7 recherche sur le mot-clé 'gut-brain axis'

Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders / Maria FIORENTINO in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 49p. Titre : Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders Type de document : texte imprimé Auteurs : Maria FIORENTINO, Auteur ; Anna SAPONE, Auteur ; Stefania SENGER, Auteur ; Stephanie S. CAMHI, Auteur ; Sarah M. KADZIELSKI, Auteur ; Timothy M. BUIE, Auteur ; Deanna L. KELLY, Auteur ; Nicola CASCELLA, Auteur ; Alessio FASANO, Auteur Article en page(s) : 49p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics/immunology/metabolism/pathology  Biopsy  Blood-Brain Barrier/immunology/metabolism/pathology  Case-Control Studies  Cerebellum/immunology/metabolism/pathology  Cerebral Cortex/immunology/metabolism/pathology  Child  Child, Preschool  Claudin-3/genetics/immunology  Claudin-5/genetics/immunology  Claudins/genetics/immunology  DNA-Binding Proteins/genetics/immunology  Duodenum/immunology/metabolism/pathology  Female  Gene Expression  Humans  Interleukin-1beta/genetics/immunology  Interleukin-8/genetics/immunology  MARVEL Domain Containing 2 Protein/genetics/immunology  Male  Matrix Metalloproteinase 9/genetics/immunology  Middle Aged  Permeability  Schizophrenia/genetics/immunology/metabolism/pathology  Tight Junctions/immunology/metabolism/pathology  Autism spectrum disorders  Blood-brain barrier  Duodenal biopsies  Gut permeability  Gut-brain axis  Neuroinflammation  Postmortem brain  Schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood-brain barrier (BBB), can be part of the chain of events leading to these disorders. Our goal was to investigate whether an altered BBB and gut permeability is part of the pathophysiology of ASD. METHODS: Postmortem cerebral cortex and cerebellum tissues from ASD, schizophrenia (SCZ), and healthy subjects (HC) and duodenal biopsies from ASD and HC were analyzed for gene and protein expression profiles. Tight junctions and other key molecules associated with the neurovascular unit integrity and function and neuroinflammation were investigated. RESULTS: Claudin (CLDN)-5 and -12 were increased in the ASD cortex and cerebellum. CLDN-3, tricellulin, and MMP-9 were higher in the ASD cortex. IL-8, tPA, and IBA-1 were downregulated in SCZ cortex; IL-1b was increased in the SCZ cerebellum. Differences between SCZ and ASD were observed for most of the genes analyzed in both brain areas. CLDN-5 protein was increased in ASD cortex and cerebellum, while CLDN-12 appeared reduced in both ASD and SCZ cortexes. In the intestine, 75% of the ASD samples analyzed had reduced expression of barrier-forming TJ components (CLDN-1, OCLN, TRIC), whereas 66% had increased pore-forming CLDNs (CLDN-2, -10, -15) compared to controls. CONCLUSIONS: In the ASD brain, there is an altered expression of genes associated with BBB integrity coupled with increased neuroinflammation and possibly impaired gut barrier integrity. While these findings seem to be specific for ASD, the possibility of more distinct SCZ subgroups should be explored with additional studies. En ligne : http://dx.doi.org/10.1186/s13229-016-0110-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders [texte imprimé] / Maria FIORENTINO, Auteur ; Anna SAPONE, Auteur ; Stefania SENGER, Auteur ; Stephanie S. CAMHI, Auteur ; Sarah M. KADZIELSKI, Auteur ; Timothy M. BUIE, Auteur ; Deanna L. KELLY, Auteur ; Nicola CASCELLA, Auteur ; Alessio FASANO, Auteur . - 49p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 49p. Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics/immunology/metabolism/pathology  Biopsy  Blood-Brain Barrier/immunology/metabolism/pathology  Case-Control Studies  Cerebellum/immunology/metabolism/pathology  Cerebral Cortex/immunology/metabolism/pathology  Child  Child, Preschool  Claudin-3/genetics/immunology  Claudin-5/genetics/immunology  Claudins/genetics/immunology  DNA-Binding Proteins/genetics/immunology  Duodenum/immunology/metabolism/pathology  Female  Gene Expression  Humans  Interleukin-1beta/genetics/immunology  Interleukin-8/genetics/immunology  MARVEL Domain Containing 2 Protein/genetics/immunology  Male  Matrix Metalloproteinase 9/genetics/immunology  Middle Aged  Permeability  Schizophrenia/genetics/immunology/metabolism/pathology  Tight Junctions/immunology/metabolism/pathology  Autism spectrum disorders  Blood-brain barrier  Duodenal biopsies  Gut permeability  Gut-brain axis  Neuroinflammation  Postmortem brain  Schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood-brain barrier (BBB), can be part of the chain of events leading to these disorders. Our goal was to investigate whether an altered BBB and gut permeability is part of the pathophysiology of ASD. METHODS: Postmortem cerebral cortex and cerebellum tissues from ASD, schizophrenia (SCZ), and healthy subjects (HC) and duodenal biopsies from ASD and HC were analyzed for gene and protein expression profiles. Tight junctions and other key molecules associated with the neurovascular unit integrity and function and neuroinflammation were investigated. RESULTS: Claudin (CLDN)-5 and -12 were increased in the ASD cortex and cerebellum. CLDN-3, tricellulin, and MMP-9 were higher in the ASD cortex. IL-8, tPA, and IBA-1 were downregulated in SCZ cortex; IL-1b was increased in the SCZ cerebellum. Differences between SCZ and ASD were observed for most of the genes analyzed in both brain areas. CLDN-5 protein was increased in ASD cortex and cerebellum, while CLDN-12 appeared reduced in both ASD and SCZ cortexes. In the intestine, 75% of the ASD samples analyzed had reduced expression of barrier-forming TJ components (CLDN-1, OCLN, TRIC), whereas 66% had increased pore-forming CLDNs (CLDN-2, -10, -15) compared to controls. CONCLUSIONS: In the ASD brain, there is an altered expression of genes associated with BBB integrity coupled with increased neuroinflammation and possibly impaired gut barrier integrity. While these findings seem to be specific for ASD, the possibility of more distinct SCZ subgroups should be explored with additional studies. En ligne : http://dx.doi.org/10.1186/s13229-016-0110-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Autism Spectrum and gastrointestinal health: Screening on the influence of environmental factors on gastrointestinal problems / Anita BRITO in Autism Research, 17-12 (December 2024)  

Public ISBD [article]  inAutism Research > 17-12 (December 2024) . - p.2535-2546 Titre : Autism Spectrum and gastrointestinal health: Screening on the influence of environmental factors on gastrointestinal problems Type de document : texte imprimé Auteurs : Anita BRITO, Auteur ; Fernando Ribeiro TOCANTINS, Auteur ; Helena BRENTANI, Auteur ; André FUJITA, Auteur ; Carla Romano TADDEI, Auteur ; Patricia Cristina Baleeiro BELTRÃO-BRAGA, Auteur Article en page(s) : p.2535-2546 Langues : Anglais (eng) Mots-clés : ASD  autism  breastfeeding  gastrointestinal  genetic  gut-brain axis  microbiota  neurodevelopment Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that combines genetic and environmental factors. The human microbiota is colonized by permanent or transitory microorganisms, depending on the host and the external factors controlling their permanence. The composition of the gut microbiota (GM) in ASD individuals is notably different from that in controls, which may contribute to the clinical conditions observed in these individuals. This study aimed to indirectly investigate the influence of GM on the gut-brain axis in individuals with ASD and controls by analyzing environmental factors that contribute to the microbiota composition. Two questionnaires were designed to collect data, one for the ASD Group (ASDG) and the other one for the Control Group (CG). The raw data from both questionnaires were collected from 2772 respondents. After triage, answers from 1687 ASD individuals, along with 466 respondents from the CG, were analyzed, resulting in a total of 2237 respondents. Our results showed that gastrointestinal problems (GP) escalate as individuals age and become more prominent in ASD individuals. In contrast, feeding problems (FP) did not appear to escalate in either group as individuals aged, even though the FP decreased in the CG. ANOVA revealed significant differences in breastfeeding status compared to GPs among preterm control individuals born via cesarean section (p-value 0.027). The mean values of GP for breastfed and nonbreastfed individuals, for ASDG (0.257; 0.268) and CG (0.105; 0.248), highlighted the differences in breastfeeding effects on GP for the study groups. The use of antibiotics during pregnancy seemed to be significant for GPs in the ASDG only for breastfed individuals (p-value <0.001), but not in the CG group. In conclusion, variables such as mode of delivery, FPs, type of birth, and length of breastfeeding do not seem to be determining factors for GP in the ASDG but are relevant for the CG. However, for ASDG individuals whose mothers took antibiotics during pregnancy, breastfeeding may act as a protective factor, as maternal antibiotic administration during pregnancy seems to aggravate GP-values across the ages of the participants. Considering GP as a proxy for GM and recognizing the importance of GM composition for central nervous system (CNS) function, it appears that in individuals with ASD, GM seems to be more dependent on other factors, which might be linked to the genetic background of each one. These findings suggest that future studies of the gut-brain axis in individuals with ASD might consider the individual's genetic background, environmental factors, and GM. En ligne : https://dx.doi.org/10.1002/aur.3263 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 [article] Autism Spectrum and gastrointestinal health: Screening on the influence of environmental factors on gastrointestinal problems [texte imprimé] / Anita BRITO, Auteur ; Fernando Ribeiro TOCANTINS, Auteur ; Helena BRENTANI, Auteur ; André FUJITA, Auteur ; Carla Romano TADDEI, Auteur ; Patricia Cristina Baleeiro BELTRÃO-BRAGA, Auteur . - p.2535-2546. Langues : Anglais (eng) in Autism Research > 17-12 (December 2024) . - p.2535-2546 Mots-clés : ASD  autism  breastfeeding  gastrointestinal  genetic  gut-brain axis  microbiota  neurodevelopment Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that combines genetic and environmental factors. The human microbiota is colonized by permanent or transitory microorganisms, depending on the host and the external factors controlling their permanence. The composition of the gut microbiota (GM) in ASD individuals is notably different from that in controls, which may contribute to the clinical conditions observed in these individuals. This study aimed to indirectly investigate the influence of GM on the gut-brain axis in individuals with ASD and controls by analyzing environmental factors that contribute to the microbiota composition. Two questionnaires were designed to collect data, one for the ASD Group (ASDG) and the other one for the Control Group (CG). The raw data from both questionnaires were collected from 2772 respondents. After triage, answers from 1687 ASD individuals, along with 466 respondents from the CG, were analyzed, resulting in a total of 2237 respondents. Our results showed that gastrointestinal problems (GP) escalate as individuals age and become more prominent in ASD individuals. In contrast, feeding problems (FP) did not appear to escalate in either group as individuals aged, even though the FP decreased in the CG. ANOVA revealed significant differences in breastfeeding status compared to GPs among preterm control individuals born via cesarean section (p-value 0.027). The mean values of GP for breastfed and nonbreastfed individuals, for ASDG (0.257; 0.268) and CG (0.105; 0.248), highlighted the differences in breastfeeding effects on GP for the study groups. The use of antibiotics during pregnancy seemed to be significant for GPs in the ASDG only for breastfed individuals (p-value <0.001), but not in the CG group. In conclusion, variables such as mode of delivery, FPs, type of birth, and length of breastfeeding do not seem to be determining factors for GP in the ASDG but are relevant for the CG. However, for ASDG individuals whose mothers took antibiotics during pregnancy, breastfeeding may act as a protective factor, as maternal antibiotic administration during pregnancy seems to aggravate GP-values across the ages of the participants. Considering GP as a proxy for GM and recognizing the importance of GM composition for central nervous system (CNS) function, it appears that in individuals with ASD, GM seems to be more dependent on other factors, which might be linked to the genetic background of each one. These findings suggest that future studies of the gut-brain axis in individuals with ASD might consider the individual's genetic background, environmental factors, and GM. En ligne : https://dx.doi.org/10.1002/aur.3263 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544

Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder / Baptiste GANACHAUD in Autism Research, 19-8 (August 2026)  

Public ISBD [article]  inAutism Research > 19-8 (August 2026) . - p.e70328 Titre : Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Baptiste GANACHAUD, Auteur ; María José MENDOZA-LEÓN, Auteur ; Justine MARCHIX, Auteur ; Alonso Fernandez TELLO, Auteur ; Catherine Le Berre SCOUL, Auteur ; Ma Cecilia OPAZO, Auteur ; Michel NEUNLIST, Auteur ; Claudia A. RIEDEL, Auteur ; Martial CAILLAUD, Auteur ; Hélène BOUDIN, Auteur Article en page(s) : p.e70328 Langues : Anglais (eng) Mots-clés : autism  bacterial metabolites  enteric nervous system  enteric neuron  gut-brain axis  microbiota Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction, restricted interests, and repetitive behaviors. In addition to these core behavioral symptoms, gastrointestinal (GI) disorders are frequently reported, ranging from severe constipation to diarrhea. The links between ASD and gut dysfunction are further supported by alterations in gut microbiota composition and in bacteria-derived metabolites. As the intrinsic nervous system of the digestive tract, the enteric nervous system (ENS) plays a central role in gut physiology by exerting neuronal control on several gut functions, including motility. Located at the interface between the gut microbiota and intestinal function, the ENS may play a key role in the GI symptoms associated with ASD, as demonstrated in several mouse models. This review aims to summarize the interconnected alterations of the gut microbiota and the ENS in ASD, with a particular focus on the microbiota-derived mediators that are altered in ASD, among patients and animal models, and that may affect ENS development and function. By highlighting these interactions, this review seeks to provide new insights on the digestive pathophysiology of ASD, which may also contribute to the severity of behavioral symptoms. En ligne : https://doi.org/10.1002/aur.70328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder [texte imprimé] / Baptiste GANACHAUD, Auteur ; María José MENDOZA-LEÓN, Auteur ; Justine MARCHIX, Auteur ; Alonso Fernandez TELLO, Auteur ; Catherine Le Berre SCOUL, Auteur ; Ma Cecilia OPAZO, Auteur ; Michel NEUNLIST, Auteur ; Claudia A. RIEDEL, Auteur ; Martial CAILLAUD, Auteur ; Hélène BOUDIN, Auteur . - p.e70328. Langues : Anglais (eng) in Autism Research > 19-8 (August 2026) . - p.e70328 Mots-clés : autism  bacterial metabolites  enteric nervous system  enteric neuron  gut-brain axis  microbiota Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction, restricted interests, and repetitive behaviors. In addition to these core behavioral symptoms, gastrointestinal (GI) disorders are frequently reported, ranging from severe constipation to diarrhea. The links between ASD and gut dysfunction are further supported by alterations in gut microbiota composition and in bacteria-derived metabolites. As the intrinsic nervous system of the digestive tract, the enteric nervous system (ENS) plays a central role in gut physiology by exerting neuronal control on several gut functions, including motility. Located at the interface between the gut microbiota and intestinal function, the ENS may play a key role in the GI symptoms associated with ASD, as demonstrated in several mouse models. This review aims to summarize the interconnected alterations of the gut microbiota and the ENS in ASD, with a particular focus on the microbiota-derived mediators that are altered in ASD, among patients and animal models, and that may affect ENS development and function. By highlighting these interactions, this review seeks to provide new insights on the digestive pathophysiology of ASD, which may also contribute to the severity of behavioral symptoms. En ligne : https://doi.org/10.1002/aur.70328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders / Isaac Ho Wai WONG in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2478-2489 Titre : The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders Type de document : texte imprimé Auteurs : Isaac Ho Wai WONG, Auteur ; Sze-Mai NG, Auteur ; Angela Man Wai LAM, Auteur ; Sandra Sau Man CHAN, Auteur ; Shing-Him NG, Auteur ; Jet LEUNG, Auteur ; Keith Chun Lok LEE, Auteur ; Arthur Chun Chi WONG, Auteur ; Yuqi WU, Auteur ; Francis Ka Leung CHAN, Auteur ; Siew Chien NG, Auteur ; Oscar Wing Ho WONG, Auteur Article en page(s) : p.2478-2489 Langues : Anglais (eng) Mots-clés : anxiety  autism  feeding problems  functional gastrointestinal disorder  gut-brain axis  nutrition  sensory hyperresponsiveness Index. décimale : PER Périodiques Résumé : ABSTRACT Functional gastrointestinal disorders (FGIDs) are prevalent in children with autism and can interact with the neuropsychiatric symptoms bidirectionally. Moreover, FGIDs may affect feeding to jeopardize nutritional intake. Existing research often overlooks the heterogeneity of FGIDs. Understanding the clinical correlates of individual FGID subtypes may clarify the underlying gut-brain interactions to guide management. This study compared the core autistic symptoms, co-occurring psychopathologies, feeding behavior and dietary intake among 737 Chinese children with autism (mean age?=?7.76?years; 642 males and 95 females) who either experienced no FGID or experienced one of the three subtypes of ROME-IV FGID. FGIDs were present in 19.8% of participants and MANCOVA revealed distinct clinical profiles across FGID subtypes. Functional abdominal pain disorders (FAPD) were associated with more severe neuropsychiatric symptoms, including restricted and repetitive behavior, anxiety, sensory hyperresponsiveness, externalizing behavior, and feeding patterns of emotional under-eating, slowness in eating, and increased satiety response. Functional defecation disorders (FDD) were characterized by food fussiness, slowness in eating, increased satiety response, and decreased intake of water, protein and fiber. With a small sample size of six, functional nausea and vomiting disorders (FNVD) were associated with emotional overeating. These findings suggest FGID subtypes involve distinct gut-brain interactions. Sensory dysregulation may underlie the link between FAPD and neuropsychiatric symptoms, while food fussiness in FDD may contribute to constipation via reduced fiber and water intake. The management of FGIDs in autism should be tailored to specific subtypes and their clinical correlates. En ligne : https://doi.org/10.1002/aur.70138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders [texte imprimé] / Isaac Ho Wai WONG, Auteur ; Sze-Mai NG, Auteur ; Angela Man Wai LAM, Auteur ; Sandra Sau Man CHAN, Auteur ; Shing-Him NG, Auteur ; Jet LEUNG, Auteur ; Keith Chun Lok LEE, Auteur ; Arthur Chun Chi WONG, Auteur ; Yuqi WU, Auteur ; Francis Ka Leung CHAN, Auteur ; Siew Chien NG, Auteur ; Oscar Wing Ho WONG, Auteur . - p.2478-2489. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2478-2489 Mots-clés : anxiety  autism  feeding problems  functional gastrointestinal disorder  gut-brain axis  nutrition  sensory hyperresponsiveness Index. décimale : PER Périodiques Résumé : ABSTRACT Functional gastrointestinal disorders (FGIDs) are prevalent in children with autism and can interact with the neuropsychiatric symptoms bidirectionally. Moreover, FGIDs may affect feeding to jeopardize nutritional intake. Existing research often overlooks the heterogeneity of FGIDs. Understanding the clinical correlates of individual FGID subtypes may clarify the underlying gut-brain interactions to guide management. This study compared the core autistic symptoms, co-occurring psychopathologies, feeding behavior and dietary intake among 737 Chinese children with autism (mean age?=?7.76?years; 642 males and 95 females) who either experienced no FGID or experienced one of the three subtypes of ROME-IV FGID. FGIDs were present in 19.8% of participants and MANCOVA revealed distinct clinical profiles across FGID subtypes. Functional abdominal pain disorders (FAPD) were associated with more severe neuropsychiatric symptoms, including restricted and repetitive behavior, anxiety, sensory hyperresponsiveness, externalizing behavior, and feeding patterns of emotional under-eating, slowness in eating, and increased satiety response. Functional defecation disorders (FDD) were characterized by food fussiness, slowness in eating, increased satiety response, and decreased intake of water, protein and fiber. With a small sample size of six, functional nausea and vomiting disorders (FNVD) were associated with emotional overeating. These findings suggest FGID subtypes involve distinct gut-brain interactions. Sensory dysregulation may underlie the link between FAPD and neuropsychiatric symptoms, while food fussiness in FDD may contribute to constipation via reduced fiber and water intake. The management of FGIDs in autism should be tailored to specific subtypes and their clinical correlates. En ligne : https://doi.org/10.1002/aur.70138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

The Role of Microbiota Metabolites Propionic Acid, p-Cresol, and 4-Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review / Laura SANDONI in Autism Research, 19-5 (May 2026)  

Public ISBD [article]  inAutism Research > 19-5 (May 2026) . - p.e70237 Titre : The Role of Microbiota Metabolites Propionic Acid, p-Cresol, and 4-Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review Type de document : texte imprimé Auteurs : Laura SANDONI, Auteur ; Lisa ASTA, Auteur ; Nicole GIOMPAOLO, Auteur ; Rinvil RENALDI, Auteur ; Alberto AMARETTI, Auteur ; Maddalena ROSSI, Auteur ; Antonio M. PERSICO, Auteur Article en page(s) : p.e70237 Langues : Anglais (eng) Mots-clés : 4-ethylphenyl sulfate  autism spectrum disorder  gut microbiota  gut-brain axis  propionic acid  p-cresol Index. décimale : PER Périodiques Résumé : ABSTRACT The etiopathogenesis of Autism Spectrum Disorder (ASD) encompasses complex interactions between genetic and environmental risk factors. The high prevalence of gastrointestinal disorders in autistic individuals has propelled a growing interest in the possible involvement of gut dysbiosis in ASD pathogenesis. Thousands of different bacterial strains are found in the human gut, which produce numerous metabolites that can enter the bloodstream and often pass the blood?brain barrier, potentially influencing neurodevelopment and brain function. This systematic review aims to provide a comprehensive outlook on the role of three metabolic compounds derived from gut bacteria, propionic acid (PPA), p-cresol, and 4-ethylphenyl sulfate (4-EPS), in modulating neuronal function and conferring susceptibility to ASD. To achieve this, we screened 411 records collected through a systematic search of current scientific literature in PubMed, Web of Science, and Scopus, ultimately reviewing a total of 90 records, which included data from ASD human cohorts as well as animal and cellular models of autism. Human studies provided compelling evidence of altered metabolic profiles in ASD individuals, especially for PPA and p-cresol, but also to a smaller extent, for 4-EPS. Furthermore, data obtained from the exposure of experimental models to each one of these three metabolic compounds identified several behavioral anomalies induced in treated animals and highlighted common neurobiological mechanisms. Overall, current literature supports the contribution of gut metabolites to ASD susceptibility and/or a significant modulatory role on the clinical expression of ASD, strongly encouraging further research in the field in order to improve autism diagnostics and management. En ligne : https://doi.org/10.1002/aur.70237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587 [article] The Role of Microbiota Metabolites Propionic Acid, p-Cresol, and 4-Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review [texte imprimé] / Laura SANDONI, Auteur ; Lisa ASTA, Auteur ; Nicole GIOMPAOLO, Auteur ; Rinvil RENALDI, Auteur ; Alberto AMARETTI, Auteur ; Maddalena ROSSI, Auteur ; Antonio M. PERSICO, Auteur . - p.e70237. Langues : Anglais (eng) in Autism Research > 19-5 (May 2026) . - p.e70237 Mots-clés : 4-ethylphenyl sulfate  autism spectrum disorder  gut microbiota  gut-brain axis  propionic acid  p-cresol Index. décimale : PER Périodiques Résumé : ABSTRACT The etiopathogenesis of Autism Spectrum Disorder (ASD) encompasses complex interactions between genetic and environmental risk factors. The high prevalence of gastrointestinal disorders in autistic individuals has propelled a growing interest in the possible involvement of gut dysbiosis in ASD pathogenesis. Thousands of different bacterial strains are found in the human gut, which produce numerous metabolites that can enter the bloodstream and often pass the blood?brain barrier, potentially influencing neurodevelopment and brain function. This systematic review aims to provide a comprehensive outlook on the role of three metabolic compounds derived from gut bacteria, propionic acid (PPA), p-cresol, and 4-ethylphenyl sulfate (4-EPS), in modulating neuronal function and conferring susceptibility to ASD. To achieve this, we screened 411 records collected through a systematic search of current scientific literature in PubMed, Web of Science, and Scopus, ultimately reviewing a total of 90 records, which included data from ASD human cohorts as well as animal and cellular models of autism. Human studies provided compelling evidence of altered metabolic profiles in ASD individuals, especially for PPA and p-cresol, but also to a smaller extent, for 4-EPS. Furthermore, data obtained from the exposure of experimental models to each one of these three metabolic compounds identified several behavioral anomalies induced in treated animals and highlighted common neurobiological mechanisms. Overall, current literature supports the contribution of gut metabolites to ASD susceptibility and/or a significant modulatory role on the clinical expression of ASD, strongly encouraging further research in the field in order to improve autism diagnostics and management. En ligne : https://doi.org/10.1002/aur.70237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587

An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study / Oscar W.H. WONG in Autism Research, 14-10 (October 2021)  

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Probiotics in autism spectrum disorder: Recent insights from animal models / Navid GOLBAGHI in Autism, 28-11 (November 2024)  

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