Association between infant and toddler gut microbiota composition and later executive functioning / Venla HUOVINEN in Development and Psychopathology, 38-4 (October 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-4 (October 2026) . - p.1677-1691 Titre : Association between infant and toddler gut microbiota composition and later executive functioning Type de document : texte imprimé Auteurs : Venla HUOVINEN, Auteur ; Anna-Katariina AATSINKI, Auteur ; Eeva ESKOLA, Auteur ; Giulio BENEDETTI, Auteur ; Heidi ISOKÄÄNTÄ, Auteur ; Elisabeth NORDENSWAN, Auteur ; Eveliina MUNUKKA, Auteur ; Santosh LAMICHHANE, Auteur ; Akie YADA, Auteur ; Siobhain M. O’MAHONY, Auteur ; Alex DICKENS, Auteur ; Leo LAHTI, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Saara NOLVI, Auteur ; Linnea KARLSSON, Auteur Article en page(s) : p.1677-1691 Langues : Anglais (eng) Mots-clés : Child development  executive functions  gut microbiota  gut-brain axis  microbial metabolites Index. décimale : PER Périodiques Résumé : Background:Studies indicate that alterations in gut microbiota composition (GMC) during the first 1,000 days of life are associated with neurodevelopment and further behavioral development. However, research on the associations between GMC and executive functions (EFs) in childhood is scarce. This study aims to improve the understanding of the biological processes underlying behavioral development by exploring the associations between GMC and EFs early in life.Methods:Study population (n = 373) is part of the longitudinal FinnBrain Birth Cohort Study. GMC was analyzed using infant and toddler stool sample 16S rRNA sequencing and targeted and untargeted metabolomic assays. EF was assessed using the Spin the Pots and Snack Delay tasks at 2.5 years and the Spin the Pots task, Delay of Gratification task, EF Touch battery and BRIEF-2 questionnaire at 5 years.Conclusions:Alpha diversity in infancy was negatively associated with preschool EF. Additionally, EFs differed between microbial groups based on dominant genera. Bacterial genera abundances were related to some EFs, but no associations were found between microbial metabolites and EF. This study is among the first to investigate associations between GMC and EF in childhood, a crucial developmental stage characterized by significant changes in both the brain and microbiota. En ligne : https://dx.doi.org/10.1017/S0954579426101527 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Association between infant and toddler gut microbiota composition and later executive functioning [texte imprimé] / Venla HUOVINEN, Auteur ; Anna-Katariina AATSINKI, Auteur ; Eeva ESKOLA, Auteur ; Giulio BENEDETTI, Auteur ; Heidi ISOKÄÄNTÄ, Auteur ; Elisabeth NORDENSWAN, Auteur ; Eveliina MUNUKKA, Auteur ; Santosh LAMICHHANE, Auteur ; Akie YADA, Auteur ; Siobhain M. O’MAHONY, Auteur ; Alex DICKENS, Auteur ; Leo LAHTI, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Saara NOLVI, Auteur ; Linnea KARLSSON, Auteur . - p.1677-1691. Langues : Anglais (eng) in Development and Psychopathology > 38-4 (October 2026) . - p.1677-1691 Mots-clés : Child development  executive functions  gut microbiota  gut-brain axis  microbial metabolites Index. décimale : PER Périodiques Résumé : Background:Studies indicate that alterations in gut microbiota composition (GMC) during the first 1,000 days of life are associated with neurodevelopment and further behavioral development. However, research on the associations between GMC and executive functions (EFs) in childhood is scarce. This study aims to improve the understanding of the biological processes underlying behavioral development by exploring the associations between GMC and EFs early in life.Methods:Study population (n = 373) is part of the longitudinal FinnBrain Birth Cohort Study. GMC was analyzed using infant and toddler stool sample 16S rRNA sequencing and targeted and untargeted metabolomic assays. EF was assessed using the Spin the Pots and Snack Delay tasks at 2.5 years and the Spin the Pots task, Delay of Gratification task, EF Touch battery and BRIEF-2 questionnaire at 5 years.Conclusions:Alpha diversity in infancy was negatively associated with preschool EF. Additionally, EFs differed between microbial groups based on dominant genera. Bacterial genera abundances were related to some EFs, but no associations were found between microbial metabolites and EF. This study is among the first to investigate associations between GMC and EF in childhood, a crucial developmental stage characterized by significant changes in both the brain and microbiota. En ligne : https://dx.doi.org/10.1017/S0954579426101527 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

Infant gut microbiota and negative and fear reactivity / Venla HUOVINEN in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.2016-2031 Titre : Infant gut microbiota and negative and fear reactivity Type de document : texte imprimé Auteurs : Venla HUOVINEN, Auteur ; Anna-Katariina AATSINKI, Auteur ; Eeva-Leena KATAJA, Auteur ; Eveliina MUNUKKA, Auteur ; Anniina KESKITALO, Auteur ; Santosh LAMICHHANE, Auteur ; Peppi RAUNIONIEMI, Auteur ; David J. BRIDGETT, Auteur ; Leo LAHTI, Auteur ; Siobhain M. O'MAHONY, Auteur ; Alex DICKENS, Auteur ; Riikka KORJA, Auteur ; Hasse KARLSSON, Auteur ; Saara NOLVI, Auteur ; Linnea KARLSSON, Auteur Article en page(s) : p.2016-2031 Langues : Anglais (eng) Mots-clés : alpha diversity  beta diversity  fear reactivity  genus abundance  negative reactivity Index. décimale : PER Périodiques Résumé : Background:Studies indicate that gut microbiota is related to neurodevelopmental and behavioral outcomes. Accordingly, early gut microbiota composition (GMC) has been linked to child temperament, but research is still scarce. The aim of this study was to examine how early GMC at 2.5 months is associated with child negative and fear reactivity at 8 and 12 months since they are potentially important intermediate phenotypes of later child psychiatric disorders.Methods:Our study population was 330 infants enrolled in the longitudinal FinnBrain Birth Cohort Study. Gut microbiota composition was analyzed using stool sample 16s rRNA sequencing. Negative and fear reactivity were assessed using the Laboratory Temperament Assessment Battery (Lab-TAB) at child?s age of 8 months (n =150) and the Infant Behavior Questionnaire-Revised Short Form (IBQ-R SF) at child?s age of 12 months (n = 276).Conclusions:We found a positive association between alpha diversity and reported fear reactivity and differing microbial community composition based on negative reactivity for boys. Isobutyric acid correlated with observed negative reactivity, however, this association attenuated in the linear model. Several genera were associated with the selected infant temperament traits. This study adds to the growing literature on links between infant gut microbiota and temperament informing future mechanistic studies. En ligne : https://dx.doi.org/10.1017/S0954579423001396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Infant gut microbiota and negative and fear reactivity [texte imprimé] / Venla HUOVINEN, Auteur ; Anna-Katariina AATSINKI, Auteur ; Eeva-Leena KATAJA, Auteur ; Eveliina MUNUKKA, Auteur ; Anniina KESKITALO, Auteur ; Santosh LAMICHHANE, Auteur ; Peppi RAUNIONIEMI, Auteur ; David J. BRIDGETT, Auteur ; Leo LAHTI, Auteur ; Siobhain M. O'MAHONY, Auteur ; Alex DICKENS, Auteur ; Riikka KORJA, Auteur ; Hasse KARLSSON, Auteur ; Saara NOLVI, Auteur ; Linnea KARLSSON, Auteur . - p.2016-2031. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.2016-2031 Mots-clés : alpha diversity  beta diversity  fear reactivity  genus abundance  negative reactivity Index. décimale : PER Périodiques Résumé : Background:Studies indicate that gut microbiota is related to neurodevelopmental and behavioral outcomes. Accordingly, early gut microbiota composition (GMC) has been linked to child temperament, but research is still scarce. The aim of this study was to examine how early GMC at 2.5 months is associated with child negative and fear reactivity at 8 and 12 months since they are potentially important intermediate phenotypes of later child psychiatric disorders.Methods:Our study population was 330 infants enrolled in the longitudinal FinnBrain Birth Cohort Study. Gut microbiota composition was analyzed using stool sample 16s rRNA sequencing. Negative and fear reactivity were assessed using the Laboratory Temperament Assessment Battery (Lab-TAB) at child?s age of 8 months (n =150) and the Infant Behavior Questionnaire-Revised Short Form (IBQ-R SF) at child?s age of 12 months (n = 276).Conclusions:We found a positive association between alpha diversity and reported fear reactivity and differing microbial community composition based on negative reactivity for boys. Isobutyric acid correlated with observed negative reactivity, however, this association attenuated in the linear model. Several genera were associated with the selected infant temperament traits. This study adds to the growing literature on links between infant gut microbiota and temperament informing future mechanistic studies. En ligne : https://dx.doi.org/10.1017/S0954579423001396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

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