Nucleus accumbens volume mediates the association between prenatal adversity and attention problems in youth / Chase ANTONACCI in Development and Psychopathology, 38-1 (February 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-1 (February 2026) . - p.117-129 Titre : Nucleus accumbens volume mediates the association between prenatal adversity and attention problems in youth Type de document : texte imprimé Auteurs : Chase ANTONACCI, Auteur ; Jessica L. BUTHMANN, Auteur ; Lauren R. BORCHERS, Auteur ; Marielle V. FORTIER, Auteur ; Yap Seng CHONG, Auteur ; Peter GLUCKMAN, Auteur ; Johan ERIKSSON, Auteur ; Helen Y. CHEN, Auteur ; Evelyn LAW, Auteur ; Michael J. MEANEY, Auteur ; Ai Peng TAN, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.117-129 Langues : Anglais (eng) Mots-clés : adversity attention maternal mental health nucleus accumbens perinatal Index. décimale : PER Périodiques Résumé : Exposure to adversity during the perinatal period has been associated with cognitive difficulties in children. Given the role of the nucleus accumbens (NAcc) in attention and impulsivity, we examined whether NAcc volume at age six mediates the relations between pre- and postnatal adversity and subsequent attention problems in offspring. 306 pregnant women were recruited as part of the Growing Up in Singapore Towards Healthy Outcomes Study. Psychosocial stress was assessed during pregnancy and across the first 5 years postpartum. At six years of age, children underwent structural MRI and, at age seven years, mothers reported on their children’s attention problems. Separate factor analyses conducted on measures of pre- and postnatal adversity each yielded two latent factors: maternal mental health and socioeconomic status. Both pre- and postnatal maternal mental health predicted children’s attention difficulties. Further, NAcc volume mediated the relation between prenatal, but not postnatal, maternal mental health and children’s attention problems. These findings suggest that the NAcc is particularly vulnerable to prenatal maternal mental health challenges and contributes to offspring attention problems. Characterizing the temporal sensitivity of neurobiological structures to adversity will help to elucidate mechanisms linking environmental exposures and behavior, facilitating the development of neuroscience-informed interventions for childhood difficulties. En ligne : https://dx.doi.org/10.1017/S0954579425000240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Nucleus accumbens volume mediates the association between prenatal adversity and attention problems in youth [texte imprimé] / Chase ANTONACCI, Auteur ; Jessica L. BUTHMANN, Auteur ; Lauren R. BORCHERS, Auteur ; Marielle V. FORTIER, Auteur ; Yap Seng CHONG, Auteur ; Peter GLUCKMAN, Auteur ; Johan ERIKSSON, Auteur ; Helen Y. CHEN, Auteur ; Evelyn LAW, Auteur ; Michael J. MEANEY, Auteur ; Ai Peng TAN, Auteur ; Ian H. GOTLIB, Auteur . - p.117-129. Langues : Anglais (eng) in Development and Psychopathology > 38-1 (February 2026) . - p.117-129 Mots-clés : adversity attention maternal mental health nucleus accumbens perinatal Index. décimale : PER Périodiques Résumé : Exposure to adversity during the perinatal period has been associated with cognitive difficulties in children. Given the role of the nucleus accumbens (NAcc) in attention and impulsivity, we examined whether NAcc volume at age six mediates the relations between pre- and postnatal adversity and subsequent attention problems in offspring. 306 pregnant women were recruited as part of the Growing Up in Singapore Towards Healthy Outcomes Study. Psychosocial stress was assessed during pregnancy and across the first 5 years postpartum. At six years of age, children underwent structural MRI and, at age seven years, mothers reported on their children’s attention problems. Separate factor analyses conducted on measures of pre- and postnatal adversity each yielded two latent factors: maternal mental health and socioeconomic status. Both pre- and postnatal maternal mental health predicted children’s attention difficulties. Further, NAcc volume mediated the relation between prenatal, but not postnatal, maternal mental health and children’s attention problems. These findings suggest that the NAcc is particularly vulnerable to prenatal maternal mental health challenges and contributes to offspring attention problems. Characterizing the temporal sensitivity of neurobiological structures to adversity will help to elucidate mechanisms linking environmental exposures and behavior, facilitating the development of neuroscience-informed interventions for childhood difficulties. En ligne : https://dx.doi.org/10.1017/S0954579425000240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

Reward-network connectivity in childhood predicts multi-domain dysregulation in adolescence / Eugenia GIAMPETRUZZI in Journal of Child Psychology and Psychiatry, 67-8 (August 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-8 (August 2026) . - p.1348-1360 Titre : Reward-network connectivity in childhood predicts multi-domain dysregulation in adolescence Type de document : texte imprimé Auteurs : Eugenia GIAMPETRUZZI, Auteur ; Parmis KHOSRAVI, Auteur ; Katharina KIRCANSKI, Auteur ; Chase ANTONACCI, Auteur ; Daniel S. PINE, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1348-1360 Langues : Anglais (eng) Mots-clés : Dysregulation profile  reward network connectivity  adolescence Index. décimale : PER Périodiques Résumé : Background Multi-domain dysregulation in adolescence, indexed by co-occurring affective, cognitive, and behavioural difficulties, is a robust transdiagnostic risk factor. However, its developmental course and neural antecedents are poorly understood. Given heightened emotional reactivity and impulsivity in adolescence, alterations in reward-network connectivity may represent an early neural marker of risk. Methods Adolescents completed four assessments approximately two years apart between ages 9?13 and 15?18?years. Multi-domain dysregulation was assessed at each wave using the Youth Self-Report Dysregulation Profile (YSR-DP), computed as the sum of the anxious/depressed, aggressive behaviour, and attention problems subscales. Resting-state fMRI was acquired at baseline (Mage?=?11.34?years). Piecewise linear mixed-effects models (N?=?211) characterized trajectories of YSR-DP scores across adolescence. Principal component scores indexing a Latent Dysregulation Factor were used to derive residualised change in dysregulation, and regression analyses (N?=?94) tested whether baseline reward-network connectivity predicted this change. Results YSR-DP scores declined from late childhood to early adolescence, increased from early to mid-adolescence, and then stabilized in late adolescence. Weaker connectivity within the reward network in late childhood predicted greater increases in the latent dysregulation factor from early to mid-adolescence, above and beyond baseline dysregulation. Connectivity in seven large-scale control networks did not predict changes in dysregulation. Conclusions Multi-domain dysregulation follows a nonlinear trajectory across adolescence, and weaker reward-network connectivity in childhood prospectively predicts subsequent escalation of this phenotype. Prevention and intervention efforts may benefit from targeting reward processing and regulatory skills in late childhood and early adolescence. En ligne : https://doi.org/10.1111/jcpp.70143 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591 [article] Reward-network connectivity in childhood predicts multi-domain dysregulation in adolescence [texte imprimé] / Eugenia GIAMPETRUZZI, Auteur ; Parmis KHOSRAVI, Auteur ; Katharina KIRCANSKI, Auteur ; Chase ANTONACCI, Auteur ; Daniel S. PINE, Auteur ; Ian H. GOTLIB, Auteur . - p.1348-1360. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-8 (August 2026) . - p.1348-1360 Mots-clés : Dysregulation profile  reward network connectivity  adolescence Index. décimale : PER Périodiques Résumé : Background Multi-domain dysregulation in adolescence, indexed by co-occurring affective, cognitive, and behavioural difficulties, is a robust transdiagnostic risk factor. However, its developmental course and neural antecedents are poorly understood. Given heightened emotional reactivity and impulsivity in adolescence, alterations in reward-network connectivity may represent an early neural marker of risk. Methods Adolescents completed four assessments approximately two years apart between ages 9?13 and 15?18?years. Multi-domain dysregulation was assessed at each wave using the Youth Self-Report Dysregulation Profile (YSR-DP), computed as the sum of the anxious/depressed, aggressive behaviour, and attention problems subscales. Resting-state fMRI was acquired at baseline (Mage?=?11.34?years). Piecewise linear mixed-effects models (N?=?211) characterized trajectories of YSR-DP scores across adolescence. Principal component scores indexing a Latent Dysregulation Factor were used to derive residualised change in dysregulation, and regression analyses (N?=?94) tested whether baseline reward-network connectivity predicted this change. Results YSR-DP scores declined from late childhood to early adolescence, increased from early to mid-adolescence, and then stabilized in late adolescence. Weaker connectivity within the reward network in late childhood predicted greater increases in the latent dysregulation factor from early to mid-adolescence, above and beyond baseline dysregulation. Connectivity in seven large-scale control networks did not predict changes in dysregulation. Conclusions Multi-domain dysregulation follows a nonlinear trajectory across adolescence, and weaker reward-network connectivity in childhood prospectively predicts subsequent escalation of this phenotype. Prevention and intervention efforts may benefit from targeting reward processing and regulatory skills in late childhood and early adolescence. En ligne : https://doi.org/10.1111/jcpp.70143 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591

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