The role of zinc dysregulation in Autism Spectrum Disorder: A systematic review of genetic and environmental influences and therapeutic potential / Mohammed Rushdhi IRFAN ; Ali RAJA ; Mohamed Akram SATTAR ; Alzahra?a AL MATAIRI ; Rushdan Mohamed FIRDOUS ; Aksh SHARMA ; Jamil ALGHANEM ; Adel KALOU ; Youmna Hassan Hashim ABDALGADER ; Wael KALOU ; Ahmed YAQINUDDIN in Research in Autism, 124 (June 2025)  

Public ISBD [article]  inResearch in Autism > 124 (June 2025) . - 202579 Titre : The role of zinc dysregulation in Autism Spectrum Disorder: A systematic review of genetic and environmental influences and therapeutic potential Type de document : Texte imprimé et/ou numérique Auteurs : Mohammed Rushdhi IRFAN, Auteur ; Ali RAJA, Auteur ; Mohamed Akram SATTAR, Auteur ; Alzahra?a AL MATAIRI, Auteur ; Rushdan Mohamed FIRDOUS, Auteur ; Aksh SHARMA, Auteur ; Jamil ALGHANEM, Auteur ; Adel KALOU, Auteur ; Youmna Hassan Hashim ABDALGADER, Auteur ; Wael KALOU, Auteur ; Ahmed YAQINUDDIN, Auteur Article en page(s) : 202579 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Zinc dysregulation  Neurodevelopment  Genetic factors  Environmental factors  Zinc supplementation  Synaptic function Index. décimale : PER Périodiques Résumé : This systematic review examines the role of zinc (Zn) dysregulation in the development and management of Autism Spectrum Disorder (ASD), focusing on genetic and environmental factors, as well as the therapeutic potential of Zn supplementation. Zn is crucial for neurodevelopmental processes, and disruptions in Zn homeostasis have been associated with ASD symptoms. Genetic factors, such as mutations in Zn transporter genes (such as, SLC39A8, SHANK3), impact Zn regulation and synaptic function, contributing to ASD pathophysiology. Additionally, prenatal and early-life environmental exposures (such as, maternal diet, heavy metal exposure) can exacerbate Zn dysregulation. This review synthesizes data from both human and animal studies to explore these mechanisms and evaluates clinical trials on Zn supplementation, which show mixed results in symptom management. The findings highlight the need for standardized Zn assessment and intervention protocols to further investigate Zn?s role as a therapeutic target for ASD. En ligne : https://doi.org/10.1016/j.reia.2025.202579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] The role of zinc dysregulation in Autism Spectrum Disorder: A systematic review of genetic and environmental influences and therapeutic potential [Texte imprimé et/ou numérique] / Mohammed Rushdhi IRFAN, Auteur ; Ali RAJA, Auteur ; Mohamed Akram SATTAR, Auteur ; Alzahra?a AL MATAIRI, Auteur ; Rushdan Mohamed FIRDOUS, Auteur ; Aksh SHARMA, Auteur ; Jamil ALGHANEM, Auteur ; Adel KALOU, Auteur ; Youmna Hassan Hashim ABDALGADER, Auteur ; Wael KALOU, Auteur ; Ahmed YAQINUDDIN, Auteur . - 202579. Langues : Anglais (eng) in Research in Autism > 124 (June 2025) . - 202579 Mots-clés : Autism Spectrum Disorder  Zinc dysregulation  Neurodevelopment  Genetic factors  Environmental factors  Zinc supplementation  Synaptic function Index. décimale : PER Périodiques Résumé : This systematic review examines the role of zinc (Zn) dysregulation in the development and management of Autism Spectrum Disorder (ASD), focusing on genetic and environmental factors, as well as the therapeutic potential of Zn supplementation. Zn is crucial for neurodevelopmental processes, and disruptions in Zn homeostasis have been associated with ASD symptoms. Genetic factors, such as mutations in Zn transporter genes (such as, SLC39A8, SHANK3), impact Zn regulation and synaptic function, contributing to ASD pathophysiology. Additionally, prenatal and early-life environmental exposures (such as, maternal diet, heavy metal exposure) can exacerbate Zn dysregulation. This review synthesizes data from both human and animal studies to explore these mechanisms and evaluates clinical trials on Zn supplementation, which show mixed results in symptom management. The findings highlight the need for standardized Zn assessment and intervention protocols to further investigate Zn?s role as a therapeutic target for ASD. En ligne : https://doi.org/10.1016/j.reia.2025.202579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

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