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Retinal alterations in a pre-clinical model of an autism spectrum disorder / E. M. GUIMARAES-SOUZA in Molecular Autism, 10 (2019)
[article]
Titre : Retinal alterations in a pre-clinical model of an autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : E. M. GUIMARAES-SOUZA, Auteur ; C. JOSELEVITCH, Auteur ; L. R. G. BRITTO, Auteur ; S. CHIAVEGATTO, Auteur Article en page(s) : 19 p. Langues : Anglais (eng) Mots-clés : Adolescence Autism gaba Glutamate Neurodevelopment Retina Valproate Vision Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) affect around 1.5% of people worldwide. Symptoms start around age 2, when children fail to maintain eye contact and to develop speech and other forms of communication. Disturbances in glutamatergic and GABAergic signaling that lead to synaptic changes and alter the balance between excitation and inhibition in the developing brain are consistently found in ASD. One of the hallmarks of these disorders is hypersensitivity to sensory stimuli; however, little is known about its underlying causes. Since the retina is the part of the CNS that converts light into a neuronal signal, we set out to study how it is affected in adolescent mice prenatally exposed to valproic acid (VPA), a useful tool to study ASD endophenotypes. Methods: Pregnant female mice received VPA (600 mg/kg, ip) or saline at gestational day 11. Their male adolescent pups (P29-35) were behaviorally tested for anxiety and social interaction. Proteins known to be related with ASD were quantified and visualized in their retinas by immunoassays, and retinal function was assessed by full-field scotopic electroretinograms (ERGs). Results: Early adolescent mice prenatally exposed to VPA displayed impaired social interest and increased anxiety-like behaviors consistent with an ASD phenotype. The expression of GABA, GAD, synapsin-1, and FMRP proteins were reduced in their retinas, while mGluR5 was increased. The a-wave amplitudes of VPA-exposed were smaller than those of CTR animals, whereas the b-wave and oscillatory potentials were normal. Conclusions: This study establishes that adolescent male mice of the VPA-induced ASD model have alterations in retinal function and protein expression compatible with those found in several brain areas of other autism models. These results support the view that synaptic disturbances with excitatory/inhibitory imbalance early in life are associated with ASD and point to the retina as a window to understand their subjacent mechanisms. En ligne : http://dx.doi.org/10.1186/s13229-019-0270-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=398
in Molecular Autism > 10 (2019) . - 19 p.[article] Retinal alterations in a pre-clinical model of an autism spectrum disorder [Texte imprimé et/ou numérique] / E. M. GUIMARAES-SOUZA, Auteur ; C. JOSELEVITCH, Auteur ; L. R. G. BRITTO, Auteur ; S. CHIAVEGATTO, Auteur . - 19 p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 19 p.
Mots-clés : Adolescence Autism gaba Glutamate Neurodevelopment Retina Valproate Vision Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) affect around 1.5% of people worldwide. Symptoms start around age 2, when children fail to maintain eye contact and to develop speech and other forms of communication. Disturbances in glutamatergic and GABAergic signaling that lead to synaptic changes and alter the balance between excitation and inhibition in the developing brain are consistently found in ASD. One of the hallmarks of these disorders is hypersensitivity to sensory stimuli; however, little is known about its underlying causes. Since the retina is the part of the CNS that converts light into a neuronal signal, we set out to study how it is affected in adolescent mice prenatally exposed to valproic acid (VPA), a useful tool to study ASD endophenotypes. Methods: Pregnant female mice received VPA (600 mg/kg, ip) or saline at gestational day 11. Their male adolescent pups (P29-35) were behaviorally tested for anxiety and social interaction. Proteins known to be related with ASD were quantified and visualized in their retinas by immunoassays, and retinal function was assessed by full-field scotopic electroretinograms (ERGs). Results: Early adolescent mice prenatally exposed to VPA displayed impaired social interest and increased anxiety-like behaviors consistent with an ASD phenotype. The expression of GABA, GAD, synapsin-1, and FMRP proteins were reduced in their retinas, while mGluR5 was increased. The a-wave amplitudes of VPA-exposed were smaller than those of CTR animals, whereas the b-wave and oscillatory potentials were normal. Conclusions: This study establishes that adolescent male mice of the VPA-induced ASD model have alterations in retinal function and protein expression compatible with those found in several brain areas of other autism models. These results support the view that synaptic disturbances with excitatory/inhibitory imbalance early in life are associated with ASD and point to the retina as a window to understand their subjacent mechanisms. En ligne : http://dx.doi.org/10.1186/s13229-019-0270-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=398 Investigation of retinal layers thicknesses in autism spectrum disorder and comparison with healthy siblings and control group / Kardelen Akbal BA?C? in Research in Autism Spectrum Disorders, 108 (October 2023)
[article]
Titre : Investigation of retinal layers thicknesses in autism spectrum disorder and comparison with healthy siblings and control group Type de document : Texte imprimé et/ou numérique Auteurs : Kardelen Akbal BA?C?, Auteur ; Esra ÇÖP, Auteur ; P?nar Nalçac?o?lu MEMI?, Auteur ; Feyza Dicle I??K, Auteur Article en page(s) : p.102242 Mots-clés : Autism Siblings Retina Segmental analysis OCT Index. décimale : PER Périodiques Résumé : Background This study aimed to evaluate the segmented peripapillary retina nerve fiber layer (RNFL) and all neurosensorial retinal layer thicknesses of children with autism spectrum disorder (ASD) and compare these parameters with healthy siblings and control by spectral domain optical coherence tomography (SD-OCT). Methods 41 children with ASD, 38 healthy siblings and 43 healthy control were included. Peripapillary RNFL thickness, total macula, inner retinal layers [including macular RNFL, ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL)] and outer retinal layers [including outer plexiform layer (OPL), outer nuclear layer (ONL)] thickness of all participants were measured by SD-OCT. First, the average inner and outer retina layer values were compared between the three groups. Secondly, subsegmental analysis was performed on the layers whose average value was statistically significant. Segmental analysis of all retinal layer thicknesses was evaluated in 9 distinct macular areas defined based on the Early Treatment Diabetic Retinopathy Study Group (ETDS). Results All inner retinal layers thicknesses in children with ASD were found thicker than healthy siblings and control groups. Consistent with these results, the average total macular thickness was statistically significantly thicker in ASD than in healthy siblings and control groups. Conclusion All inner retinal layers were thicker in ASD. Since the retina originates from the same place as the central nervous system, this might reflect the brain abnormalities seen in individuals with ASD. En ligne : https://doi.org/10.1016/j.rasd.2023.102242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514
in Research in Autism Spectrum Disorders > 108 (October 2023) . - p.102242[article] Investigation of retinal layers thicknesses in autism spectrum disorder and comparison with healthy siblings and control group [Texte imprimé et/ou numérique] / Kardelen Akbal BA?C?, Auteur ; Esra ÇÖP, Auteur ; P?nar Nalçac?o?lu MEMI?, Auteur ; Feyza Dicle I??K, Auteur . - p.102242.
in Research in Autism Spectrum Disorders > 108 (October 2023) . - p.102242
Mots-clés : Autism Siblings Retina Segmental analysis OCT Index. décimale : PER Périodiques Résumé : Background This study aimed to evaluate the segmented peripapillary retina nerve fiber layer (RNFL) and all neurosensorial retinal layer thicknesses of children with autism spectrum disorder (ASD) and compare these parameters with healthy siblings and control by spectral domain optical coherence tomography (SD-OCT). Methods 41 children with ASD, 38 healthy siblings and 43 healthy control were included. Peripapillary RNFL thickness, total macula, inner retinal layers [including macular RNFL, ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL)] and outer retinal layers [including outer plexiform layer (OPL), outer nuclear layer (ONL)] thickness of all participants were measured by SD-OCT. First, the average inner and outer retina layer values were compared between the three groups. Secondly, subsegmental analysis was performed on the layers whose average value was statistically significant. Segmental analysis of all retinal layer thicknesses was evaluated in 9 distinct macular areas defined based on the Early Treatment Diabetic Retinopathy Study Group (ETDS). Results All inner retinal layers thicknesses in children with ASD were found thicker than healthy siblings and control groups. Consistent with these results, the average total macular thickness was statistically significantly thicker in ASD than in healthy siblings and control groups. Conclusion All inner retinal layers were thicker in ASD. Since the retina originates from the same place as the central nervous system, this might reflect the brain abnormalities seen in individuals with ASD. En ligne : https://doi.org/10.1016/j.rasd.2023.102242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514