Untangling the Molecular Mechanisms Contributing to Autism Spectrum Disorder Using Stem Cells / Zoe MATTINGLY in Autism Research, 18-3 (March 2025)  

Public ISBD [article]  inAutism Research > 18-3 (March 2025) . - p.476-485 Titre : Untangling the Molecular Mechanisms Contributing to Autism Spectrum Disorder Using Stem Cells Type de document : Texte imprimé et/ou numérique Auteurs : Zoe MATTINGLY, Auteur ; Sundari CHETTY, Auteur Article en page(s) : p.476-485 Langues : Anglais (eng) Mots-clés : autism  disease modeling  molecular and cellular mechanisms  personalized medicine  stem cells Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a complex neuro developmental condition characterized by significant genetic and phenotypic variability, making diagnosis and treatment challenging. The heterogeneity of ASD-associated genetic variants and the absence of clear causal factors in many cases complicate personalized care. Traditional models, such as postmortem brain tissue and animal studies, have provided valuable insights but are limited in capturing the dynamic processes and human-specific aspects of ASD pathology. Recent advances in human induced pluripotent stem cell (iPSC) technology have transformed ASD research by enabling the generation of patient-derived neural cells in both two-dimensional cultures and three-dimensional brain organoid models. These models retain the donor's genetic background, allowing researchers to investigate disease-specific cellular and molecular mechanisms while identifying potential therapeutic targets tailored to individual patients. This commentary highlights how stem cell-based approaches are advancing our understanding of ASD and paving the way for more personalized diagnostic and therapeutic strategies. En ligne : https://doi.org/10.1002/aur.70005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550 [article] Untangling the Molecular Mechanisms Contributing to Autism Spectrum Disorder Using Stem Cells [Texte imprimé et/ou numérique] / Zoe MATTINGLY, Auteur ; Sundari CHETTY, Auteur . - p.476-485. Langues : Anglais (eng) in Autism Research > 18-3 (March 2025) . - p.476-485 Mots-clés : autism  disease modeling  molecular and cellular mechanisms  personalized medicine  stem cells Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a complex neuro developmental condition characterized by significant genetic and phenotypic variability, making diagnosis and treatment challenging. The heterogeneity of ASD-associated genetic variants and the absence of clear causal factors in many cases complicate personalized care. Traditional models, such as postmortem brain tissue and animal studies, have provided valuable insights but are limited in capturing the dynamic processes and human-specific aspects of ASD pathology. Recent advances in human induced pluripotent stem cell (iPSC) technology have transformed ASD research by enabling the generation of patient-derived neural cells in both two-dimensional cultures and three-dimensional brain organoid models. These models retain the donor's genetic background, allowing researchers to investigate disease-specific cellular and molecular mechanisms while identifying potential therapeutic targets tailored to individual patients. This commentary highlights how stem cell-based approaches are advancing our understanding of ASD and paving the way for more personalized diagnostic and therapeutic strategies. En ligne : https://doi.org/10.1002/aur.70005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550

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