Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder / Yu WANG ; Aihua Cao ; Jing WANG ; He Bai ; Tianci Liu ; Chenxi Sun ; Zhuoran Li ; Yuchun Tang ; Feifei Xu ; Shuwei Liu in Autism Research, 18-1 (January 2025)  

Public ISBD [article]  inAutism Research > 18-1 (January 2025) . - p.83-97 Titre : Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Yu WANG, Auteur ; Aihua Cao, Auteur ; Jing WANG, Auteur ; He Bai, Auteur ; Tianci Liu, Auteur ; Chenxi Sun, Auteur ; Zhuoran Li, Auteur ; Yuchun Tang, Auteur ; Feifei Xu, Auteur ; Shuwei Liu, Auteur Article en page(s) : p.83-97 Langues : Anglais (eng) Mots-clés : atypical patterns  autism  cerebellar subregions' volume  cerebellocerebral structural covariance  pars opercularis Index. décimale : PER Périodiques Résumé : Abstract The cerebellum plays a crucial role in functions, including sensory-motor coordination, cognition, and emotional processing. Compared to the neocortex, the human cerebellum exhibits a protracted developmental trajectory. This delayed developmental timeline may lead to increased sensitivity of the cerebellum to external influences, potentially extending the vulnerability period for neurological disorders. Abnormal cerebellar development in individuals with autism has been confirmed, and these atypical cerebellar changes may affect the development of the neocortex. However, due to the heterogeneity of autism spectrum disorder (ASD), the regional changes in the cerebellum and cerebellocerebral structural relationship remain unknown. To address these issues, we utilized imaging methods optimized for the cerebellum and cerebrum on 817 individuals aged 5?18?years in the ABIDE II dataset. After FDR correction, significant differences between groups were found in the right crus II/VIIB and vermis VI-VII. Structural covariance analysis revealed enhanced structural covariance in individuals with autism between the cerebellum and parahippocampal gyrus, pars opercularis, and transverse temporal gyrus in the right hemisphere after FDR correction. Furthermore, the structural covariance between the cerebellum and some regions of the cerebrum varied across sexes. A significant increase in structural covariance between the cerebellum and specific subcortical structures was also observed in individuals with ASD. Our study found atypical patterns in the structural covariance between the cerebellum and cerebrum in individuals with autism, which suggested that the underlying pathological processes of ASD might concurrently affect these brain regions. This study provided insight into the potential of cerebellocerebral pathways as therapeutic targets for ASD. En ligne : https://doi.org/10.1002/aur.3287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder : Autism Research [Texte imprimé et/ou numérique] / Yu WANG, Auteur ; Aihua Cao, Auteur ; Jing WANG, Auteur ; He Bai, Auteur ; Tianci Liu, Auteur ; Chenxi Sun, Auteur ; Zhuoran Li, Auteur ; Yuchun Tang, Auteur ; Feifei Xu, Auteur ; Shuwei Liu, Auteur . - p.83-97. Langues : Anglais (eng) in Autism Research > 18-1 (January 2025) . - p.83-97 Mots-clés : atypical patterns  autism  cerebellar subregions' volume  cerebellocerebral structural covariance  pars opercularis Index. décimale : PER Périodiques Résumé : Abstract The cerebellum plays a crucial role in functions, including sensory-motor coordination, cognition, and emotional processing. Compared to the neocortex, the human cerebellum exhibits a protracted developmental trajectory. This delayed developmental timeline may lead to increased sensitivity of the cerebellum to external influences, potentially extending the vulnerability period for neurological disorders. Abnormal cerebellar development in individuals with autism has been confirmed, and these atypical cerebellar changes may affect the development of the neocortex. However, due to the heterogeneity of autism spectrum disorder (ASD), the regional changes in the cerebellum and cerebellocerebral structural relationship remain unknown. To address these issues, we utilized imaging methods optimized for the cerebellum and cerebrum on 817 individuals aged 5?18?years in the ABIDE II dataset. After FDR correction, significant differences between groups were found in the right crus II/VIIB and vermis VI-VII. Structural covariance analysis revealed enhanced structural covariance in individuals with autism between the cerebellum and parahippocampal gyrus, pars opercularis, and transverse temporal gyrus in the right hemisphere after FDR correction. Furthermore, the structural covariance between the cerebellum and some regions of the cerebrum varied across sexes. A significant increase in structural covariance between the cerebellum and specific subcortical structures was also observed in individuals with ASD. Our study found atypical patterns in the structural covariance between the cerebellum and cerebrum in individuals with autism, which suggested that the underlying pathological processes of ASD might concurrently affect these brain regions. This study provided insight into the potential of cerebellocerebral pathways as therapeutic targets for ASD. En ligne : https://doi.org/10.1002/aur.3287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

Common Gut Microbial Signatures in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder / Chao CHE ; Dong LI ; Xiaoli LI ; Xiaoxiao YU ; Lianhu YU ; Qin SUN ; Yaofang NIU ; Aihua Cao in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.741-751 Titre : Common Gut Microbial Signatures in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chao CHE, Auteur ; Dong LI, Auteur ; Xiaoli LI, Auteur ; Xiaoxiao YU, Auteur ; Lianhu YU, Auteur ; Qin SUN, Auteur ; Yaofang NIU, Auteur ; Aihua Cao, Auteur Article en page(s) : p.741-751 Langues : Anglais (eng) Mots-clés : 16S rRNA sequencing  attention deficit hyperactivity disorder  autism spectrum disorder  gut microbiota  metabolic functions Index. décimale : PER Périodiques Résumé : ABSTRACT The potential etiological and diagnostic values of the gut microbiota in children with neurodevelopmental disorders are encouraging but controversial. In particular, the composition and characteristics of the gut microbiota in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) remain largely unidentified. Herein, we analyzed stool samples from 113 participants with a clinical diagnosis of ASD, 43 with ADHD, 8 with both ASD and ADHD, and 120 healthy controls between 2 and 11?years of age using 16S rRNA sequencing. We observed that clinical diagnosis, age, comorbidities, food sensitivities, and antibiotic use significantly affected the gut microbiota. The enriched genera in the control group were relatively common and dominant human gut bacteria, such as Bacteroides, Faecalibacterium, and Roseburia. The genera present in children with neurodevelopmental disorders showed greater heterogeneity, and the abundance of Bifidobacterium was consistently increased. We found 4899 deregulated microbial metabolic functions and revealed the formation of a divergent genus-level network in patients. This analysis demonstrated that the gut microbial signatures efficiently discriminated patients from healthy participants in both the discovery (area under the curve [AUC]: 0.95?0.98) and validation (AUC: 0.69?0.74) sets. Importantly, although ASD and ADHD share several gut microbial characteristics, specific bacteria that contribute to the disease pathogenesis may have different metabolic functions. En ligne : https://doi.org/10.1002/aur.70016 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Common Gut Microbial Signatures in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder [Texte imprimé et/ou numérique] / Chao CHE, Auteur ; Dong LI, Auteur ; Xiaoli LI, Auteur ; Xiaoxiao YU, Auteur ; Lianhu YU, Auteur ; Qin SUN, Auteur ; Yaofang NIU, Auteur ; Aihua Cao, Auteur . - p.741-751. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.741-751 Mots-clés : 16S rRNA sequencing  attention deficit hyperactivity disorder  autism spectrum disorder  gut microbiota  metabolic functions Index. décimale : PER Périodiques Résumé : ABSTRACT The potential etiological and diagnostic values of the gut microbiota in children with neurodevelopmental disorders are encouraging but controversial. In particular, the composition and characteristics of the gut microbiota in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) remain largely unidentified. Herein, we analyzed stool samples from 113 participants with a clinical diagnosis of ASD, 43 with ADHD, 8 with both ASD and ADHD, and 120 healthy controls between 2 and 11?years of age using 16S rRNA sequencing. We observed that clinical diagnosis, age, comorbidities, food sensitivities, and antibiotic use significantly affected the gut microbiota. The enriched genera in the control group were relatively common and dominant human gut bacteria, such as Bacteroides, Faecalibacterium, and Roseburia. The genera present in children with neurodevelopmental disorders showed greater heterogeneity, and the abundance of Bifidobacterium was consistently increased. We found 4899 deregulated microbial metabolic functions and revealed the formation of a divergent genus-level network in patients. This analysis demonstrated that the gut microbial signatures efficiently discriminated patients from healthy participants in both the discovery (area under the curve [AUC]: 0.95?0.98) and validation (AUC: 0.69?0.74) sets. Importantly, although ASD and ADHD share several gut microbial characteristics, specific bacteria that contribute to the disease pathogenesis may have different metabolic functions. En ligne : https://doi.org/10.1002/aur.70016 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

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