Autism Spectrum Disorder Symptom Profiles in Fragile X Syndrome, Angelman Syndrome, Tuberous Sclerosis Complex and Neurofibromatosis Type 1 / Kyra LUBBERS in Journal of Autism and Developmental Disorders, 56-2 (February 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-2 (February 2026) . - p.793-807 Titre : Autism Spectrum Disorder Symptom Profiles in Fragile X Syndrome, Angelman Syndrome, Tuberous Sclerosis Complex and Neurofibromatosis Type 1 Type de document : texte imprimé Auteurs : Kyra LUBBERS, Auteur ; Kamil R. HIRALAL, Auteur ; Gwendolyn C. DIELEMAN, Auteur ; Doesjka A. HAGENAAR, Auteur ; Bram DIERCKX, Auteur ; Jeroen S. LEGERSTEE, Auteur ; Pieter F. A. DE NIJS, Auteur ; André B. RIETMAN, Auteur ; Rianne OOSTENBRINK, Auteur ; Karen G. C. B. BINDELS-DE HEUS, Auteur ; Marie-Claire Y. DE WIT, Auteur ; Manon H. J. HILLEGERS, Auteur ; Leontine W. TEN HOOPEN, Auteur ; Sabine E. MOUS, Auteur Article en page(s) : p.793-807 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Studying Autism Spectrum Disorder (ASD) heterogeneity in biologically homogeneous samples may increase our knowledge of ASD etiology. Fragile X syndrome (FXS), Angelman syndrome (AS), Tuberous Sclerosis Complex (TSC), and Neurofibromatosis type 1 (NF1) are monogenic disorders with high a prevalence of ASD symptomatology. This study aimed to identify ASD symptom profiles in a large group of children and adolescents (0;9–28 years) with FXS, AS, TSC, and NF1. Data on ASD symptomatology (Autism Diagnostic Observation Scale (ADOS-2) & Social Responsiveness Scale (SRS-2)) were collected from children and adolescents with FXS (n = 54), AS (n = 93), TSC (n = 112), and NF1 (n = 278). To identify groups of individuals with similar ASD profiles, we performed two latent profile analyses. We identified a four-profile model based on the ADOS-2, with a (1) ‘Non-spectrum symptom profile’, (2) ‘Social Affect symptom profile’, (3)‘Restricted/Repetitive Behaviors symptom profile’, and (4)‘ASD symptom profile’. We also identified a four-profile model based on the SRS, with a (1)‘Non-clinical symptom profile’, (2)‘Mild symptom profile’, (3)‘Moderate symptom profile’, and (4)‘Severe symptom profile’. Although each syndrome group exhibited varying degrees of severity, they also displayed heterogeneity in the profiles in which they were classified. We found distinct ASD symptom profiles in a population consisting of children and adolescents with FXS, AS, TSC, and NF1. Our study highlights the importance of a personalized approach to the identification and management of ASD symptoms in rare genetic syndromes. Future studies should aim to include more domains of functioning and investigate the stability of latent profiles over time. En ligne : https://doi.org/10.1007/s10803-024-06557-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580 [article] Autism Spectrum Disorder Symptom Profiles in Fragile X Syndrome, Angelman Syndrome, Tuberous Sclerosis Complex and Neurofibromatosis Type 1 [texte imprimé] / Kyra LUBBERS, Auteur ; Kamil R. HIRALAL, Auteur ; Gwendolyn C. DIELEMAN, Auteur ; Doesjka A. HAGENAAR, Auteur ; Bram DIERCKX, Auteur ; Jeroen S. LEGERSTEE, Auteur ; Pieter F. A. DE NIJS, Auteur ; André B. RIETMAN, Auteur ; Rianne OOSTENBRINK, Auteur ; Karen G. C. B. BINDELS-DE HEUS, Auteur ; Marie-Claire Y. DE WIT, Auteur ; Manon H. J. HILLEGERS, Auteur ; Leontine W. TEN HOOPEN, Auteur ; Sabine E. MOUS, Auteur . - p.793-807. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-2 (February 2026) . - p.793-807 Index. décimale : PER Périodiques Résumé : Studying Autism Spectrum Disorder (ASD) heterogeneity in biologically homogeneous samples may increase our knowledge of ASD etiology. Fragile X syndrome (FXS), Angelman syndrome (AS), Tuberous Sclerosis Complex (TSC), and Neurofibromatosis type 1 (NF1) are monogenic disorders with high a prevalence of ASD symptomatology. This study aimed to identify ASD symptom profiles in a large group of children and adolescents (0;9–28 years) with FXS, AS, TSC, and NF1. Data on ASD symptomatology (Autism Diagnostic Observation Scale (ADOS-2) & Social Responsiveness Scale (SRS-2)) were collected from children and adolescents with FXS (n = 54), AS (n = 93), TSC (n = 112), and NF1 (n = 278). To identify groups of individuals with similar ASD profiles, we performed two latent profile analyses. We identified a four-profile model based on the ADOS-2, with a (1) ‘Non-spectrum symptom profile’, (2) ‘Social Affect symptom profile’, (3)‘Restricted/Repetitive Behaviors symptom profile’, and (4)‘ASD symptom profile’. We also identified a four-profile model based on the SRS, with a (1)‘Non-clinical symptom profile’, (2)‘Mild symptom profile’, (3)‘Moderate symptom profile’, and (4)‘Severe symptom profile’. Although each syndrome group exhibited varying degrees of severity, they also displayed heterogeneity in the profiles in which they were classified. We found distinct ASD symptom profiles in a population consisting of children and adolescents with FXS, AS, TSC, and NF1. Our study highlights the importance of a personalized approach to the identification and management of ASD symptoms in rare genetic syndromes. Future studies should aim to include more domains of functioning and investigate the stability of latent profiles over time. En ligne : https://doi.org/10.1007/s10803-024-06557-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580

Daily resilience: A systematic review of measures and associations with well-being and mental health in experience sampling studies / Juul ZIETSE in Development and Psychopathology, 38-1 (February 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-1 (February 2026) . - p.130-155 Titre : Daily resilience: A systematic review of measures and associations with well-being and mental health in experience sampling studies Type de document : texte imprimé Auteurs : Juul ZIETSE, Auteur ; Loes KEIJSERS, Auteur ; Manon H. J. HILLEGERS, Auteur ; Annabel VREEKER, Auteur ; Anne-Laura VAN HARMELEN, Auteur ; Lianne P. DE VRIES, Auteur Article en page(s) : p.130-155 Langues : Anglais (eng) Mots-clés : adolescents daily life ecological momentary assessment experience sampling method resilience systematic review youth Index. décimale : PER Périodiques Résumé : Resilience is the dynamic process of adapting to or recovering from stressors, maintaining positive mental health. While most studies have investigated resilience after major life events, less is known about resilience in everyday life. To understand how individuals recover from everyday stressors, and associations with other psychosocial variables, well-being and mental health, we conducted a systematic review of studies to daily resilience, i.e., recovery from daily stressors, using the experience sampling method (ESM). Out of 36 included studies, 11 studies investigated daily resilience in youth (10.9–24.7 years) and 25 in adult samples. Daily resilience was operationalized either with self-report items adapted from trait measures (17 studies) or in terms of affective recovery from daily stressors (20 studies). The self-reported ability to recover from daily stressors reflects subjective experiences of coping with stressors, whereas daily resilience as recovery from daily stressors captures the dynamic process, but is understudied in youth. Daily resilience was associated with psychosocial variables, including better sleep quality and greater optimism. Furthermore, individuals with mental health problems consistently showed longer recovery times after daily stressors. Overall, ESM studies highlight that daily resilience could help to identify individuals at-risk for mental health problems. The findings may facilitate timely interventions. En ligne : https://dx.doi.org/10.1017/S0954579425000197 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Daily resilience: A systematic review of measures and associations with well-being and mental health in experience sampling studies [texte imprimé] / Juul ZIETSE, Auteur ; Loes KEIJSERS, Auteur ; Manon H. J. HILLEGERS, Auteur ; Annabel VREEKER, Auteur ; Anne-Laura VAN HARMELEN, Auteur ; Lianne P. DE VRIES, Auteur . - p.130-155. Langues : Anglais (eng) in Development and Psychopathology > 38-1 (February 2026) . - p.130-155 Mots-clés : adolescents daily life ecological momentary assessment experience sampling method resilience systematic review youth Index. décimale : PER Périodiques Résumé : Resilience is the dynamic process of adapting to or recovering from stressors, maintaining positive mental health. While most studies have investigated resilience after major life events, less is known about resilience in everyday life. To understand how individuals recover from everyday stressors, and associations with other psychosocial variables, well-being and mental health, we conducted a systematic review of studies to daily resilience, i.e., recovery from daily stressors, using the experience sampling method (ESM). Out of 36 included studies, 11 studies investigated daily resilience in youth (10.9–24.7 years) and 25 in adult samples. Daily resilience was operationalized either with self-report items adapted from trait measures (17 studies) or in terms of affective recovery from daily stressors (20 studies). The self-reported ability to recover from daily stressors reflects subjective experiences of coping with stressors, whereas daily resilience as recovery from daily stressors captures the dynamic process, but is understudied in youth. Daily resilience was associated with psychosocial variables, including better sleep quality and greater optimism. Furthermore, individuals with mental health problems consistently showed longer recovery times after daily stressors. Overall, ESM studies highlight that daily resilience could help to identify individuals at-risk for mental health problems. The findings may facilitate timely interventions. En ligne : https://dx.doi.org/10.1017/S0954579425000197 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

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