Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes / Elisabeth CONRADT in Journal of Child Psychology and Psychiatry, 64-4 (April 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.566-578 Titre : Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes Type de document : texte imprimé Auteurs : Elisabeth CONRADT, Auteur ; Marie CAMEROTA, Auteur ; Sarah E. MAYLOTT, Auteur ; Barry M. LESTER, Auteur Article en page(s) : p.566-578 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Opioid use during pregnancy impacts the health and well-being of two generations: the pregnant person and the child. The factors that increase risk for opioid use in the adult, as well as those that perpetuate risk for the caregiver and child, oftentimes replicate across generations and may be more likely to affect child neurodevelopment than the opioid exposure itself. In this article, we review the prenatal opioid exposure literature with the perspective that this is not a singular event but an intergenerational cascade of events. We highlight several mechanisms of transmission across generations: biological factors, including genetics and epigenetics and the gut-brain axis; parent-child mechanisms, such as prepregnancy experience of child maltreatment, quality of parenting, infant behaviors, neonatal opioid withdrawal diagnosis, and broader environmental contributors including poverty, violence exposure, stigma, and Child Protective Services involvement. We conclude by describing ways in which intergenerational transmission can be disrupted by early intervention. En ligne : https://doi.org/10.1111/jcpp.13761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 [article] Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes [texte imprimé] / Elisabeth CONRADT, Auteur ; Marie CAMEROTA, Auteur ; Sarah E. MAYLOTT, Auteur ; Barry M. LESTER, Auteur . - p.566-578. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.566-578 Index. décimale : PER Périodiques Résumé : Opioid use during pregnancy impacts the health and well-being of two generations: the pregnant person and the child. The factors that increase risk for opioid use in the adult, as well as those that perpetuate risk for the caregiver and child, oftentimes replicate across generations and may be more likely to affect child neurodevelopment than the opioid exposure itself. In this article, we review the prenatal opioid exposure literature with the perspective that this is not a singular event but an intergenerational cascade of events. We highlight several mechanisms of transmission across generations: biological factors, including genetics and epigenetics and the gut-brain axis; parent-child mechanisms, such as prepregnancy experience of child maltreatment, quality of parenting, infant behaviors, neonatal opioid withdrawal diagnosis, and broader environmental contributors including poverty, violence exposure, stigma, and Child Protective Services involvement. We conclude by describing ways in which intergenerational transmission can be disrupted by early intervention. En ligne : https://doi.org/10.1111/jcpp.13761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501

From prenatal maternal anxiety and respiratory sinus arrhythmia to toddler internalizing problems: The role of infant negative affectivity / Anna M. ZHOU in Development and Psychopathology, 37-3 (August 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-3 (August 2025) . - p.1482-1494 Titre : From prenatal maternal anxiety and respiratory sinus arrhythmia to toddler internalizing problems: The role of infant negative affectivity Type de document : texte imprimé Auteurs : Anna M. ZHOU, Auteur ; Mengyu GAO, Auteur ; Brendan OSTLUND, Auteur ; Sarah E. MAYLOTT, Auteur ; Nicolette C. MOLINA, Auteur ; Madeleine BRUCE, Auteur ; K. Lee RABY, Auteur ; Elisabeth CONRADT, Auteur ; Sheila E. CROWELL, Auteur Article en page(s) : p.1482-1494 Langues : Anglais (eng) Mots-clés : internalizing problems  negative affectivity  prenatal anxiety  respiratory sinus arrhythmia Index. décimale : PER Périodiques Résumé : Prenatal maternal anxiety is considered a risk factor for the development of child internalizing problems. However, little is known about potential mechanisms that account for these associations. The current study examined whether prenatal maternal anxiety was indirectly associated with toddler internalizing problems via prenatal maternal physiology and infant negative affectivity. We examined these associations in a longitudinal study of 162 expectant mothers from their third trimester until 18 months postpartum. Path analyses showed that higher prenatal anxiety was associated with higher infant negative affectivity at 7 months, which in turn was associated with higher toddler internalizing problems at 18 months. Prenatal anxiety was not indirectly associated with child outcomes via baseline or task-evoked respiratory sinus arrhythmia (RSA) in response to an infant cry while pregnant. However, pregnant women with greater decreases in task-evoked RSA had toddlers with greater internalizing problems, which was mediated by infant negative affectivity at 7 months. Findings suggest that prenatal anxiety and RSA reactivity to an infant cry may be independent risk factors for the development of infant negative affectivity, which in turn increases risk for toddler internalizing problems. These findings contribute to a growing literature on mechanisms that underlie intergenerational transmission of internalizing problems. En ligne : https://www.cambridge.org/core/product/CF53D676EA68F7C244BBE0D9682B22DC Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] From prenatal maternal anxiety and respiratory sinus arrhythmia to toddler internalizing problems: The role of infant negative affectivity [texte imprimé] / Anna M. ZHOU, Auteur ; Mengyu GAO, Auteur ; Brendan OSTLUND, Auteur ; Sarah E. MAYLOTT, Auteur ; Nicolette C. MOLINA, Auteur ; Madeleine BRUCE, Auteur ; K. Lee RABY, Auteur ; Elisabeth CONRADT, Auteur ; Sheila E. CROWELL, Auteur . - p.1482-1494. Langues : Anglais (eng) in Development and Psychopathology > 37-3 (August 2025) . - p.1482-1494 Mots-clés : internalizing problems  negative affectivity  prenatal anxiety  respiratory sinus arrhythmia Index. décimale : PER Périodiques Résumé : Prenatal maternal anxiety is considered a risk factor for the development of child internalizing problems. However, little is known about potential mechanisms that account for these associations. The current study examined whether prenatal maternal anxiety was indirectly associated with toddler internalizing problems via prenatal maternal physiology and infant negative affectivity. We examined these associations in a longitudinal study of 162 expectant mothers from their third trimester until 18 months postpartum. Path analyses showed that higher prenatal anxiety was associated with higher infant negative affectivity at 7 months, which in turn was associated with higher toddler internalizing problems at 18 months. Prenatal anxiety was not indirectly associated with child outcomes via baseline or task-evoked respiratory sinus arrhythmia (RSA) in response to an infant cry while pregnant. However, pregnant women with greater decreases in task-evoked RSA had toddlers with greater internalizing problems, which was mediated by infant negative affectivity at 7 months. Findings suggest that prenatal anxiety and RSA reactivity to an infant cry may be independent risk factors for the development of infant negative affectivity, which in turn increases risk for toddler internalizing problems. These findings contribute to a growing literature on mechanisms that underlie intergenerational transmission of internalizing problems. En ligne : https://www.cambridge.org/core/product/CF53D676EA68F7C244BBE0D9682B22DC Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

---

1 (1 - 2 / 2) Par page : 25 50 100 200