Methylome-wide association study of multidimensional resilience / S. Alexandra BURT ; Colter MITCHELL ; Kelly L. KLUMP ; Luke W. HYDE ; Shaunna L. CLARK in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.1730-1741 Titre : Methylome-wide association study of multidimensional resilience Type de document : texte imprimé Auteurs : S. Alexandra BURT, Auteur ; Colter MITCHELL, Auteur ; Kelly L. KLUMP, Auteur ; Luke W. HYDE, Auteur ; Shaunna L. CLARK, Auteur Article en page(s) : p.1730-1741 Langues : Anglais (eng) Mots-clés : DNA methylation  Youth  epigenetics  neighborhood disadvantage  resilience Index. décimale : PER Périodiques Résumé : Although resilient youth provide an important model of successful adaptation to adversity, we know relatively little about the origins of their positive outcomes, particularly the role of biological mechanisms. The current study employed a series of methylome-wide association studies to identify methylomic biomarkers of resilience in a unique sample of 276 twins within 141 families residing in disadvantaged neighborhoods. Results revealed methylome-wide significant differentially methylated probes (DMPs) for social and academic resilience and suggestive DMPs for psychological resilience and resilience across domains. Pathway analyses informed our understanding of the biological underpinnings of significant differentially methylated probes. Monozygotic twin difference analyses were then employed to narrow in on DMPs that were specifically environmental in origin. Our findings suggest that alterations in the DNA methylome may be implicated in youth resilience to neighborhood adversity and that some of the suggestive DMPs may be environmentally engendered. Importantly, our ability to replicate our findings in a well-powered sample was hindered by the scarcity of twin samples with youth exposed to moderate to substantial levels of adversity. Thus, although preliminary, the present study is the first to identify DNA methylation biomarkers of academic and social resilience. En ligne : https://dx.doi.org/10.1017/S0954579424001330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Methylome-wide association study of multidimensional resilience [texte imprimé] / S. Alexandra BURT, Auteur ; Colter MITCHELL, Auteur ; Kelly L. KLUMP, Auteur ; Luke W. HYDE, Auteur ; Shaunna L. CLARK, Auteur . - p.1730-1741. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.1730-1741 Mots-clés : DNA methylation  Youth  epigenetics  neighborhood disadvantage  resilience Index. décimale : PER Périodiques Résumé : Although resilient youth provide an important model of successful adaptation to adversity, we know relatively little about the origins of their positive outcomes, particularly the role of biological mechanisms. The current study employed a series of methylome-wide association studies to identify methylomic biomarkers of resilience in a unique sample of 276 twins within 141 families residing in disadvantaged neighborhoods. Results revealed methylome-wide significant differentially methylated probes (DMPs) for social and academic resilience and suggestive DMPs for psychological resilience and resilience across domains. Pathway analyses informed our understanding of the biological underpinnings of significant differentially methylated probes. Monozygotic twin difference analyses were then employed to narrow in on DMPs that were specifically environmental in origin. Our findings suggest that alterations in the DNA methylome may be implicated in youth resilience to neighborhood adversity and that some of the suggestive DMPs may be environmentally engendered. Importantly, our ability to replicate our findings in a well-powered sample was hindered by the scarcity of twin samples with youth exposed to moderate to substantial levels of adversity. Thus, although preliminary, the present study is the first to identify DNA methylation biomarkers of academic and social resilience. En ligne : https://dx.doi.org/10.1017/S0954579424001330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

Understanding desistance from aggression: A joint interpretation of person-centered and variable-centered approaches / Sarah L. CARROLL in Development and Psychopathology, 38-1 (February 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-1 (February 2026) . - p.441-455 Titre : Understanding desistance from aggression: A joint interpretation of person-centered and variable-centered approaches Type de document : texte imprimé Auteurs : Sarah L. CARROLL, Auteur ; Alaina M. DI DIO, Auteur ; Shaunna L. CLARK, Auteur ; Kelly L. KLUMP, Auteur ; Luke W. HYDE, Auteur ; S. Alexandra BURT, Auteur Article en page(s) : p.441-455 Langues : Anglais (eng) Mots-clés : aggression desistance developmental trajectories person-centered variable-centered Index. décimale : PER Périodiques Résumé : When leveraged together, variable-centered and person-centered statistical methods have the potential to illuminate the factors predicting mental health recovery. However, because extant studies have largely relied on only one of these methods, we do not yet understand why some youth demonstrate recovery while others experience chronic symptoms. This omission limits our understanding of trajectories of physical aggression (AGG) in particular, which are frequently characterized by desistance. The present study examined the development of AGG across childhood and adolescence via variable-centered and person-centered modeling, with neighborhood and family characteristics considered as predictors. Variable-centered results indicated a mean-level decline in AGG with age but were more useful for illuminating predictors of AGG at baseline than predictors of declining engagement. Person-centered analyses, by contrast, identified low parent-child conflict and high household income as predictors of desistance. Although variable-centered analyses were integral to modeling the average AGG trajectory and identifying predictors of engagement at baseline, person-centered techniques proved more useful for understanding predictors of desistance. En ligne : https://dx.doi.org/10.1017/S0954579425100382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Understanding desistance from aggression: A joint interpretation of person-centered and variable-centered approaches [texte imprimé] / Sarah L. CARROLL, Auteur ; Alaina M. DI DIO, Auteur ; Shaunna L. CLARK, Auteur ; Kelly L. KLUMP, Auteur ; Luke W. HYDE, Auteur ; S. Alexandra BURT, Auteur . - p.441-455. Langues : Anglais (eng) in Development and Psychopathology > 38-1 (February 2026) . - p.441-455 Mots-clés : aggression desistance developmental trajectories person-centered variable-centered Index. décimale : PER Périodiques Résumé : When leveraged together, variable-centered and person-centered statistical methods have the potential to illuminate the factors predicting mental health recovery. However, because extant studies have largely relied on only one of these methods, we do not yet understand why some youth demonstrate recovery while others experience chronic symptoms. This omission limits our understanding of trajectories of physical aggression (AGG) in particular, which are frequently characterized by desistance. The present study examined the development of AGG across childhood and adolescence via variable-centered and person-centered modeling, with neighborhood and family characteristics considered as predictors. Variable-centered results indicated a mean-level decline in AGG with age but were more useful for illuminating predictors of AGG at baseline than predictors of declining engagement. Person-centered analyses, by contrast, identified low parent-child conflict and high household income as predictors of desistance. Although variable-centered analyses were integral to modeling the average AGG trajectory and identifying predictors of engagement at baseline, person-centered techniques proved more useful for understanding predictors of desistance. En ligne : https://dx.doi.org/10.1017/S0954579425100382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

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