33 recherche sur le mot-clé 'environment'

Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition / William MANDY in Journal of Child Psychology and Psychiatry, 57-3 (March 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.271-292 Titre : Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition Type de document : texte imprimé Auteurs : William MANDY, Auteur ; Meng-Chuan LAI, Auteur Article en page(s) : p.271-292 Langues : Anglais (eng) Mots-clés : Autism spectrum condition  autism spectrum disorder  autism  Asperger's syndrome  genetics  environment  developmental psychopathology Index. décimale : PER Périodiques Résumé : Background Although autism spectrum condition (ASC) is strongly genetic in origin, accumulating evidence points to the critical roles of various environmental influences on its emergence and subsequent developmental course. Methods A developmental psychopathology framework was used to synthesise literature on environmental factors associated with the onset and course of ASC (based on a systematic search of the literature using PubMed, PsychInfo and Google Scholar databases). Particular emphasis was placed on gene–environment interplay, including gene–environment interaction (G × E) and gene–environment correlation (rGE). Results Before conception, advanced paternal and maternal ages may independently enhance offspring risk for ASC. Exogenous prenatal risks are evident (e.g. valproate and toxic chemicals) or possible (e.g. selective serotonin reuptake inhibitors), and processes endogenous to the materno-foeto-placental unit (e.g. maternal diabetes, enhanced steroidogenic activities and maternal immune activation) likely heighten offspring vulnerability to ASC. Folate intake is a prenatal protective factor, with a particular window of action around 4 weeks preconception and during the first trimester. These prenatal risks and protective mechanisms appear to involve G × E and potentially rGE. A variety of perinatal risks are related to offspring ASC risk, possibly reflecting rGE. Postnatal social factors (e.g. caregiver–infant interaction, severe early deprivation) during the first years of life may operate through rGE to influence the likelihood of manifesting a full ASC phenotype from a ‘prodromal’ phase (a proposal distinct to the discredited and harmful ‘refrigerator mother hypothesis’); and later postnatal risks, after the full manifestation of ASC, shape life span development through transactions mediated by rGE. There is no evidence that vaccination is a postnatal risk for ASC. Conclusions Future investigations should consider the specificity of risks for ASC versus other atypical neurodevelopmental trajectories, timing of risk and protective mechanisms, animal model systems to study mechanisms underlying gene–environment interplay, large-sample genome–envirome designs to address G × E and longitudinal studies to elucidate how rGE plays out over time. Clinical and public health implications are discussed. En ligne : http://dx.doi.org/10.1111/jcpp.12501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition [texte imprimé] / William MANDY, Auteur ; Meng-Chuan LAI, Auteur . - p.271-292. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.271-292 Mots-clés : Autism spectrum condition  autism spectrum disorder  autism  Asperger's syndrome  genetics  environment  developmental psychopathology Index. décimale : PER Périodiques Résumé : Background Although autism spectrum condition (ASC) is strongly genetic in origin, accumulating evidence points to the critical roles of various environmental influences on its emergence and subsequent developmental course. Methods A developmental psychopathology framework was used to synthesise literature on environmental factors associated with the onset and course of ASC (based on a systematic search of the literature using PubMed, PsychInfo and Google Scholar databases). Particular emphasis was placed on gene–environment interplay, including gene–environment interaction (G × E) and gene–environment correlation (rGE). Results Before conception, advanced paternal and maternal ages may independently enhance offspring risk for ASC. Exogenous prenatal risks are evident (e.g. valproate and toxic chemicals) or possible (e.g. selective serotonin reuptake inhibitors), and processes endogenous to the materno-foeto-placental unit (e.g. maternal diabetes, enhanced steroidogenic activities and maternal immune activation) likely heighten offspring vulnerability to ASC. Folate intake is a prenatal protective factor, with a particular window of action around 4 weeks preconception and during the first trimester. These prenatal risks and protective mechanisms appear to involve G × E and potentially rGE. A variety of perinatal risks are related to offspring ASC risk, possibly reflecting rGE. Postnatal social factors (e.g. caregiver–infant interaction, severe early deprivation) during the first years of life may operate through rGE to influence the likelihood of manifesting a full ASC phenotype from a ‘prodromal’ phase (a proposal distinct to the discredited and harmful ‘refrigerator mother hypothesis’); and later postnatal risks, after the full manifestation of ASC, shape life span development through transactions mediated by rGE. There is no evidence that vaccination is a postnatal risk for ASC. Conclusions Future investigations should consider the specificity of risks for ASC versus other atypical neurodevelopmental trajectories, timing of risk and protective mechanisms, animal model systems to study mechanisms underlying gene–environment interplay, large-sample genome–envirome designs to address G × E and longitudinal studies to elucidate how rGE plays out over time. Clinical and public health implications are discussed. En ligne : http://dx.doi.org/10.1111/jcpp.12501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Brief Report: Reliability of the Participation and Sensory Environment Questionnaire: Home Scales / Beth PFEIFFER in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2567-2576 Titre : Brief Report: Reliability of the Participation and Sensory Environment Questionnaire: Home Scales Type de document : texte imprimé Auteurs : Beth PFEIFFER, Auteur ; Aimee PILLER, Auteur ; Laura SLUGG, Auteur ; Chengshi SHIU, Auteur Article en page(s) : p.2567-2576 Langues : Anglais (eng) Mots-clés : Environment  Home  Participation  Reliability  Sensory Index. décimale : PER Périodiques Résumé : The Participation and Sensory Environment Questionnaire: Home Scales (P-SEQ): Home Scales is a parent report tool designed to assess the impact of the sensory environment on participation in daily activities in the home of children with and without autism spectrum disorder. A cross-sectional study was completed to determine internal consistency, test-retest reliability, and examine item distribution. A total of 304 parents of children between the ages of 2 and 7 years of age completed the P-SEQ: Home Scales. Results identified excellent internal consistency (alpha = 0.96), moderate test-retest reliability (r = .62), and reasonable item distribution. Results suggest that the P-SEQ: Home Scales provides reliable estimates of the impact of the sensory environment on children's participation in home activities. En ligne : http://dx.doi.org/10.1007/s10803-018-3499-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Brief Report: Reliability of the Participation and Sensory Environment Questionnaire: Home Scales [texte imprimé] / Beth PFEIFFER, Auteur ; Aimee PILLER, Auteur ; Laura SLUGG, Auteur ; Chengshi SHIU, Auteur . - p.2567-2576. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2567-2576 Mots-clés : Environment  Home  Participation  Reliability  Sensory Index. décimale : PER Périodiques Résumé : The Participation and Sensory Environment Questionnaire: Home Scales (P-SEQ): Home Scales is a parent report tool designed to assess the impact of the sensory environment on participation in daily activities in the home of children with and without autism spectrum disorder. A cross-sectional study was completed to determine internal consistency, test-retest reliability, and examine item distribution. A total of 304 parents of children between the ages of 2 and 7 years of age completed the P-SEQ: Home Scales. Results identified excellent internal consistency (alpha = 0.96), moderate test-retest reliability (r = .62), and reasonable item distribution. Results suggest that the P-SEQ: Home Scales provides reliable estimates of the impact of the sensory environment on children's participation in home activities. En ligne : http://dx.doi.org/10.1007/s10803-018-3499-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Gene by environment interactions influencing reading disability and the inattentive symptom dimension of attention deficit/hyperactivity disorder / Jenni ROSENBERG in Journal of Child Psychology and Psychiatry, 53-3 (March 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.243-251 Titre : Gene by environment interactions influencing reading disability and the inattentive symptom dimension of attention deficit/hyperactivity disorder Type de document : texte imprimé Auteurs : Jenni ROSENBERG, Auteur ; Bruce F. PENNINGTON, Auteur ; Erik G. WILLCUTT, Auteur ; Richard K. OLSON, Auteur Année de publication : 2012 Article en page(s) : p.243-251 Langues : Anglais (eng) Mots-clés : Gene  environment  interactions  reading disability  attention deficit/hyperactivity disorder  bioecological  diathesis-stress Index. décimale : PER Périodiques Résumé : Background:  Reading disability (RD) and attention deficit/hyperactivity disorder (ADHD) are comorbid and genetically correlated, especially the inattentive dimension of ADHD (ADHD-I). However, previous research indicates that RD and ADHD enter into opposite gene by environment (G × E) interactions. Methods:  This study used behavioral genetic methods to replicate these opposite G × E interactions in a sample of same-sex monozygotic and dizygotic twin pairs from the Colorado Learning Disabilities Research Center (CLDRC; DeFries et al., 1997) and to test a genetic hypothesis for why these opposite interactions occur. Results:  We replicated opposite G × E interactions for RD (bioecological) and ADHD-I (diathesis-stress) with parental education in the same sample of participants. The genetic hypothesis for this opposite pattern of interactions is that only genes specific to each disorder enter into these opposite interactions, not the shared genes underlying their comorbidity. To test this hypothesis, we used single models with an exploratory three-way interaction, in which the G × E interactions for each disorder were moderated by comorbidity. Neither three-way interaction was significant. The heritability of RD did not vary as a function of parental education and ADHD-I. Similarly, the heritability of ADHD-I did not vary as a function of parental education and RD. Conclusions:  We documented opposite G × E interactions in RD and ADHD-I in the same overall twin sample, but the explanation for this apparent paradox remains unclear. Examining specific genes and more specific environmental factors may help resolve the paradox. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02452.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Gene by environment interactions influencing reading disability and the inattentive symptom dimension of attention deficit/hyperactivity disorder [texte imprimé] / Jenni ROSENBERG, Auteur ; Bruce F. PENNINGTON, Auteur ; Erik G. WILLCUTT, Auteur ; Richard K. OLSON, Auteur . - 2012 . - p.243-251. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.243-251 Mots-clés : Gene  environment  interactions  reading disability  attention deficit/hyperactivity disorder  bioecological  diathesis-stress Index. décimale : PER Périodiques Résumé : Background:  Reading disability (RD) and attention deficit/hyperactivity disorder (ADHD) are comorbid and genetically correlated, especially the inattentive dimension of ADHD (ADHD-I). However, previous research indicates that RD and ADHD enter into opposite gene by environment (G × E) interactions. Methods:  This study used behavioral genetic methods to replicate these opposite G × E interactions in a sample of same-sex monozygotic and dizygotic twin pairs from the Colorado Learning Disabilities Research Center (CLDRC; DeFries et al., 1997) and to test a genetic hypothesis for why these opposite interactions occur. Results:  We replicated opposite G × E interactions for RD (bioecological) and ADHD-I (diathesis-stress) with parental education in the same sample of participants. The genetic hypothesis for this opposite pattern of interactions is that only genes specific to each disorder enter into these opposite interactions, not the shared genes underlying their comorbidity. To test this hypothesis, we used single models with an exploratory three-way interaction, in which the G × E interactions for each disorder were moderated by comorbidity. Neither three-way interaction was significant. The heritability of RD did not vary as a function of parental education and ADHD-I. Similarly, the heritability of ADHD-I did not vary as a function of parental education and RD. Conclusions:  We documented opposite G × E interactions in RD and ADHD-I in the same overall twin sample, but the explanation for this apparent paradox remains unclear. Examining specific genes and more specific environmental factors may help resolve the paradox. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02452.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Gene–Environment Interactions in Autism Spectrum Disorders: The Role of Bisphenol A in Modulating Genetic Susceptibility / Eduardo QUIÑONES-MEDINA in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70186 Titre : Gene–Environment Interactions in Autism Spectrum Disorders: The Role of Bisphenol A in Modulating Genetic Susceptibility Type de document : texte imprimé Auteurs : Eduardo QUIÑONES-MEDINA, Auteur ; Felipe GALLEGUILLOS, Auteur ; Valentina PARRA, Auteur ; Gloria ARRIAGADA, Auteur ; Fernando J. BUSTOS, Auteur Article en page(s) : e70186 Langues : Anglais (eng) Mots-clés : ASD  Bisphenol-A  BPA  environment Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition shaped by both genetic and environmental factors. While genetic studies have identified monogenic and polygenic contributions to ASD, growing evidence suggests that environmental exposures can modulate genetic susceptibility. Among these, bisphenol A (BPA), a widely studied endocrine-disrupting chemical, has drawn attention due to its ability to cross the blood?brain barrier and placenta. BPA can influence neurodevelopment through epigenetic modifications, mitochondrial dysfunction, and oxidative stress. Elevated BPA levels have been detected in serum and urine of individuals with ASD, correlating with altered gene expression in brain regions critical for cognition and behavior. Experimental models indicate that BPA exposure disrupts neuronal viability, synaptic connectivity, and neurotransmitter regulation, potentially exacerbating ASD-like phenotypes in genetically predisposed individuals. This review explores the interaction between genetic risk factors and environmental toxins, particularly BPA, in ASD pathogenesis. By integrating findings from epidemiological studies, molecular analyses, and animal models, we highlight the need for further research into gene?environment interactions to refine ASD risk assessment and therapeutic strategies. En ligne : https://doi.org/10.1002/aur.70186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Gene–Environment Interactions in Autism Spectrum Disorders: The Role of Bisphenol A in Modulating Genetic Susceptibility [texte imprimé] / Eduardo QUIÑONES-MEDINA, Auteur ; Felipe GALLEGUILLOS, Auteur ; Valentina PARRA, Auteur ; Gloria ARRIAGADA, Auteur ; Fernando J. BUSTOS, Auteur . - e70186. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70186 Mots-clés : ASD  Bisphenol-A  BPA  environment Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition shaped by both genetic and environmental factors. While genetic studies have identified monogenic and polygenic contributions to ASD, growing evidence suggests that environmental exposures can modulate genetic susceptibility. Among these, bisphenol A (BPA), a widely studied endocrine-disrupting chemical, has drawn attention due to its ability to cross the blood?brain barrier and placenta. BPA can influence neurodevelopment through epigenetic modifications, mitochondrial dysfunction, and oxidative stress. Elevated BPA levels have been detected in serum and urine of individuals with ASD, correlating with altered gene expression in brain regions critical for cognition and behavior. Experimental models indicate that BPA exposure disrupts neuronal viability, synaptic connectivity, and neurotransmitter regulation, potentially exacerbating ASD-like phenotypes in genetically predisposed individuals. This review explores the interaction between genetic risk factors and environmental toxins, particularly BPA, in ASD pathogenesis. By integrating findings from epidemiological studies, molecular analyses, and animal models, we highlight the need for further research into gene?environment interactions to refine ASD risk assessment and therapeutic strategies. En ligne : https://doi.org/10.1002/aur.70186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Investigating the impact of the environment on neurodevelopmental disorder / Heather VOLK in Journal of Neurodevelopmental Disorders, 12 (2020)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 12 (2020) Titre : Investigating the impact of the environment on neurodevelopmental disorder Type de document : texte imprimé Auteurs : Heather VOLK, Auteur ; Margaret A. SHERIDAN, Auteur Langues : Anglais (eng) Mots-clés : Environment  Humans  Neurodevelopmental Disorders Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.1186/s11689-020-09345-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Investigating the impact of the environment on neurodevelopmental disorder [texte imprimé] / Heather VOLK, Auteur ; Margaret A. SHERIDAN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 12 (2020) Mots-clés : Environment  Humans  Neurodevelopmental Disorders Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.1186/s11689-020-09345-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation / Sandra MACHLITT-NORTHEN in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

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Reliability of the participation and sensory environment questionnaire: Community scales / Beth PFEIFFER in Research in Autism Spectrum Disorders, 64 (August 2019)  

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Reliability of the Participation and Sensory Environment Questionnaire: Teacher Version / Aimee PILLER in Journal of Autism and Developmental Disorders, 47-11 (November 2017)  

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Research Review: Gene–environment interaction research in youth depression – a systematic review with recommendations for future research / Erin C. DUNN in Journal of Child Psychology and Psychiatry, 52-12 (December 2011)  

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Environmental interventions supporting autistic transition-age youth employability: A scoping review / Mehmet KARAKUS ; Filiz POLAT in Research in Autism Spectrum Disorders, 109 (November 2023)  

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