Personalized estimates of brain cortical structural variability in individuals with Autism spectrum disorder: the predictor of brain age and neurobiology relevance / Jie SUN ; Weiqi MAN ; Zhang ZHANG ; Ningnannan ZHANG in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 27 p. Titre : Personalized estimates of brain cortical structural variability in individuals with Autism spectrum disorder: the predictor of brain age and neurobiology relevance Type de document : texte imprimé Auteurs : Jie SUN, Auteur ; Weiqi MAN, Auteur ; Zhang ZHANG, Auteur ; Ningnannan ZHANG, Auteur Article en page(s) : 27 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a heritable condition related to brain development that affects a person's perception and socialization with others. Here, we examined variability in the brain morphology in ASD children and adolescent individuals at the level of brain cortical structural profiles and the level of each brain regional measure. METHODS: We selected brain structural MRI data in 600 ASDs and 729 normal controls (NCs) from Autism Brain Imaging Data Exchange (ABIDE). The personalized estimate of similarity between gray matter volume (GMV) profiles of an individual to that of others in the same group was assessed by using the person-based similarity index (PBSI). Regional contributions to PBSI score were utilized for brain age gap estimation (BrainAGE) prediction model establishment, including support vector regression (SVR), relevance vector regression (RVR), and Gaussian process regression (GPR). The association between BrainAGE prediction in ASD and clinical performance was investigated. We further explored the related inter-regional profiles of gene expression from the Allen Human Brain Atlas with variability differences in the brain morphology between groups. RESULTS: The PBSI score of GMV was negatively related to age regardless of the sample group, and the PBSI score was significantly lower in ASDs than in NCs. The regional contributions to the PBSI score of 126 brain regions in ASDs showed significant differences compared to NCs. RVR model achieved the best performance for predicting brain age. Higher inter-individual brain morphology variability was related to increased brain age, specific to communication symptoms. A total of 430 genes belonging to various pathways were identified as associated with brain cortical morphometric variation. The pathways, including short-term memory, regulation of system process, and regulation of nervous system process, were dominated mainly by gene sets for manno midbrain neurotypes. LIMITATIONS: There is a sample mismatch between the gene expression data and brain imaging data from ABIDE. A larger sample size can contribute to the model training of BrainAGE and the validation of the results. CONCLUSIONS: ASD has personalized heterogeneity brain morphology. The brain age gap estimation and transcription-neuroimaging associations derived from this trait are replenished in an additional direction to boost the understanding of the ASD brain. En ligne : http://dx.doi.org/10.1186/s13229-023-00558-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Personalized estimates of brain cortical structural variability in individuals with Autism spectrum disorder: the predictor of brain age and neurobiology relevance [texte imprimé] / Jie SUN, Auteur ; Weiqi MAN, Auteur ; Zhang ZHANG, Auteur ; Ningnannan ZHANG, Auteur . - 27 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 27 p. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a heritable condition related to brain development that affects a person's perception and socialization with others. Here, we examined variability in the brain morphology in ASD children and adolescent individuals at the level of brain cortical structural profiles and the level of each brain regional measure. METHODS: We selected brain structural MRI data in 600 ASDs and 729 normal controls (NCs) from Autism Brain Imaging Data Exchange (ABIDE). The personalized estimate of similarity between gray matter volume (GMV) profiles of an individual to that of others in the same group was assessed by using the person-based similarity index (PBSI). Regional contributions to PBSI score were utilized for brain age gap estimation (BrainAGE) prediction model establishment, including support vector regression (SVR), relevance vector regression (RVR), and Gaussian process regression (GPR). The association between BrainAGE prediction in ASD and clinical performance was investigated. We further explored the related inter-regional profiles of gene expression from the Allen Human Brain Atlas with variability differences in the brain morphology between groups. RESULTS: The PBSI score of GMV was negatively related to age regardless of the sample group, and the PBSI score was significantly lower in ASDs than in NCs. The regional contributions to the PBSI score of 126 brain regions in ASDs showed significant differences compared to NCs. RVR model achieved the best performance for predicting brain age. Higher inter-individual brain morphology variability was related to increased brain age, specific to communication symptoms. A total of 430 genes belonging to various pathways were identified as associated with brain cortical morphometric variation. The pathways, including short-term memory, regulation of system process, and regulation of nervous system process, were dominated mainly by gene sets for manno midbrain neurotypes. LIMITATIONS: There is a sample mismatch between the gene expression data and brain imaging data from ABIDE. A larger sample size can contribute to the model training of BrainAGE and the validation of the results. CONCLUSIONS: ASD has personalized heterogeneity brain morphology. The brain age gap estimation and transcription-neuroimaging associations derived from this trait are replenished in an additional direction to boost the understanding of the ASD brain. En ligne : http://dx.doi.org/10.1186/s13229-023-00558-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Pictures or texts: Eye gazing patterns of preschoolers with ASD in picture book reading / Huilin LUO in Research in Autism, 137 (September 2026)  

Public ISBD [article]  inResearch in Autism > 137 (September 2026) . - 202990 Titre : Pictures or texts: Eye gazing patterns of preschoolers with ASD in picture book reading Type de document : texte imprimé Auteurs : Huilin LUO, Auteur ; Xinyue PENG, Auteur ; Jie SUN, Auteur ; Jing ZHAO, Auteur Article en page(s) : 202990 Langues : Anglais (eng) Mots-clés : Children with ASD  Eye-tracking  Picture book reading  Orthographic awareness Index. décimale : PER Périodiques Résumé : This study aimed to compare the eye-gazing patterns of children with autism spectrum disorder (ASD) during picture book reading, based on their distinct reading profiles. Eighty-one children with ASD were divided into three groups based on reading assessments: ASD with imbalanced reading profile (high word reading but low comprehension; n = 32), ASD with average reading profile (n = 25), and ASD with low reading profile (n = 24). A control group of 32 TD children was matched on age and Chinese orthographic symbols (i.e., character) recognition to the imbalanced and average reading profiles groups. Eye-tracking was used to measure fixation duration, fixation numbers, and fixation density on pictures and texts while participants read a picture book under three orthographic symbol conditions: common, rare, and foreign characters. Children with ASD and imbalanced reading profiles demonstrated statistically significantly longer fixation duration on text and shorter fixations on pictures compared to all other groups (ASD average, ASD low, and TD). All children exhibited similar fixation durations, fixation numbers, and fixation densities for rare and common characters but had fewer fixations on foreign characters. The findings underscore the critical importance of subgrouping children with ASD by their reading profiles in research, as their cognitive-linguistic profiles significantly influence visual attention during reading. The results highlight the role of orthographic awareness in character recognition and suggest that imbalanced reading profiles in ASD are characterized by a unique visual attention preference for text over contextual images. En ligne : https://doi.org/10.1016/j.reia.2026.202990 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Pictures or texts: Eye gazing patterns of preschoolers with ASD in picture book reading [texte imprimé] / Huilin LUO, Auteur ; Xinyue PENG, Auteur ; Jie SUN, Auteur ; Jing ZHAO, Auteur . - 202990. Langues : Anglais (eng) in Research in Autism > 137 (September 2026) . - 202990 Mots-clés : Children with ASD  Eye-tracking  Picture book reading  Orthographic awareness Index. décimale : PER Périodiques Résumé : This study aimed to compare the eye-gazing patterns of children with autism spectrum disorder (ASD) during picture book reading, based on their distinct reading profiles. Eighty-one children with ASD were divided into three groups based on reading assessments: ASD with imbalanced reading profile (high word reading but low comprehension; n = 32), ASD with average reading profile (n = 25), and ASD with low reading profile (n = 24). A control group of 32 TD children was matched on age and Chinese orthographic symbols (i.e., character) recognition to the imbalanced and average reading profiles groups. Eye-tracking was used to measure fixation duration, fixation numbers, and fixation density on pictures and texts while participants read a picture book under three orthographic symbol conditions: common, rare, and foreign characters. Children with ASD and imbalanced reading profiles demonstrated statistically significantly longer fixation duration on text and shorter fixations on pictures compared to all other groups (ASD average, ASD low, and TD). All children exhibited similar fixation durations, fixation numbers, and fixation densities for rare and common characters but had fewer fixations on foreign characters. The findings underscore the critical importance of subgrouping children with ASD by their reading profiles in research, as their cognitive-linguistic profiles significantly influence visual attention during reading. The results highlight the role of orthographic awareness in character recognition and suggest that imbalanced reading profiles in ASD are characterized by a unique visual attention preference for text over contextual images. En ligne : https://doi.org/10.1016/j.reia.2026.202990 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

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