Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social-Emotional Reciprocity in Autistic Adults / Radek MAREČEK ; Rostislav STANĚK ; Calum HARTLEY ; Klaus KESSLER ; Pavlína HLAVATÁ ; Hana OŠLEJŠKOVÁ ; Milan BRÁZDIL ; Daniel Joel SHAW in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.725-740 Titre : Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social-Emotional Reciprocity in Autistic Adults Type de document : texte imprimé Auteurs : Radek MAREČEK, Auteur ; Rostislav STANĚK, Auteur ; Calum HARTLEY, Auteur ; Klaus KESSLER, Auteur ; Pavlína HLAVATÁ, Auteur ; Hana OŠLEJŠKOVÁ, Auteur ; Milan BRÁZDIL, Auteur ; Daniel Joel SHAW, Auteur Article en page(s) : p.725-740 Langues : Anglais (eng) Mots-clés : autism  dynamic functional connectivity  reciprocity  social interaction Index. décimale : PER Périodiques Résumé : ABSTRACT To identify the neurocognitive mechanisms underpinning the social difficulties that characterize autism, we performed functional magnetic resonance imaging on pairs of autistic and non-autistic adults simultaneously whilst they interacted with one another on the iterated Ultimatum Game (iUG)?an interactive task that emulates the reciprocal characteristic of naturalistic interpersonal exchanges. Two age-matched sets of male?male dyads were investigated: 16 comprised an autistic Responder and a non-autistic Proposer, and 19 comprised non-autistic pairs of Responder and Proposer. Players' round-by-round behavior on the iUG was modeled as reciprocal choices, and dynamic functional connectivity (dFC) was measured to identify the neural mechanisms underpinning reciprocal behaviors. Behavioral expressions of reciprocity were significantly reduced in autistic compared with non-autistic Responders, yet no such differences were observed between the non-autistic Proposers in either set of dyads. Furthermore, we identified latent dFC states with temporal properties associated with reciprocity. Autistic interactants spent less time in brain states characterized by dynamic inter-network integration and segregation among the Default Mode Network and cognitive control networks, suggesting that their reduced expressions of social?emotional reciprocity reflect less efficient reconfigurations among brain networks supporting flexible cognition and behavior. These findings advance our mechanistic understanding of the social difficulties characterizing autism. En ligne : https://doi.org/10.1002/aur.70010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social-Emotional Reciprocity in Autistic Adults [texte imprimé] / Radek MAREČEK, Auteur ; Rostislav STANĚK, Auteur ; Calum HARTLEY, Auteur ; Klaus KESSLER, Auteur ; Pavlína HLAVATÁ, Auteur ; Hana OŠLEJŠKOVÁ, Auteur ; Milan BRÁZDIL, Auteur ; Daniel Joel SHAW, Auteur . - p.725-740. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.725-740 Mots-clés : autism  dynamic functional connectivity  reciprocity  social interaction Index. décimale : PER Périodiques Résumé : ABSTRACT To identify the neurocognitive mechanisms underpinning the social difficulties that characterize autism, we performed functional magnetic resonance imaging on pairs of autistic and non-autistic adults simultaneously whilst they interacted with one another on the iterated Ultimatum Game (iUG)?an interactive task that emulates the reciprocal characteristic of naturalistic interpersonal exchanges. Two age-matched sets of male?male dyads were investigated: 16 comprised an autistic Responder and a non-autistic Proposer, and 19 comprised non-autistic pairs of Responder and Proposer. Players' round-by-round behavior on the iUG was modeled as reciprocal choices, and dynamic functional connectivity (dFC) was measured to identify the neural mechanisms underpinning reciprocal behaviors. Behavioral expressions of reciprocity were significantly reduced in autistic compared with non-autistic Responders, yet no such differences were observed between the non-autistic Proposers in either set of dyads. Furthermore, we identified latent dFC states with temporal properties associated with reciprocity. Autistic interactants spent less time in brain states characterized by dynamic inter-network integration and segregation among the Default Mode Network and cognitive control networks, suggesting that their reduced expressions of social?emotional reciprocity reflect less efficient reconfigurations among brain networks supporting flexible cognition and behavior. These findings advance our mechanistic understanding of the social difficulties characterizing autism. En ligne : https://doi.org/10.1002/aur.70010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Use of Telehealth in Autism Spectrum Disorder Assessment in Children: Evaluation of an Online Diagnostic Protocol Including the Brief Observation of Symptoms of Autism / Lucie STROUPKOVÁ in Journal of Autism and Developmental Disorders, 56-1 (January 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-1 (January 2026) . - p.148-161 Titre : Use of Telehealth in Autism Spectrum Disorder Assessment in Children: Evaluation of an Online Diagnostic Protocol Including the Brief Observation of Symptoms of Autism Type de document : texte imprimé Auteurs : Lucie STROUPKOVÁ, Auteur ; Martina VYHNALOVÁ, Auteur ; Senad KOLÁŘ, Auteur ; Lenka KNEDLÍKOVÁ, Auteur ; Ivona PACKANOVÁ, Auteur ; Anna Marie BITTNEROVÁ, Auteur ; Nela NOVÁKOVÁ, Auteur ; Hana Přikrylová KUČEROVÁ, Auteur ; Ondřej HORÁK, Auteur ; Hana OŠLEJŠKOVÁ, Auteur ; Pavel THEINER, Auteur ; Pavlína DANHOFER, Auteur Article en page(s) : p.148-161 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic revealed the need to develop the field of remote assessment for autism spectrum disorders (ASD). The purpose of the study was to evaluate an online assessment protocol that includes the Brief Observation of Symptoms of Autism (BOSA). The online protocol consisting of BOSA and the Autism Diagnostic Interview—Revised (ADI-R) was administered by experienced examiners to 29 children with suspected ASD. The participants were then evaluated by clinical psychologists in a standard clinical setting using the Autism Diagnostic Observation Schedule-2 (ADOS-2) and other methods, and the ASD diagnosis was confirmed or ruled out. The results show substantial to moderate inter-rater agreement between the online and face-to-face raters with the value of Cohen’s Kappa = 0.66 (P < 0.001); this corresponds with 79.8% agreement. The sensitivity of the protocol was approx. 94.7%, the specificity was 70%, the positive predictive value was 85.7%, and the negative predictive value was 87.5%. Further, direct false positive or false negative diagnostic conclusions based on the online protocol were absent when the possible conclusion of “I cannot decide” was included. The items B9 Showing, B10 Spontaneous Initiation of Joint Attention, B1 Unusual Eye Contact, B3 Facial Expressions Directed to Others, and C2 Imagination/Creativity were shown to be well observable in BOSA when related to ADOS-2 scoring. The results indicate that the protocol consisting of BOSA and ADI-R administered by an experienced examiner is a promising combination of tools for remote autism assessment. En ligne : https://doi.org/10.1007/s10803-024-06524-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580 [article] Use of Telehealth in Autism Spectrum Disorder Assessment in Children: Evaluation of an Online Diagnostic Protocol Including the Brief Observation of Symptoms of Autism [texte imprimé] / Lucie STROUPKOVÁ, Auteur ; Martina VYHNALOVÁ, Auteur ; Senad KOLÁŘ, Auteur ; Lenka KNEDLÍKOVÁ, Auteur ; Ivona PACKANOVÁ, Auteur ; Anna Marie BITTNEROVÁ, Auteur ; Nela NOVÁKOVÁ, Auteur ; Hana Přikrylová KUČEROVÁ, Auteur ; Ondřej HORÁK, Auteur ; Hana OŠLEJŠKOVÁ, Auteur ; Pavel THEINER, Auteur ; Pavlína DANHOFER, Auteur . - p.148-161. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-1 (January 2026) . - p.148-161 Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic revealed the need to develop the field of remote assessment for autism spectrum disorders (ASD). The purpose of the study was to evaluate an online assessment protocol that includes the Brief Observation of Symptoms of Autism (BOSA). The online protocol consisting of BOSA and the Autism Diagnostic Interview—Revised (ADI-R) was administered by experienced examiners to 29 children with suspected ASD. The participants were then evaluated by clinical psychologists in a standard clinical setting using the Autism Diagnostic Observation Schedule-2 (ADOS-2) and other methods, and the ASD diagnosis was confirmed or ruled out. The results show substantial to moderate inter-rater agreement between the online and face-to-face raters with the value of Cohen’s Kappa = 0.66 (P < 0.001); this corresponds with 79.8% agreement. The sensitivity of the protocol was approx. 94.7%, the specificity was 70%, the positive predictive value was 85.7%, and the negative predictive value was 87.5%. Further, direct false positive or false negative diagnostic conclusions based on the online protocol were absent when the possible conclusion of “I cannot decide” was included. The items B9 Showing, B10 Spontaneous Initiation of Joint Attention, B1 Unusual Eye Contact, B3 Facial Expressions Directed to Others, and C2 Imagination/Creativity were shown to be well observable in BOSA when related to ADOS-2 scoring. The results indicate that the protocol consisting of BOSA and ADI-R administered by an experienced examiner is a promising combination of tools for remote autism assessment. En ligne : https://doi.org/10.1007/s10803-024-06524-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580

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