The association between temperament and polygenic score for psychopathology from infancy to middle childhood / Eloise FREITAG in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1155-1169 Titre : The association between temperament and polygenic score for psychopathology from infancy to middle childhood Type de document : Texte imprimé et/ou numérique Auteurs : Eloise FREITAG, Auteur ; Caroline KELSEY, Auteur ; Euclides José DE MENDONÇA FILHO, Auteur ; Irina POKHVISNEVA, Auteur ; Sachin PATEL, Auteur ; Patricia Pelufo SILVEIRA, Auteur ; Michelle BOSQUET ENLOW, Auteur ; Charles A. NELSON, Auteur Article en page(s) : p.1155-1169 Langues : Anglais (eng) Mots-clés : ADHD  anxiety  childhood  infancy  polygenic scores  temperament Index. décimale : PER Périodiques Résumé : Background Certain temperament characteristics, such as low effortful control and high negative affectivity, are linked to an elevated likelihood for later psychopathology. Although genetic vulnerability has been associated with a number of psychiatric conditions, little work has examined the genetic architecture underlying temperament or the genetic overlap between early temperament profiles and later mental health outcomes. The present study examined associations of polygenic scores for anxiety (PGS-Anxiety) and ADHD (PGS-ADHD) with temperament characteristics in a longitudinal sample of children assessed from infancy through age 7?years. Methods Analyses were conducted in a sample of children (European Ancestry n?=?476; Full Sample [European and other ancestries] N?=?606). Results We observed an age-by-PGS interaction on effortful control. As children aged, there appeared to be stronger negative associations between PGS-ADHD and effortful control. No associations were observed between PGS-Anxiety and negative affectivity. Conclusions Overall, the findings suggest some support for associations between genetic underpinnings for externalizing psychopathology and temperament that increase over time. En ligne : https://doi.org/10.1111/jcpp.14140 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] The association between temperament and polygenic score for psychopathology from infancy to middle childhood [Texte imprimé et/ou numérique] / Eloise FREITAG, Auteur ; Caroline KELSEY, Auteur ; Euclides José DE MENDONÇA FILHO, Auteur ; Irina POKHVISNEVA, Auteur ; Sachin PATEL, Auteur ; Patricia Pelufo SILVEIRA, Auteur ; Michelle BOSQUET ENLOW, Auteur ; Charles A. NELSON, Auteur . - p.1155-1169. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1155-1169 Mots-clés : ADHD  anxiety  childhood  infancy  polygenic scores  temperament Index. décimale : PER Périodiques Résumé : Background Certain temperament characteristics, such as low effortful control and high negative affectivity, are linked to an elevated likelihood for later psychopathology. Although genetic vulnerability has been associated with a number of psychiatric conditions, little work has examined the genetic architecture underlying temperament or the genetic overlap between early temperament profiles and later mental health outcomes. The present study examined associations of polygenic scores for anxiety (PGS-Anxiety) and ADHD (PGS-ADHD) with temperament characteristics in a longitudinal sample of children assessed from infancy through age 7?years. Methods Analyses were conducted in a sample of children (European Ancestry n?=?476; Full Sample [European and other ancestries] N?=?606). Results We observed an age-by-PGS interaction on effortful control. As children aged, there appeared to be stronger negative associations between PGS-ADHD and effortful control. No associations were observed between PGS-Anxiety and negative affectivity. Conclusions Overall, the findings suggest some support for associations between genetic underpinnings for externalizing psychopathology and temperament that increase over time. En ligne : https://doi.org/10.1111/jcpp.14140 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

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