Corneal structural alterations in autism spectrum disorder: An in vivo confocal microscopy study / Po-Ying WU ; Jo-Hsuan WU ; Wei-Lun HUANG ; Chia-Chieh HSIAO ; Yi-Ting HSIEH ; Ting CHENG ; Susan Shur-Fen GAU ; Wei-Li CHEN in Autism Research, 16-12 (December 2023)  

Public ISBD [article]  inAutism Research > 16-12 (December 2023) . - p.2316-2325 Titre : Corneal structural alterations in autism spectrum disorder: An in vivo confocal microscopy study Type de document : Texte imprimé et/ou numérique Auteurs : Po-Ying WU, Auteur ; Jo-Hsuan WU, Auteur ; Wei-Lun HUANG, Auteur ; Chia-Chieh HSIAO, Auteur ; Yi-Ting HSIEH, Auteur ; Ting CHENG, Auteur ; Susan Shur-Fen GAU, Auteur ; Wei-Li CHEN, Auteur Article en page(s) : p.2316-2325 Index. décimale : PER Périodiques Résumé : Abstract Individuals with autism spectrum disorder (ASD) often exhibit joint hypermobility and connective tissue disorders. However, it remains unclear if ASD individuals also have structural alterations in the connective tissue of the cornea. This study aims to determine whether the Kobayashi structure (K-structure) characteristics differ between adults with ASD and typically developing controls (TDC) and explore the clinical correlates of the K-structure abnormality. We recruited 30 ASD adults and 35 TDC. Corneal structures, particularly the K-structure in the Bowman's layer, of the participants were examined using in vivo confocal microscopy (IVCM), and a K-grading ranging from 1 to 4 was given to each eye based on the level of morphological mosaicism. The ASD participants' eyes received a significantly higher single-eye K-grading than that of the TDC eyes (p<0.001), and the medians [25th, 75th percentile] of bilateral-eye summed K-grading were 8 [7, 8] and 5 [4, 6] in ASD and TDC, respectively (p<0.001). A significantly higher K-grading in the ASD participants' eyes was still observed after adjusting for the within-subject inter-eye correlation (p<0.001). Youden Index showed the optimal cutoffs to differentiate ASD from TDC by bilateral-eye summed K-grading and single-eye K-grading was >6 and?>3, respectively. Additionally, a higher K-grading was associated with fewer visual sensation seeking in ASD (Spearman's correlation coefficient ? = ?0.518, p = 0.008) and low visual registration (i.e., higher sensory threshold) in TDC (? = 0.446, p = 0.023). This study provided novel evidence of corneal structural alterations in ASD by IVCM. Our findings may not only support the prior hypothesis of the association between ASD and connective tissue abnormalities but also shed light on the relationship between connective tissue disorder and neurodevelopmental disorders. En ligne : https://doi.org/10.1002/aur.3050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 [article] Corneal structural alterations in autism spectrum disorder: An in vivo confocal microscopy study [Texte imprimé et/ou numérique] / Po-Ying WU, Auteur ; Jo-Hsuan WU, Auteur ; Wei-Lun HUANG, Auteur ; Chia-Chieh HSIAO, Auteur ; Yi-Ting HSIEH, Auteur ; Ting CHENG, Auteur ; Susan Shur-Fen GAU, Auteur ; Wei-Li CHEN, Auteur . - p.2316-2325. in Autism Research > 16-12 (December 2023) . - p.2316-2325 Index. décimale : PER Périodiques Résumé : Abstract Individuals with autism spectrum disorder (ASD) often exhibit joint hypermobility and connective tissue disorders. However, it remains unclear if ASD individuals also have structural alterations in the connective tissue of the cornea. This study aims to determine whether the Kobayashi structure (K-structure) characteristics differ between adults with ASD and typically developing controls (TDC) and explore the clinical correlates of the K-structure abnormality. We recruited 30 ASD adults and 35 TDC. Corneal structures, particularly the K-structure in the Bowman's layer, of the participants were examined using in vivo confocal microscopy (IVCM), and a K-grading ranging from 1 to 4 was given to each eye based on the level of morphological mosaicism. The ASD participants' eyes received a significantly higher single-eye K-grading than that of the TDC eyes (p<0.001), and the medians [25th, 75th percentile] of bilateral-eye summed K-grading were 8 [7, 8] and 5 [4, 6] in ASD and TDC, respectively (p<0.001). A significantly higher K-grading in the ASD participants' eyes was still observed after adjusting for the within-subject inter-eye correlation (p<0.001). Youden Index showed the optimal cutoffs to differentiate ASD from TDC by bilateral-eye summed K-grading and single-eye K-grading was >6 and?>3, respectively. Additionally, a higher K-grading was associated with fewer visual sensation seeking in ASD (Spearman's correlation coefficient ? = ?0.518, p = 0.008) and low visual registration (i.e., higher sensory threshold) in TDC (? = 0.446, p = 0.023). This study provided novel evidence of corneal structural alterations in ASD by IVCM. Our findings may not only support the prior hypothesis of the association between ASD and connective tissue abnormalities but also shed light on the relationship between connective tissue disorder and neurodevelopmental disorders. En ligne : https://doi.org/10.1002/aur.3050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518

Ophthalmologic diagnoses in youths with autism spectrum disorder: Prevalence and clinical correlates / Chi-Shin WU in Autism Research, 16-10 (October 2023)  

Public ISBD [article]  inAutism Research > 16-10 (October 2023) . - p.2008-2020 Titre : Ophthalmologic diagnoses in youths with autism spectrum disorder: Prevalence and clinical correlates Type de document : Texte imprimé et/ou numérique Auteurs : Chi-Shin WU, Auteur ; Tzu-Hsun TSAI, Auteur ; Wei-Li CHEN, Auteur ; Hui-Ju TSAI, Auteur ; Yi-Ling CHIEN, Auteur Article en page(s) : p.2008-2020 Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is associated with a high prevalence of visual dysfunction. This study aimed to investigate the rates of amblyopia, refractive errors, and strabismus, as well as their clinical correlates in ASD. This population-based matched-cohort study used data from the Taiwan National Health Insurance Research Database. A total of 3,551 youths with ASD and 35,510 non-autistic control participants matched by age and sex were included. All the participants were followed-up until they were 18?years old. The prevalence of amblyopia, refractive errors, and strabismus was compared between the ASD and control groups. Effect modifiers, including sex, ASD subgroup, and co-diagnosis of intelligence disability, were examined. Compared to the control group, youths with ASD had a significantly increased risk of amblyopia (adjusted odds ratio [aOR]?=?1.75), anisometropia (aOR?=?1.66), astigmatism (aOR?=?1.51), hypermetropia (aOR?=?2.08), exotropia (aOR?=?2.86), and esotropia (aOR?=?2.63), but a comparable likelihood of myopia according to age. Males with ASD had a significantly lower likelihood of exotropia, but a higher likelihood of myopia than females with ASD. The autism subgroup had a higher OR for hypermetropia, but a lower OR for myopia than the other ASD subgroups. ASD youths with intelligence disabilities demonstrated significantly higher ORs for amblyopia, hypermetropia, and all types of strabismus and lower OR for myopia than those without intelligence disabilities. In conclusion, the rates of amblyopia, refractive errors, and strabismus were higher in youths with ASD. Ocular abnormalities in youths with ASD require a comprehensive assessment and management. En ligne : https://doi.org/10.1002/aur.3019 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Ophthalmologic diagnoses in youths with autism spectrum disorder: Prevalence and clinical correlates [Texte imprimé et/ou numérique] / Chi-Shin WU, Auteur ; Tzu-Hsun TSAI, Auteur ; Wei-Li CHEN, Auteur ; Hui-Ju TSAI, Auteur ; Yi-Ling CHIEN, Auteur . - p.2008-2020. in Autism Research > 16-10 (October 2023) . - p.2008-2020 Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is associated with a high prevalence of visual dysfunction. This study aimed to investigate the rates of amblyopia, refractive errors, and strabismus, as well as their clinical correlates in ASD. This population-based matched-cohort study used data from the Taiwan National Health Insurance Research Database. A total of 3,551 youths with ASD and 35,510 non-autistic control participants matched by age and sex were included. All the participants were followed-up until they were 18?years old. The prevalence of amblyopia, refractive errors, and strabismus was compared between the ASD and control groups. Effect modifiers, including sex, ASD subgroup, and co-diagnosis of intelligence disability, were examined. Compared to the control group, youths with ASD had a significantly increased risk of amblyopia (adjusted odds ratio [aOR]?=?1.75), anisometropia (aOR?=?1.66), astigmatism (aOR?=?1.51), hypermetropia (aOR?=?2.08), exotropia (aOR?=?2.86), and esotropia (aOR?=?2.63), but a comparable likelihood of myopia according to age. Males with ASD had a significantly lower likelihood of exotropia, but a higher likelihood of myopia than females with ASD. The autism subgroup had a higher OR for hypermetropia, but a lower OR for myopia than the other ASD subgroups. ASD youths with intelligence disabilities demonstrated significantly higher ORs for amblyopia, hypermetropia, and all types of strabismus and lower OR for myopia than those without intelligence disabilities. In conclusion, the rates of amblyopia, refractive errors, and strabismus were higher in youths with ASD. Ocular abnormalities in youths with ASD require a comprehensive assessment and management. En ligne : https://doi.org/10.1002/aur.3019 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

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