[article] 
inJournal of Autism and Developmental Disorders > 39-11 (November 2009) . - p.1542-1551

Titre :	Association of COMT (Val158Met) and BDNF (Val66Met) Gene Polymorphisms with Anxiety, ADHD and Tics in Children with Autism Spectrum Disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur ; Sarah KIRSCH, Auteur
Année de publication :	2009
Article en page(s) :	p.1542-1551
Langues :	Anglais (eng)
Mots-clés :	Autism Autism-spectrum-disorder Anxiety Attention-deficit-hyperactivity-disorder Tourette-syndrome BDNF COMT DAT1
Index. décimale :	PER Périodiques
Résumé :	The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp 2 = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp 2 = 0.10) and teacher-rated tics (p = 0.04; ηp 2 = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp 2 = 0.09) of BDNF genotype with DAT1 3′ VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples.
En ligne :	http://dx.doi.org/10.1007/s10803-009-0794-4
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=849

[article] Association of COMT (Val158Met) and BDNF (Val66Met) Gene Polymorphisms with Anxiety, ADHD and Tics in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur ; Sarah KIRSCH, Auteur . - 2009 . - p.1542-1551.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-11 (November 2009) . - p.1542-1551

Mots-clés :	Autism Autism-spectrum-disorder Anxiety Attention-deficit-hyperactivity-disorder Tourette-syndrome BDNF COMT DAT1
Index. décimale :	PER Périodiques
Résumé :	The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp 2 = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp 2 = 0.10) and teacher-rated tics (p = 0.04; ηp 2 = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp 2 = 0.09) of BDNF genotype with DAT1 3′ VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples.
En ligne :	http://dx.doi.org/10.1007/s10803-009-0794-4
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=849