Investigation of retinal layers thicknesses in autism spectrum disorder and comparison with healthy siblings and control group / Kardelen Akbal BA?C? in Research in Autism Spectrum Disorders, 108 (October 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 108 (October 2023) . - p.102242 Titre : Investigation of retinal layers thicknesses in autism spectrum disorder and comparison with healthy siblings and control group Type de document : Texte imprimé et/ou numérique Auteurs : Kardelen Akbal BA?C?, Auteur ; Esra ÇÖP, Auteur ; P?nar Nalçac?o?lu MEMI?, Auteur ; Feyza Dicle I??K, Auteur Article en page(s) : p.102242 Mots-clés : Autism  Siblings  Retina  Segmental analysis  OCT Index. décimale : PER Périodiques Résumé : Background This study aimed to evaluate the segmented peripapillary retina nerve fiber layer (RNFL) and all neurosensorial retinal layer thicknesses of children with autism spectrum disorder (ASD) and compare these parameters with healthy siblings and control by spectral domain optical coherence tomography (SD-OCT). Methods 41 children with ASD, 38 healthy siblings and 43 healthy control were included. Peripapillary RNFL thickness, total macula, inner retinal layers [including macular RNFL, ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL)] and outer retinal layers [including outer plexiform layer (OPL), outer nuclear layer (ONL)] thickness of all participants were measured by SD-OCT. First, the average inner and outer retina layer values were compared between the three groups. Secondly, subsegmental analysis was performed on the layers whose average value was statistically significant. Segmental analysis of all retinal layer thicknesses was evaluated in 9 distinct macular areas defined based on the Early Treatment Diabetic Retinopathy Study Group (ETDS). Results All inner retinal layers thicknesses in children with ASD were found thicker than healthy siblings and control groups. Consistent with these results, the average total macular thickness was statistically significantly thicker in ASD than in healthy siblings and control groups. Conclusion All inner retinal layers were thicker in ASD. Since the retina originates from the same place as the central nervous system, this might reflect the brain abnormalities seen in individuals with ASD. En ligne : https://doi.org/10.1016/j.rasd.2023.102242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514 [article] Investigation of retinal layers thicknesses in autism spectrum disorder and comparison with healthy siblings and control group [Texte imprimé et/ou numérique] / Kardelen Akbal BA?C?, Auteur ; Esra ÇÖP, Auteur ; P?nar Nalçac?o?lu MEMI?, Auteur ; Feyza Dicle I??K, Auteur . - p.102242. in Research in Autism Spectrum Disorders > 108 (October 2023) . - p.102242 Mots-clés : Autism  Siblings  Retina  Segmental analysis  OCT Index. décimale : PER Périodiques Résumé : Background This study aimed to evaluate the segmented peripapillary retina nerve fiber layer (RNFL) and all neurosensorial retinal layer thicknesses of children with autism spectrum disorder (ASD) and compare these parameters with healthy siblings and control by spectral domain optical coherence tomography (SD-OCT). Methods 41 children with ASD, 38 healthy siblings and 43 healthy control were included. Peripapillary RNFL thickness, total macula, inner retinal layers [including macular RNFL, ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL)] and outer retinal layers [including outer plexiform layer (OPL), outer nuclear layer (ONL)] thickness of all participants were measured by SD-OCT. First, the average inner and outer retina layer values were compared between the three groups. Secondly, subsegmental analysis was performed on the layers whose average value was statistically significant. Segmental analysis of all retinal layer thicknesses was evaluated in 9 distinct macular areas defined based on the Early Treatment Diabetic Retinopathy Study Group (ETDS). Results All inner retinal layers thicknesses in children with ASD were found thicker than healthy siblings and control groups. Consistent with these results, the average total macular thickness was statistically significantly thicker in ASD than in healthy siblings and control groups. Conclusion All inner retinal layers were thicker in ASD. Since the retina originates from the same place as the central nervous system, this might reflect the brain abnormalities seen in individuals with ASD. En ligne : https://doi.org/10.1016/j.rasd.2023.102242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514

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