Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes / Christy D. YOON in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2140-2165 Titre : Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes Type de document : texte imprimé Auteurs : Christy D. YOON, Auteur ; Douglas C. DEAN III, Auteur Article en page(s) : p.2140-2165 Langues : Anglais (eng) Mots-clés : advanced quantitative MRI  autism  CSD  DKI  microstructure  MTI  NODDI  relaxometry Index. décimale : PER Périodiques Résumé : ABSTRACT Emerging evidence highlights widespread alterations in white matter microstructure in autism. Advances in magnetic resonance imaging (MRI) have enabled more precise examinations of these microstructural changes, leading to increased use of quantitative MRI techniques in autism research. This review summarizes the current landscape of these techniques, focusing on methodology, group differences, developmental associations, and regional variations. Following PRISMA guidelines, 34 studies published between 2006 and 2024 that employed advanced MRI techniques were reviewed. These included diffusion MRI signal representations (diffusion kurtosis imaging [DKI] and constrained spherical deconvolution [CSD]) and biophysical models (neurite orientation dispersion and density imaging [NODDI] and white matter tract integrity [WMTI]), as well as relaxometry and magnetization transfer imaging (MTI). CSD and NODDI were the most frequently used, while MTI was the least utilized, with notable variations in acquisition parameters and processing methods across the techniques. Findings suggest relatively consistent lower values of fixel-based analysis measures (CSD) and neurite density index (NODDI) across major white matter regions, while findings from DKI, WMTI, and relaxometry varied. Measures from these techniques were associated with various developmental outcomes, including cognitive, emotional, and social behaviors. Limitations and implications are also discussed. En ligne : https://doi.org/10.1002/aur.70122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes [texte imprimé] / Christy D. YOON, Auteur ; Douglas C. DEAN III, Auteur . - p.2140-2165. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2140-2165 Mots-clés : advanced quantitative MRI  autism  CSD  DKI  microstructure  MTI  NODDI  relaxometry Index. décimale : PER Périodiques Résumé : ABSTRACT Emerging evidence highlights widespread alterations in white matter microstructure in autism. Advances in magnetic resonance imaging (MRI) have enabled more precise examinations of these microstructural changes, leading to increased use of quantitative MRI techniques in autism research. This review summarizes the current landscape of these techniques, focusing on methodology, group differences, developmental associations, and regional variations. Following PRISMA guidelines, 34 studies published between 2006 and 2024 that employed advanced MRI techniques were reviewed. These included diffusion MRI signal representations (diffusion kurtosis imaging [DKI] and constrained spherical deconvolution [CSD]) and biophysical models (neurite orientation dispersion and density imaging [NODDI] and white matter tract integrity [WMTI]), as well as relaxometry and magnetization transfer imaging (MTI). CSD and NODDI were the most frequently used, while MTI was the least utilized, with notable variations in acquisition parameters and processing methods across the techniques. Findings suggest relatively consistent lower values of fixel-based analysis measures (CSD) and neurite density index (NODDI) across major white matter regions, while findings from DKI, WMTI, and relaxometry varied. Measures from these techniques were associated with various developmental outcomes, including cognitive, emotional, and social behaviors. Limitations and implications are also discussed. En ligne : https://doi.org/10.1002/aur.70122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Correlation Between Gaze Behaviors and Social Communication Skills of Young Autistic Children: A Meta-Analysis of Eye-Tracking Studies / Christy D. YOON in Journal of Autism and Developmental Disorders, 55-3 (March 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-3 (March 2025) . - p.843-861 Titre : Correlation Between Gaze Behaviors and Social Communication Skills of Young Autistic Children: A Meta-Analysis of Eye-Tracking Studies Type de document : texte imprimé Auteurs : Christy D. YOON, Auteur ; Yan XIA, Auteur ; Adriana Kaori TEROL, Auteur ; Hedda MEADAN, Auteur ; James D. LEE, Auteur Article en page(s) : p.843-861 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This meta-analysis examined correlations between eye-tracking measures of gaze behaviors manifested during dynamic salient social stimuli and behavioral assessment measures of social communication skills of young autistic children. We employed a multilevel model with random effects to perform three separate meta-analyses for correlation between social communication skills and (a) all gaze behaviors, (b) gaze duration, and (c) gaze transition. Subsequently, we performed meta-regression to assess the role of four moderators, including age, continuum of naturalness of stimuli, gaze metric, and area of interest, on correlation effect sizes that were heterogeneous at the population level. A total of 111 correlation coefficients from 17 studies for 1132 young autistic children or children with high-likelihood for autism (Mage range = 6-95 months) were included in this meta-analysis. The correlation effect sizes for all three meta-analyses were significant, supporting the relation between improved gaze behaviors and better social communication skills. In addition, age, gaze metric, and area of interest were significant moderators. This suggests the importance of identifying meaningful gaze behaviors related to social communication skills and the increasingly influential role of gaze behaviors in shaping social communication skills as young autistic children progress through the early childhood stage. The continuum of naturalness of stimuli, however, was revealed to trend towards having a significant moderating effect. Lastly, it is important to note the evidence of potential publication bias. Our findings are discussed in the context of early identification and intervention and unraveling the complex nature of autism. En ligne : https://doi.org/10.1007/s10803-024-06257-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Correlation Between Gaze Behaviors and Social Communication Skills of Young Autistic Children: A Meta-Analysis of Eye-Tracking Studies [texte imprimé] / Christy D. YOON, Auteur ; Yan XIA, Auteur ; Adriana Kaori TEROL, Auteur ; Hedda MEADAN, Auteur ; James D. LEE, Auteur . - p.843-861. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-3 (March 2025) . - p.843-861 Index. décimale : PER Périodiques Résumé : This meta-analysis examined correlations between eye-tracking measures of gaze behaviors manifested during dynamic salient social stimuli and behavioral assessment measures of social communication skills of young autistic children. We employed a multilevel model with random effects to perform three separate meta-analyses for correlation between social communication skills and (a) all gaze behaviors, (b) gaze duration, and (c) gaze transition. Subsequently, we performed meta-regression to assess the role of four moderators, including age, continuum of naturalness of stimuli, gaze metric, and area of interest, on correlation effect sizes that were heterogeneous at the population level. A total of 111 correlation coefficients from 17 studies for 1132 young autistic children or children with high-likelihood for autism (Mage range = 6-95 months) were included in this meta-analysis. The correlation effect sizes for all three meta-analyses were significant, supporting the relation between improved gaze behaviors and better social communication skills. In addition, age, gaze metric, and area of interest were significant moderators. This suggests the importance of identifying meaningful gaze behaviors related to social communication skills and the increasingly influential role of gaze behaviors in shaping social communication skills as young autistic children progress through the early childhood stage. The continuum of naturalness of stimuli, however, was revealed to trend towards having a significant moderating effect. Lastly, it is important to note the evidence of potential publication bias. Our findings are discussed in the context of early identification and intervention and unraveling the complex nature of autism. En ligne : https://doi.org/10.1007/s10803-024-06257-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Parent-to-parent support among parents of children with autism: A review of the literature / Adriana Kaori TEROL ; Christy D. YOON ; Hedda MEADAN in Autism, 28-2 (February 2024)  

Public ISBD [article]  inAutism > 28-2 (February 2024) . - p.263?275 Titre : Parent-to-parent support among parents of children with autism: A review of the literature Type de document : texte imprimé Auteurs : Adriana Kaori TEROL, Auteur ; Christy D. YOON, Auteur ; Hedda MEADAN, Auteur Article en page(s) : p.263?275 Mots-clés : cascading model  intervention delivery  parent-to-parent support Index. décimale : PER Périodiques Résumé : Parents of autistic children have historically reported hardships related to raising their children. However, the access to resources related to the childrearing of an autistic child is not equitable, therefore resulting in exacerbated difficulties for parents in low-resource settings. In these situations, peer support may be a protective factor for parental resilience in which they receive various supports from other parents of an autistic child with similar experiences. Despite its potential utility, little is known about such parent-to-parent support as evidenced by no synthesis of relevant literature. To address this gap, we present a scoping review of 25 studies that included parent-to-parent support among parents of autistic children. Across these studies, a total of 141 and 747 parents participated as parent mentors and mentees with some heterogeneity in their demographic characteristics. We also identified how parent mentors were trained to provide support to their peers and social validity data related to parent-to-parent support and provided implications for future intervention research. Lay Abstract Parents of autistic children have long reported feelings of isolation and increased stress during and after receiving their child?s diagnosis. Increasing global prevalence of autism also calls for increased services and supports to meet the needs of these families, but most parents who live in low-resource settings still report exacerbated barriers. This may indicate the need for diversifying intervention delivery models to increase contextual fit and enhance implementation effects for different populations. For example, many parents have reported parent-to-parent (P2P) model to be a source of emotional support, advocacy, and knowledge related to their child?s diagnosis, and practical advice. However, little is known about this topic due to the lack of synthesis of relevant autism literature. To address this gap, we conducted a literature review to gain a deeper understanding of how P2P support is used. We identified 25 studies based on our inclusion and exclusion criteria, which we coded to extract variables such as demographic information of participants, types of P2P, dosage, target outcomes, and social validity. About half of studies focused on providing support groups for parents, and the other half focused on individual matching and mentoring for skill acquisition of parents. Across the included 25 studies, a total of 141 parents participated as parent mentors and 747 parents as parent mentees. We also present implications for future research. En ligne : https://dx.doi.org/10.1177/13623613221146444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Parent-to-parent support among parents of children with autism: A review of the literature [texte imprimé] / Adriana Kaori TEROL, Auteur ; Christy D. YOON, Auteur ; Hedda MEADAN, Auteur . - p.263?275. in Autism > 28-2 (February 2024) . - p.263?275 Mots-clés : cascading model  intervention delivery  parent-to-parent support Index. décimale : PER Périodiques Résumé : Parents of autistic children have historically reported hardships related to raising their children. However, the access to resources related to the childrearing of an autistic child is not equitable, therefore resulting in exacerbated difficulties for parents in low-resource settings. In these situations, peer support may be a protective factor for parental resilience in which they receive various supports from other parents of an autistic child with similar experiences. Despite its potential utility, little is known about such parent-to-parent support as evidenced by no synthesis of relevant literature. To address this gap, we present a scoping review of 25 studies that included parent-to-parent support among parents of autistic children. Across these studies, a total of 141 and 747 parents participated as parent mentors and mentees with some heterogeneity in their demographic characteristics. We also identified how parent mentors were trained to provide support to their peers and social validity data related to parent-to-parent support and provided implications for future intervention research. Lay Abstract Parents of autistic children have long reported feelings of isolation and increased stress during and after receiving their child?s diagnosis. Increasing global prevalence of autism also calls for increased services and supports to meet the needs of these families, but most parents who live in low-resource settings still report exacerbated barriers. This may indicate the need for diversifying intervention delivery models to increase contextual fit and enhance implementation effects for different populations. For example, many parents have reported parent-to-parent (P2P) model to be a source of emotional support, advocacy, and knowledge related to their child?s diagnosis, and practical advice. However, little is known about this topic due to the lack of synthesis of relevant autism literature. To address this gap, we conducted a literature review to gain a deeper understanding of how P2P support is used. We identified 25 studies based on our inclusion and exclusion criteria, which we coded to extract variables such as demographic information of participants, types of P2P, dosage, target outcomes, and social validity. About half of studies focused on providing support groups for parents, and the other half focused on individual matching and mentoring for skill acquisition of parents. Across the included 25 studies, a total of 141 parents participated as parent mentors and 747 parents as parent mentees. We also present implications for future research. En ligne : https://dx.doi.org/10.1177/13623613221146444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

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