Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence / E. Leighton DURHAM ; Sarah J. BRISLIN ; Peter B. BARR ; Danielle M. DICK ; Tyler M. MOORE ; Brandon L. PIERCE ; Lin TONG ; Gabrielle E. REIMANN ; Hee Jung JEONG ; Randolph M. DUPONT ; Antonia N. KACZKURKIN in Journal of Child Psychology and Psychiatry, 65-8 (August 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1047-1060 Titre : Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence Type de document : texte imprimé Auteurs : E. Leighton DURHAM, Auteur ; Sarah J. BRISLIN, Auteur ; Peter B. BARR, Auteur ; Danielle M. DICK, Auteur ; Tyler M. MOORE, Auteur ; Brandon L. PIERCE, Auteur ; Lin TONG, Auteur ; Gabrielle E. REIMANN, Auteur ; Hee Jung JEONG, Auteur ; Randolph M. DUPONT, Auteur ; Antonia N. KACZKURKIN, Auteur Article en page(s) : p.1047-1060 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background We used a polygenic score for externalizing behavior (extPGS) and structural MRI to examine potential pathways from genetic liability to conduct problems via the brain across the adolescent transition. Methods Three annual assessments of child conduct problems, attention-deficit/hyperactivity problems, and internalizing problems were conducted across across 9-13 years of age among 4,475 children of European ancestry in the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®). Results The extPGS predicted conduct problems in each wave (R2 = 2.0%-2.9%). Bifactor models revealed that the extPRS predicted variance specific to conduct problems (R2 = 1.7%-2.1%), but also variance that conduct problems shared with other measured problems (R2 = .8%-1.4%). Longitudinally, extPGS predicted levels of specific conduct problems (R2 = 2.0%), but not their slope of change across age. The extPGS was associated with total gray matter volume (TGMV; R2 = .4%) and lower TGMV predicted both specific conduct problems (R2 = 1.7%-2.1%) and the variance common to all problems in each wave (R2 = 1.6%-3.1%). A modest proportion of the polygenic liability specific to conduct problems in each wave was statistically mediated by TGMV. Conclusions Across the adolescent transition, the extPGS predicted both variance specific to conduct problems and variance shared by all measured problems. The extPGS also was associated with TGMV, which robustly predicted conduct problems. Statistical mediation analyses suggested the hypothesis that polygenic variation influences individual differences in brain development that are related to the likelihood of conduct problems during the adolescent transition, justifying new research to test this causal hypothesis. En ligne : https://doi.org/10.1111/jcpp.13944 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence [texte imprimé] / E. Leighton DURHAM, Auteur ; Sarah J. BRISLIN, Auteur ; Peter B. BARR, Auteur ; Danielle M. DICK, Auteur ; Tyler M. MOORE, Auteur ; Brandon L. PIERCE, Auteur ; Lin TONG, Auteur ; Gabrielle E. REIMANN, Auteur ; Hee Jung JEONG, Auteur ; Randolph M. DUPONT, Auteur ; Antonia N. KACZKURKIN, Auteur . - p.1047-1060. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1047-1060 Index. décimale : PER Périodiques Résumé : Background We used a polygenic score for externalizing behavior (extPGS) and structural MRI to examine potential pathways from genetic liability to conduct problems via the brain across the adolescent transition. Methods Three annual assessments of child conduct problems, attention-deficit/hyperactivity problems, and internalizing problems were conducted across across 9-13 years of age among 4,475 children of European ancestry in the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®). Results The extPGS predicted conduct problems in each wave (R2 = 2.0%-2.9%). Bifactor models revealed that the extPRS predicted variance specific to conduct problems (R2 = 1.7%-2.1%), but also variance that conduct problems shared with other measured problems (R2 = .8%-1.4%). Longitudinally, extPGS predicted levels of specific conduct problems (R2 = 2.0%), but not their slope of change across age. The extPGS was associated with total gray matter volume (TGMV; R2 = .4%) and lower TGMV predicted both specific conduct problems (R2 = 1.7%-2.1%) and the variance common to all problems in each wave (R2 = 1.6%-3.1%). A modest proportion of the polygenic liability specific to conduct problems in each wave was statistically mediated by TGMV. Conclusions Across the adolescent transition, the extPGS predicted both variance specific to conduct problems and variance shared by all measured problems. The extPGS also was associated with TGMV, which robustly predicted conduct problems. Statistical mediation analyses suggested the hypothesis that polygenic variation influences individual differences in brain development that are related to the likelihood of conduct problems during the adolescent transition, justifying new research to test this causal hypothesis. En ligne : https://doi.org/10.1111/jcpp.13944 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits / Stuart F. WHITE in Development and Psychopathology, 24-3 (August 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-3 (August 2012) . - p.1105-16. Titre : Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits Type de document : texte imprimé Auteurs : Stuart F. WHITE, Auteur ; Craig WILLIAMS W., Auteur ; Sarah J. BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Karina S. BLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Daniel Samuel PINE, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur Année de publication : 2012 Article en page(s) : p.1105-16. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Using behavioral and blood oxygen level dependent (BOLD) response indices through functional magnetic resonance imaging (fMRI), the current study investigated whether youths with disruptive behavior disorders (conduct disorder and oppositional defiant disorder) plus psychopathic traits (DBD + PT) show aberrant sensitivity to eye gaze information generally and/or whether they show particular insensitivity to eye gaze information in the context of fearful expressions. The participants were 36 children and adolescents (ages 10–17 years); 17 had DBD + PT and 19 were healthy comparison subjects. Participants performed a spatial attention paradigm where spatial attention was cued by eye gaze in faces displaying fearful, angry, or neutral affect. Eye gaze sensitivity was indexed both behaviorally and as BOLD response. There were no group differences in behavioral response: both groups showed significantly faster responses if the target was in the congruent spatial direction indicated by eye gaze. Neither group showed a Congruence × Emotion interaction; neither group showed an advantage from the displayer's emotional expression behaviorally. However, the BOLD response revealed a significant Group × Congruence × Emotion interaction. The comparison youth showed increased activity within the dorsal endogenous orienting network (superior parietal lobule and inferior parietal sulcus) for fearful congruent relative to incongruent trials relative to the youth with DBD + PT. The results are discussed with reference to current models of DBD + PT and possible treatment innovations. En ligne : http://dx.doi.org/10.1017/S0954579412000569 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits [texte imprimé] / Stuart F. WHITE, Auteur ; Craig WILLIAMS W., Auteur ; Sarah J. BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Karina S. BLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Daniel Samuel PINE, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur . - 2012 . - p.1105-16. Langues : Anglais (eng) in Development and Psychopathology > 24-3 (August 2012) . - p.1105-16. Index. décimale : PER Périodiques Résumé : Using behavioral and blood oxygen level dependent (BOLD) response indices through functional magnetic resonance imaging (fMRI), the current study investigated whether youths with disruptive behavior disorders (conduct disorder and oppositional defiant disorder) plus psychopathic traits (DBD + PT) show aberrant sensitivity to eye gaze information generally and/or whether they show particular insensitivity to eye gaze information in the context of fearful expressions. The participants were 36 children and adolescents (ages 10–17 years); 17 had DBD + PT and 19 were healthy comparison subjects. Participants performed a spatial attention paradigm where spatial attention was cued by eye gaze in faces displaying fearful, angry, or neutral affect. Eye gaze sensitivity was indexed both behaviorally and as BOLD response. There were no group differences in behavioral response: both groups showed significantly faster responses if the target was in the congruent spatial direction indicated by eye gaze. Neither group showed a Congruence × Emotion interaction; neither group showed an advantage from the displayer's emotional expression behaviorally. However, the BOLD response revealed a significant Group × Congruence × Emotion interaction. The comparison youth showed increased activity within the dorsal endogenous orienting network (superior parietal lobule and inferior parietal sulcus) for fearful congruent relative to incongruent trials relative to the youth with DBD + PT. The results are discussed with reference to current models of DBD + PT and possible treatment innovations. En ligne : http://dx.doi.org/10.1017/S0954579412000569 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents / Stuart F. WHITE in Journal of Child Psychology and Psychiatry, 54-5 (May 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.575-581 Titre : The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents Type de document : texte imprimé Auteurs : Stuart F. WHITE, Auteur ; Sarah J. BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur Article en page(s) : p.575-581 Langues : Anglais (eng) Mots-clés : Conduct disorder  development Index. décimale : PER Périodiques Résumé : Background: The presence of a large cavum septum pellucidum (CSP) has been previously associated with antisocial behavior/psychopathic traits in an adult community sample. Aims: The current study investigated the relationship between a large CSP and symptom severity in disruptive behavior disorders (DBD; conduct disorder and oppositional defiant disorder). Method: Structural MRI scans of youth with DBDs (N = 32) and healthy comparison youth (N = 27) were examined for the presence of a large CSP and if this was related to symptom severity. Results: Replicating previous results, a large CSP was associated with DBD diagnosis, proactive aggression, and level of psychopathic traits in youth. However, the presence of a large CSP was unrelated to aggression or psychopathic traits within the DBD sample. Conclusions: Early brain mal-development may increase the risk of a DBD diagnosis, but does not mark a particularly severe form of DBD within patients receiving these diagnoses. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02603.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196 [article] The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents [texte imprimé] / Stuart F. WHITE, Auteur ; Sarah J. BRISLIN, Auteur ; Stephen SINCLAIR, Auteur ; Katherine A. FOWLER, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur . - p.575-581. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.575-581 Mots-clés : Conduct disorder  development Index. décimale : PER Périodiques Résumé : Background: The presence of a large cavum septum pellucidum (CSP) has been previously associated with antisocial behavior/psychopathic traits in an adult community sample. Aims: The current study investigated the relationship between a large CSP and symptom severity in disruptive behavior disorders (DBD; conduct disorder and oppositional defiant disorder). Method: Structural MRI scans of youth with DBDs (N = 32) and healthy comparison youth (N = 27) were examined for the presence of a large CSP and if this was related to symptom severity. Results: Replicating previous results, a large CSP was associated with DBD diagnosis, proactive aggression, and level of psychopathic traits in youth. However, the presence of a large CSP was unrelated to aggression or psychopathic traits within the DBD sample. Conclusions: Early brain mal-development may increase the risk of a DBD diagnosis, but does not mark a particularly severe form of DBD within patients receiving these diagnoses. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02603.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196

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