Comparison of the oral microbiota of children with autism spectrum disorder in primary dentition with neurotypical controls / Gülsevim ODA in Research in Autism Spectrum Disorders, 118 (October 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 118 (October 2024) . - 102480 Titre : Comparison of the oral microbiota of children with autism spectrum disorder in primary dentition with neurotypical controls Type de document : Texte imprimé et/ou numérique Auteurs : Gülsevim ODA, Auteur ; Deniz Ece KAYA, Auteur ; Tuba Bilbay KAYNAR, Auteur ; Emine Nursen TOPCUO?LU, Auteur ; Murat CO?KUN, Auteur ; Gamze AREN, Auteur Article en page(s) : 102480 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Microbiota analysis  Saliva Index. décimale : PER Périodiques Résumé : Background The number of studies suggesting differences in oral microbiota in autism spectrum disorders (ASDs) is increasing. However, the relationship between oral microbiota and ASD has not been determined. Therefore, this study aimed to examine the oral microbiota of children with ASD compared with neurotypical controls. Method Nine boys with a diagnosis of ASD according to the Diagnostic and Statistical Manual of the American Psychiatric Association, Fifth Edition who were aged 36 to 60 months (44 + 6.34), and nine neurotypical age-matched boys were included in the study. After detailed clinical examinations, saliva samples were collected. DNA from the samples was investigated by high-throughput sequencing of the 16S rRNA gene. The Childhood Autism Rating Scale was used to assess the severity of ASD in the case group. Results An analysis of alpha and beta diversity indexes and principal coordinate analysis revealed no significant differences between ASD and neurotypical controls nor were there significant differences in the relative abundance of the phyla and genera between the two groups. However, the distribution of operational taxonomic units (with a relative abundance> 1 %) for Bacillales, Granulicatella elegans, Micrococcaceae, Micrococcales, Neisseria zalophi, S. anginosus SK52 = DSM 2563, S. cristatus AS 1.389, S. mitis, S. oralis subsp. dentisani and S. pneumoniae were significantly higher in the ASD group (p < 0.05). Conclusions Differences in the relative abundance of some taxa in the saliva of children with ASD compared with neurotypical controls were found. Further studies are needed to understand the relationship between oral microbiota and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102480 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540 [article] Comparison of the oral microbiota of children with autism spectrum disorder in primary dentition with neurotypical controls [Texte imprimé et/ou numérique] / Gülsevim ODA, Auteur ; Deniz Ece KAYA, Auteur ; Tuba Bilbay KAYNAR, Auteur ; Emine Nursen TOPCUO?LU, Auteur ; Murat CO?KUN, Auteur ; Gamze AREN, Auteur . - 102480. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 118 (October 2024) . - 102480 Mots-clés : Autism spectrum disorder  Microbiota analysis  Saliva Index. décimale : PER Périodiques Résumé : Background The number of studies suggesting differences in oral microbiota in autism spectrum disorders (ASDs) is increasing. However, the relationship between oral microbiota and ASD has not been determined. Therefore, this study aimed to examine the oral microbiota of children with ASD compared with neurotypical controls. Method Nine boys with a diagnosis of ASD according to the Diagnostic and Statistical Manual of the American Psychiatric Association, Fifth Edition who were aged 36 to 60 months (44 + 6.34), and nine neurotypical age-matched boys were included in the study. After detailed clinical examinations, saliva samples were collected. DNA from the samples was investigated by high-throughput sequencing of the 16S rRNA gene. The Childhood Autism Rating Scale was used to assess the severity of ASD in the case group. Results An analysis of alpha and beta diversity indexes and principal coordinate analysis revealed no significant differences between ASD and neurotypical controls nor were there significant differences in the relative abundance of the phyla and genera between the two groups. However, the distribution of operational taxonomic units (with a relative abundance> 1 %) for Bacillales, Granulicatella elegans, Micrococcaceae, Micrococcales, Neisseria zalophi, S. anginosus SK52 = DSM 2563, S. cristatus AS 1.389, S. mitis, S. oralis subsp. dentisani and S. pneumoniae were significantly higher in the ASD group (p < 0.05). Conclusions Differences in the relative abundance of some taxa in the saliva of children with ASD compared with neurotypical controls were found. Further studies are needed to understand the relationship between oral microbiota and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102480 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540

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