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Editorial: Biomarkers in precision medicine for mental illnesses / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 61-12 (December 2020)
[article]
Titre : Editorial: Biomarkers in precision medicine for mental illnesses Type de document : Texte imprimé et/ou numérique Auteurs : Bradley S. PETERSON, Auteur Article en page(s) : p.1279-1281 Langues : Anglais (eng) Mots-clés : Precision medicine biomarkers endophenotype mental illness personalized medicine prediction public health treatment validation Index. décimale : PER Périodiques Résumé : Precision medicine and biomarker development have become the prevailing paradigm for mental health research. Despite its conceptual elegance and dominance as a research framework, precision medicine has a very limited track record of demonstrable success thus far for mental illnesses, due in varying degrees to the complexity of both the brain and the pathophysiology of mental illnesses, which limits our ability to develop, replicate, and validate biomarkers for use in enhancing clinical care for mental illnesses, especially in high-risk and complex clinical populations. Research and funding priorities should integrate biomarker development and precision medicine interventions that target the robust behavioral, environmental, and social determinants that we know are important for population-based mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Journal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1279-1281[article] Editorial: Biomarkers in precision medicine for mental illnesses [Texte imprimé et/ou numérique] / Bradley S. PETERSON, Auteur . - p.1279-1281.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1279-1281
Mots-clés : Precision medicine biomarkers endophenotype mental illness personalized medicine prediction public health treatment validation Index. décimale : PER Périodiques Résumé : Precision medicine and biomarker development have become the prevailing paradigm for mental health research. Despite its conceptual elegance and dominance as a research framework, precision medicine has a very limited track record of demonstrable success thus far for mental illnesses, due in varying degrees to the complexity of both the brain and the pathophysiology of mental illnesses, which limits our ability to develop, replicate, and validate biomarkers for use in enhancing clinical care for mental illnesses, especially in high-risk and complex clinical populations. Research and funding priorities should integrate biomarker development and precision medicine interventions that target the robust behavioral, environmental, and social determinants that we know are important for population-based mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 Do Student Characteristics Affect Teachers' Decisions to Use 1:1 Instruction? / H. J. NUSKE in Journal of Autism and Developmental Disorders, 49-7 (July 2019)
[article]
Titre : Do Student Characteristics Affect Teachers' Decisions to Use 1:1 Instruction? Type de document : Texte imprimé et/ou numérique Auteurs : H. J. NUSKE, Auteur ; M. PELLECCHIA, Auteur ; V. LUSHIN, Auteur ; K. RUMP, Auteur ; M. SEIDMAN, Auteur ; R. R. OUELLETTE, Auteur ; D. COONEY, Auteur ; B. B. MADDOX, Auteur ; G. M. LAWSON, Auteur ; A. SONG, Auteur ; E. M. REISINGER, Auteur ; D. S. MANDELL, Auteur Article en page(s) : p.2864-2872 Langues : Anglais (eng) Mots-clés : 1:1 Instruction Child characteristics Personalized medicine Teacher decisions Index. décimale : PER Périodiques Résumé : One-to-one instruction is a critical component of evidence-based instruction for students with autism spectrum disorder, but is not used as often as recommended. Student characteristics may affect teachers' decisions to select a treatment and/or implement it. This study examined the associations between students' clinical and demographic characteristics and teachers' reported use of discrete trial training (DTT) and pivotal response training (PRT). Children's higher sensory symptoms, lower social approach, lower verbal skills and higher self-regulation difficulties were associated with more frequent 1:1 DTT and PRT. Results suggest that teachers give more frequent 1:1 instruction to children with more observable impairments, do not match children to type of 1:1 intervention, and may inadvertently neglect other students for whom individualized intervention may still be beneficial. En ligne : http://dx.doi.org/10.1007/s10803-019-04004-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2864-2872[article] Do Student Characteristics Affect Teachers' Decisions to Use 1:1 Instruction? [Texte imprimé et/ou numérique] / H. J. NUSKE, Auteur ; M. PELLECCHIA, Auteur ; V. LUSHIN, Auteur ; K. RUMP, Auteur ; M. SEIDMAN, Auteur ; R. R. OUELLETTE, Auteur ; D. COONEY, Auteur ; B. B. MADDOX, Auteur ; G. M. LAWSON, Auteur ; A. SONG, Auteur ; E. M. REISINGER, Auteur ; D. S. MANDELL, Auteur . - p.2864-2872.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2864-2872
Mots-clés : 1:1 Instruction Child characteristics Personalized medicine Teacher decisions Index. décimale : PER Périodiques Résumé : One-to-one instruction is a critical component of evidence-based instruction for students with autism spectrum disorder, but is not used as often as recommended. Student characteristics may affect teachers' decisions to select a treatment and/or implement it. This study examined the associations between students' clinical and demographic characteristics and teachers' reported use of discrete trial training (DTT) and pivotal response training (PRT). Children's higher sensory symptoms, lower social approach, lower verbal skills and higher self-regulation difficulties were associated with more frequent 1:1 DTT and PRT. Results suggest that teachers give more frequent 1:1 instruction to children with more observable impairments, do not match children to type of 1:1 intervention, and may inadvertently neglect other students for whom individualized intervention may still be beneficial. En ligne : http://dx.doi.org/10.1007/s10803-019-04004-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay / Ozlem BOZDAGI in Molecular Autism, (April 2013)
[article]
Titre : Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay Type de document : Texte imprimé et/ou numérique Auteurs : Ozlem BOZDAGI, Auteur ; Teresa TAVASSOLI, Auteur ; Joseph D. BUXBAUM, Auteur Année de publication : 2013 Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : Pharmacotherapy Personalized medicine Individualized medicine 22q13 deletion syndrome Phelan-McDermid syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND:Haploinsufficiency of SHANK3, due to either hemizygous gene deletion (termed 22q13 deletion syndrome or Phelan-McDermid syndrome) or to gene mutation, accounts for about 0.5% of the cases of autism spectrum disorder (ASD) and/or developmental delay, and there is evidence for a wider role for SHANK3 and glutamate signaling abnormalities in ASD and related conditions. Therapeutic approaches that reverse deficits in SHANK3-haploinsufficiency may therefore be broadly beneficial in ASD and in developmental delay.FINDINGS:We observed that daily intraperitoneal injections of human insulin-like growth factor 1 (IGF-1) over a 2-week period reversed deficits in hippocampal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) signaling, long-term potentiation (LTP), and motor performance that we had previously reported in Shank3-deficient mice. Positive effects were observed with an IGF-1 peptide derivative as well.CONCLUSIONS:We observed significant beneficial effects of IGF-1 in a mouse model of ASD and of developmental delay. Studies in mouse and human neuronal models of Rett syndrome also show benefits with IGF-1, raising the possibility that this compound may have benefits broadly in ASD and related conditions, even with differing molecular etiology. Given the extensive safety data for IGF-1 in children with short stature due to primary IGF-1 deficiency, IGF-1 is an attractive candidate for controlled clinical trials in SHANK3-deficiency and in ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-4-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202
in Molecular Autism > (April 2013) . - 4 p.[article] Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay [Texte imprimé et/ou numérique] / Ozlem BOZDAGI, Auteur ; Teresa TAVASSOLI, Auteur ; Joseph D. BUXBAUM, Auteur . - 2013 . - 4 p.
Langues : Anglais (eng)
in Molecular Autism > (April 2013) . - 4 p.
Mots-clés : Pharmacotherapy Personalized medicine Individualized medicine 22q13 deletion syndrome Phelan-McDermid syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND:Haploinsufficiency of SHANK3, due to either hemizygous gene deletion (termed 22q13 deletion syndrome or Phelan-McDermid syndrome) or to gene mutation, accounts for about 0.5% of the cases of autism spectrum disorder (ASD) and/or developmental delay, and there is evidence for a wider role for SHANK3 and glutamate signaling abnormalities in ASD and related conditions. Therapeutic approaches that reverse deficits in SHANK3-haploinsufficiency may therefore be broadly beneficial in ASD and in developmental delay.FINDINGS:We observed that daily intraperitoneal injections of human insulin-like growth factor 1 (IGF-1) over a 2-week period reversed deficits in hippocampal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) signaling, long-term potentiation (LTP), and motor performance that we had previously reported in Shank3-deficient mice. Positive effects were observed with an IGF-1 peptide derivative as well.CONCLUSIONS:We observed significant beneficial effects of IGF-1 in a mouse model of ASD and of developmental delay. Studies in mouse and human neuronal models of Rett syndrome also show benefits with IGF-1, raising the possibility that this compound may have benefits broadly in ASD and related conditions, even with differing molecular etiology. Given the extensive safety data for IGF-1 in children with short stature due to primary IGF-1 deficiency, IGF-1 is an attractive candidate for controlled clinical trials in SHANK3-deficiency and in ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-4-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202