Childhood internalising symptoms at ages 3 and 6: a meta-analysis of epigenome-wide associations from cord and peripheral blood / Laura SCHELLHAS in Journal of Child Psychology and Psychiatry, 67-11 (November 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-11 (November 2026) . - p.1868-1882 Titre : Childhood internalising symptoms at ages 3 and 6: a meta-analysis of epigenome-wide associations from cord and peripheral blood Type de document : texte imprimé Auteurs : Laura SCHELLHAS, Auteur ; Mannan LUO, Auteur ; Janine F. FELIX, Auteur ; Christian M. PAGE, Auteur ; Mona BEKKHUS, Auteur ; Marcus R. MUNAFO, Auteur ; Luisa ZUCCOLO, Auteur ; Alexandra HAVDAHL, Auteur ; Charlotte A. M. CECIL, Auteur ; Gemma C. SHARP, Auteur Article en page(s) : p.1868-1882 Langues : Anglais (eng) Mots-clés : PACE consortium  internalising problems  DNA methylation Index. décimale : PER Périodiques Résumé : Background Pre- and postpartum environments and genetic effects influence childhood internalising problems, which increase depression risk. DNA methylation (DNAm) may capture some of these effects. We therefore investigated associations between child blood DNAm and internalising problems. Methods We meta-analysed probe and region-level epigenome-wide association studies using data from 3 European birth cohorts (ALSPAC, MoBa, Generation R; analytic N?=?1,121?3,011) from the Pregnancy And Childhood Epigenetics (PACE) Consortium. DNAm was assessed at birth (cord blood) and age 6?years (peripheral blood). Internalising problems (ages 3 and 6) were reported by mothers using the Child Behaviour Checklist or Strengths and Difficulties Questionnaire. Models were adjusted for age at DNAm assessment, 20 surrogate variables, estimated cell proportions, maternal education, age, smoking and, in secondary analysis, maternal anxiety and depression. Public databases were searched for mental health associations with top CpG sites and regions. Results No significant probe-level associations were found between cord- or peripheral-blood DNAm and internalising problems. In region-level analyses, two differentially methylated regions (DMRs) in cord blood were associated with internalising problems at age 3 (annotated to STK32C, MIR886) and one at age 6 (PFKFB2). At age 6, peripheral-blood analyses identified two DMRs (C10orf26 (WBP1L), FAM125A). Several genes showed prior associations with psychiatric phenotypes, including depression. Conclusions The higher-powered regional-level analyses revealed more associations than probe-level. Among others, we identified a region annotated to STK32C that has previously been linked to adolescent depression. Larger samples and refined phenotyping are needed to clarify the role of DNAm in internalising problems. En ligne : https://doi.org/10.1111/jcpp.70186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Childhood internalising symptoms at ages 3 and 6: a meta-analysis of epigenome-wide associations from cord and peripheral blood [texte imprimé] / Laura SCHELLHAS, Auteur ; Mannan LUO, Auteur ; Janine F. FELIX, Auteur ; Christian M. PAGE, Auteur ; Mona BEKKHUS, Auteur ; Marcus R. MUNAFO, Auteur ; Luisa ZUCCOLO, Auteur ; Alexandra HAVDAHL, Auteur ; Charlotte A. M. CECIL, Auteur ; Gemma C. SHARP, Auteur . - p.1868-1882. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-11 (November 2026) . - p.1868-1882 Mots-clés : PACE consortium  internalising problems  DNA methylation Index. décimale : PER Périodiques Résumé : Background Pre- and postpartum environments and genetic effects influence childhood internalising problems, which increase depression risk. DNA methylation (DNAm) may capture some of these effects. We therefore investigated associations between child blood DNAm and internalising problems. Methods We meta-analysed probe and region-level epigenome-wide association studies using data from 3 European birth cohorts (ALSPAC, MoBa, Generation R; analytic N?=?1,121?3,011) from the Pregnancy And Childhood Epigenetics (PACE) Consortium. DNAm was assessed at birth (cord blood) and age 6?years (peripheral blood). Internalising problems (ages 3 and 6) were reported by mothers using the Child Behaviour Checklist or Strengths and Difficulties Questionnaire. Models were adjusted for age at DNAm assessment, 20 surrogate variables, estimated cell proportions, maternal education, age, smoking and, in secondary analysis, maternal anxiety and depression. Public databases were searched for mental health associations with top CpG sites and regions. Results No significant probe-level associations were found between cord- or peripheral-blood DNAm and internalising problems. In region-level analyses, two differentially methylated regions (DMRs) in cord blood were associated with internalising problems at age 3 (annotated to STK32C, MIR886) and one at age 6 (PFKFB2). At age 6, peripheral-blood analyses identified two DMRs (C10orf26 (WBP1L), FAM125A). Several genes showed prior associations with psychiatric phenotypes, including depression. Conclusions The higher-powered regional-level analyses revealed more associations than probe-level. Among others, we identified a region annotated to STK32C that has previously been linked to adolescent depression. Larger samples and refined phenotyping are needed to clarify the role of DNAm in internalising problems. En ligne : https://doi.org/10.1111/jcpp.70186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Exposure to prenatal infection and the development of internalizing and externalizing problems in children: a longitudinal population-based study / Anna-Sophie ROMMEL ; Alexander NEUMANN ; Mannan LUO ; Manon H.J. HILLEGERS ; Lotje DE WITTE ; Veerle BERGINK ; Charlotte A.M. CECIL in Journal of Child Psychology and Psychiatry, 65-7 (July 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-7 (July 2024) . - p.874-886 Titre : Exposure to prenatal infection and the development of internalizing and externalizing problems in children: a longitudinal population-based study Type de document : texte imprimé Auteurs : Anna-Sophie ROMMEL, Auteur ; Alexander NEUMANN, Auteur ; Mannan LUO, Auteur ; Manon H.J. HILLEGERS, Auteur ; Lotje DE WITTE, Auteur ; Veerle BERGINK, Auteur ; Charlotte A.M. CECIL, Auteur Article en page(s) : p.874-886 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background A large body of work has reported a link between prenatal exposure to infection and increased psychiatric risk in offspring. However, studies to date have focused primarily on exposure to severe prenatal infections and/or individual psychiatric diagnoses in clinical samples, typically measured at single time points, and without accounting for important genetic and environmental confounders. In this study, we investigated whether exposure to common infections during pregnancy is prospectively associated with repeatedly assessed child psychiatric symptoms in a large population-based study. Methods Our study was embedded in a prospective pregnancy cohort (Generation R; n = 3,598 mother-child dyads). We constructed a comprehensive prenatal infection score comprising common infections for each trimester of pregnancy. Child total, internalizing, and externalizing problems were assessed repeatedly using the parent-rated Child Behavioral Checklist (average age: 1.5, 3, 6, 10, and 14 years). Linear mixed-effects models were run adjusting for a range of confounders, including child polygenic scores for psychopathology, maternal chronic illness, birth complications, and infections during childhood. We also investigated trimester-specific effects and child sex as a potential moderator. Results Prenatal exposure to infections was associated with higher child total, internalizing, and externalizing problems, showing temporally persistent effects, even after adjusting for important genetic and environmental confounders. We found no evidence that prenatal infections were associated with changes in child psychiatric symptoms over time. Moreover, in our trimester-specific analysis, we did not find evidence of significant timing effects of prenatal infection on child psychiatric symptoms. No interactions with child sex were identified. Conclusions Our research adds to evidence that common prenatal infections may be a risk factor for psychiatric symptoms in children. We also extend previous findings by showing that these associations are present early on, and that rather than changing over time, they persist into adolescence. However, unmeasured confounding may still explain in part these associations. In the future, employing more advanced causal inference designs will be crucial to establishing the degree to which these effects are causal. En ligne : https://doi.org/10.1111/jcpp.13923 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Exposure to prenatal infection and the development of internalizing and externalizing problems in children: a longitudinal population-based study [texte imprimé] / Anna-Sophie ROMMEL, Auteur ; Alexander NEUMANN, Auteur ; Mannan LUO, Auteur ; Manon H.J. HILLEGERS, Auteur ; Lotje DE WITTE, Auteur ; Veerle BERGINK, Auteur ; Charlotte A.M. CECIL, Auteur . - p.874-886. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-7 (July 2024) . - p.874-886 Index. décimale : PER Périodiques Résumé : Background A large body of work has reported a link between prenatal exposure to infection and increased psychiatric risk in offspring. However, studies to date have focused primarily on exposure to severe prenatal infections and/or individual psychiatric diagnoses in clinical samples, typically measured at single time points, and without accounting for important genetic and environmental confounders. In this study, we investigated whether exposure to common infections during pregnancy is prospectively associated with repeatedly assessed child psychiatric symptoms in a large population-based study. Methods Our study was embedded in a prospective pregnancy cohort (Generation R; n = 3,598 mother-child dyads). We constructed a comprehensive prenatal infection score comprising common infections for each trimester of pregnancy. Child total, internalizing, and externalizing problems were assessed repeatedly using the parent-rated Child Behavioral Checklist (average age: 1.5, 3, 6, 10, and 14 years). Linear mixed-effects models were run adjusting for a range of confounders, including child polygenic scores for psychopathology, maternal chronic illness, birth complications, and infections during childhood. We also investigated trimester-specific effects and child sex as a potential moderator. Results Prenatal exposure to infections was associated with higher child total, internalizing, and externalizing problems, showing temporally persistent effects, even after adjusting for important genetic and environmental confounders. We found no evidence that prenatal infections were associated with changes in child psychiatric symptoms over time. Moreover, in our trimester-specific analysis, we did not find evidence of significant timing effects of prenatal infection on child psychiatric symptoms. No interactions with child sex were identified. Conclusions Our research adds to evidence that common prenatal infections may be a risk factor for psychiatric symptoms in children. We also extend previous findings by showing that these associations are present early on, and that rather than changing over time, they persist into adolescence. However, unmeasured confounding may still explain in part these associations. In the future, employing more advanced causal inference designs will be crucial to establishing the degree to which these effects are causal. En ligne : https://doi.org/10.1111/jcpp.13923 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

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