Intestinal Symptoms Among Children aged 2-7 Years with Autism Spectrum Disorder in 13 Cities of China / Ting YANG in Journal of Autism and Developmental Disorders, 54-11 (November)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-11 (November) . - p.4302-4310 Titre : Intestinal Symptoms Among Children aged 2-7 Years with Autism Spectrum Disorder in 13 Cities of China Type de document : Texte imprimé et/ou numérique Auteurs : Ting YANG, Auteur ; Qian ZHANG, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Fei-Yong JIA, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Li-Jie WU, Auteur ; Xiao-Yan KE, Auteur ; Ming-Ji YI, Auteur ; Qi HONG, Auteur ; Jin-Jin CHEN, Auteur ; Shuan-Feng FANG, Auteur ; Yi-Chao WANG, Auteur ; Qi WANG, Auteur ; Chun-Hua JIN, Auteur ; Jie CHEN, Auteur ; Ting-Yu LI, Auteur Article en page(s) : p.4302-4310 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a multifactorial, pervasive, neurodevelopmental disorder, of which intestinal symptoms collectively represent one of the most common comorbidities. Methods: In this study, 1,222 children with ASD and 1,206 typically developing (TD) children aged 2-7 years were enrolled from 13 cities in China. Physical measurement and basic information questionnaires were conducted in ASD and TD children. The Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and Autism Behavior Checklist (ABC) were used to evaluate the clinical symptoms of children with ASD. The six-item Gastrointestinal Severity Index (6-GSI) was used to evaluate the prevalence of intestinal symptoms in two groups. Results: The detection rates of constipation, stool odor, and total intestinal symptoms in ASD children were significantly higher than those in TD children (40.098% vs. 25.622%, 17.021% vs. 9.287%, and 53.601% vs. 41.294%, respectively). Autistic children presenting with intestinal comorbidity had significantly higher scores on the ABC, SRS, CARS, and multiple subscales than autistic children without intestinal symptoms, suggesting that intestinal comorbidity may exacerbates the core symptoms of ASD children. Conclusion: Intestinal dysfunction was significantly more common in autistic than in TD children. This dysfunction may aggravate the core symptoms of children with ASD. En ligne : https://doi.org/10.1007/s10803-023-06122-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] Intestinal Symptoms Among Children aged 2-7 Years with Autism Spectrum Disorder in 13 Cities of China [Texte imprimé et/ou numérique] / Ting YANG, Auteur ; Qian ZHANG, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Fei-Yong JIA, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Li-Jie WU, Auteur ; Xiao-Yan KE, Auteur ; Ming-Ji YI, Auteur ; Qi HONG, Auteur ; Jin-Jin CHEN, Auteur ; Shuan-Feng FANG, Auteur ; Yi-Chao WANG, Auteur ; Qi WANG, Auteur ; Chun-Hua JIN, Auteur ; Jie CHEN, Auteur ; Ting-Yu LI, Auteur . - p.4302-4310. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-11 (November) . - p.4302-4310 Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a multifactorial, pervasive, neurodevelopmental disorder, of which intestinal symptoms collectively represent one of the most common comorbidities. Methods: In this study, 1,222 children with ASD and 1,206 typically developing (TD) children aged 2-7 years were enrolled from 13 cities in China. Physical measurement and basic information questionnaires were conducted in ASD and TD children. The Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and Autism Behavior Checklist (ABC) were used to evaluate the clinical symptoms of children with ASD. The six-item Gastrointestinal Severity Index (6-GSI) was used to evaluate the prevalence of intestinal symptoms in two groups. Results: The detection rates of constipation, stool odor, and total intestinal symptoms in ASD children were significantly higher than those in TD children (40.098% vs. 25.622%, 17.021% vs. 9.287%, and 53.601% vs. 41.294%, respectively). Autistic children presenting with intestinal comorbidity had significantly higher scores on the ABC, SRS, CARS, and multiple subscales than autistic children without intestinal symptoms, suggesting that intestinal comorbidity may exacerbates the core symptoms of ASD children. Conclusion: Intestinal dysfunction was significantly more common in autistic than in TD children. This dysfunction may aggravate the core symptoms of children with ASD. En ligne : https://doi.org/10.1007/s10803-023-06122-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China / Ting YANG ; Jie CHEN ; Li CHEN ; Ying DAI ; Hua WEI ; Feiyong JIA ; Lijie WU ; Yan HAO ; Ling LI ; Jie ZHANG ; Xiaoyan KE ; Mingji YI ; Qi HONG ; Jinjin CHEN ; Shuanfeng FANG ; Yichao WANG ; Qi WANG ; Chunhua JIN ; Tingyu LI in Research in Autism Spectrum Disorders, 111 (March 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 111 (March 2024) . - p.102309 Titre : Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China Type de document : Texte imprimé et/ou numérique Auteurs : Ting YANG, Auteur ; Jie CHEN, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Hua WEI, Auteur ; Feiyong JIA, Auteur ; Lijie WU, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Xiaoyan KE, Auteur ; Mingji YI, Auteur ; Qi HONG, Auteur ; Jinjin CHEN, Auteur ; Shuanfeng FANG, Auteur ; Yichao WANG, Auteur ; Qi WANG, Auteur ; Chunhua JIN, Auteur ; Tingyu LI, Auteur Article en page(s) : p.102309 Mots-clés : Vitamin D  Multivitamin  Pregnancy  Autism spectrum disorder  Symptom  Children Index. décimale : PER Périodiques Résumé : Background We aimed to investigate the relationship between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of autism spectrum disorder (ASD) and symptoms in offspring with ASD. Methods This study enrolled 1321 children with ASD and 1200 typically developing (TD) children under 7 years old in China. Maternal vitamin supplements were classified for vitamin D, multivitamin (with or without vitamin D), and none (no use of vitamin D or multivitamin). For children with ASD, symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). Results Maternal vitamin D and multivitamin supplementation during pregnancy were both significantly associated with a decreased risk of ASD in offspring (P = 0.024 and P < 0.001). The ASD children born to mothers with gestational multivitamin supplementation had lower CARS [? = ?1.342 (?2.275, ?0.409), P = 0.005] and communication warning behavior [? = ?6.631 (?9.899, ?3.363), P < 0.001] scores and higher personal-social quotient [? = 3.347 (0.190, 6.504), P = 0.038] than children born to mothers without supplementation. Maternal vitamin D supplementation was not associated with symptoms and development quotients in ASD children (P > 0.05). Conclusions This study supports a protective association between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of ASD in offspring. Maternal multivitamin supplementation may potentially moderate the symptoms and personal-social ability in ASD children. Further studies are needed on the role of maternal nutrition in the etiology and autistic symptoms and the underlying molecular mechanisms. En ligne : https://doi.org/10.1016/j.rasd.2023.102309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521 [article] Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China [Texte imprimé et/ou numérique] / Ting YANG, Auteur ; Jie CHEN, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Hua WEI, Auteur ; Feiyong JIA, Auteur ; Lijie WU, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Xiaoyan KE, Auteur ; Mingji YI, Auteur ; Qi HONG, Auteur ; Jinjin CHEN, Auteur ; Shuanfeng FANG, Auteur ; Yichao WANG, Auteur ; Qi WANG, Auteur ; Chunhua JIN, Auteur ; Tingyu LI, Auteur . - p.102309. in Research in Autism Spectrum Disorders > 111 (March 2024) . - p.102309 Mots-clés : Vitamin D  Multivitamin  Pregnancy  Autism spectrum disorder  Symptom  Children Index. décimale : PER Périodiques Résumé : Background We aimed to investigate the relationship between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of autism spectrum disorder (ASD) and symptoms in offspring with ASD. Methods This study enrolled 1321 children with ASD and 1200 typically developing (TD) children under 7 years old in China. Maternal vitamin supplements were classified for vitamin D, multivitamin (with or without vitamin D), and none (no use of vitamin D or multivitamin). For children with ASD, symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). Results Maternal vitamin D and multivitamin supplementation during pregnancy were both significantly associated with a decreased risk of ASD in offspring (P = 0.024 and P < 0.001). The ASD children born to mothers with gestational multivitamin supplementation had lower CARS [? = ?1.342 (?2.275, ?0.409), P = 0.005] and communication warning behavior [? = ?6.631 (?9.899, ?3.363), P < 0.001] scores and higher personal-social quotient [? = 3.347 (0.190, 6.504), P = 0.038] than children born to mothers without supplementation. Maternal vitamin D supplementation was not associated with symptoms and development quotients in ASD children (P > 0.05). Conclusions This study supports a protective association between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of ASD in offspring. Maternal multivitamin supplementation may potentially moderate the symptoms and personal-social ability in ASD children. Further studies are needed on the role of maternal nutrition in the etiology and autistic symptoms and the underlying molecular mechanisms. En ligne : https://doi.org/10.1016/j.rasd.2023.102309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521

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