Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry / Stephane A. DE BRITO ; Graeme FAIRCHILD ; Christine M. FREITAG ; Karen GONZALEZ-MADRUGA ; Catherine HAMILTON-GIACHRITSIS ; Gregor KOHLS ; Kerstin KONRAD ; Anne MARTINELLI ; Nora RASCHLE ; Jack C. ROGERS ; Areti SMARAGDI ; Christina STADLER ; Marlene STAGINNUS ; Nicola TOSCHI in Development and Psychopathology, 35-5 (December 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-5 (December 2023) . - p.2302-2314 Titre : Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry Type de document : texte imprimé Auteurs : Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur ; Christine M. FREITAG, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Catherine HAMILTON-GIACHRITSIS, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Anne MARTINELLI, Auteur ; Nora RASCHLE, Auteur ; Jack C. ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Christina STADLER, Auteur ; Marlene STAGINNUS, Auteur ; Nicola TOSCHI, Auteur Article en page(s) : p.2302-2314 Mots-clés : Resilience  adversity  brain structure  voxel-based morphometry  youth Index. décimale : PER Périodiques Résumé : There is increasing evidence that resilience in youth may have a neurobiological basis. However, the existing literature lacks a consistent way of operationalizing resilience, often relying on arbitrary judgments or narrow definitions (e.g., not developing PTSD) to classify individuals as resilient. Therefore, this study used data-driven, continuous resilience scores based on adversity and psychopathology to investigate associations between resilience and brain structure in youth. Structural MRI data from 298 youth aged 9 18 years (Mage = 13.51; 51% female) who participated in the European multisite FemNAT-CD study were preprocessed using SPM12 and analyzed using voxel-based morphometry. Resilience scores were derived by regressing data on adversity exposure against current/lifetime psychopathology and quantifying each individual?s distance from the regression line. General linear models tested for associations between resilience and gray matter volume (GMV) and examined whether associations between resilience and GMV differed by sex. Resilience was positively correlated with GMV in the right inferior frontal and medial frontal gyri. Sex-by-resilience interactions were observed in the middle temporal and middle frontal gyri. These findings demonstrate that resilience in youth is associated with volume in brain regions implicated in executive functioning, emotion regulation, and attention. Our results also provide evidence for sex differences in the neurobiology of resilience. En ligne : https://dx.doi.org/10.1017/S0954579423000718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry [texte imprimé] / Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur ; Christine M. FREITAG, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Catherine HAMILTON-GIACHRITSIS, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Anne MARTINELLI, Auteur ; Nora RASCHLE, Auteur ; Jack C. ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Christina STADLER, Auteur ; Marlene STAGINNUS, Auteur ; Nicola TOSCHI, Auteur . - p.2302-2314. in Development and Psychopathology > 35-5 (December 2023) . - p.2302-2314 Mots-clés : Resilience  adversity  brain structure  voxel-based morphometry  youth Index. décimale : PER Périodiques Résumé : There is increasing evidence that resilience in youth may have a neurobiological basis. However, the existing literature lacks a consistent way of operationalizing resilience, often relying on arbitrary judgments or narrow definitions (e.g., not developing PTSD) to classify individuals as resilient. Therefore, this study used data-driven, continuous resilience scores based on adversity and psychopathology to investigate associations between resilience and brain structure in youth. Structural MRI data from 298 youth aged 9 18 years (Mage = 13.51; 51% female) who participated in the European multisite FemNAT-CD study were preprocessed using SPM12 and analyzed using voxel-based morphometry. Resilience scores were derived by regressing data on adversity exposure against current/lifetime psychopathology and quantifying each individual?s distance from the regression line. General linear models tested for associations between resilience and gray matter volume (GMV) and examined whether associations between resilience and GMV differed by sex. Resilience was positively correlated with GMV in the right inferior frontal and medial frontal gyri. Sex-by-resilience interactions were observed in the middle temporal and middle frontal gyri. These findings demonstrate that resilience in youth is associated with volume in brain regions implicated in executive functioning, emotion regulation, and attention. Our results also provide evidence for sex differences in the neurobiology of resilience. En ligne : https://dx.doi.org/10.1017/S0954579423000718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Testing the ecophenotype hypothesis: Differences in white matter microstructure in youth with conduct disorder with versus without a history of childhood abuse / Sophie TOWNEND in Development and Psychopathology, 38-1 (February 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-1 (February 2026) . - p.211-225 Titre : Testing the ecophenotype hypothesis: Differences in white matter microstructure in youth with conduct disorder with versus without a history of childhood abuse Type de document : texte imprimé Auteurs : Sophie TOWNEND, Auteur ; Marlene STAGINNUS, Auteur ; Jack ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Anne MARTINELLI, Auteur ; Anka BERNHARD, Auteur ; Nora Maria RASCHLE, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Christina STADLER, Auteur ; Christine M. FREITAG, Auteur ; Esther WALTON, Auteur ; Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur Article en page(s) : p.211-225 Langues : Anglais (eng) Mots-clés : antisocial behavior child abuse childhood maltreatment conduct disorder diffusion tensor imaging sex differences Index. décimale : PER Périodiques Résumé : Childhood maltreatment is a key risk factor for conduct disorder (CD), and the “ecophenotype hypothesis” suggests that maltreatment-related versus non-maltreatment-related CD are neurobiologically distinct. This may explain inconsistent findings in previous structural connectivity studies of CD. We tested this hypothesis by comparing youth with CD with (CD/+) versus without (CD/−) childhood physical or sexual abuse in white-matter microstructure. Diffusion tensor imaging data were collected from 100 CD and 169 control participants aged 9–18 years. Using Tract-Based Spatial Statistics, we compared the CD and control groups in fractional anisotropy, and axial, radial and mean diffusivity, then compared the CD/+ (n = 39) and CD/− (n = 61) subgroups and controls. The combined CD group had higher fractional anisotropy in the corpus callosum than controls. When divided by abuse history, only the CD/− subgroup exhibited higher corpus callosum fractional anisotropy than controls; the CD/+ subgroup did not differ from controls. Comparing the CD subgroups, the CD/+ subgroup displayed higher superior longitudinal fasciculus axial diffusivity than the CD/− subgroup. Notably, sex-stratified analyses yielded different findings in all-male and all-female samples. Findings support the ecophenotype hypothesis, demonstrating microstructural differences between the CD/+ and CD/− subgroups and emphasizing the importance of considering abuse/maltreatment (and sex) in future studies. En ligne : https://dx.doi.org/10.1017/S0954579425000367 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Testing the ecophenotype hypothesis: Differences in white matter microstructure in youth with conduct disorder with versus without a history of childhood abuse [texte imprimé] / Sophie TOWNEND, Auteur ; Marlene STAGINNUS, Auteur ; Jack ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Anne MARTINELLI, Auteur ; Anka BERNHARD, Auteur ; Nora Maria RASCHLE, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Christina STADLER, Auteur ; Christine M. FREITAG, Auteur ; Esther WALTON, Auteur ; Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur . - p.211-225. Langues : Anglais (eng) in Development and Psychopathology > 38-1 (February 2026) . - p.211-225 Mots-clés : antisocial behavior child abuse childhood maltreatment conduct disorder diffusion tensor imaging sex differences Index. décimale : PER Périodiques Résumé : Childhood maltreatment is a key risk factor for conduct disorder (CD), and the “ecophenotype hypothesis” suggests that maltreatment-related versus non-maltreatment-related CD are neurobiologically distinct. This may explain inconsistent findings in previous structural connectivity studies of CD. We tested this hypothesis by comparing youth with CD with (CD/+) versus without (CD/−) childhood physical or sexual abuse in white-matter microstructure. Diffusion tensor imaging data were collected from 100 CD and 169 control participants aged 9–18 years. Using Tract-Based Spatial Statistics, we compared the CD and control groups in fractional anisotropy, and axial, radial and mean diffusivity, then compared the CD/+ (n = 39) and CD/− (n = 61) subgroups and controls. The combined CD group had higher fractional anisotropy in the corpus callosum than controls. When divided by abuse history, only the CD/− subgroup exhibited higher corpus callosum fractional anisotropy than controls; the CD/+ subgroup did not differ from controls. Comparing the CD subgroups, the CD/+ subgroup displayed higher superior longitudinal fasciculus axial diffusivity than the CD/− subgroup. Notably, sex-stratified analyses yielded different findings in all-male and all-female samples. Findings support the ecophenotype hypothesis, demonstrating microstructural differences between the CD/+ and CD/− subgroups and emphasizing the importance of considering abuse/maltreatment (and sex) in future studies. En ligne : https://dx.doi.org/10.1017/S0954579425000367 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

---

1 (1 - 2 / 2) Par page : 25 50 100 200