Social connection and its prospective association with adolescent internalising and externalising symptoms: an exploratory cross-country study using retrospective harmonisation / João VILLANOVA DO AMARAL ; Giovanni Abrahão SALUM ; Euripedes Constantino MIGUEL ; Luis Augusto ROHDE ; George B. PLOUBIDIS ; Eoin MCELROY ; Mauricio Scopel HOFFMANN in Journal of Child Psychology and Psychiatry, 66-5 (May 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.725-736 Titre : Social connection and its prospective association with adolescent internalising and externalising symptoms: an exploratory cross-country study using retrospective harmonisation Type de document : Texte imprimé et/ou numérique Auteurs : João VILLANOVA DO AMARAL, Auteur ; Giovanni Abrahão SALUM, Auteur ; Euripedes Constantino MIGUEL, Auteur ; Luis Augusto ROHDE, Auteur ; George B. PLOUBIDIS, Auteur ; Eoin MCELROY, Auteur ; Mauricio Scopel HOFFMANN, Auteur Article en page(s) : p.725-736 Langues : Anglais (eng) Mots-clés : Adolescent mental health  social connection  country comparison  harmonisation Index. décimale : PER Périodiques Résumé : Background Social connection factors play a key role for young people's mental health. It is important to understand how their influence may vary across contexts. We investigated structural (e.g. household size), functional (e.g. social support) and quality (e.g. feeling close) social connection factors in relation to adolescent internalising and externalising symptoms, comparing two countries Brazil and the United Kingdom (UK). Methods We pooled data from the UK Millennium Cohort Study (MCS) and the Brazilian High Risk Cohort Study (BHRCS). We included 12 social connection variables, identified through retrospective harmonisation and lived experience expert involvement. We tested measurement invariance and conducted multiple regressions to analyse associations between the social connection factors (age 14) and later internalising and externalising difficulties (age 17.5) in both cohorts. We investigated country-level interactions and used weights to account for attrition, survey design, population representativeness and sample size. Results We found pooled main associations with later internalising symptoms for ?living with half-siblings? (p? En ligne : https://doi.org/10.1111/jcpp.14080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Social connection and its prospective association with adolescent internalising and externalising symptoms: an exploratory cross-country study using retrospective harmonisation [Texte imprimé et/ou numérique] / João VILLANOVA DO AMARAL, Auteur ; Giovanni Abrahão SALUM, Auteur ; Euripedes Constantino MIGUEL, Auteur ; Luis Augusto ROHDE, Auteur ; George B. PLOUBIDIS, Auteur ; Eoin MCELROY, Auteur ; Mauricio Scopel HOFFMANN, Auteur . - p.725-736. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.725-736 Mots-clés : Adolescent mental health  social connection  country comparison  harmonisation Index. décimale : PER Périodiques Résumé : Background Social connection factors play a key role for young people's mental health. It is important to understand how their influence may vary across contexts. We investigated structural (e.g. household size), functional (e.g. social support) and quality (e.g. feeling close) social connection factors in relation to adolescent internalising and externalising symptoms, comparing two countries Brazil and the United Kingdom (UK). Methods We pooled data from the UK Millennium Cohort Study (MCS) and the Brazilian High Risk Cohort Study (BHRCS). We included 12 social connection variables, identified through retrospective harmonisation and lived experience expert involvement. We tested measurement invariance and conducted multiple regressions to analyse associations between the social connection factors (age 14) and later internalising and externalising difficulties (age 17.5) in both cohorts. We investigated country-level interactions and used weights to account for attrition, survey design, population representativeness and sample size. Results We found pooled main associations with later internalising symptoms for ?living with half-siblings? (p? En ligne : https://doi.org/10.1111/jcpp.14080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

The synergistic effect of genetic and environmental factors in the development of attention-deficit/hyperactivity disorder symptoms in children and adolescents / Douglas Teixeira LEFFA in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1134-1144 Titre : The synergistic effect of genetic and environmental factors in the development of attention-deficit/hyperactivity disorder symptoms in children and adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Douglas Teixeira LEFFA, Auteur ; Arthur CAYE, Auteur ; Sintia I. BELANGERO, Auteur ; Ary GADELHA, Auteur ; Pedro Mario PAN, Auteur ; Giovanni Abrahão SALUM, Auteur ; Luis Augusto ROHDE, Auteur Article en page(s) : p.1134-1144 Langues : Anglais (eng) Mots-clés : ADHD  environment  epidemiology  genetics  risk factors Index. décimale : PER Périodiques Résumé : Gene-environment interactions (GxE) have been increasingly explored in psychiatry but with low replication rates. Attention-deficit/hyperactivity disorder (ADHD) is a suitable candidate for studying GxE due to its high heritability and well-defined environmental risk factors. Here, we explored GxE using polygenic risk score (PRS) to represent the genetic liability to ADHD (ADHD-PRS) and environmental risk score (ERS) to represent the combined effects of environmental risk factors. We analyzed longitudinal data of 2,046 individuals (6-14 years of age at baseline and 14-23 at the last follow-up) from the Brazilian High-Risk Cohort Study for Psychiatric Disorders. Psychiatric evaluation included the Child Behavior Checklist and the Strength and Difficulties Questionnaire. Statistical analyses were performed using mixed-effects models. We observed statistically significant interactions between ADHD-PRS and ERS, suggesting that environmental and genetic factors act synergistically in the development of ADHD symptoms. These effects were not present for depression or anxiety symptoms. No evidence of GxE correlation was detected. Mechanistically, our findings suggest that environmental stressors modulate the genetic risk for ADHD. Future studies should investigate whether the reduction of environmental risks can prevent the development of symptoms of ADHD, especially in children with a family history of the disorder. En ligne : https://dx.doi.org/10.1017/S0954579423000366 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] The synergistic effect of genetic and environmental factors in the development of attention-deficit/hyperactivity disorder symptoms in children and adolescents [Texte imprimé et/ou numérique] / Douglas Teixeira LEFFA, Auteur ; Arthur CAYE, Auteur ; Sintia I. BELANGERO, Auteur ; Ary GADELHA, Auteur ; Pedro Mario PAN, Auteur ; Giovanni Abrahão SALUM, Auteur ; Luis Augusto ROHDE, Auteur . - p.1134-1144. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1134-1144 Mots-clés : ADHD  environment  epidemiology  genetics  risk factors Index. décimale : PER Périodiques Résumé : Gene-environment interactions (GxE) have been increasingly explored in psychiatry but with low replication rates. Attention-deficit/hyperactivity disorder (ADHD) is a suitable candidate for studying GxE due to its high heritability and well-defined environmental risk factors. Here, we explored GxE using polygenic risk score (PRS) to represent the genetic liability to ADHD (ADHD-PRS) and environmental risk score (ERS) to represent the combined effects of environmental risk factors. We analyzed longitudinal data of 2,046 individuals (6-14 years of age at baseline and 14-23 at the last follow-up) from the Brazilian High-Risk Cohort Study for Psychiatric Disorders. Psychiatric evaluation included the Child Behavior Checklist and the Strength and Difficulties Questionnaire. Statistical analyses were performed using mixed-effects models. We observed statistically significant interactions between ADHD-PRS and ERS, suggesting that environmental and genetic factors act synergistically in the development of ADHD symptoms. These effects were not present for depression or anxiety symptoms. No evidence of GxE correlation was detected. Mechanistically, our findings suggest that environmental stressors modulate the genetic risk for ADHD. Future studies should investigate whether the reduction of environmental risks can prevent the development of symptoms of ADHD, especially in children with a family history of the disorder. En ligne : https://dx.doi.org/10.1017/S0954579423000366 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

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