17 recherche sur le mot-clé 'Bipolar disorder'

A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder / C. J. R. SEWALL in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.905-915 Titre : A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : C. J. R. SEWALL, Auteur ; J. M. GIRARD, Auteur ; J. MERRANKO, Auteur ; D. HAFEMAN, Auteur ; B. I. GOLDSTEIN, Auteur ; M. STROBER, Auteur ; H. HOWER, Auteur ; L. M. WEINSTOCK, Auteur ; S. YEN, Auteur ; N. D. RYAN, Auteur ; M. B. KELLER, Auteur ; F. LIAO, Auteur ; Rasim S. DILER, Auteur ; M. KAY GILL, Auteur ; David A. AXELSON, Auteur ; Boris BIRMAHER, Auteur ; Tina R. GOLDSTEIN, Auteur Article en page(s) : p.905-915 Langues : Anglais (eng) Mots-clés : Adolescent  Bayes Theorem  Bipolar Disorder/epidemiology  Humans  Multilevel Analysis  Risk Factors  Suicidal Ideation  Suicide, Attempted  Bayesian analysis  Suicide  adolescence  bipolar disorder  parent-child relationships  peer relationships Index. décimale : PER Périodiques Résumé : BACKGROUND: Youth with bipolar disorder (BD) are at high risk for suicidal thoughts and behaviors and frequently experience interpersonal impairment, which is a risk factor for suicide. Yet, no study to date has examined the longitudinal associations between relationship quality in family/peer domains and suicidal thoughts and behaviors among youth with BD. Thus, we investigated how between-person differences - reflecting the average relationship quality across time - and within-person changes, reflecting recent fluctuations in relationship quality, act as distal and/or proximal risk factors for suicidal ideation (SI) and suicide attempts. METHODS: We used longitudinal data from the Course and Outcome of Bipolar Youth Study (N = 413). Relationship quality variables were decomposed into stable (i.e., average) and varying (i.e., recent) components and entered, along with major clinical covariates, into separate Bayesian multilevel models predicting SI and suicide attempt. We also examined how the relationship quality effects interacted with age and sex. RESULTS: Poorer average relationship quality with parents (? = -.33, 95% Bayesian highest density interval (HDI) [-0.54, -0.11]) or friends (? = -.33, 95% HDI [-0.55, -0.11]) was longitudinally associated with increased risk of SI but not suicide attempt. Worsening recent relationship quality with parents (? = -.10, 95% HDI [-0.19, -0.03]) and, to a lesser extent, friends (? = -.06, 95% HDI [-0.15, 0.03]) was longitudinally associated with increased risk of SI, but only worsening recent relationship quality with parents was also associated with increased risk of suicide attempt (? = -.15, 95% HDI [-0.31, 0.01]). The effects of certain relationship quality variables were moderated by gender but not age. CONCLUSIONS: Among youth with BD, having poorer average relationship quality with peers and/or parents represents a distal risk factor for SI but not suicide attempts. Additionally, worsening recent relationship quality with parents may be a time-sensitive indicator of increased risk for SI or suicide attempt. En ligne : http://dx.doi.org/10.1111/jcpp.13343 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder [Texte imprimé et/ou numérique] / C. J. R. SEWALL, Auteur ; J. M. GIRARD, Auteur ; J. MERRANKO, Auteur ; D. HAFEMAN, Auteur ; B. I. GOLDSTEIN, Auteur ; M. STROBER, Auteur ; H. HOWER, Auteur ; L. M. WEINSTOCK, Auteur ; S. YEN, Auteur ; N. D. RYAN, Auteur ; M. B. KELLER, Auteur ; F. LIAO, Auteur ; Rasim S. DILER, Auteur ; M. KAY GILL, Auteur ; David A. AXELSON, Auteur ; Boris BIRMAHER, Auteur ; Tina R. GOLDSTEIN, Auteur . - p.905-915. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.905-915 Mots-clés : Adolescent  Bayes Theorem  Bipolar Disorder/epidemiology  Humans  Multilevel Analysis  Risk Factors  Suicidal Ideation  Suicide, Attempted  Bayesian analysis  Suicide  adolescence  bipolar disorder  parent-child relationships  peer relationships Index. décimale : PER Périodiques Résumé : BACKGROUND: Youth with bipolar disorder (BD) are at high risk for suicidal thoughts and behaviors and frequently experience interpersonal impairment, which is a risk factor for suicide. Yet, no study to date has examined the longitudinal associations between relationship quality in family/peer domains and suicidal thoughts and behaviors among youth with BD. Thus, we investigated how between-person differences - reflecting the average relationship quality across time - and within-person changes, reflecting recent fluctuations in relationship quality, act as distal and/or proximal risk factors for suicidal ideation (SI) and suicide attempts. METHODS: We used longitudinal data from the Course and Outcome of Bipolar Youth Study (N = 413). Relationship quality variables were decomposed into stable (i.e., average) and varying (i.e., recent) components and entered, along with major clinical covariates, into separate Bayesian multilevel models predicting SI and suicide attempt. We also examined how the relationship quality effects interacted with age and sex. RESULTS: Poorer average relationship quality with parents (? = -.33, 95% Bayesian highest density interval (HDI) [-0.54, -0.11]) or friends (? = -.33, 95% HDI [-0.55, -0.11]) was longitudinally associated with increased risk of SI but not suicide attempt. Worsening recent relationship quality with parents (? = -.10, 95% HDI [-0.19, -0.03]) and, to a lesser extent, friends (? = -.06, 95% HDI [-0.15, 0.03]) was longitudinally associated with increased risk of SI, but only worsening recent relationship quality with parents was also associated with increased risk of suicide attempt (? = -.15, 95% HDI [-0.31, 0.01]). The effects of certain relationship quality variables were moderated by gender but not age. CONCLUSIONS: Among youth with BD, having poorer average relationship quality with peers and/or parents represents a distal risk factor for SI but not suicide attempts. Additionally, worsening recent relationship quality with parents may be a time-sensitive indicator of increased risk for SI or suicide attempt. En ligne : http://dx.doi.org/10.1111/jcpp.13343 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 / Maja GREGERSEN in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1046-1056 Titre : Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 Type de document : Texte imprimé et/ou numérique Auteurs : Maja GREGERSEN, Auteur ; Anne SØNDERGAARD, Auteur ; Julie Marie BRANDT, Auteur ; Ditte ELLERSGAARD, Auteur ; Sinnika Birkehoj ROHD, Auteur ; Carsten HJORTHØJ, Auteur ; Jessica OHLAND, Auteur ; Mette Falkenberg KRANTZ, Auteur ; Martin WILMS, Auteur ; Anna Krogh ANDREASSEN, Auteur ; Christina Bruun KNUDSEN, Auteur ; Lotte VEDDUM, Auteur ; Aja GREVE, Auteur ; Vibeke BLIKSTED, Auteur ; Ole MORS, Auteur ; Lars CLEMMENSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Merete NORDENTOFT, Auteur ; Nicoline HEMAGER, Auteur ; Anne Amalie Elgaard THORUP, Auteur Article en page(s) : p.1046-1056 Langues : Anglais (eng) Mots-clés : Bipolar Disorder/epidemiology  Child  Child, Preschool  Denmark/epidemiology  Follow-Up Studies  Humans  Longitudinal Studies  Schizophrenia/epidemiology  Child and adolescent psychiatry  bipolar disorder  familial high-risk  psychopathology  schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Children at familial high-risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and early intervention. METHODS: The authors examined mental disorders and global functioning in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) compared with population-based controls. In a longitudinal cohort study, 450 children (FHR-SZ, n=171; FHR-BP, n=104; controls, n=175), were assessed for Axis I disorders at baseline and four-year follow-up (mean age 11.9, SD 0.2) with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children and for global functioning with Children's Global Assessment Scale. RESULTS: Cumulative incidence of Any Axis I disorder was elevated by age 11 in children at FHR-SZ (54.4%, OR 3.0, 95% CI 1.9-4.7, p<.001) and children at FHR-BP (52.9%, OR 2.8, 95% CI 1.7-4.7, p<.001) compared with controls (28.6%). Children at FHR-SZ and FHR-BP had higher rates of affective disorders (OR 4.4, 95% CI 1.4-13.5, p=.009; OR 5.1, 95% CI 1.6-16.4, p=.007), anxiety disorders (OR 2.1, 95% CI 1.1-4.0, p=.02; OR 3.0, 95% CI 1.5-6.1, p=.002), and stress and adjustment disorders (OR 3.3, 95% CI 1.4-7.5, p=.006; OR 5.3, 95% CI 2.2-12.4, p<.001). Disruptive behavior disorders (OR 2.8, 95% CI 1.0-7.3, p=.04) and ADHD (OR 2.9, 95% CI 1.6-5.3, p<.001) were elevated in children at FHR-SZ. Both FHR groups had lower global functioning than controls. Cumulative incidence of disorders increased equally across the three groups from early childhood to preadolescence and level of functioning did not change differentially. CONCLUSIONS: Children at FHR-SZ and FHR-BP have an elevated prevalence of mental disorders and poorer functioning than controls. Vulnerability in children at FHR manifests early and remains stable throughout childhood. Early attention toward their mental health and identification of those in need of intervention is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 [Texte imprimé et/ou numérique] / Maja GREGERSEN, Auteur ; Anne SØNDERGAARD, Auteur ; Julie Marie BRANDT, Auteur ; Ditte ELLERSGAARD, Auteur ; Sinnika Birkehoj ROHD, Auteur ; Carsten HJORTHØJ, Auteur ; Jessica OHLAND, Auteur ; Mette Falkenberg KRANTZ, Auteur ; Martin WILMS, Auteur ; Anna Krogh ANDREASSEN, Auteur ; Christina Bruun KNUDSEN, Auteur ; Lotte VEDDUM, Auteur ; Aja GREVE, Auteur ; Vibeke BLIKSTED, Auteur ; Ole MORS, Auteur ; Lars CLEMMENSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Merete NORDENTOFT, Auteur ; Nicoline HEMAGER, Auteur ; Anne Amalie Elgaard THORUP, Auteur . - p.1046-1056. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1046-1056 Mots-clés : Bipolar Disorder/epidemiology  Child  Child, Preschool  Denmark/epidemiology  Follow-Up Studies  Humans  Longitudinal Studies  Schizophrenia/epidemiology  Child and adolescent psychiatry  bipolar disorder  familial high-risk  psychopathology  schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Children at familial high-risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and early intervention. METHODS: The authors examined mental disorders and global functioning in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) compared with population-based controls. In a longitudinal cohort study, 450 children (FHR-SZ, n=171; FHR-BP, n=104; controls, n=175), were assessed for Axis I disorders at baseline and four-year follow-up (mean age 11.9, SD 0.2) with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children and for global functioning with Children's Global Assessment Scale. RESULTS: Cumulative incidence of Any Axis I disorder was elevated by age 11 in children at FHR-SZ (54.4%, OR 3.0, 95% CI 1.9-4.7, p<.001) and children at FHR-BP (52.9%, OR 2.8, 95% CI 1.7-4.7, p<.001) compared with controls (28.6%). Children at FHR-SZ and FHR-BP had higher rates of affective disorders (OR 4.4, 95% CI 1.4-13.5, p=.009; OR 5.1, 95% CI 1.6-16.4, p=.007), anxiety disorders (OR 2.1, 95% CI 1.1-4.0, p=.02; OR 3.0, 95% CI 1.5-6.1, p=.002), and stress and adjustment disorders (OR 3.3, 95% CI 1.4-7.5, p=.006; OR 5.3, 95% CI 2.2-12.4, p<.001). Disruptive behavior disorders (OR 2.8, 95% CI 1.0-7.3, p=.04) and ADHD (OR 2.9, 95% CI 1.6-5.3, p<.001) were elevated in children at FHR-SZ. Both FHR groups had lower global functioning than controls. Cumulative incidence of disorders increased equally across the three groups from early childhood to preadolescence and level of functioning did not change differentially. CONCLUSIONS: Children at FHR-SZ and FHR-BP have an elevated prevalence of mental disorders and poorer functioning than controls. Vulnerability in children at FHR manifests early and remains stable throughout childhood. Early attention toward their mental health and identification of those in need of intervention is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Actigraph measures discriminate pediatric bipolar disorder from attention-deficit/hyperactivity disorder and typically developing controls / Gianni L. FAEDDA in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.706-716 Titre : Actigraph measures discriminate pediatric bipolar disorder from attention-deficit/hyperactivity disorder and typically developing controls Type de document : Texte imprimé et/ou numérique Auteurs : Gianni L. FAEDDA, Auteur ; Kyoko OHASHI, Auteur ; Mariely HERNANDEZ, Auteur ; Cynthia E. MCGREENERY, Auteur ; Marie C. GRANT, Auteur ; Argelinda BARONI, Auteur ; Ann POLCARI, Auteur ; Martin H. TEICHER, Auteur Article en page(s) : p.706-716 Langues : Anglais (eng) Mots-clés : Actigraphy  ADHD  bipolar disorder  child  circadian rhythms  sleep Index. décimale : PER Périodiques Résumé : Background Distinguishing pediatric bipolar disorder (BD) from attention-deficit hyperactivity disorder (ADHD) can be challenging. Hyperactivity is a core feature of both disorders, but severely disturbed sleep and circadian dysregulation are more characteristic of BD, at least in adults. We tested the hypothesis that objective measures of activity, sleep, and circadian rhythms would help differentiate pediatric subjects with BD from ADHD and typically developing controls. Methods Unmedicated youths (N = 155, 97 males, age 5–18) were diagnosed using DSM-IV criteria with Kiddie-SADS PL/E. BD youths (n = 48) were compared to typically developing controls (n = 42) and children with ADHD (n = 44) or ADHD plus comorbid depressive disorders (n = 21). Three-to-five days of minute-to-minute belt-worn actigraph data (Ambulatory Monitoring Inc.), collected during the school week, were processed to yield 28 metrics per subject, and assessed for group differences with analysis of covariance. Cross-validated machine learning algorithms were used to determine the predictive accuracy of a four-parameter model, with measures reflecting sleep, hyperactivity, and circadian dysregulation, plus Indic's bipolar vulnerability index (VI). Results There were prominent group differences in several activity measures, notably mean 5 lowest hours of activity, skewness of diurnal activity, relative circadian amplitude, and VI. A predictive support vector machine model discriminated bipolar from non-bipolar with mean accuracy of 83.1 ± 5.4%, ROC area of 0.781 ± 0.071, kappa of 0.587 ± 0.136, specificity of 91.7 ± 5.3%, and sensitivity of 64.4 ± 13.6%. Conclusions Objective measures of sleep, circadian rhythmicity, and hyperactivity were abnormal in BD. Wearable sensor technology may provide bio-behavioral markers that can help differentiate children with BD from ADHD and healthy controls. En ligne : http://dx.doi.org/10.1111/jcpp.12520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Actigraph measures discriminate pediatric bipolar disorder from attention-deficit/hyperactivity disorder and typically developing controls [Texte imprimé et/ou numérique] / Gianni L. FAEDDA, Auteur ; Kyoko OHASHI, Auteur ; Mariely HERNANDEZ, Auteur ; Cynthia E. MCGREENERY, Auteur ; Marie C. GRANT, Auteur ; Argelinda BARONI, Auteur ; Ann POLCARI, Auteur ; Martin H. TEICHER, Auteur . - p.706-716. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.706-716 Mots-clés : Actigraphy  ADHD  bipolar disorder  child  circadian rhythms  sleep Index. décimale : PER Périodiques Résumé : Background Distinguishing pediatric bipolar disorder (BD) from attention-deficit hyperactivity disorder (ADHD) can be challenging. Hyperactivity is a core feature of both disorders, but severely disturbed sleep and circadian dysregulation are more characteristic of BD, at least in adults. We tested the hypothesis that objective measures of activity, sleep, and circadian rhythms would help differentiate pediatric subjects with BD from ADHD and typically developing controls. Methods Unmedicated youths (N = 155, 97 males, age 5–18) were diagnosed using DSM-IV criteria with Kiddie-SADS PL/E. BD youths (n = 48) were compared to typically developing controls (n = 42) and children with ADHD (n = 44) or ADHD plus comorbid depressive disorders (n = 21). Three-to-five days of minute-to-minute belt-worn actigraph data (Ambulatory Monitoring Inc.), collected during the school week, were processed to yield 28 metrics per subject, and assessed for group differences with analysis of covariance. Cross-validated machine learning algorithms were used to determine the predictive accuracy of a four-parameter model, with measures reflecting sleep, hyperactivity, and circadian dysregulation, plus Indic's bipolar vulnerability index (VI). Results There were prominent group differences in several activity measures, notably mean 5 lowest hours of activity, skewness of diurnal activity, relative circadian amplitude, and VI. A predictive support vector machine model discriminated bipolar from non-bipolar with mean accuracy of 83.1 ± 5.4%, ROC area of 0.781 ± 0.071, kappa of 0.587 ± 0.136, specificity of 91.7 ± 5.3%, and sensitivity of 64.4 ± 13.6%. Conclusions Objective measures of sleep, circadian rhythmicity, and hyperactivity were abnormal in BD. Wearable sensor technology may provide bio-behavioral markers that can help differentiate children with BD from ADHD and healthy controls. En ligne : http://dx.doi.org/10.1111/jcpp.12520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Affective prosody labeling in youths with bipolar disorder or severe mood dysregulation / Christen M. DEVENEY in Journal of Child Psychology and Psychiatry, 53-3 (March 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.262-270 Titre : Affective prosody labeling in youths with bipolar disorder or severe mood dysregulation Type de document : Texte imprimé et/ou numérique Auteurs : Christen M. DEVENEY, Auteur ; Melissa A. BROTMAN, Auteur ; Ann Marie DECKER, Auteur ; Stephanie S. DANIEL, Auteur ; Ellen LEIBENLUFT, Auteur Année de publication : 2012 Article en page(s) : p.262-270 Langues : Anglais (eng) Mots-clés : Bipolar disorder  emotion recognition Index. décimale : PER Périodiques Résumé : Background:  Accurate identification of nonverbal emotional cues is essential to successful social interactions, yet most research is limited to emotional face expression labeling. Little research focuses on the processing of emotional prosody, or tone of verbal speech, in clinical populations. Methods:  Using the Diagnostic Analysis of Nonverbal Accuracy, the current study examined whether youths with pediatric-onset bipolar disorder (BD) and/or those with chronic and severe irritability (i.e. the severe mood dysregulation phenotype) are impaired in their ability to identify the emotional prosody of a spoken sentence with neutral content. Results:  Youths with severe mood dysregulation (n = 67) performed more poorly than healthy comparison children (n = 57), even when the sample was limited to unmedicated patients. Medicated BD youths (n = 52) exhibited impairment relative to healthy comparison children. No interactions between group and emotion were observed, suggesting that emotional prosody labeling problems may represent a general deficit in chronically irritable youths and in medicated youths with BD. Conclusion:  In concert with previously documented facial emotion labeling deficits, difficulties ascertaining the correct emotional tone of a spoken sentence may contribute to emotion dysregulation in chronically irritable children, and possibly also in youths with BD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02482.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Affective prosody labeling in youths with bipolar disorder or severe mood dysregulation [Texte imprimé et/ou numérique] / Christen M. DEVENEY, Auteur ; Melissa A. BROTMAN, Auteur ; Ann Marie DECKER, Auteur ; Stephanie S. DANIEL, Auteur ; Ellen LEIBENLUFT, Auteur . - 2012 . - p.262-270. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.262-270 Mots-clés : Bipolar disorder  emotion recognition Index. décimale : PER Périodiques Résumé : Background:  Accurate identification of nonverbal emotional cues is essential to successful social interactions, yet most research is limited to emotional face expression labeling. Little research focuses on the processing of emotional prosody, or tone of verbal speech, in clinical populations. Methods:  Using the Diagnostic Analysis of Nonverbal Accuracy, the current study examined whether youths with pediatric-onset bipolar disorder (BD) and/or those with chronic and severe irritability (i.e. the severe mood dysregulation phenotype) are impaired in their ability to identify the emotional prosody of a spoken sentence with neutral content. Results:  Youths with severe mood dysregulation (n = 67) performed more poorly than healthy comparison children (n = 57), even when the sample was limited to unmedicated patients. Medicated BD youths (n = 52) exhibited impairment relative to healthy comparison children. No interactions between group and emotion were observed, suggesting that emotional prosody labeling problems may represent a general deficit in chronically irritable youths and in medicated youths with BD. Conclusion:  In concert with previously documented facial emotion labeling deficits, difficulties ascertaining the correct emotional tone of a spoken sentence may contribute to emotion dysregulation in chronically irritable children, and possibly also in youths with BD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02482.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder / Nancy E. ADLEMAN in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1149-1156 Titre : Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nancy E. ADLEMAN, Auteur ; Stephen J. FROMM, Auteur ; Varun RAZDAN, Auteur ; Reilly KAYSER, Auteur ; Daniel P. DICKSTEIN, Auteur ; Melissa A. BROTMAN, Auteur ; Daniel Samuel PINE, Auteur ; Ellen LEIBENLUFT, Auteur Année de publication : 2012 Article en page(s) : p.1149-1156 Langues : Anglais (eng) Mots-clés : Severe mood dysregulation  bipolar disorder  pediatric  longitudinal  neuroimaging  voxel-based morphometry  Trouble de l'humeur Index. décimale : PER Périodiques Résumé : Background:  There is debate as to whether chronic irritability (operationalized as severe mood dysregulation, SMD) is a developmental form of bipolar disorder (BD). Although structural brain abnormalities in BD have been demonstrated, no study compares neuroanatomy among SMD, BD, and healthy volunteers (HV) either cross-sectionally or over time. Furthermore, the developmental trajectories of structural abnormalities in BD or SMD are unknown. This study provides such data in BD, SMD, and HV. Methods:  An optimized, modulated voxel-based morphometry (VBM) analysis was conducted on structural MRI scans from 201 children (78 SMD, 55 BD, and 68 HV). In addition, 92 children (31 SMD, 34 BD, and 27 HV) were rescanned after 2 years (mean interval 1.99 ± 0.94 years), to compare time-related changes among the three groups. Results:  Cross-sectionally, the groups differed in gray matter (GM) volume in presupplementary motor area (pre-SMA), dorsolateral prefrontal cortex (DLPFC), insula, and globus pallidus. The cortical differences were driven mainly by increased GM volume in HV compared with BD and SMD. In globus pallidus, there was increased GM in BD compared with HV and SMD. Longitudinally, group-by-time interactions were evident in two clusters in the superior/inferior parietal lobule (R SPL/IPL) and in the precuneus. In both clusters, the interactions were driven by an abnormal increase in volume in BD. Conclusions:  Cross-sectionally, both BD and SMD are associated with structural abnormalities in frontal cortex, insula, and basal ganglia. Although some of these deficits overlap (insula and DLPFC), others differentiate SMD and BD (pre-SMA and globus pallidus). Abnormal developmental trajectories in lateral parietal cortex and precuneus are present in, and unique to, BD. Because of the high proportion of co-occurring ADHD in the SMD subjects, we could not separate effects of ADHD from those of SMD, and future research including a nonirritable ADHD group must address this issue. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02568.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder [Texte imprimé et/ou numérique] / Nancy E. ADLEMAN, Auteur ; Stephen J. FROMM, Auteur ; Varun RAZDAN, Auteur ; Reilly KAYSER, Auteur ; Daniel P. DICKSTEIN, Auteur ; Melissa A. BROTMAN, Auteur ; Daniel Samuel PINE, Auteur ; Ellen LEIBENLUFT, Auteur . - 2012 . - p.1149-1156. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1149-1156 Mots-clés : Severe mood dysregulation  bipolar disorder  pediatric  longitudinal  neuroimaging  voxel-based morphometry  Trouble de l'humeur Index. décimale : PER Périodiques Résumé : Background:  There is debate as to whether chronic irritability (operationalized as severe mood dysregulation, SMD) is a developmental form of bipolar disorder (BD). Although structural brain abnormalities in BD have been demonstrated, no study compares neuroanatomy among SMD, BD, and healthy volunteers (HV) either cross-sectionally or over time. Furthermore, the developmental trajectories of structural abnormalities in BD or SMD are unknown. This study provides such data in BD, SMD, and HV. Methods:  An optimized, modulated voxel-based morphometry (VBM) analysis was conducted on structural MRI scans from 201 children (78 SMD, 55 BD, and 68 HV). In addition, 92 children (31 SMD, 34 BD, and 27 HV) were rescanned after 2 years (mean interval 1.99 ± 0.94 years), to compare time-related changes among the three groups. Results:  Cross-sectionally, the groups differed in gray matter (GM) volume in presupplementary motor area (pre-SMA), dorsolateral prefrontal cortex (DLPFC), insula, and globus pallidus. The cortical differences were driven mainly by increased GM volume in HV compared with BD and SMD. In globus pallidus, there was increased GM in BD compared with HV and SMD. Longitudinally, group-by-time interactions were evident in two clusters in the superior/inferior parietal lobule (R SPL/IPL) and in the precuneus. In both clusters, the interactions were driven by an abnormal increase in volume in BD. Conclusions:  Cross-sectionally, both BD and SMD are associated with structural abnormalities in frontal cortex, insula, and basal ganglia. Although some of these deficits overlap (insula and DLPFC), others differentiate SMD and BD (pre-SMA and globus pallidus). Abnormal developmental trajectories in lateral parietal cortex and precuneus are present in, and unique to, BD. Because of the high proportion of co-occurring ADHD in the SMD subjects, we could not separate effects of ADHD from those of SMD, and future research including a nonirritable ADHD group must address this issue. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02568.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

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