Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism / S. Jill JAMES in Journal of Autism and Developmental Disorders, 38-10 (November 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1966-1975 Titre : Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : S. Jill JAMES, Auteur ; Stepan MELNYK, Auteur ; Stefanie JERNIGAN, Auteur ; Amanda HUBANKS, Auteur ; Shannon ROSE, Auteur ; David W. GAYLOR, Auteur Année de publication : 2008 Article en page(s) : p.1966-1975 Note générale : An erratum to this article can be found at http://dx.doi.org/10.1007/s10803-008-0614-2 Langues : Anglais (eng) Mots-clés : Autism Homocysteine Glutathione DNA-methylation Parents Index. décimale : PER Périodiques Résumé : An integrated metabolic profile reflects the combined influence of genetic, epigenetic, and environmental factors that affect the candidate pathway of interest. Recent evidence suggests that some autistic children may have reduced detoxification capacity and may be under chronic oxidative stress. Based on reports of abnormal methionine and glutathione metabolism in autistic children, it was of interest to examine the same metabolic profile in the parents. The results indicated that parents share similar metabolic deficits in methylation capacity and glutathione-dependent antioxidant/detoxification capacity observed in many autistic children. Studies are underway to determine whether the abnormal profile in parents reflects linked genetic polymorphisms in these pathways or whether it simply reflects the chronic stress of coping with an autistic child. En ligne : http://dx.doi.org/10.1007/s10803-008-0591-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=642 [article] Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism [Texte imprimé et/ou numérique] / S. Jill JAMES, Auteur ; Stepan MELNYK, Auteur ; Stefanie JERNIGAN, Auteur ; Amanda HUBANKS, Auteur ; Shannon ROSE, Auteur ; David W. GAYLOR, Auteur . - 2008 . - p.1966-1975. An erratum to this article can be found at http://dx.doi.org/10.1007/s10803-008-0614-2 Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1966-1975 Mots-clés : Autism Homocysteine Glutathione DNA-methylation Parents Index. décimale : PER Périodiques Résumé : An integrated metabolic profile reflects the combined influence of genetic, epigenetic, and environmental factors that affect the candidate pathway of interest. Recent evidence suggests that some autistic children may have reduced detoxification capacity and may be under chronic oxidative stress. Based on reports of abnormal methionine and glutathione metabolism in autistic children, it was of interest to examine the same metabolic profile in the parents. The results indicated that parents share similar metabolic deficits in methylation capacity and glutathione-dependent antioxidant/detoxification capacity observed in many autistic children. Studies are underway to determine whether the abnormal profile in parents reflects linked genetic polymorphisms in these pathways or whether it simply reflects the chronic stress of coping with an autistic child. En ligne : http://dx.doi.org/10.1007/s10803-008-0591-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=642

Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism - Erratum / S. Jill JAMES in Journal of Autism and Developmental Disorders, 38-10 (November 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1976 Titre : Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism - Erratum Type de document : Texte imprimé et/ou numérique Auteurs : S. Jill JAMES, Auteur ; Stepan MELNYK, Auteur ; Stefanie JERNIGAN, Auteur ; Amanda HUBANKS, Auteur ; Shannon ROSE, Auteur ; David W. GAYLOR, Auteur Année de publication : 2008 Article en page(s) : p.1976 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-008-0614-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=642 [article] Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism - Erratum [Texte imprimé et/ou numérique] / S. Jill JAMES, Auteur ; Stepan MELNYK, Auteur ; Stefanie JERNIGAN, Auteur ; Amanda HUBANKS, Auteur ; Shannon ROSE, Auteur ; David W. GAYLOR, Auteur . - 2008 . - p.1976. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1976 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-008-0614-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=642

Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders / Joanna C. HAMLIN in Autism Research and Treatment, (January 2014)  

Public ISBD [article]  inAutism Research and Treatment > (January 2014) . - 7 p. Titre : Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Joanna C. HAMLIN, Auteur ; Margaret PAULY, Auteur ; Stepan MELNYK, Auteur ; Oleksandra PAVLIV, Auteur ; William STARRETT, Auteur ; Tina A. CROOK, Auteur ; S. Jill JAMES, Auteur Année de publication : 2014 Article en page(s) : 7 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abnormalities in folate-dependent one-carbon metabolism have been reported in many children with autism. Because inadequate choline and betaine can negatively affect folate metabolism and in turn downstream methylation and antioxidant capacity, we sought to determine whether dietary intake of choline and betaine in children with autism was adequate to meet nutritional needs based on national recommendations. Three-day food records were analyzed for 288 children with autism (ASDs) who participated in the national Autism Intervention Research Network for Physical Health (AIR-P) Study on Diet and Nutrition in children with autism. Plasma concentrations of choline and betaine were measured in a subgroup of 35 children with ASDs and 32 age-matched control children. The results indicated that 60–93% of children with ASDs were consuming less than the recommended Adequate Intake (AI) for choline. Strong positive correlations were found between dietary intake and plasma concentrations of choline and betaine in autistic children as well as lower plasma concentrations compared to the control group. We conclude that choline and betaine intake is inadequate in a significant subgroup of children with ASDs and is reflected in lower plasma levels. Inadequate intake of choline and betaine may contribute to the metabolic abnormalities observed in many children with autism and warrants attention in nutritional counseling. En ligne : http://dx.doi.org/10.1155/2013/578429 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Joanna C. HAMLIN, Auteur ; Margaret PAULY, Auteur ; Stepan MELNYK, Auteur ; Oleksandra PAVLIV, Auteur ; William STARRETT, Auteur ; Tina A. CROOK, Auteur ; S. Jill JAMES, Auteur . - 2014 . - 7 p. Langues : Anglais (eng) in Autism Research and Treatment > (January 2014) . - 7 p. Index. décimale : PER Périodiques Résumé : Abnormalities in folate-dependent one-carbon metabolism have been reported in many children with autism. Because inadequate choline and betaine can negatively affect folate metabolism and in turn downstream methylation and antioxidant capacity, we sought to determine whether dietary intake of choline and betaine in children with autism was adequate to meet nutritional needs based on national recommendations. Three-day food records were analyzed for 288 children with autism (ASDs) who participated in the national Autism Intervention Research Network for Physical Health (AIR-P) Study on Diet and Nutrition in children with autism. Plasma concentrations of choline and betaine were measured in a subgroup of 35 children with ASDs and 32 age-matched control children. The results indicated that 60–93% of children with ASDs were consuming less than the recommended Adequate Intake (AI) for choline. Strong positive correlations were found between dietary intake and plasma concentrations of choline and betaine in autistic children as well as lower plasma concentrations compared to the control group. We conclude that choline and betaine intake is inadequate in a significant subgroup of children with ASDs and is reflected in lower plasma levels. Inadequate intake of choline and betaine may contribute to the metabolic abnormalities observed in many children with autism and warrants attention in nutritional counseling. En ligne : http://dx.doi.org/10.1155/2013/578429 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status / Richard E. FRYE in Autism Research and Treatment, (November 2013)  

Public ISBD [article]  inAutism Research and Treatment > (November 2013) . - 9 p. Titre : Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status Type de document : Texte imprimé et/ou numérique Auteurs : Richard E. FRYE, Auteur ; Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Tyra REID, Auteur ; Stefanie JERNIGAN, Auteur ; Oleksandra PAVLIV, Auteur ; Amanda HUBANKS, Auteur ; David W. GAYLOR, Auteur ; Laura WALTERS, Auteur ; S. Jill JAMES, Auteur Année de publication : 2013 Article en page(s) : 9 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Treatments targeting metabolic abnormalities in children with autism are limited. Previously we reported that a nutritional treatment significantly improved glutathione metabolism in children with autistic disorder. In this study we evaluated changes in adaptive behaviors in this cohort and determined whether such changes are related to changes in glutathione metabolism. Thirty-seven children diagnosed with autistic disorder and abnormal glutathione and methylation metabolism were treated with twice weekly 75?µg/Kg methylcobalamin and twice daily 400?µg folinic acid for 3 months in an open-label fashion. The Vineland Adaptive Behavior Scale (VABS) and glutathione redox metabolites were measured at baseline and at the end of the treatment period. Over the treatment period, all VABS subscales significantly improved with an average effect size of 0.59, and an average improvement in skills of 7.7 months. A greater improvement in glutathione redox status was associated with a greater improvement in expressive communication, personal and domestic daily living skills, and interpersonal, play-leisure, and coping social skills. Age, gender, and history of regression did not influence treatment response. The significant behavioral improvements observed and the relationship between these improvements to glutathione redox status suggest that nutritional interventions targeting redox metabolism may benefit some children with autism. En ligne : http://dx.doi.org/10.1155/2013/609705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status [Texte imprimé et/ou numérique] / Richard E. FRYE, Auteur ; Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Tyra REID, Auteur ; Stefanie JERNIGAN, Auteur ; Oleksandra PAVLIV, Auteur ; Amanda HUBANKS, Auteur ; David W. GAYLOR, Auteur ; Laura WALTERS, Auteur ; S. Jill JAMES, Auteur . - 2013 . - 9 p. Langues : Anglais (eng) in Autism Research and Treatment > (November 2013) . - 9 p. Index. décimale : PER Périodiques Résumé : Treatments targeting metabolic abnormalities in children with autism are limited. Previously we reported that a nutritional treatment significantly improved glutathione metabolism in children with autistic disorder. In this study we evaluated changes in adaptive behaviors in this cohort and determined whether such changes are related to changes in glutathione metabolism. Thirty-seven children diagnosed with autistic disorder and abnormal glutathione and methylation metabolism were treated with twice weekly 75?µg/Kg methylcobalamin and twice daily 400?µg folinic acid for 3 months in an open-label fashion. The Vineland Adaptive Behavior Scale (VABS) and glutathione redox metabolites were measured at baseline and at the end of the treatment period. Over the treatment period, all VABS subscales significantly improved with an average effect size of 0.59, and an average improvement in skills of 7.7 months. A greater improvement in glutathione redox status was associated with a greater improvement in expressive communication, personal and domestic daily living skills, and interpersonal, play-leisure, and coping social skills. Age, gender, and history of regression did not influence treatment response. The significant behavioral improvements observed and the relationship between these improvements to glutathione redox status suggest that nutritional interventions targeting redox metabolism may benefit some children with autism. En ligne : http://dx.doi.org/10.1155/2013/609705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression / Meghan E. Carey in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2975-2985 Titre : Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression Type de document : Texte imprimé et/ou numérique Auteurs : Meghan E. Carey, Auteur ; Juliette RANDO, Auteur ; Stepan MELNYK, Auteur ; S. Jill JAMES, Auteur ; Nathaniel SNYDER, Auteur ; Carolyn SALAFIA, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Heather VOLK, Auteur ; Craig NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.2975-2985 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling?s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile ?: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. En ligne : https://doi.org/10.1007/s10803-022-05625-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression [Texte imprimé et/ou numérique] / Meghan E. Carey, Auteur ; Juliette RANDO, Auteur ; Stepan MELNYK, Auteur ; S. Jill JAMES, Auteur ; Nathaniel SNYDER, Auteur ; Carolyn SALAFIA, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Heather VOLK, Auteur ; Craig NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur . - p.2975-2985. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2975-2985 Index. décimale : PER Périodiques Résumé : We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling?s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile ?: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. En ligne : https://doi.org/10.1007/s10803-022-05625-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Intracellular and Extracellular Redox Status and Free Radical Generation in Primary Immune Cells from Children with Autism / Shannon ROSE in Autism Research and Treatment, (September 2011)  

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Maternal metabolic profile predicts high or low risk of an autism pregnancy outcome / Kathryn HOLLOWOOD in Research in Autism Spectrum Disorders, 56 (December 2018)  

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Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism / Stepan MELNYK in Journal of Autism and Developmental Disorders, 42-3 (March 2012)  

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Oxidative Stress and the Metabolic Pathology of Autism / S. Jill JAMES

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