The influence of deprivation on cortical development and psychotic symptoms in youth / Megan THOMAS in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1249-1262 Titre : The influence of deprivation on cortical development and psychotic symptoms in youth Type de document : Texte imprimé et/ou numérique Auteurs : Megan THOMAS, Auteur ; Sarah WHITTLE, Auteur ; Vanessa CROPLEY, Auteur Article en page(s) : p.1249-1262 Langues : Anglais (eng) Mots-clés : Deprivation  psychotic-like experiences  neurodevelopment Index. décimale : PER Périodiques Résumé : Background People with early-life experiences of deprivation are more likely to develop psychotic symptoms. While the mechanisms of this relationship are poorly understood, research suggests a role of cortical development. Methods In 6323 youth from the Adolescent Brain Cognitive Development study, we examined associations between total, material, interpersonal, cognitive and neighbourhood deprivation at age 9?11?years and psychotic-like experiences (PLEs) 2?years later. We then investigated whether associations were mediated by variation in cortical volume at baseline or rate of change from baseline to follow-up. Sex-specific effects were examined throughout. Results All deprivation measures were associated with greater PLEs. Most of these associations were partially mediated by variation in cortical structure in widespread regions, including lower baseline cortical volume in ventral visual and sensorimotor regions and particularly in females, steeper cortical volume decline in association areas. Conclusions Early-life deprivation may be associated with psychotic-like experiences via disruption to cortical structure. This phenomenon is common to several forms of deprivation and continues into early adolescence in certain regions. En ligne : https://doi.org/10.1111/jcpp.14150 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] The influence of deprivation on cortical development and psychotic symptoms in youth [Texte imprimé et/ou numérique] / Megan THOMAS, Auteur ; Sarah WHITTLE, Auteur ; Vanessa CROPLEY, Auteur . - p.1249-1262. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1249-1262 Mots-clés : Deprivation  psychotic-like experiences  neurodevelopment Index. décimale : PER Périodiques Résumé : Background People with early-life experiences of deprivation are more likely to develop psychotic symptoms. While the mechanisms of this relationship are poorly understood, research suggests a role of cortical development. Methods In 6323 youth from the Adolescent Brain Cognitive Development study, we examined associations between total, material, interpersonal, cognitive and neighbourhood deprivation at age 9?11?years and psychotic-like experiences (PLEs) 2?years later. We then investigated whether associations were mediated by variation in cortical volume at baseline or rate of change from baseline to follow-up. Sex-specific effects were examined throughout. Results All deprivation measures were associated with greater PLEs. Most of these associations were partially mediated by variation in cortical structure in widespread regions, including lower baseline cortical volume in ventral visual and sensorimotor regions and particularly in females, steeper cortical volume decline in association areas. Conclusions Early-life deprivation may be associated with psychotic-like experiences via disruption to cortical structure. This phenomenon is common to several forms of deprivation and continues into early adolescence in certain regions. En ligne : https://doi.org/10.1111/jcpp.14150 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

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