Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social-Emotional Reciprocity in Autistic Adults / Radek MARE?EK ; Rostislav STAN?K ; Calum HARTLEY ; Klaus KESSLER ; Pavlína HLAVATÁ ; Hana O?LEJ?KOVÁ ; Milan BRÁZDIL ; Daniel Joel SHAW in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.725-740 Titre : Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social-Emotional Reciprocity in Autistic Adults Type de document : Texte imprimé et/ou numérique Auteurs : Radek MARE?EK, Auteur ; Rostislav STAN?K, Auteur ; Calum HARTLEY, Auteur ; Klaus KESSLER, Auteur ; Pavlína HLAVATÁ, Auteur ; Hana O?LEJ?KOVÁ, Auteur ; Milan BRÁZDIL, Auteur ; Daniel Joel SHAW, Auteur Article en page(s) : p.725-740 Langues : Anglais (eng) Mots-clés : autism  dynamic functional connectivity  reciprocity  social interaction Index. décimale : PER Périodiques Résumé : ABSTRACT To identify the neurocognitive mechanisms underpinning the social difficulties that characterize autism, we performed functional magnetic resonance imaging on pairs of autistic and non-autistic adults simultaneously whilst they interacted with one another on the iterated Ultimatum Game (iUG)?an interactive task that emulates the reciprocal characteristic of naturalistic interpersonal exchanges. Two age-matched sets of male?male dyads were investigated: 16 comprised an autistic Responder and a non-autistic Proposer, and 19 comprised non-autistic pairs of Responder and Proposer. Players' round-by-round behavior on the iUG was modeled as reciprocal choices, and dynamic functional connectivity (dFC) was measured to identify the neural mechanisms underpinning reciprocal behaviors. Behavioral expressions of reciprocity were significantly reduced in autistic compared with non-autistic Responders, yet no such differences were observed between the non-autistic Proposers in either set of dyads. Furthermore, we identified latent dFC states with temporal properties associated with reciprocity. Autistic interactants spent less time in brain states characterized by dynamic inter-network integration and segregation among the Default Mode Network and cognitive control networks, suggesting that their reduced expressions of social?emotional reciprocity reflect less efficient reconfigurations among brain networks supporting flexible cognition and behavior. These findings advance our mechanistic understanding of the social difficulties characterizing autism. En ligne : https://doi.org/10.1002/aur.70010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social-Emotional Reciprocity in Autistic Adults [Texte imprimé et/ou numérique] / Radek MARE?EK, Auteur ; Rostislav STAN?K, Auteur ; Calum HARTLEY, Auteur ; Klaus KESSLER, Auteur ; Pavlína HLAVATÁ, Auteur ; Hana O?LEJ?KOVÁ, Auteur ; Milan BRÁZDIL, Auteur ; Daniel Joel SHAW, Auteur . - p.725-740. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.725-740 Mots-clés : autism  dynamic functional connectivity  reciprocity  social interaction Index. décimale : PER Périodiques Résumé : ABSTRACT To identify the neurocognitive mechanisms underpinning the social difficulties that characterize autism, we performed functional magnetic resonance imaging on pairs of autistic and non-autistic adults simultaneously whilst they interacted with one another on the iterated Ultimatum Game (iUG)?an interactive task that emulates the reciprocal characteristic of naturalistic interpersonal exchanges. Two age-matched sets of male?male dyads were investigated: 16 comprised an autistic Responder and a non-autistic Proposer, and 19 comprised non-autistic pairs of Responder and Proposer. Players' round-by-round behavior on the iUG was modeled as reciprocal choices, and dynamic functional connectivity (dFC) was measured to identify the neural mechanisms underpinning reciprocal behaviors. Behavioral expressions of reciprocity were significantly reduced in autistic compared with non-autistic Responders, yet no such differences were observed between the non-autistic Proposers in either set of dyads. Furthermore, we identified latent dFC states with temporal properties associated with reciprocity. Autistic interactants spent less time in brain states characterized by dynamic inter-network integration and segregation among the Default Mode Network and cognitive control networks, suggesting that their reduced expressions of social?emotional reciprocity reflect less efficient reconfigurations among brain networks supporting flexible cognition and behavior. These findings advance our mechanistic understanding of the social difficulties characterizing autism. En ligne : https://doi.org/10.1002/aur.70010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

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