Childhood obsessive-compulsive disorder, epigenetics, and heterochrony: An evolutionary and developmental approach / Matteo TONNA in Development and Psychopathology, 37-5 (December 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-5 (December 2025) . - p.2476-2490 Titre : Childhood obsessive-compulsive disorder, epigenetics, and heterochrony: An evolutionary and developmental approach Type de document : texte imprimé Auteurs : Matteo TONNA, Auteur ; Davide Fausto BORRELLI, Auteur ; Carlo MARCHESI, Auteur ; Maria Carla GERRA, Auteur ; Cristina DALLABONA, Auteur Article en page(s) : p.2476-2490 Langues : Anglais (eng) Mots-clés : autism  neurodevelopment  ritual behavior  schizophrenia  sensorimotor Index. décimale : PER Périodiques Résumé : Childhood obsessive-compulsive disorder (OCD) stems from a bunch of restricted and repetitive behaviors, which are part of normal behavioral repertoire up to the age of 7. The persistence of compulsive-like behaviors after that age is often associated with unique comorbidity patterns, which are age-at-onset dependent and reflect different developmental stages. In particular, OCD synchronically co-occurs with a broad constellation of neurodevelopmental disorders, whereas diachronically it is related to an increased risk of major adult psychoses. Moreover, OCD is associated with trait-like sensory phenomena, suggesting a common disrupted sensorimotor grounding.The present study is aimed at exploring the hypothesis that this specific temporal and comorbidity OCD profile may be due to a developmental heterochronic mechanism of delay in attenuation of ontogenetically early behavioral patterns. The developmental shift of highly evolutionarily conserved behavioral phenotypes might be regulated by epigenetic changes induced by different conditions of sensory unbalance. This evolutionary and developmental model allows capturing childhood OCD in light of the ultimate causes of ritual behavior throughout phylogeny, namely its "homeostatic" function over conditions of unpredictability. Moreover, it may have important clinical implications, as OCD symptoms could represent putative biomarkers of early divergent developmental trajectories, with a pathoplastic effect on course and outcome. En ligne : https://dx.doi.org/10.1017/S0954579425000124 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Childhood obsessive-compulsive disorder, epigenetics, and heterochrony: An evolutionary and developmental approach [texte imprimé] / Matteo TONNA, Auteur ; Davide Fausto BORRELLI, Auteur ; Carlo MARCHESI, Auteur ; Maria Carla GERRA, Auteur ; Cristina DALLABONA, Auteur . - p.2476-2490. Langues : Anglais (eng) in Development and Psychopathology > 37-5 (December 2025) . - p.2476-2490 Mots-clés : autism  neurodevelopment  ritual behavior  schizophrenia  sensorimotor Index. décimale : PER Périodiques Résumé : Childhood obsessive-compulsive disorder (OCD) stems from a bunch of restricted and repetitive behaviors, which are part of normal behavioral repertoire up to the age of 7. The persistence of compulsive-like behaviors after that age is often associated with unique comorbidity patterns, which are age-at-onset dependent and reflect different developmental stages. In particular, OCD synchronically co-occurs with a broad constellation of neurodevelopmental disorders, whereas diachronically it is related to an increased risk of major adult psychoses. Moreover, OCD is associated with trait-like sensory phenomena, suggesting a common disrupted sensorimotor grounding.The present study is aimed at exploring the hypothesis that this specific temporal and comorbidity OCD profile may be due to a developmental heterochronic mechanism of delay in attenuation of ontogenetically early behavioral patterns. The developmental shift of highly evolutionarily conserved behavioral phenotypes might be regulated by epigenetic changes induced by different conditions of sensory unbalance. This evolutionary and developmental model allows capturing childhood OCD in light of the ultimate causes of ritual behavior throughout phylogeny, namely its "homeostatic" function over conditions of unpredictability. Moreover, it may have important clinical implications, as OCD symptoms could represent putative biomarkers of early divergent developmental trajectories, with a pathoplastic effect on course and outcome. En ligne : https://dx.doi.org/10.1017/S0954579425000124 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

Cross-sectional and prospective relations between dysfunctional cognitive beliefs and obsessive-compulsive symptoms during late childhood and early adolescence: a test of two aetiological models / Barbara BARCACCIA in Journal of Child Psychology and Psychiatry, 67-6 (June 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-6 (June 2026) . - p.859-868 Titre : Cross-sectional and prospective relations between dysfunctional cognitive beliefs and obsessive-compulsive symptoms during late childhood and early adolescence: a test of two aetiological models Type de document : texte imprimé Auteurs : Barbara BARCACCIA, Auteur ; Matti CERVIN, Auteur ; Davide Fausto BORRELLI, Auteur ; Giulia MIGNARRI, Auteur ; Francesco MANCINI, Auteur ; Andrea POZZA, Auteur Article en page(s) : p.859-868 Langues : Anglais (eng) Mots-clés : Obsessive-compulsive disorder  anxiety  child development Index. décimale : PER Périodiques Résumé : Background Obsessive-compulsive symptoms (OCS) often emerge during childhood and adolescence, and two aetiological models have been proposed. According to the first model, maladaptive cognitive beliefs facilitate the transformation of transient intrusive thoughts into OCS. The second model suggests that dysfunctional cognitive beliefs develop in response to increased levels of OCS. Few studies have contrasted these models, and no study has used a prospective design. Methods In this study, dysfunctional cognitive beliefs, OCS, depressive symptoms, and anxiety symptoms were measured repeatedly on three occasions during a year in a sample of 950 late-childhood children and early adolescents (Mage?=?10.80 [SD?=?1.23], 51% female). Network analysis was used to examine cross-sectional between-person associations, and a random-intercept cross-lagged panel model was used to examine prospective within-person associations. Results Cross-sectional network analyses indicated that dysfunctional cognitive beliefs were uniquely linked to OCS and significantly more strongly linked to these symptoms than to depression and anxiety. Prospective data did not support either model, but OCS and anxiety symptoms uniquely predicted each other. Sex-stratified analyses showed that dysfunctional cognitive beliefs predicted all types of symptoms at later time points in boys, while in girls, OCS and anxiety symptoms predicted each other. Assumptions of the two aetiological models of OCD were supported by cross-sectional but not prospective data. Conclusions During late childhood and early adolescence dysfunctional cognitive beliefs may play a more prominent role in the emergence of mental health symptoms in boys than in girls, but more prospective studies are needed. En ligne : https://doi.org/10.1111/jcpp.70077 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587 [article] Cross-sectional and prospective relations between dysfunctional cognitive beliefs and obsessive-compulsive symptoms during late childhood and early adolescence: a test of two aetiological models [texte imprimé] / Barbara BARCACCIA, Auteur ; Matti CERVIN, Auteur ; Davide Fausto BORRELLI, Auteur ; Giulia MIGNARRI, Auteur ; Francesco MANCINI, Auteur ; Andrea POZZA, Auteur . - p.859-868. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-6 (June 2026) . - p.859-868 Mots-clés : Obsessive-compulsive disorder  anxiety  child development Index. décimale : PER Périodiques Résumé : Background Obsessive-compulsive symptoms (OCS) often emerge during childhood and adolescence, and two aetiological models have been proposed. According to the first model, maladaptive cognitive beliefs facilitate the transformation of transient intrusive thoughts into OCS. The second model suggests that dysfunctional cognitive beliefs develop in response to increased levels of OCS. Few studies have contrasted these models, and no study has used a prospective design. Methods In this study, dysfunctional cognitive beliefs, OCS, depressive symptoms, and anxiety symptoms were measured repeatedly on three occasions during a year in a sample of 950 late-childhood children and early adolescents (Mage?=?10.80 [SD?=?1.23], 51% female). Network analysis was used to examine cross-sectional between-person associations, and a random-intercept cross-lagged panel model was used to examine prospective within-person associations. Results Cross-sectional network analyses indicated that dysfunctional cognitive beliefs were uniquely linked to OCS and significantly more strongly linked to these symptoms than to depression and anxiety. Prospective data did not support either model, but OCS and anxiety symptoms uniquely predicted each other. Sex-stratified analyses showed that dysfunctional cognitive beliefs predicted all types of symptoms at later time points in boys, while in girls, OCS and anxiety symptoms predicted each other. Assumptions of the two aetiological models of OCD were supported by cross-sectional but not prospective data. Conclusions During late childhood and early adolescence dysfunctional cognitive beliefs may play a more prominent role in the emergence of mental health symptoms in boys than in girls, but more prospective studies are needed. En ligne : https://doi.org/10.1111/jcpp.70077 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587

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