9 recherche sur le mot-clé 'Saliva'

Caregiving quality modulates neuroendocrine and immunological markers in young children in foster care who have experienced early adversity / Vanessa REINDL in Journal of Child Psychology and Psychiatry, 63-5 (May 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.535-543 Titre : Caregiving quality modulates neuroendocrine and immunological markers in young children in foster care who have experienced early adversity Type de document : Texte imprimé et/ou numérique Auteurs : Vanessa REINDL, Auteur ; Anastasia SCHIPPERS, Auteur ; Klaus TENBROCK, Auteur ; Ann-Katrin JOB, Auteur ; Christian GERLOFF, Auteur ; Arnold LOHAUS, Auteur ; Nina HEINRICHS, Auteur ; Kerstin KONRAD, Auteur Article en page(s) : p.535-543 Langues : Anglais (eng) Mots-clés : Child, Preschool  Dehydroepiandrosterone  Foster Home Care  Humans  Hydrocortisone  Immunoglobulin A, Secretory  Longitudinal Studies  Progesterone  Saliva  Cortisol  Dhea  caregiving  children in foster care  hair steroids  longitudinal  maltreatment  sIgA Index. décimale : PER Périodiques Résumé : BACKGROUND: Early adversity is believed to alter the body's stress-response systems, putting children at increased risk for somatic and mental health problems. However, it remains unclear whether such alterations normalize under improved caregiving experiences. Thus, the goal of the present study was to investigate (a) whether children in foster care show endocrine and immunological alterations relative to children living with their biological families, (b) whether these alterations change over time spent with the foster family, and (c) whether the alterations are modulated by current caregiving experiences. METHODS: A total of 94 children in foster care and 157 biological children, aged two to seven years, took part in a longitudinal study with three assessments conducted over a 12-month study period. At the initial assessment, children lived for an average of 18?months with their current foster families. Children's cortisol, dehydroepiandrosterone (DHEA) and progesterone concentrations and cortisol/DHEA ratios were measured in scalp hair and children's secretory immunoglobulin A (sIgA) levels in saliva. Caregiving quality was assessed based on caregiver-reports and observational measures of caregiver-child interactions. RESULTS: Children in foster care had lower cortisol/DHEA ratios and higher progesterone concentrations than biological children, while no group differences were found for cortisol, DHEA or sIgA. Time spent with the current foster family did not significantly influence the child's endocrine or immunological markers. Importantly, caregiving quality modulated cortisol/DHEA ratios and sIgA concentrations: children in foster care of lower caregiving quality had lower cortisol/DHEA ratios than children in foster care of higher caregiving quality and showed decreasing, rather than increasing, sIgA concentrations across the study period. CONCLUSIONS: Our results indicate that caregiving quality in the foster family may have an important modulating effect on selected indicators of the child's stress response and could thereby mitigate the possible consequences of early childhood adversity. En ligne : http://dx.doi.org/10.1111/jcpp.13488 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Caregiving quality modulates neuroendocrine and immunological markers in young children in foster care who have experienced early adversity [Texte imprimé et/ou numérique] / Vanessa REINDL, Auteur ; Anastasia SCHIPPERS, Auteur ; Klaus TENBROCK, Auteur ; Ann-Katrin JOB, Auteur ; Christian GERLOFF, Auteur ; Arnold LOHAUS, Auteur ; Nina HEINRICHS, Auteur ; Kerstin KONRAD, Auteur . - p.535-543. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.535-543 Mots-clés : Child, Preschool  Dehydroepiandrosterone  Foster Home Care  Humans  Hydrocortisone  Immunoglobulin A, Secretory  Longitudinal Studies  Progesterone  Saliva  Cortisol  Dhea  caregiving  children in foster care  hair steroids  longitudinal  maltreatment  sIgA Index. décimale : PER Périodiques Résumé : BACKGROUND: Early adversity is believed to alter the body's stress-response systems, putting children at increased risk for somatic and mental health problems. However, it remains unclear whether such alterations normalize under improved caregiving experiences. Thus, the goal of the present study was to investigate (a) whether children in foster care show endocrine and immunological alterations relative to children living with their biological families, (b) whether these alterations change over time spent with the foster family, and (c) whether the alterations are modulated by current caregiving experiences. METHODS: A total of 94 children in foster care and 157 biological children, aged two to seven years, took part in a longitudinal study with three assessments conducted over a 12-month study period. At the initial assessment, children lived for an average of 18?months with their current foster families. Children's cortisol, dehydroepiandrosterone (DHEA) and progesterone concentrations and cortisol/DHEA ratios were measured in scalp hair and children's secretory immunoglobulin A (sIgA) levels in saliva. Caregiving quality was assessed based on caregiver-reports and observational measures of caregiver-child interactions. RESULTS: Children in foster care had lower cortisol/DHEA ratios and higher progesterone concentrations than biological children, while no group differences were found for cortisol, DHEA or sIgA. Time spent with the current foster family did not significantly influence the child's endocrine or immunological markers. Importantly, caregiving quality modulated cortisol/DHEA ratios and sIgA concentrations: children in foster care of lower caregiving quality had lower cortisol/DHEA ratios than children in foster care of higher caregiving quality and showed decreasing, rather than increasing, sIgA concentrations across the study period. CONCLUSIONS: Our results indicate that caregiving quality in the foster family may have an important modulating effect on selected indicators of the child's stress response and could thereby mitigate the possible consequences of early childhood adversity. En ligne : http://dx.doi.org/10.1111/jcpp.13488 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Comparison of the oral microbiota of children with autism spectrum disorder in primary dentition with neurotypical controls / Gülsevim ODA in Research in Autism Spectrum Disorders, 118 (October 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 118 (October 2024) . - 102480 Titre : Comparison of the oral microbiota of children with autism spectrum disorder in primary dentition with neurotypical controls Type de document : Texte imprimé et/ou numérique Auteurs : Gülsevim ODA, Auteur ; Deniz Ece KAYA, Auteur ; Tuba Bilbay KAYNAR, Auteur ; Emine Nursen TOPCUO?LU, Auteur ; Murat CO?KUN, Auteur ; Gamze AREN, Auteur Article en page(s) : 102480 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Microbiota analysis  Saliva Index. décimale : PER Périodiques Résumé : Background The number of studies suggesting differences in oral microbiota in autism spectrum disorders (ASDs) is increasing. However, the relationship between oral microbiota and ASD has not been determined. Therefore, this study aimed to examine the oral microbiota of children with ASD compared with neurotypical controls. Method Nine boys with a diagnosis of ASD according to the Diagnostic and Statistical Manual of the American Psychiatric Association, Fifth Edition who were aged 36 to 60 months (44 + 6.34), and nine neurotypical age-matched boys were included in the study. After detailed clinical examinations, saliva samples were collected. DNA from the samples was investigated by high-throughput sequencing of the 16S rRNA gene. The Childhood Autism Rating Scale was used to assess the severity of ASD in the case group. Results An analysis of alpha and beta diversity indexes and principal coordinate analysis revealed no significant differences between ASD and neurotypical controls nor were there significant differences in the relative abundance of the phyla and genera between the two groups. However, the distribution of operational taxonomic units (with a relative abundance> 1 %) for Bacillales, Granulicatella elegans, Micrococcaceae, Micrococcales, Neisseria zalophi, S. anginosus SK52 = DSM 2563, S. cristatus AS 1.389, S. mitis, S. oralis subsp. dentisani and S. pneumoniae were significantly higher in the ASD group (p < 0.05). Conclusions Differences in the relative abundance of some taxa in the saliva of children with ASD compared with neurotypical controls were found. Further studies are needed to understand the relationship between oral microbiota and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102480 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540 [article] Comparison of the oral microbiota of children with autism spectrum disorder in primary dentition with neurotypical controls [Texte imprimé et/ou numérique] / Gülsevim ODA, Auteur ; Deniz Ece KAYA, Auteur ; Tuba Bilbay KAYNAR, Auteur ; Emine Nursen TOPCUO?LU, Auteur ; Murat CO?KUN, Auteur ; Gamze AREN, Auteur . - 102480. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 118 (October 2024) . - 102480 Mots-clés : Autism spectrum disorder  Microbiota analysis  Saliva Index. décimale : PER Périodiques Résumé : Background The number of studies suggesting differences in oral microbiota in autism spectrum disorders (ASDs) is increasing. However, the relationship between oral microbiota and ASD has not been determined. Therefore, this study aimed to examine the oral microbiota of children with ASD compared with neurotypical controls. Method Nine boys with a diagnosis of ASD according to the Diagnostic and Statistical Manual of the American Psychiatric Association, Fifth Edition who were aged 36 to 60 months (44 + 6.34), and nine neurotypical age-matched boys were included in the study. After detailed clinical examinations, saliva samples were collected. DNA from the samples was investigated by high-throughput sequencing of the 16S rRNA gene. The Childhood Autism Rating Scale was used to assess the severity of ASD in the case group. Results An analysis of alpha and beta diversity indexes and principal coordinate analysis revealed no significant differences between ASD and neurotypical controls nor were there significant differences in the relative abundance of the phyla and genera between the two groups. However, the distribution of operational taxonomic units (with a relative abundance> 1 %) for Bacillales, Granulicatella elegans, Micrococcaceae, Micrococcales, Neisseria zalophi, S. anginosus SK52 = DSM 2563, S. cristatus AS 1.389, S. mitis, S. oralis subsp. dentisani and S. pneumoniae were significantly higher in the ASD group (p < 0.05). Conclusions Differences in the relative abundance of some taxa in the saliva of children with ASD compared with neurotypical controls were found. Further studies are needed to understand the relationship between oral microbiota and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102480 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540

Longitudinal stability of salivary microRNA biomarkers in children and adolescents with autism spectrum disorder / David LEVITSKIY in Research in Autism Spectrum Disorders, 85 (July 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 85 (July 2021) . - 101788 Titre : Longitudinal stability of salivary microRNA biomarkers in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : David LEVITSKIY, Auteur ; Alexandra CONFAIR, Auteur ; Kayla E. WAGNER, Auteur ; Samantha DEVITA, Auteur ; Nicole SHEA, Auteur ; Elizabeth P. MCKERNAN, Auteur ; Justin KOPEC, Auteur ; Natalie RUSSO, Auteur ; Frank A. MIDDLETON, Auteur ; Steven D. HICKS, Auteur Article en page(s) : 101788 Langues : Anglais (eng) Mots-clés : Prognosis  Biomarkers  Saliva  RNA  microRNA  Autism Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a complex neurological condition with increasing prevalence. Few tools accurately predict the developmental trajectory of children with ASD. Such tools would allow clinicians to provide accurate prognoses and track the efficacy of therapeutic interventions. Salivary RNAs that reflect the genetic-environmental interactions underlying ASD may provide objective measures of symptom severity and developmental outcomes. This study investigated whether salivary RNAs previously identified in childhood ASD remain perturbed in older children. We also explored whether RNA candidates changed with therapeutic intervention. Method A case-control design was used to characterize levels of 78 saliva RNA candidates among 96 children (48 ASD, 48 non-ASD, mean age: 11 years). Thirty-one children (22 ASD, 9 non-ASD developmental delay, mean age: 4 years) were followed longitudinally to explore changes of RNA candidates during early intervention. Saliva RNA and standardized behavioral assessments were collected for each participant. Associations between candidate RNAs and behavioral scores were determined in both groups via Spearman Correlation. Changes in candidate RNAs across two time-points were assessed in the younger cohort via Wilcoxon rank-sum test. Results Seven RNAs were associated with VABS-II and BASC scores in the older group ([R] >0.25, FDR? En ligne : https://doi.org/10.1016/j.rasd.2021.101788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Longitudinal stability of salivary microRNA biomarkers in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / David LEVITSKIY, Auteur ; Alexandra CONFAIR, Auteur ; Kayla E. WAGNER, Auteur ; Samantha DEVITA, Auteur ; Nicole SHEA, Auteur ; Elizabeth P. MCKERNAN, Auteur ; Justin KOPEC, Auteur ; Natalie RUSSO, Auteur ; Frank A. MIDDLETON, Auteur ; Steven D. HICKS, Auteur . - 101788. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101788 Mots-clés : Prognosis  Biomarkers  Saliva  RNA  microRNA  Autism Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a complex neurological condition with increasing prevalence. Few tools accurately predict the developmental trajectory of children with ASD. Such tools would allow clinicians to provide accurate prognoses and track the efficacy of therapeutic interventions. Salivary RNAs that reflect the genetic-environmental interactions underlying ASD may provide objective measures of symptom severity and developmental outcomes. This study investigated whether salivary RNAs previously identified in childhood ASD remain perturbed in older children. We also explored whether RNA candidates changed with therapeutic intervention. Method A case-control design was used to characterize levels of 78 saliva RNA candidates among 96 children (48 ASD, 48 non-ASD, mean age: 11 years). Thirty-one children (22 ASD, 9 non-ASD developmental delay, mean age: 4 years) were followed longitudinally to explore changes of RNA candidates during early intervention. Saliva RNA and standardized behavioral assessments were collected for each participant. Associations between candidate RNAs and behavioral scores were determined in both groups via Spearman Correlation. Changes in candidate RNAs across two time-points were assessed in the younger cohort via Wilcoxon rank-sum test. Results Seven RNAs were associated with VABS-II and BASC scores in the older group ([R] >0.25, FDR? En ligne : https://doi.org/10.1016/j.rasd.2021.101788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation / Adrienne A. VANZOMEREN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1838-1853 Titre : Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation Type de document : Texte imprimé et/ou numérique Auteurs : Adrienne A. VANZOMEREN, Auteur ; Jingchen ZHANG, Auteur ; Sun-Kyung LEE, Auteur ; Meredith GUNLICKS-STOESSEL, Auteur ; Timothy PIEHLER, Auteur ; Dante CICCHETTI, Auteur Article en page(s) : p.1838-1853 Langues : Anglais (eng) Mots-clés : Adolescent  African Americans  Child  *Depression  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  Pituitary-Adrenal System  Saliva  *African American youth  *HPA axis  *maltreatment  *multigenic risk Index. décimale : PER Périodiques Résumé : Utilizing a large (N = 739), ancestrally homogenous sample, the current study aimed to better understand biological risk processes involved in the development of depressive symptoms in maltreated, African American children age 8-12 years. Maltreatment was independently coded from Child Protective Services records and maternal report. Self-reported depressive symptoms were attained in the context of a week-long, summer research camp. DNA was acquired from buccal cell or saliva samples and genotyped for nine polymorphisms in four hypothalamic-pituitary-adrenal (HPA)-axis-related genes: FKBP5, NR3C1, NR3C2, and CRHR1. Salivary cortisol samples were collected each morning (9 a.m.) and late afternoon (4 p.m.) throughout the week to assess HPA functioning. Results revealed that experiences of maltreatment beginning prior to age 5 were most predictive of depressive symptoms, whereas maltreatment onset after age 5 was most predictive of HPA axis dysregulation (blunted daytime cortisol patterns). Multigenic risk did not relate to HPA functioning, nor did it moderate the relationship between maltreatment and HPA activity. There was no mediation of the relationship between maltreatment and depressive symptoms by HPA dysfunction. Results are interpreted through a developmental psychopathology lens, emphasizing the principle of equifinality while carefully appraising racial differences. Implications for future research, particularly the need for longitudinal studies, and important methodological considerations are discussed. En ligne : http://dx.doi.org/10.1017/s0954579420000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation [Texte imprimé et/ou numérique] / Adrienne A. VANZOMEREN, Auteur ; Jingchen ZHANG, Auteur ; Sun-Kyung LEE, Auteur ; Meredith GUNLICKS-STOESSEL, Auteur ; Timothy PIEHLER, Auteur ; Dante CICCHETTI, Auteur . - p.1838-1853. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1838-1853 Mots-clés : Adolescent  African Americans  Child  *Depression  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  Pituitary-Adrenal System  Saliva  *African American youth  *HPA axis  *maltreatment  *multigenic risk Index. décimale : PER Périodiques Résumé : Utilizing a large (N = 739), ancestrally homogenous sample, the current study aimed to better understand biological risk processes involved in the development of depressive symptoms in maltreated, African American children age 8-12 years. Maltreatment was independently coded from Child Protective Services records and maternal report. Self-reported depressive symptoms were attained in the context of a week-long, summer research camp. DNA was acquired from buccal cell or saliva samples and genotyped for nine polymorphisms in four hypothalamic-pituitary-adrenal (HPA)-axis-related genes: FKBP5, NR3C1, NR3C2, and CRHR1. Salivary cortisol samples were collected each morning (9 a.m.) and late afternoon (4 p.m.) throughout the week to assess HPA functioning. Results revealed that experiences of maltreatment beginning prior to age 5 were most predictive of depressive symptoms, whereas maltreatment onset after age 5 was most predictive of HPA axis dysregulation (blunted daytime cortisol patterns). Multigenic risk did not relate to HPA functioning, nor did it moderate the relationship between maltreatment and HPA activity. There was no mediation of the relationship between maltreatment and depressive symptoms by HPA dysfunction. Results are interpreted through a developmental psychopathology lens, emphasizing the principle of equifinality while carefully appraising racial differences. Implications for future research, particularly the need for longitudinal studies, and important methodological considerations are discussed. En ligne : http://dx.doi.org/10.1017/s0954579420000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Associations between stress reactivity and behavior problems for previously institutionalized youth across puberty / Nicole B. PERRY in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1854-1863 Titre : Associations between stress reactivity and behavior problems for previously institutionalized youth across puberty Type de document : Texte imprimé et/ou numérique Auteurs : Nicole B. PERRY, Auteur ; Carrie E. DEPASQUALE, Auteur ; Bonny DONZELLA, Auteur ; Megan R. GUNNAR, Auteur Article en page(s) : p.1854-1863 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Hydrocortisone  Parents  *Problem Behavior  Puberty  Saliva  *Stress, Psychological  *cortisol  *externalizing  *institutions  *internalizing  *puberty  *stress Index. décimale : PER Périodiques Résumé : Megan Gunnar's pubertal stress recalibration hypothesis was supported in a recent study of previously institutionalized (PI) youth such that increases in pubertal stage were associated with increases in cortisol stress reactivity. This work provides evidence that puberty may open up a window of recalibration for PI youth, resulting in a shift from a blunted to a more typical cortisol stress response. Using the same sample (N = 132), the current study aimed to elucidate whether increases in cortisol are associated with increases in adaptive functioning or whether they further underlie potential links to developmental psychopathology. Specifically, we examined the bidirectional associations between cortisol stress reactivity and both internalizing and externalizing symptoms across three timepoints during the pubertal period. Youth reported on their own internalizing symptoms and parents reported on youths' externalizing symptoms. Cortisol reactivity was assessed during the Trier social stress test. Analyses revealed no associations between cortisol reactivity and externalizing symptoms across puberty for PI youth. However, longitudinal bidirectional associations did emerge for internalizing symptoms such that increases in cortisol reactivity predicted increases in internalizing symptoms and increases in internalizing symptoms predicted increases in cortisol reactivity. Findings suggest that recalibrating to more normative levels of cortisol reactivity may not always be associated with adaptive outcomes for PI youth. En ligne : http://dx.doi.org/10.1017/s0954579420001297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Associations between stress reactivity and behavior problems for previously institutionalized youth across puberty [Texte imprimé et/ou numérique] / Nicole B. PERRY, Auteur ; Carrie E. DEPASQUALE, Auteur ; Bonny DONZELLA, Auteur ; Megan R. GUNNAR, Auteur . - p.1854-1863. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1854-1863 Mots-clés : Adolescent  Humans  Hydrocortisone  Parents  *Problem Behavior  Puberty  Saliva  *Stress, Psychological  *cortisol  *externalizing  *institutions  *internalizing  *puberty  *stress Index. décimale : PER Périodiques Résumé : Megan Gunnar's pubertal stress recalibration hypothesis was supported in a recent study of previously institutionalized (PI) youth such that increases in pubertal stage were associated with increases in cortisol stress reactivity. This work provides evidence that puberty may open up a window of recalibration for PI youth, resulting in a shift from a blunted to a more typical cortisol stress response. Using the same sample (N = 132), the current study aimed to elucidate whether increases in cortisol are associated with increases in adaptive functioning or whether they further underlie potential links to developmental psychopathology. Specifically, we examined the bidirectional associations between cortisol stress reactivity and both internalizing and externalizing symptoms across three timepoints during the pubertal period. Youth reported on their own internalizing symptoms and parents reported on youths' externalizing symptoms. Cortisol reactivity was assessed during the Trier social stress test. Analyses revealed no associations between cortisol reactivity and externalizing symptoms across puberty for PI youth. However, longitudinal bidirectional associations did emerge for internalizing symptoms such that increases in cortisol reactivity predicted increases in internalizing symptoms and increases in internalizing symptoms predicted increases in cortisol reactivity. Findings suggest that recalibrating to more normative levels of cortisol reactivity may not always be associated with adaptive outcomes for PI youth. En ligne : http://dx.doi.org/10.1017/s0954579420001297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Maternal caregiving moderates the impact of antenatal maternal cortisol on infant stress regulation / Sarah NAZZARI in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)  

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Oral microbiome activity in children with autism spectrum disorder / S. D. HICKS in Autism Research, 11-9 (September 2018)  

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Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies / S. JOHN in Autism, 25-8 (November 2021)  

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Parental buffering in the context of poverty: positive parenting behaviors differentiate young children's stress reactivity profiles / Samantha M. BROWN in Development and Psychopathology, 32-5 (December 2020)  

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