Atypical Scene-Selectivity in the Retrosplenial Complex in Individuals With Autism Spectrum Disorder / Andrew S. PERSICHETTI in Autism Research, 18-8 (August 2025)  

Public ISBD [article]  inAutism Research > 18-8 (August 2025) . - p.1563-1567 Titre : Atypical Scene-Selectivity in the Retrosplenial Complex in Individuals With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Andrew S. PERSICHETTI, Auteur ; Taylor L. LI, Auteur ; W. Dale STEVENS, Auteur ; Alex MARTIN, Auteur ; Adrian W. GILMORE, Auteur Article en page(s) : p.1563-1567 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  functional MRI  navigation  scene perception  spatial cognition Index. décimale : PER Périodiques Résumé : ABSTRACT A small behavioral literature on individuals with autism spectrum disorder (ASD) has shown that they can be impaired when navigating using map-based strategies (i.e., memory-guided navigation), but not during visually-guided navigation. Meanwhile, there is neuroimaging evidence in typically developing (TD) individuals demonstrating that the retrosplenial complex (RSC) is part of a memory-guided navigation system, while the occipital place area (OPA) is part of a visually-guided navigation system. A key identifying feature of the RSC and OPA is that they respond significantly more to pictures of places compared to faces or objects?i.e., they demonstrate scene-selectivity. Therefore, we predicted that scene-selectivity would be weaker in the RSC of individuals with ASD compared to a TD control group, while the OPA would not show such a difference between the groups. We used functional MRI to scan groups of ASD individuals and matched TD individuals while they viewed pictures of places and faces and performed a one-back task. As predicted, scene-selectivity was significantly lower in the RSC, but not OPA, in the ASD group compared to the TD group. These results suggest that impaired memory-guided navigation in individuals with ASD may, in part, be due to atypical functioning in the RSC. En ligne : https://doi.org/10.1002/aur.70079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566 [article] Atypical Scene-Selectivity in the Retrosplenial Complex in Individuals With Autism Spectrum Disorder [texte imprimé] / Andrew S. PERSICHETTI, Auteur ; Taylor L. LI, Auteur ; W. Dale STEVENS, Auteur ; Alex MARTIN, Auteur ; Adrian W. GILMORE, Auteur . - p.1563-1567. Langues : Anglais (eng) in Autism Research > 18-8 (August 2025) . - p.1563-1567 Mots-clés : autism spectrum disorder  functional MRI  navigation  scene perception  spatial cognition Index. décimale : PER Périodiques Résumé : ABSTRACT A small behavioral literature on individuals with autism spectrum disorder (ASD) has shown that they can be impaired when navigating using map-based strategies (i.e., memory-guided navigation), but not during visually-guided navigation. Meanwhile, there is neuroimaging evidence in typically developing (TD) individuals demonstrating that the retrosplenial complex (RSC) is part of a memory-guided navigation system, while the occipital place area (OPA) is part of a visually-guided navigation system. A key identifying feature of the RSC and OPA is that they respond significantly more to pictures of places compared to faces or objects?i.e., they demonstrate scene-selectivity. Therefore, we predicted that scene-selectivity would be weaker in the RSC of individuals with ASD compared to a TD control group, while the OPA would not show such a difference between the groups. We used functional MRI to scan groups of ASD individuals and matched TD individuals while they viewed pictures of places and faces and performed a one-back task. As predicted, scene-selectivity was significantly lower in the RSC, but not OPA, in the ASD group compared to the TD group. These results suggest that impaired memory-guided navigation in individuals with ASD may, in part, be due to atypical functioning in the RSC. En ligne : https://doi.org/10.1002/aur.70079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566

Scene construction and autobiographical memory retrieval in autism spectrum disorder / Anna M. AGRON in Autism Research, 17-2 (February 2024)  

Public ISBD [article]  inAutism Research > 17-2 (February 2024) . - p.204-214 Titre : Scene construction and autobiographical memory retrieval in autism spectrum disorder Type de document : texte imprimé Auteurs : Anna M. AGRON, Auteur ; Alex MARTIN, Auteur ; Adrian W. GILMORE, Auteur Article en page(s) : p.204-214 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Individuals with autism spectrum disorder (ASD) frequently exhibit difficulties in retrieving autobiographical memories (AMs) of specific events from their life. Such memory deficits are frequently attributed to underlying disruptions in self-referential or social cognition processes. This makes intuitive sense as these are hallmarks of ASD. However, an emerging literature suggests that parallel deficits also exist in ASD individuals' ability to reconstruct the rich spatial contexts in which events occur. This is a capacity known as scene construction, and in typically developing individuals is considered a core process in retrieving AMs. In this review, we discuss evidence of difficulties with scene construction in ASD, drawing upon experiments that involve AM retrieval, other forms of mental time travel, and spatial navigation. We also highlight aspects of extant data that cannot be accounted for using purely social explanations of memory deficits in ASD. We conclude by identifying key questions raised by our framework and suggest how they might be addressed in future research. En ligne : https://doi.org/10.1002/aur.3066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522 [article] Scene construction and autobiographical memory retrieval in autism spectrum disorder [texte imprimé] / Anna M. AGRON, Auteur ; Alex MARTIN, Auteur ; Adrian W. GILMORE, Auteur . - p.204-214. Langues : Anglais (eng) in Autism Research > 17-2 (February 2024) . - p.204-214 Index. décimale : PER Périodiques Résumé : Abstract Individuals with autism spectrum disorder (ASD) frequently exhibit difficulties in retrieving autobiographical memories (AMs) of specific events from their life. Such memory deficits are frequently attributed to underlying disruptions in self-referential or social cognition processes. This makes intuitive sense as these are hallmarks of ASD. However, an emerging literature suggests that parallel deficits also exist in ASD individuals' ability to reconstruct the rich spatial contexts in which events occur. This is a capacity known as scene construction, and in typically developing individuals is considered a core process in retrieving AMs. In this review, we discuss evidence of difficulties with scene construction in ASD, drawing upon experiments that involve AM retrieval, other forms of mental time travel, and spatial navigation. We also highlight aspects of extant data that cannot be accounted for using purely social explanations of memory deficits in ASD. We conclude by identifying key questions raised by our framework and suggest how they might be addressed in future research. En ligne : https://doi.org/10.1002/aur.3066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522

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