to investigate the utility of FYI within the Chinese community and develop a short version, encompassing both a low-risk sample and a high-risk sample comprising infants with older siblings diagnosed with ASD. Parents of 53 high-risk (HR) infants and 519 low-risk (LR) infants, aged 11 to 13 months, were recruited. After comparing response distributions across Chinese and American samples, a new factorial structure was developed according to the factor analyses. The construct validity and internal consistency of the two FYI versions were examined. The implementation of FYI in the HR sample was also assessed. Noteworthy disparities in response distribution were observed between the Chinese and American samples. Both FYI 2.0 and the FYI short version demonstrated moderate construct validity and internal consistency, with the FYI short version exhibiting better predictive ability in the HR sample. Significant lower risk scores was observed in the HR sample compared to the LR sample. These findings substantiate the applicability and validity of the Chinese short version of FYI. Future research should include follow-up assessments with the Chinese sample to evaluate cutoff scores, considering the cutoff between sensitivity and specificity and the sample?s characteristics. En ligne : https://doi.org/10.1007/s10803-024-06358-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559 [article] Cross-Cultural Generalizability of the First Year Inventory for Early ASD Screening in China [texte imprimé] / Qingyao ZHU, Auteur ; Tianshu GAO, Auteur ; Kaiyan GAN, Auteur ; Fei WANG, Auteur ; Luyang GUAN, Auteur ; Xiaoyan KE, Auteur . - p.2480-2491. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-7 (July 2025) . - p.2480-2491 Index. décimale : PER Périodiques Résumé : The First Year Inventory (FYI) is a parent report screening measure, aimed at identifying the risk of autism spectrum disorder (ASD) in 12-month-old infants. This study aimed to investigate the utility of FYI within the Chinese community and develop a short version, encompassing both a low-risk sample and a high-risk sample comprising infants with older siblings diagnosed with ASD. Parents of 53 high-risk (HR) infants and 519 low-risk (LR) infants, aged 11 to 13 months, were recruited. After comparing response distributions across Chinese and American samples, a new factorial structure was developed according to the factor analyses. The construct validity and internal consistency of the two FYI versions were examined. The implementation of FYI in the HR sample was also assessed. Noteworthy disparities in response distribution were observed between the Chinese and American samples. Both FYI 2.0 and the FYI short version demonstrated moderate construct validity and internal consistency, with the FYI short version exhibiting better predictive ability in the HR sample. Significant lower risk scores was observed in the HR sample compared to the LR sample. These findings substantiate the applicability and validity of the Chinese short version of FYI. Future research should include follow-up assessments with the Chinese sample to evaluate cutoff scores, considering the cutoff between sensitivity and specificity and the sample?s characteristics. En ligne : https://doi.org/10.1007/s10803-024-06358-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559

High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study / Yonglu WANG in Autism Research, 16-10 (October 2023)  

Public ISBD [article]  inAutism Research > 16-10 (October 2023) . - p.2035-2048 Titre : High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study Type de document : texte imprimé Auteurs : Yonglu WANG, Auteur ; Fei WANG, Auteur ; Yue KONG, Auteur ; Tianshu GAO, Auteur ; Qingyao ZHU, Auteur ; Lu HAN, Auteur ; Bei SUN, Auteur ; Luyang GUAN, Auteur ; Ziyi ZHANG, Auteur ; Yuxin QIAN, Auteur ; Lingxi XU, Auteur ; Yun LI, Auteur ; Hui FANG, Auteur ; Gongkai JIAO, Auteur ; Xiaoyan KE, Auteur Article en page(s) : p.2035-2048 Index. décimale : PER Périodiques Résumé : Abstract The purpose of this study was to determine the effect of the Cz of high-definition 5-channel tDCS (HD-tDCS) on social function in 4-12 years-old children with autism spectrum disorder (ASD). This study was a randomized, double-blind, pseudo-controlled trial in which 45 ASD children were recruited and divided into three groups with sex, age, and rehabilitation treatment as control variables. Each group of 15 children with ASD was randomly administered active HD-tDCS with the Cz as the central anode, active HD-tDCS with the left dorsolateral prefrontal cortex (F3) as the central anode, and sham HD-tDCS with the Cz as the central anode with 14 daily sessions in 3 weeks. The Social Responsiveness Scale Chinese Version (SRS-Chinese Version) was compared 1 week after stimulation with values recorded 1 week prior to stimulation. At the end of treatment, both the anodal Cz and anodal left DLFPC tDCS decreased the measures of SRS-Chinese Version. The total score of SRS-Chinese Version decreased by 13.08%, social cognition decreased by 18.33%, and social communication decreased by 10.79%, which were significantly improved over the Cz central anode active stimulation group, especially in children with young age, and middle and low function. There was no significant change in the total score and subscale score of SRS-Chinese Version over the Cz central anode sham stimulation group. In the F3 central anode active stimulation group, the total score of SRS-Chinese Version decreased by 13%, autistic behavior decreased by 19.39%, and social communication decreased by 14.39%, which were all significantly improved. However, there was no significant difference in effect between the Cz and left DLPFC stimulation conditions. HD-tDCS of the Cz central anode may be an effective treatment for social dysfunction in children with ASD. En ligne : https://doi.org/10.1002/aur.3018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study [texte imprimé] / Yonglu WANG, Auteur ; Fei WANG, Auteur ; Yue KONG, Auteur ; Tianshu GAO, Auteur ; Qingyao ZHU, Auteur ; Lu HAN, Auteur ; Bei SUN, Auteur ; Luyang GUAN, Auteur ; Ziyi ZHANG, Auteur ; Yuxin QIAN, Auteur ; Lingxi XU, Auteur ; Yun LI, Auteur ; Hui FANG, Auteur ; Gongkai JIAO, Auteur ; Xiaoyan KE, Auteur . - p.2035-2048. in Autism Research > 16-10 (October 2023) . - p.2035-2048 Index. décimale : PER Périodiques Résumé : Abstract The purpose of this study was to determine the effect of the Cz of high-definition 5-channel tDCS (HD-tDCS) on social function in 4-12 years-old children with autism spectrum disorder (ASD). This study was a randomized, double-blind, pseudo-controlled trial in which 45 ASD children were recruited and divided into three groups with sex, age, and rehabilitation treatment as control variables. Each group of 15 children with ASD was randomly administered active HD-tDCS with the Cz as the central anode, active HD-tDCS with the left dorsolateral prefrontal cortex (F3) as the central anode, and sham HD-tDCS with the Cz as the central anode with 14 daily sessions in 3 weeks. The Social Responsiveness Scale Chinese Version (SRS-Chinese Version) was compared 1 week after stimulation with values recorded 1 week prior to stimulation. At the end of treatment, both the anodal Cz and anodal left DLFPC tDCS decreased the measures of SRS-Chinese Version. The total score of SRS-Chinese Version decreased by 13.08%, social cognition decreased by 18.33%, and social communication decreased by 10.79%, which were significantly improved over the Cz central anode active stimulation group, especially in children with young age, and middle and low function. There was no significant change in the total score and subscale score of SRS-Chinese Version over the Cz central anode sham stimulation group. In the F3 central anode active stimulation group, the total score of SRS-Chinese Version decreased by 13%, autistic behavior decreased by 19.39%, and social communication decreased by 14.39%, which were all significantly improved. However, there was no significant difference in effect between the Cz and left DLPFC stimulation conditions. HD-tDCS of the Cz central anode may be an effective treatment for social dysfunction in children with ASD. En ligne : https://doi.org/10.1002/aur.3018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Machine Learning-Based Early Prediction Model for Autism Spectrum Disorder in Infants Using Acoustic Feature / Shengjian YIN in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70179 Titre : Machine Learning-Based Early Prediction Model for Autism Spectrum Disorder in Infants Using Acoustic Feature Type de document : texte imprimé Auteurs : Shengjian YIN, Auteur ; Zhijia LI, Auteur ; Luyang GUAN, Auteur ; Zenghe YUE, Auteur ; Jincen WANG, Auteur ; Jinyi ZHU, Auteur ; Yazhu HAN, Auteur ; Qian LI, Auteur ; Lan LIN, Auteur ; Yaxin DAI, Auteur ; Haozhen CHEN, Auteur ; Yuheng CHEN, Auteur ; Yun LI, Auteur ; Xiaoyan KE, Auteur Article en page(s) : e70179 Langues : Anglais (eng) Mots-clés : acoustic features  autism spectrum disorder  machine learning  model  support vector machine Index. décimale : PER Périodiques Résumé : ABSTRACT This study aimed to create a machine learning-based predictive model for early detection of autism spectrum disorder (ASD) in infants using acoustic features. Conducted as a prospective cohort at Nanjing Medical University from 2019 to 2024, infants aged 9?18?months from an ASD sibling cohort participated. Behavioral and vocalization data were gathered during the Still-Face Paradigm, with ASD diagnoses confirmed at 36?months through ADOS and ADI-R assessments. Researchers extracted 4368 acoustic features from the recordings and applied LASSO regression for dimensionality reduction, identifying 39 key features. A support vector machine (SVM) classifier was then developed, tested with four kernel functions?linear, radial basis function, polynomial, and sigmoid?via tenfold cross-validation. The final sample included 88 infants, 28 of whom were diagnosed with ASD. The sigmoid kernel yielded the best results, achieving a 92.86% sensitivity, 93.33% specificity, and a 93.18% accuracy. Notably, spectral and energy-related features were significantly higher in ASD infants (p? En ligne : https://doi.org/10.1002/aur.70179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Machine Learning-Based Early Prediction Model for Autism Spectrum Disorder in Infants Using Acoustic Feature [texte imprimé] / Shengjian YIN, Auteur ; Zhijia LI, Auteur ; Luyang GUAN, Auteur ; Zenghe YUE, Auteur ; Jincen WANG, Auteur ; Jinyi ZHU, Auteur ; Yazhu HAN, Auteur ; Qian LI, Auteur ; Lan LIN, Auteur ; Yaxin DAI, Auteur ; Haozhen CHEN, Auteur ; Yuheng CHEN, Auteur ; Yun LI, Auteur ; Xiaoyan KE, Auteur . - e70179. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70179 Mots-clés : acoustic features  autism spectrum disorder  machine learning  model  support vector machine Index. décimale : PER Périodiques Résumé : ABSTRACT This study aimed to create a machine learning-based predictive model for early detection of autism spectrum disorder (ASD) in infants using acoustic features. Conducted as a prospective cohort at Nanjing Medical University from 2019 to 2024, infants aged 9?18?months from an ASD sibling cohort participated. Behavioral and vocalization data were gathered during the Still-Face Paradigm, with ASD diagnoses confirmed at 36?months through ADOS and ADI-R assessments. Researchers extracted 4368 acoustic features from the recordings and applied LASSO regression for dimensionality reduction, identifying 39 key features. A support vector machine (SVM) classifier was then developed, tested with four kernel functions?linear, radial basis function, polynomial, and sigmoid?via tenfold cross-validation. The final sample included 88 infants, 28 of whom were diagnosed with ASD. The sigmoid kernel yielded the best results, achieving a 92.86% sensitivity, 93.33% specificity, and a 93.18% accuracy. Notably, spectral and energy-related features were significantly higher in ASD infants (p? En ligne : https://doi.org/10.1002/aur.70179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Risk factors and clinical characteristics of autism spectrum disorder with regression in China / Lu HAN in Autism Research, 16-9 (September 2023)  

Public ISBD [article]  inAutism Research > 16-9 (September 2023) . - p.1836-1846 Titre : Risk factors and clinical characteristics of autism spectrum disorder with regression in China Type de document : texte imprimé Auteurs : Lu HAN, Auteur ; Luyang GUAN, Auteur ; Ziyi ZHANG, Auteur ; Wenqing LI, Auteur ; Jinhui LI, Auteur ; Chenxi BAO, Auteur ; Mei YE, Auteur ; Min TANG, Auteur ; Xiaoyan KE, Auteur Article en page(s) : p.1836-1846 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder with regression (ASD-R) is characterized by the loss of previously acquired skills during the initial year of life. This study aimed to investigate the clinical characteristics, patterns of regression, and potential risk factors associated with ASD-R in the Chinese Han population. A case-control study was conducted between September 2020 and March 2022. A total of 186 children were enrolled, including 58 children with ASD-R, 70 with ASD without regression (ASD-NR), and 58 typically developing children. Demographic information, clinical characteristics, and potential risk factors related to ASD-R were assessed using a combination of questionnaires, interviews, and physician assessments. The results revealed that children with ASD-R exhibited more severe impairments in social communication and stereotyped behaviors compared with those with ASD-NR. Language regression, constituting 40% of cases within the ASD-R group, was found to be the most common type of regression. Furthermore, our analysis revealed that fever (OR=4.01, 95% CI: 1.26-12.76) and diarrhea (OR=6.32, 95% CI: 1.38-29.03) were identified as significant risk factors for ASD-R. These findings contribute to our understanding of the heterogeneity of ASD and highlight the importance of considering immune responses and gastrointestinal factors in the etiology of ASD-R. En ligne : https://doi.org/10.1002/aur.3008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Risk factors and clinical characteristics of autism spectrum disorder with regression in China [texte imprimé] / Lu HAN, Auteur ; Luyang GUAN, Auteur ; Ziyi ZHANG, Auteur ; Wenqing LI, Auteur ; Jinhui LI, Auteur ; Chenxi BAO, Auteur ; Mei YE, Auteur ; Min TANG, Auteur ; Xiaoyan KE, Auteur . - p.1836-1846. Langues : Anglais (eng) in Autism Research > 16-9 (September 2023) . - p.1836-1846 Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder with regression (ASD-R) is characterized by the loss of previously acquired skills during the initial year of life. This study aimed to investigate the clinical characteristics, patterns of regression, and potential risk factors associated with ASD-R in the Chinese Han population. A case-control study was conducted between September 2020 and March 2022. A total of 186 children were enrolled, including 58 children with ASD-R, 70 with ASD without regression (ASD-NR), and 58 typically developing children. Demographic information, clinical characteristics, and potential risk factors related to ASD-R were assessed using a combination of questionnaires, interviews, and physician assessments. The results revealed that children with ASD-R exhibited more severe impairments in social communication and stereotyped behaviors compared with those with ASD-NR. Language regression, constituting 40% of cases within the ASD-R group, was found to be the most common type of regression. Furthermore, our analysis revealed that fever (OR=4.01, 95% CI: 1.26-12.76) and diarrhea (OR=6.32, 95% CI: 1.38-29.03) were identified as significant risk factors for ASD-R. These findings contribute to our understanding of the heterogeneity of ASD and highlight the importance of considering immune responses and gastrointestinal factors in the etiology of ASD-R. En ligne : https://doi.org/10.1002/aur.3008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

---

1 (1 - 5 / 5) Par page : 25 50 100 200