Early language ability and depressive symptoms in preadolescence: Sex-specific mediating effects of self-concept domains / Sharon TING in Development and Psychopathology, 38-3 (August 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-3 (August 2026) . - p.1468-1483 Titre : Early language ability and depressive symptoms in preadolescence: Sex-specific mediating effects of self-concept domains Type de document : texte imprimé Auteurs : Sharon TING, Auteur ; Germaine Y. Q. TNG, Auteur ; Pei HUANG, Auteur ; Jordan LEGASPI, Auteur ; Helen CHEN, Auteur ; Johan Gunnar ERIKSSON, Auteur ; Yap Seng CHONG, Auteur ; Henning TIEMEIER, Auteur ; Peipei SETOH, Auteur Article en page(s) : p.1468-1483 Langues : Anglais (eng) Mots-clés : depressive symptoms  language ability  longitudinal research  mediation  self-concept Index. décimale : PER Périodiques Résumé : Poorer language ability is a known risk factor for elevated depressive symptoms. However, the cognitive mechanisms underlying this association remain underexplored. Utilizing data from a comprehensive pre-birth cohort in Singapore (N = 473; 49.9% boys; 57.3% Chinese, 27.9% Malay, 14.8% Indian), the present study examined whether (i) self-concept domains mediate the association between early language ability and depressive symptoms during preadolescence, and (ii) these indirect pathways differ by child sex. Children’s early language ability was assessed at ages 2 and 4 using standardized assessments of vocabulary and phonological processing. Self-concept and depressive symptoms were measured at ages 8.5 and 10, respectively. Results indicated that the domain of behavioral adjustment mediated the relationship between early language ability and subsequent depressive symptoms for girls (β = −0.07, 95% CI [−0.15, −0.01]), whereas happiness and satisfaction served as a key mediator for boys (β = −0.12, 95% CI [−0.24, −0.03]). After accounting for these mediators, there was no direct association between early language ability and depressive symptoms. These findings highlight potential sex-specific mechanisms through which early language ability is prospectively associated with depressive symptoms. Future research is necessary to determine whether enhancing self-concept can mitigate depressive symptoms in children with early language difficulties. En ligne : https://dx.doi.org/10.1017/S0954579426101308 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Early language ability and depressive symptoms in preadolescence: Sex-specific mediating effects of self-concept domains [texte imprimé] / Sharon TING, Auteur ; Germaine Y. Q. TNG, Auteur ; Pei HUANG, Auteur ; Jordan LEGASPI, Auteur ; Helen CHEN, Auteur ; Johan Gunnar ERIKSSON, Auteur ; Yap Seng CHONG, Auteur ; Henning TIEMEIER, Auteur ; Peipei SETOH, Auteur . - p.1468-1483. Langues : Anglais (eng) in Development and Psychopathology > 38-3 (August 2026) . - p.1468-1483 Mots-clés : depressive symptoms  language ability  longitudinal research  mediation  self-concept Index. décimale : PER Périodiques Résumé : Poorer language ability is a known risk factor for elevated depressive symptoms. However, the cognitive mechanisms underlying this association remain underexplored. Utilizing data from a comprehensive pre-birth cohort in Singapore (N = 473; 49.9% boys; 57.3% Chinese, 27.9% Malay, 14.8% Indian), the present study examined whether (i) self-concept domains mediate the association between early language ability and depressive symptoms during preadolescence, and (ii) these indirect pathways differ by child sex. Children’s early language ability was assessed at ages 2 and 4 using standardized assessments of vocabulary and phonological processing. Self-concept and depressive symptoms were measured at ages 8.5 and 10, respectively. Results indicated that the domain of behavioral adjustment mediated the relationship between early language ability and subsequent depressive symptoms for girls (β = −0.07, 95% CI [−0.15, −0.01]), whereas happiness and satisfaction served as a key mediator for boys (β = −0.12, 95% CI [−0.24, −0.03]). After accounting for these mediators, there was no direct association between early language ability and depressive symptoms. These findings highlight potential sex-specific mechanisms through which early language ability is prospectively associated with depressive symptoms. Future research is necessary to determine whether enhancing self-concept can mitigate depressive symptoms in children with early language difficulties. En ligne : https://dx.doi.org/10.1017/S0954579426101308 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

Subregion-specific thalamocortical functional connectivity, executive function, and social behavior in children with autism spectrum disorders / Jasmine Si Min CHUAH ; Aisleen M.A. MANAHAN ; Shi Yu CHAN ; Zhen Ming NGOH ; Pei HUANG ; Ai Peng TAN in Autism Research, 18-1 (January 2025)  

Public ISBD [article]  inAutism Research > 18-1 (January 2025) . - p.70-82 Titre : Subregion-specific thalamocortical functional connectivity, executive function, and social behavior in children with autism spectrum disorders : Autism Research Type de document : texte imprimé Auteurs : Jasmine Si Min CHUAH, Auteur ; Aisleen M.A. MANAHAN, Auteur ; Shi Yu CHAN, Auteur ; Zhen Ming NGOH, Auteur ; Pei HUANG, Auteur ; Ai Peng TAN, Auteur Article en page(s) : p.70-82 Langues : Anglais (eng) Mots-clés : autism spectrum disorders (ASDs)  children  executive function  resting-state functional connectivity (RSFC)  social behavior  thalamocortical connectivity Index. décimale : PER Périodiques Résumé : Abstract The thalamus has extensive cortical connections and is an integrative hub for cognitive functions governing social behavior. This study examined (1) associations between thalamocortical resting-state functional connectivity (RSFC) and social behavior in children and (2) how various executive function (EF) subdomains mediate the association between thalamocortical RSFC and social behavior. Children from the autism brain imaging data exchange (ABIDE) initiative with neuroimaging, behavioral, and demographic data were included in our study (age < 14, ASD; n 207, typically developing; n 259). Thalamocortical RSFC was examined for associations with social communication and interaction (SCI) scores (SRS; social responsiveness scale) using Spearman's rank-order correlation, first in ASD children and then in typically developing children. This was followed by a more granular analysis at the thalamic subregion level. We then examined the mediating roles of eight EF subdomains in ASD children (n 139). Right thalamus-default mode network (DMN) RSFC was significantly associated with SCI scores in ASD children (? 0.23, pFDR 0.012), primarily driven by the medial (? 0.22, pFDR 0.013), ventral (? 0.17, pFDR 0.036), and intralaminar (? 0.17, pFDR 0.036) thalamic subregions. Cognitive flexibility (ACME 0.13, punc 0.016) and emotional control (ACME 0.08, punc 0.020) significantly mediated the association between right thalamus-DMN RSFC and SCI scores. This study provided novel insights into the association between thalamocortical RSFC and social behavior in ASD children at the thalamic subregion level, providing higher levels of precision in brain-behavior mapping. Cognitive flexibility and emotion regulation were highlighted as potential targets to ameliorate the downstream effects of altered thalamocortical connectivity to improve social outcomes in ASD children. En ligne : https://doi.org/10.1002/aur.3280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Subregion-specific thalamocortical functional connectivity, executive function, and social behavior in children with autism spectrum disorders : Autism Research [texte imprimé] / Jasmine Si Min CHUAH, Auteur ; Aisleen M.A. MANAHAN, Auteur ; Shi Yu CHAN, Auteur ; Zhen Ming NGOH, Auteur ; Pei HUANG, Auteur ; Ai Peng TAN, Auteur . - p.70-82. Langues : Anglais (eng) in Autism Research > 18-1 (January 2025) . - p.70-82 Mots-clés : autism spectrum disorders (ASDs)  children  executive function  resting-state functional connectivity (RSFC)  social behavior  thalamocortical connectivity Index. décimale : PER Périodiques Résumé : Abstract The thalamus has extensive cortical connections and is an integrative hub for cognitive functions governing social behavior. This study examined (1) associations between thalamocortical resting-state functional connectivity (RSFC) and social behavior in children and (2) how various executive function (EF) subdomains mediate the association between thalamocortical RSFC and social behavior. Children from the autism brain imaging data exchange (ABIDE) initiative with neuroimaging, behavioral, and demographic data were included in our study (age < 14, ASD; n 207, typically developing; n 259). Thalamocortical RSFC was examined for associations with social communication and interaction (SCI) scores (SRS; social responsiveness scale) using Spearman's rank-order correlation, first in ASD children and then in typically developing children. This was followed by a more granular analysis at the thalamic subregion level. We then examined the mediating roles of eight EF subdomains in ASD children (n 139). Right thalamus-default mode network (DMN) RSFC was significantly associated with SCI scores in ASD children (? 0.23, pFDR 0.012), primarily driven by the medial (? 0.22, pFDR 0.013), ventral (? 0.17, pFDR 0.036), and intralaminar (? 0.17, pFDR 0.036) thalamic subregions. Cognitive flexibility (ACME 0.13, punc 0.016) and emotional control (ACME 0.08, punc 0.020) significantly mediated the association between right thalamus-DMN RSFC and SCI scores. This study provided novel insights into the association between thalamocortical RSFC and social behavior in ASD children at the thalamic subregion level, providing higher levels of precision in brain-behavior mapping. Cognitive flexibility and emotion regulation were highlighted as potential targets to ameliorate the downstream effects of altered thalamocortical connectivity to improve social outcomes in ASD children. En ligne : https://doi.org/10.1002/aur.3280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

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