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Auteur Alexandra HAVDAHL |
Documents disponibles écrits par cet auteur (7)



Attainment and loss of early social-communication skills across neurodevelopmental conditions in the Norwegian Mother, Father and Child Cohort Study / Alexandra HAVDAHL in Journal of Child Psychology and Psychiatry, 65-5 (May 2024)
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[article]
Titre : Attainment and loss of early social-communication skills across neurodevelopmental conditions in the Norwegian Mother, Father and Child Cohort Study Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra HAVDAHL, Auteur ; Cristan FARMER, Auteur ; Pål SUREN, Auteur ; Anne-Siri ØYEN, Auteur ; Per MAGNUS, Auteur ; Ezra SUSSER, Auteur ; W. Ian LIPKIN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Camilla STOLTENBERG, Auteur ; Somer BISHOP, Auteur ; Audrey THURM, Auteur Article en page(s) : p.610-619 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Delays and loss of early-emerging social-communication skills are often discussed as unique to autism. However, most studies of regression have relied on retrospective recall and clinical samples. Here, we examine attainment and loss of social-communication skills in the population-based Norwegian Mother, Father and Child Cohort Study (MoBa). Methods Mothers rated their child's attainment of 10 early-emerging social-communication skills at ages 18 and 36?months (N = 40,613, 50.9% male). Prospectively reported loss was defined as skill presence at 18?months but absence at 36?months. At 36?months, mothers also recalled whether the child had lost social-communication skills. The Norwegian Patient Registry was used to capture diagnoses of Autism Spectrum Disorder (autism) and other neurodevelopmental disabilities (NDDs). Results Delay in at least one skill was observed in 14% of the sample and loss in 5.4%. Recalled loss of social-communication skills was rare (0.86%) and showed low convergence with prospectively reported loss. Delay and especially loss were associated with elevated odds of an autism diagnosis (n = 383) versus no autism diagnosis (n = 40,230; ?3 skills delayed: OR = 7.09[4.15,12.11]; ?3 skills lost: OR = 30.66[17.30,54.33]). They were also associated with an increased likelihood of autism compared to some other NDDs. Delay (relative risk [RR] = 4.16[2.08, 8.33]) and loss (RR = 10.00[3.70, 25.00]) associated with increased likelihood of autism versus ADHD, and loss (RR = 4.35[1.28,14.29]), but not delay (RR = 2.00[0.78,5.26]), associated with increased likelihood of autism compared to language disability. Conversely, delay conferred decreased likelihood of autism versus intellectual disability (RR = 0.11[0.06,0.21]), and loss was not reliably associated with likelihood of autism versus intellectual disability (RR = 1.89[0.44,8.33]). Conclusions This population-based study suggests that loss of early social communication skills is more common than studies using retrospective reports have indicated and is observed across several NDD diagnoses (not just autism). Nevertheless, most children with NDD diagnoses showed no reported delay or loss in these prospectively measured skills. En ligne : https://doi.org/10.1111/jcpp.13792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526
in Journal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.610-619[article] Attainment and loss of early social-communication skills across neurodevelopmental conditions in the Norwegian Mother, Father and Child Cohort Study [Texte imprimé et/ou numérique] / Alexandra HAVDAHL, Auteur ; Cristan FARMER, Auteur ; Pål SUREN, Auteur ; Anne-Siri ØYEN, Auteur ; Per MAGNUS, Auteur ; Ezra SUSSER, Auteur ; W. Ian LIPKIN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Camilla STOLTENBERG, Auteur ; Somer BISHOP, Auteur ; Audrey THURM, Auteur . - p.610-619.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.610-619
Index. décimale : PER Périodiques Résumé : Background Delays and loss of early-emerging social-communication skills are often discussed as unique to autism. However, most studies of regression have relied on retrospective recall and clinical samples. Here, we examine attainment and loss of social-communication skills in the population-based Norwegian Mother, Father and Child Cohort Study (MoBa). Methods Mothers rated their child's attainment of 10 early-emerging social-communication skills at ages 18 and 36?months (N = 40,613, 50.9% male). Prospectively reported loss was defined as skill presence at 18?months but absence at 36?months. At 36?months, mothers also recalled whether the child had lost social-communication skills. The Norwegian Patient Registry was used to capture diagnoses of Autism Spectrum Disorder (autism) and other neurodevelopmental disabilities (NDDs). Results Delay in at least one skill was observed in 14% of the sample and loss in 5.4%. Recalled loss of social-communication skills was rare (0.86%) and showed low convergence with prospectively reported loss. Delay and especially loss were associated with elevated odds of an autism diagnosis (n = 383) versus no autism diagnosis (n = 40,230; ?3 skills delayed: OR = 7.09[4.15,12.11]; ?3 skills lost: OR = 30.66[17.30,54.33]). They were also associated with an increased likelihood of autism compared to some other NDDs. Delay (relative risk [RR] = 4.16[2.08, 8.33]) and loss (RR = 10.00[3.70, 25.00]) associated with increased likelihood of autism versus ADHD, and loss (RR = 4.35[1.28,14.29]), but not delay (RR = 2.00[0.78,5.26]), associated with increased likelihood of autism compared to language disability. Conversely, delay conferred decreased likelihood of autism versus intellectual disability (RR = 0.11[0.06,0.21]), and loss was not reliably associated with likelihood of autism versus intellectual disability (RR = 1.89[0.44,8.33]). Conclusions This population-based study suggests that loss of early social communication skills is more common than studies using retrospective reports have indicated and is observed across several NDD diagnoses (not just autism). Nevertheless, most children with NDD diagnoses showed no reported delay or loss in these prospectively measured skills. En ligne : https://doi.org/10.1111/jcpp.13792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 Commentary: Meeting the challenge of multidimensionality in neurodevelopmental disorders-reflections on Johnson et al. (2021) / Laurie J. HANNIGAN in Journal of Child Psychology and Psychiatry, 62-5 (May 2021)
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Titre : Commentary: Meeting the challenge of multidimensionality in neurodevelopmental disorders-reflections on Johnson et al. (2021) Type de document : Texte imprimé et/ou numérique Auteurs : Laurie J. HANNIGAN, Auteur ; Alexandra HAVDAHL, Auteur Article en page(s) : p.631-634 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders are widely acknowledged to be complex and multifactorial in origin, but this is rarely reflected in the approaches used to study them. We reflect on the 2021 Annual Research review and its introduction of a new conceptual framework designed to make the complexity of early neurodevelopment more empirically tractable. We evaluate the review authors' justification, explanation, and guidance for implementation of their framework in the context of their stated goals and highlight key assumptions that support its conceptual validity. Finally, we offer a genetic epidemiological perspective on potential applications, suggesting ways in which genomic data can be used to elucidate causal mechanistic processes within the AMEND framework. En ligne : http://dx.doi.org/10.1111/jcpp.13416 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445
in Journal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.631-634[article] Commentary: Meeting the challenge of multidimensionality in neurodevelopmental disorders-reflections on Johnson et al. (2021) [Texte imprimé et/ou numérique] / Laurie J. HANNIGAN, Auteur ; Alexandra HAVDAHL, Auteur . - p.631-634.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.631-634
Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders are widely acknowledged to be complex and multifactorial in origin, but this is rarely reflected in the approaches used to study them. We reflect on the 2021 Annual Research review and its introduction of a new conceptual framework designed to make the complexity of early neurodevelopment more empirically tractable. We evaluate the review authors' justification, explanation, and guidance for implementation of their framework in the context of their stated goals and highlight key assumptions that support its conceptual validity. Finally, we offer a genetic epidemiological perspective on potential applications, suggesting ways in which genomic data can be used to elucidate causal mechanistic processes within the AMEND framework. En ligne : http://dx.doi.org/10.1111/jcpp.13416 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 Early manifestations of genetic risk for neurodevelopmental disorders / Ragna Bugge ASKELAND in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)
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Titre : Early manifestations of genetic risk for neurodevelopmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ragna Bugge ASKELAND, Auteur ; Laurie J. HANNIGAN, Auteur ; Helga ASK, Auteur ; Ziada AYORECH, Auteur ; Martin TESLI, Auteur ; Elizabeth CORFIELD, Auteur ; Per MAGNUS, Auteur ; Pål Rasmus NJØLSTAD, Auteur ; Ole A. ANDREASSEN, Auteur ; George DAVEY SMITH, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Alexandra HAVDAHL, Auteur Article en page(s) : p.810-819 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/complications/epidemiology/genetics Autism Spectrum Disorder/complications/epidemiology/genetics Child Child, Preschool Cohort Studies Female Humans Male Mothers Neurodevelopmental Disorders/complications/epidemiology/genetics Risk Factors Adhd MoBa Polygenic risk score autism hyperactivity inattention language and motor difficulties neurodevelopmental disorders repetitive behavior schizophrenia social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important to increase our understanding of how the polygenic risk for neurodevelopmental disorders manifests during childhood in boys and girls. METHODS: Polygenic risk scores (PRS) for ADHD, autism and schizophrenia were calculated in a subsample of 15?205 children from the Norwegian Mother, Father and Child Cohort Study (MoBa). Mother-reported traits of repetitive behavior, social communication, language and motor difficulties, hyperactivity and inattention were measured in children at 6 and 18?months, 3, 5 and 8?years. Linear regression models in a multigroup framework were used to investigate associations between the three PRS and dimensional trait measures in MoBa, using sex as a grouping variable. RESULTS: Before the age of 2, the ADHD PRS was robustly associated with hyperactivity and inattention, with increasing strength up to 8?years, and with language difficulties at age 5 and 8. The autism PRS was robustly associated with language difficulties at 18?months, motor difficulties at 36?months, and hyperactivity and inattention at 8?years. We did not identify robust associations for the schizophrenia PRS. In general, the PRS associations were similar in boys and girls. The association between ADHD PRS and hyperactivity at 18?months was, however, stronger in boys. CONCLUSIONS: Polygenic risk for autism and ADHD in the general population manifests early in childhood and broadly across behavioral measures of neurodevelopmental traits. En ligne : http://dx.doi.org/10.1111/jcpp.13528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.810-819[article] Early manifestations of genetic risk for neurodevelopmental disorders [Texte imprimé et/ou numérique] / Ragna Bugge ASKELAND, Auteur ; Laurie J. HANNIGAN, Auteur ; Helga ASK, Auteur ; Ziada AYORECH, Auteur ; Martin TESLI, Auteur ; Elizabeth CORFIELD, Auteur ; Per MAGNUS, Auteur ; Pål Rasmus NJØLSTAD, Auteur ; Ole A. ANDREASSEN, Auteur ; George DAVEY SMITH, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Alexandra HAVDAHL, Auteur . - p.810-819.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.810-819
Mots-clés : Attention Deficit Disorder with Hyperactivity/complications/epidemiology/genetics Autism Spectrum Disorder/complications/epidemiology/genetics Child Child, Preschool Cohort Studies Female Humans Male Mothers Neurodevelopmental Disorders/complications/epidemiology/genetics Risk Factors Adhd MoBa Polygenic risk score autism hyperactivity inattention language and motor difficulties neurodevelopmental disorders repetitive behavior schizophrenia social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important to increase our understanding of how the polygenic risk for neurodevelopmental disorders manifests during childhood in boys and girls. METHODS: Polygenic risk scores (PRS) for ADHD, autism and schizophrenia were calculated in a subsample of 15?205 children from the Norwegian Mother, Father and Child Cohort Study (MoBa). Mother-reported traits of repetitive behavior, social communication, language and motor difficulties, hyperactivity and inattention were measured in children at 6 and 18?months, 3, 5 and 8?years. Linear regression models in a multigroup framework were used to investigate associations between the three PRS and dimensional trait measures in MoBa, using sex as a grouping variable. RESULTS: Before the age of 2, the ADHD PRS was robustly associated with hyperactivity and inattention, with increasing strength up to 8?years, and with language difficulties at age 5 and 8. The autism PRS was robustly associated with language difficulties at 18?months, motor difficulties at 36?months, and hyperactivity and inattention at 8?years. We did not identify robust associations for the schizophrenia PRS. In general, the PRS associations were similar in boys and girls. The association between ADHD PRS and hyperactivity at 18?months was, however, stronger in boys. CONCLUSIONS: Polygenic risk for autism and ADHD in the general population manifests early in childhood and broadly across behavioral measures of neurodevelopmental traits. En ligne : http://dx.doi.org/10.1111/jcpp.13528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study / Paul MADLEY-DOWD in Molecular Autism, 13 (2022)
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Titre : Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Paul MADLEY-DOWD, Auteur ; Christina DARDANI, Auteur ; Robyn E. WOOTTON, Auteur ; Kyle DACK, Auteur ; Tom PALMER, Auteur ; Rupert THURSTON, Auteur ; Alexandra HAVDAHL, Auteur ; Jean GOLDING, Auteur ; Deborah LAWLOR, Auteur ; Dheeraj RAI, Auteur Article en page(s) : 44 p. Langues : Anglais (eng) Mots-clés : Child Pregnancy Female Humans Autistic Disorder/epidemiology/etiology Longitudinal Studies Cohort Studies Prospective Studies Vitamin D Alspac Autism Mendelian randomization Index. décimale : PER Périodiques Résumé : BACKGROUND: There has been a growing interest in the association between maternal levels of vitamin D during pregnancy and offspring autism. However, whether any associations reflect causal effects is still inconclusive. METHODS: We used data from a UK-based pregnancy cohort study (Avon Longitudinal Study of Parents and Children) comprising 7689 births between 1991 and 1992 with maternal blood vitamin D levels recorded during pregnancy and at least one recorded outcome measure, including autism diagnosis and autism-associated traits. The association between each outcome with seasonal and gestational age-adjusted maternal serum 25-hydroxyvitamin D during pregnancy was estimated using confounder-adjusted regression models. Multiple imputation was used to account for missing data, and restricted cubic splines were used to investigate nonlinear associations. Mendelian randomization was used to strengthen causal inference. RESULTS: No strong evidence of an association between maternal serum 25-hydroxyvitamin D during pregnancy and any offspring autism-associated outcome was found using multivariable regression analysis (autism diagnosis: adjusted OR=0.98, 95% CI=0.90-1.06), including with multiple imputation (autism diagnosis: adjusted OR=0.99, 95% CI=0.93-1.06), and no evidence of a causal effect was suggested by Mendelian randomization (autism diagnosis: causal OR=1.08, 95% CI=0.46-2.55). Some evidence of increased odds of autism-associated traits at lower levels of maternal serum 25-hydroxyvitamin D was found using spline analysis. LIMITATIONS: Our study was potentially limited by low power, particularly for diagnosed autism cases as an outcome. The cohort may not have captured the extreme lows of the distribution of serum 25-hydroxyvitamin D, and our analyses may have been biased by residual confounding and missing data. CONCLUSIONS: The present study found no strong evidence of a causal link between maternal vitamin D levels in pregnancy and offspring diagnosis or traits of autism. En ligne : http://dx.doi.org/10.1186/s13229-022-00523-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Molecular Autism > 13 (2022) . - 44 p.[article] Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study [Texte imprimé et/ou numérique] / Paul MADLEY-DOWD, Auteur ; Christina DARDANI, Auteur ; Robyn E. WOOTTON, Auteur ; Kyle DACK, Auteur ; Tom PALMER, Auteur ; Rupert THURSTON, Auteur ; Alexandra HAVDAHL, Auteur ; Jean GOLDING, Auteur ; Deborah LAWLOR, Auteur ; Dheeraj RAI, Auteur . - 44 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 44 p.
Mots-clés : Child Pregnancy Female Humans Autistic Disorder/epidemiology/etiology Longitudinal Studies Cohort Studies Prospective Studies Vitamin D Alspac Autism Mendelian randomization Index. décimale : PER Périodiques Résumé : BACKGROUND: There has been a growing interest in the association between maternal levels of vitamin D during pregnancy and offspring autism. However, whether any associations reflect causal effects is still inconclusive. METHODS: We used data from a UK-based pregnancy cohort study (Avon Longitudinal Study of Parents and Children) comprising 7689 births between 1991 and 1992 with maternal blood vitamin D levels recorded during pregnancy and at least one recorded outcome measure, including autism diagnosis and autism-associated traits. The association between each outcome with seasonal and gestational age-adjusted maternal serum 25-hydroxyvitamin D during pregnancy was estimated using confounder-adjusted regression models. Multiple imputation was used to account for missing data, and restricted cubic splines were used to investigate nonlinear associations. Mendelian randomization was used to strengthen causal inference. RESULTS: No strong evidence of an association between maternal serum 25-hydroxyvitamin D during pregnancy and any offspring autism-associated outcome was found using multivariable regression analysis (autism diagnosis: adjusted OR=0.98, 95% CI=0.90-1.06), including with multiple imputation (autism diagnosis: adjusted OR=0.99, 95% CI=0.93-1.06), and no evidence of a causal effect was suggested by Mendelian randomization (autism diagnosis: causal OR=1.08, 95% CI=0.46-2.55). Some evidence of increased odds of autism-associated traits at lower levels of maternal serum 25-hydroxyvitamin D was found using spline analysis. LIMITATIONS: Our study was potentially limited by low power, particularly for diagnosed autism cases as an outcome. The cohort may not have captured the extreme lows of the distribution of serum 25-hydroxyvitamin D, and our analyses may have been biased by residual confounding and missing data. CONCLUSIONS: The present study found no strong evidence of a causal link between maternal vitamin D levels in pregnancy and offspring diagnosis or traits of autism. En ligne : http://dx.doi.org/10.1186/s13229-022-00523-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 Measuring autism-associated traits in the general population: Factor structure and measurement invariance across sex and diagnosis status of the Social Communication Questionnaire / Ragna BUGGE ASKELAND ; Stian BARBO VALAND ; Anne-Siri ØYEN ; Synnve SCHJØLBERG ; Vanessa H. BAL ; Somer L. BISHOP ; Camilla STOLTENBERG ; Tilmann VON SOEST ; Laurie J. HANNIGAN ; Alexandra HAVDAHL in Autism, 28-8 (August 2024)
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[article]
Titre : Measuring autism-associated traits in the general population: Factor structure and measurement invariance across sex and diagnosis status of the Social Communication Questionnaire Type de document : Texte imprimé et/ou numérique Auteurs : Ragna BUGGE ASKELAND, Auteur ; Stian BARBO VALAND, Auteur ; Anne-Siri ØYEN, Auteur ; Synnve SCHJØLBERG, Auteur ; Vanessa H. BAL, Auteur ; Somer L. BISHOP, Auteur ; Camilla STOLTENBERG, Auteur ; Tilmann VON SOEST, Auteur ; Laurie J. HANNIGAN, Auteur ; Alexandra HAVDAHL, Auteur Article en page(s) : p.2105-2119 Langues : Anglais (eng) Mots-clés : cohort studies factor analysis MBRN measurement invariance MoBa psychometrics statistical surveys and questionnaires Index. décimale : PER Périodiques Résumé : Autism screening questionnaires are sometimes used as a measure of "autism-associated traits" in samples drawn from the general population, even though such tools are primarily developed and designed for use in samples of children diagnosed with or being assessed for autism. Here, we explore the psychometric properties of the Social Communication Questionnaire (SCQ) current version reported at age 8 in a large population-based sample. Using data from the Norwegian Mother, Father and Child Cohort study (MoBa), we perform exploratory (N = 21,775) and confirmatory (N = 21,674) factor analyses on items and compare our results with previously suggested factor structure models of the SCQ. Furthermore, we test for measurement invariance across sex and registry-ascertained autism diagnostic status (Ndiagnosed = 636). A 5-factor model provided best fit to the data in both children with and without autism diagnoses, though with some qualitative differences in what the factors represent across these groups. This model performed largely consistently across boys and girls in the general population. Taken together, the SCQ?s measurement properties must be carefully considered when it is used in population-based samples and measurement invariance testing of other autism screening tools used in similar contexts is warranted. Lay abstract Using questionnaires in research relies on the expectation that they measure the same things across different groups of individuals. If this is not true, then interpretations of results can be misleading when researchers compare responses across different groups of individuals or use in it a group that differs from that in which the questionnaire was developed. For the questionnaire we investigated, the Social Communication Questionnaire (SCQ), we found that parents of boys and girls responded to questionnaire items in largely the same way but that the SCQ measured traits and behaviors slightly differently depending on whether the children had autism. Based on these results, we concluded that researchers using this questionnaire should carefully consider these differences when deciding how to interpret findings. SCQ scores as a reflection of "autism-associated traits" in samples that are mostly or entirely made up of individuals without an autism diagnosis may be misleading and we encourage a more precise interpretation of scores as a broader indication of social-communicative and behavioral traits. En ligne : https://dx.doi.org/10.1177/13623613231219306 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533
in Autism > 28-8 (August 2024) . - p.2105-2119[article] Measuring autism-associated traits in the general population: Factor structure and measurement invariance across sex and diagnosis status of the Social Communication Questionnaire [Texte imprimé et/ou numérique] / Ragna BUGGE ASKELAND, Auteur ; Stian BARBO VALAND, Auteur ; Anne-Siri ØYEN, Auteur ; Synnve SCHJØLBERG, Auteur ; Vanessa H. BAL, Auteur ; Somer L. BISHOP, Auteur ; Camilla STOLTENBERG, Auteur ; Tilmann VON SOEST, Auteur ; Laurie J. HANNIGAN, Auteur ; Alexandra HAVDAHL, Auteur . - p.2105-2119.
Langues : Anglais (eng)
in Autism > 28-8 (August 2024) . - p.2105-2119
Mots-clés : cohort studies factor analysis MBRN measurement invariance MoBa psychometrics statistical surveys and questionnaires Index. décimale : PER Périodiques Résumé : Autism screening questionnaires are sometimes used as a measure of "autism-associated traits" in samples drawn from the general population, even though such tools are primarily developed and designed for use in samples of children diagnosed with or being assessed for autism. Here, we explore the psychometric properties of the Social Communication Questionnaire (SCQ) current version reported at age 8 in a large population-based sample. Using data from the Norwegian Mother, Father and Child Cohort study (MoBa), we perform exploratory (N = 21,775) and confirmatory (N = 21,674) factor analyses on items and compare our results with previously suggested factor structure models of the SCQ. Furthermore, we test for measurement invariance across sex and registry-ascertained autism diagnostic status (Ndiagnosed = 636). A 5-factor model provided best fit to the data in both children with and without autism diagnoses, though with some qualitative differences in what the factors represent across these groups. This model performed largely consistently across boys and girls in the general population. Taken together, the SCQ?s measurement properties must be carefully considered when it is used in population-based samples and measurement invariance testing of other autism screening tools used in similar contexts is warranted. Lay abstract Using questionnaires in research relies on the expectation that they measure the same things across different groups of individuals. If this is not true, then interpretations of results can be misleading when researchers compare responses across different groups of individuals or use in it a group that differs from that in which the questionnaire was developed. For the questionnaire we investigated, the Social Communication Questionnaire (SCQ), we found that parents of boys and girls responded to questionnaire items in largely the same way but that the SCQ measured traits and behaviors slightly differently depending on whether the children had autism. Based on these results, we concluded that researchers using this questionnaire should carefully consider these differences when deciding how to interpret findings. SCQ scores as a reflection of "autism-associated traits" in samples that are mostly or entirely made up of individuals without an autism diagnosis may be misleading and we encourage a more precise interpretation of scores as a broader indication of social-communicative and behavioral traits. En ligne : https://dx.doi.org/10.1177/13623613231219306 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 Mechanisms linking parental educational attainment with child ADHD, depression, and academic problems: a study of extended families in The Norwegian Mother, Father and Child Cohort Study / Fartein Ask TORVIK in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)
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PermalinkOn the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families / Espen M. EILERTSEN in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)
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