Gastrointestinal symptoms have a non-temporal association with regression in a cohort with autism spectrum disorder using the simons simplex collection / Adriana BAGOS-ESTEVEZ ; LeeAnne GREEN SNYDER ; Athanasios TSALATSANIS ; Amelia BOEHME ; Jennifer M. BAIN in Research in Autism Spectrum Disorders, 111 (March 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 111 (March 2024) . - p.102326 Titre : Gastrointestinal symptoms have a non-temporal association with regression in a cohort with autism spectrum disorder using the simons simplex collection Type de document : texte imprimé Auteurs : Adriana BAGOS-ESTEVEZ, Auteur ; LeeAnne GREEN SNYDER, Auteur ; Athanasios TSALATSANIS, Auteur ; Amelia BOEHME, Auteur ; Jennifer M. BAIN, Auteur Article en page(s) : p.102326 Mots-clés : Gastrointestinal  Autism  Spectrum  Regression  Loss Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) can present with developmental regression. In this study, we hypothesize an association between Gastrointestinal (GI) symptoms and regression. We conducted a two-part analysis using data from the Simon Simplex Collection consisting of 2564 ASD probands. Independent sample t-tests or chi-squared tests were utilized comparing regression against no-regression groups, and regression in children with and without early onset of GI symptoms. The presence of GI symptoms of any kind is associated with regression (odds ratio= 1.51; 95% CI 1.25 - 2.82; p < 0.001). Early GI effects on subsequent development of regression demonstrate no association (OR=0.81; 95% CI 0.649 1.01; p < 0.062). Although a clear relationship between GI symptoms and regression is demonstrated in this study, the lack of temporal relationship between the two highlight the need for a better understanding of the underlying mechanism behind this phenomenon. En ligne : https://doi.org/10.1016/j.rasd.2024.102326 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521 [article] Gastrointestinal symptoms have a non-temporal association with regression in a cohort with autism spectrum disorder using the simons simplex collection [texte imprimé] / Adriana BAGOS-ESTEVEZ, Auteur ; LeeAnne GREEN SNYDER, Auteur ; Athanasios TSALATSANIS, Auteur ; Amelia BOEHME, Auteur ; Jennifer M. BAIN, Auteur . - p.102326. in Research in Autism Spectrum Disorders > 111 (March 2024) . - p.102326 Mots-clés : Gastrointestinal  Autism  Spectrum  Regression  Loss Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) can present with developmental regression. In this study, we hypothesize an association between Gastrointestinal (GI) symptoms and regression. We conducted a two-part analysis using data from the Simon Simplex Collection consisting of 2564 ASD probands. Independent sample t-tests or chi-squared tests were utilized comparing regression against no-regression groups, and regression in children with and without early onset of GI symptoms. The presence of GI symptoms of any kind is associated with regression (odds ratio= 1.51; 95% CI 1.25 - 2.82; p < 0.001). Early GI effects on subsequent development of regression demonstrate no association (OR=0.81; 95% CI 0.649 1.01; p < 0.062). Although a clear relationship between GI symptoms and regression is demonstrated in this study, the lack of temporal relationship between the two highlight the need for a better understanding of the underlying mechanism behind this phenomenon. En ligne : https://doi.org/10.1016/j.rasd.2024.102326 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521

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