Peripheral markers of nitrosative stress in children with autism spectrum disorder and bipolar disorder comorbidity during euthymic phase / Ali KARAYAGMURLU ; Canan KUCUKGERGIN ; Ilknur BINGUL ; Murat COSKUN in Research in Autism Spectrum Disorders, 109 (November 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 109 (November 2023) . - 102259 Titre : Peripheral markers of nitrosative stress in children with autism spectrum disorder and bipolar disorder comorbidity during euthymic phase Type de document : Texte imprimé et/ou numérique Auteurs : Ali KARAYAGMURLU, Auteur ; Canan KUCUKGERGIN, Auteur ; Ilknur BINGUL, Auteur ; Murat COSKUN, Auteur Article en page(s) : 102259 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Bipolar disorder  Biomarker  Nitrosative stress  Nitric oxide  3-nitrotyrosine  Nitric oxide synthetase Index. décimale : PER Périodiques Résumé : Background Bipolar Disorder (BD) is often comorbid with Autism Spectrum Disorder (ASD) (Skokauskas & Frodl, 2015). However, to our knowledge, the etiological pathways of BD comorbidity in individuals with ASD was not given a particular focus in the literature. The present study aims to investigate the link between BD comorbidity and nitrosative stress in children and adolescents with ASD. Method The case group consisted of 41 participants with comorbid ASD and BD, while the control group consisted of 39 participants with ASD who did not have any past or present mood disorders. As indicators of nitrosative stress, serum levels of NO (Nitric Oxide), NO2/NO3 (Nitrite/Nitrate), 3-NT (3-Nitrotyrosine) and NOS-I (Nitric Oxide Synthetase-I) were compared between groups. Results Serum levels of NO and 3-NT were significantly higher in the case group. As the phenomenological findings of BD, the age of onset was 10.5, mixed attack rate was 70%, seasonality rate was 63.8%, and sub-threshold symptoms were seen in 36.6% of the cases. Conclusion The present study indicated a relationship between BD comorbidity and nitrosative stress cascade among children and adolescents with ASD. Further studies with larger samples are needed to better understand the etiology of BD comorbidity in patients with ASD. En ligne : https://doi.org/10.1016/j.rasd.2023.102259 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Peripheral markers of nitrosative stress in children with autism spectrum disorder and bipolar disorder comorbidity during euthymic phase [Texte imprimé et/ou numérique] / Ali KARAYAGMURLU, Auteur ; Canan KUCUKGERGIN, Auteur ; Ilknur BINGUL, Auteur ; Murat COSKUN, Auteur . - 102259. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 109 (November 2023) . - 102259 Mots-clés : Autism spectrum disorder  Bipolar disorder  Biomarker  Nitrosative stress  Nitric oxide  3-nitrotyrosine  Nitric oxide synthetase Index. décimale : PER Périodiques Résumé : Background Bipolar Disorder (BD) is often comorbid with Autism Spectrum Disorder (ASD) (Skokauskas & Frodl, 2015). However, to our knowledge, the etiological pathways of BD comorbidity in individuals with ASD was not given a particular focus in the literature. The present study aims to investigate the link between BD comorbidity and nitrosative stress in children and adolescents with ASD. Method The case group consisted of 41 participants with comorbid ASD and BD, while the control group consisted of 39 participants with ASD who did not have any past or present mood disorders. As indicators of nitrosative stress, serum levels of NO (Nitric Oxide), NO2/NO3 (Nitrite/Nitrate), 3-NT (3-Nitrotyrosine) and NOS-I (Nitric Oxide Synthetase-I) were compared between groups. Results Serum levels of NO and 3-NT were significantly higher in the case group. As the phenomenological findings of BD, the age of onset was 10.5, mixed attack rate was 70%, seasonality rate was 63.8%, and sub-threshold symptoms were seen in 36.6% of the cases. Conclusion The present study indicated a relationship between BD comorbidity and nitrosative stress cascade among children and adolescents with ASD. Further studies with larger samples are needed to better understand the etiology of BD comorbidity in patients with ASD. En ligne : https://doi.org/10.1016/j.rasd.2023.102259 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

VEGF, IGF-1 and FGF-2 Serum Levels in Children and Adolescents with Autism Spectrum Disorder with and without Bipolar Disorder / Gokce GULDIKEN in Journal of Autism and Developmental Disorders, 54-10 (October 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-10 (October 2024) . - p.3854-3862 Titre : VEGF, IGF-1 and FGF-2 Serum Levels in Children and Adolescents with Autism Spectrum Disorder with and without Bipolar Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Gokce GULDIKEN, Auteur ; Ali KARAYAGMURLU, Auteur ; Canan KUCUKGERGIN, Auteur ; Murat COSKUN, Auteur Article en page(s) : p.3854-3862 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Purpose: To investigate serum levels of VEGF, IGF-1 and FGF-2, and relationships with several clinical characteristics in children and adolescents with autism spectrum disorder (ASD) with and without bipolar disorder (BD). Method: 40 subjects with ASD?+?BD as study group, and 40 subjects with ASD as control group were included. Serum levels of VEGF, IGF-1, and FGF-2 were measured using commercial enzyme-linked immunosorbent assay kits. Results: The study group was significantly higher than the control group in terms of ASD severity, self-harming behavior and sleep disturbance. Serum VEGF and FGF-2 levels were significantly higher in the ASD?+?BD group than in the control group. There was no significant difference in serum IGF-1 levels between the two groups. There was no correlation between VEGF, IGF-1 and FGF-2 serum levels and ASD severity in the study group. However there was a negative correlation between VEGF levels and age at first diagnosis of BD, and a positive correlation between IGF-1 levels and the number of bipolar episodes in the study group. Conclusion: Growth factors like VEGF and FGF-2 may be potential biomarkers of bipolar disorder in young subjects with ASD. Given the difficulty of clinical management of BD in young subjects with ASD, potential biomarkers would help clinicians in the diagnosis and follow up of BD in this special population. Further research is needed whether VEGF and FGF-2 can be potential biomarkers in the clinical management of young subjects with ASD and BD. En ligne : https://doi.org/10.1007/s10803-023-06089-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] VEGF, IGF-1 and FGF-2 Serum Levels in Children and Adolescents with Autism Spectrum Disorder with and without Bipolar Disorder [Texte imprimé et/ou numérique] / Gokce GULDIKEN, Auteur ; Ali KARAYAGMURLU, Auteur ; Canan KUCUKGERGIN, Auteur ; Murat COSKUN, Auteur . - p.3854-3862. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-10 (October 2024) . - p.3854-3862 Index. décimale : PER Périodiques Résumé : Purpose: To investigate serum levels of VEGF, IGF-1 and FGF-2, and relationships with several clinical characteristics in children and adolescents with autism spectrum disorder (ASD) with and without bipolar disorder (BD). Method: 40 subjects with ASD?+?BD as study group, and 40 subjects with ASD as control group were included. Serum levels of VEGF, IGF-1, and FGF-2 were measured using commercial enzyme-linked immunosorbent assay kits. Results: The study group was significantly higher than the control group in terms of ASD severity, self-harming behavior and sleep disturbance. Serum VEGF and FGF-2 levels were significantly higher in the ASD?+?BD group than in the control group. There was no significant difference in serum IGF-1 levels between the two groups. There was no correlation between VEGF, IGF-1 and FGF-2 serum levels and ASD severity in the study group. However there was a negative correlation between VEGF levels and age at first diagnosis of BD, and a positive correlation between IGF-1 levels and the number of bipolar episodes in the study group. Conclusion: Growth factors like VEGF and FGF-2 may be potential biomarkers of bipolar disorder in young subjects with ASD. Given the difficulty of clinical management of BD in young subjects with ASD, potential biomarkers would help clinicians in the diagnosis and follow up of BD in this special population. Further research is needed whether VEGF and FGF-2 can be potential biomarkers in the clinical management of young subjects with ASD and BD. En ligne : https://doi.org/10.1007/s10803-023-06089-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

---

1 (1 - 2 / 2)