Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with autism and attention deficit hyperactivity disorder / Raziyeh GHORBANZADEH ; Brandon LUCKE-WOLD ; Rebecca ZELMANOVICH ; Arshin GHAEDI ; Sahar SANJARIAN ; Peyman MOKARIAN ; Shokoufeh KHANZADEH in Research in Autism, 125 (July 2025)  

Public ISBD [article]  inResearch in Autism > 125 (July 2025) . - p.202608 Titre : Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with autism and attention deficit hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Raziyeh GHORBANZADEH, Auteur ; Brandon LUCKE-WOLD, Auteur ; Rebecca ZELMANOVICH, Auteur ; Arshin GHAEDI, Auteur ; Sahar SANJARIAN, Auteur ; Peyman MOKARIAN, Auteur ; Shokoufeh KHANZADEH, Auteur Article en page(s) : p.202608 Langues : Anglais (eng) Mots-clés : Neutrophil to lymphocyte ratio  NLR  PLR  Autism  Attention deficit hyperactivity disorder  Meta-analysis Index. décimale : PER Périodiques Résumé : Background We conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to determine the association of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), as the indicators of inflammatory stress response, with Autism Spectrum Disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Methods Two investigators searched the relevant articles of PubMed, Scopus, and Web of Science from the establishment of the database to September 7, 2024. The quality of the included literature was evaluated according to the Newcastle-Ottawa scale (NOS). The results are reflected in the form of standard mean difference (SMD) and 95 % confidence interval (CI). Results Finally, 17 articles were included in our study. The results showed that the level of NLR in peripheral blood of patients was significantly higher than that of the healthy group in either ADHD group (SMD=0.48, 95 % CI=0.17-0.79) or ASD group (SMD=0.39, 95 % CI=?0.04-0.74). Also, the PLR level in patients was significantly higher than that of healthy controls in ADHD group (SMD=0.41, 95 % CI=0.15-0.67), but not in ASD group (SMD=0.21, 95 % CI=?0.14-0.56). Conclusion Our findings suggest NLR and PLR be the potential markers of disease while also implicating a role for inflammation in the underlying pathophysiology. En ligne : https://doi.org/10.1016/j.reia.2025.202608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559 [article] Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with autism and attention deficit hyperactivity disorder [Texte imprimé et/ou numérique] / Raziyeh GHORBANZADEH, Auteur ; Brandon LUCKE-WOLD, Auteur ; Rebecca ZELMANOVICH, Auteur ; Arshin GHAEDI, Auteur ; Sahar SANJARIAN, Auteur ; Peyman MOKARIAN, Auteur ; Shokoufeh KHANZADEH, Auteur . - p.202608. Langues : Anglais (eng) in Research in Autism > 125 (July 2025) . - p.202608 Mots-clés : Neutrophil to lymphocyte ratio  NLR  PLR  Autism  Attention deficit hyperactivity disorder  Meta-analysis Index. décimale : PER Périodiques Résumé : Background We conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to determine the association of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), as the indicators of inflammatory stress response, with Autism Spectrum Disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Methods Two investigators searched the relevant articles of PubMed, Scopus, and Web of Science from the establishment of the database to September 7, 2024. The quality of the included literature was evaluated according to the Newcastle-Ottawa scale (NOS). The results are reflected in the form of standard mean difference (SMD) and 95 % confidence interval (CI). Results Finally, 17 articles were included in our study. The results showed that the level of NLR in peripheral blood of patients was significantly higher than that of the healthy group in either ADHD group (SMD=0.48, 95 % CI=0.17-0.79) or ASD group (SMD=0.39, 95 % CI=?0.04-0.74). Also, the PLR level in patients was significantly higher than that of healthy controls in ADHD group (SMD=0.41, 95 % CI=0.15-0.67), but not in ASD group (SMD=0.21, 95 % CI=?0.14-0.56). Conclusion Our findings suggest NLR and PLR be the potential markers of disease while also implicating a role for inflammation in the underlying pathophysiology. En ligne : https://doi.org/10.1016/j.reia.2025.202608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559

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