Clinical spectrum of congenital optic nerve hypoplasia: review of 51 patients / Dov MARGALITH in Developmental Medicine & Child Neurology, 26-3 (June 1984)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 26-3 (June 1984) . - p.311-322 Titre : Clinical spectrum of congenital optic nerve hypoplasia: review of 51 patients Type de document : Texte imprimé et/ou numérique Auteurs : Dov MARGALITH, Auteur ; James E. JAN, Auteur ; Andrew Q. MCCORMICK, Auteur ; Wah Jun TZE, Auteur ; Jocelyne LAPOINTE, Auteur Année de publication : 1984 Article en page(s) : p.311-322 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Fifty-one patients with congenital optic nerve hypoplasia (CONH) were reviewed. It was found that the risk of having an affected child is higher in an adolescent mother, and that maternal alcohol or drug abuse may be important factors. Frequently the disorder is associated with other neuropsychiatric handicaps, and with neuro-endocrine abnormalities. The findings suggest that CONH probably is not a homogeneous group of disorders; some may be caused by primary failure of differentiation of the retinal ganglion cells, while others may be the product of an acquired transsynaptic degeneration of optic-nerve fibres. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Clinical spectrum of congenital optic nerve hypoplasia: review of 51 patients [Texte imprimé et/ou numérique] / Dov MARGALITH, Auteur ; James E. JAN, Auteur ; Andrew Q. MCCORMICK, Auteur ; Wah Jun TZE, Auteur ; Jocelyne LAPOINTE, Auteur . - 1984 . - p.311-322. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 26-3 (June 1984) . - p.311-322 Index. décimale : PER Périodiques Résumé : Fifty-one patients with congenital optic nerve hypoplasia (CONH) were reviewed. It was found that the risk of having an affected child is higher in an adolescent mother, and that maternal alcohol or drug abuse may be important factors. Frequently the disorder is associated with other neuropsychiatric handicaps, and with neuro-endocrine abnormalities. The findings suggest that CONH probably is not a homogeneous group of disorders; some may be caused by primary failure of differentiation of the retinal ganglion cells, while others may be the product of an acquired transsynaptic degeneration of optic-nerve fibres. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

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