Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence / Amanda S. NITSCHKE in Journal of Child Psychology and Psychiatry, 67-3 (March 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-3 (March 2026) . - p.355-365 Titre : Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence Type de document : texte imprimé Auteurs : Amanda S. NITSCHKE, Auteur ; Paramdeep KAUR, Auteur ; Naomi PHAGAU, Auteur ; Helena Abreu DO VALLE, Auteur ; Jeffrey N. BONE, Auteur ; Brenda POON, Auteur ; Martin GUHN, Auteur ; Simone N. VIGOD, Auteur ; Tim F. OBERLANDER, Auteur ; Gillian E. HANLEY, Auteur Article en page(s) : p.355-365 Langues : Anglais (eng) Mots-clés : Prenatal antidepressants  childhood and adolescents mental health  anxiety  depression Index. décimale : PER Périodiques Résumé : Background To examine, using repeated measures, whether prenatal serotonin/norepinephrine reuptake inhibitor (SRI) antidepressant exposure is associated with increased anxious behaviors at kindergarten age and anxiety and/or depression behaviors after kindergarten and into adolescence. Methods This population-based retrospective cohort study included all live singleton infants delivered in British Columbia, Canada between January 2001 and December 2012 with complete outcome data. Follow-up lasted until December 2022. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR). To minimize confounding, high-dimensional propensity score adjustment and a matched discordant sibling-pair analysis were conducted. Results Prenatal SRI exposure was associated with increased anxious behaviors in kindergarten (OR 1.77 [95% CI 1.59?1.97]) and anxiety and/or depression diagnostic codes in later childhood or adolescence (OR 2.09 [95% CI 1.97?2.22]). These associations attenuated but remained positive after high-dimensional propensity score adjustment; however, the associations did not remain in the conditional logistic regression of discordant sibling pairs (aORs 0.92 [95% CI 0.61?1.37] and 1.02 [95% CI 0.79?1.33]). Regardless of SRI exposure, children with high levels of anxious behaviors at kindergarten were more likely to receive anxiety and/or depression diagnostic codes later on (SRI exposed: aOR 1.59 [95% CI 1.24?2.06]; SRI unexposed: aOR 1.64 [95% CI 1.51?1.77]). Conclusions The associations of prenatal SRI exposure with increased internalizing behaviors at kindergarten and into adolescence are likely due to shared genetics or environmental factors. Findings also suggested kindergarten as a time for targeted interventions to address developmental vulnerabilities and prevent later development of anxiety and/or depression. En ligne : https://doi.org/10.1111/jcpp.70056 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580 [article] Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence [texte imprimé] / Amanda S. NITSCHKE, Auteur ; Paramdeep KAUR, Auteur ; Naomi PHAGAU, Auteur ; Helena Abreu DO VALLE, Auteur ; Jeffrey N. BONE, Auteur ; Brenda POON, Auteur ; Martin GUHN, Auteur ; Simone N. VIGOD, Auteur ; Tim F. OBERLANDER, Auteur ; Gillian E. HANLEY, Auteur . - p.355-365. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-3 (March 2026) . - p.355-365 Mots-clés : Prenatal antidepressants  childhood and adolescents mental health  anxiety  depression Index. décimale : PER Périodiques Résumé : Background To examine, using repeated measures, whether prenatal serotonin/norepinephrine reuptake inhibitor (SRI) antidepressant exposure is associated with increased anxious behaviors at kindergarten age and anxiety and/or depression behaviors after kindergarten and into adolescence. Methods This population-based retrospective cohort study included all live singleton infants delivered in British Columbia, Canada between January 2001 and December 2012 with complete outcome data. Follow-up lasted until December 2022. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR). To minimize confounding, high-dimensional propensity score adjustment and a matched discordant sibling-pair analysis were conducted. Results Prenatal SRI exposure was associated with increased anxious behaviors in kindergarten (OR 1.77 [95% CI 1.59?1.97]) and anxiety and/or depression diagnostic codes in later childhood or adolescence (OR 2.09 [95% CI 1.97?2.22]). These associations attenuated but remained positive after high-dimensional propensity score adjustment; however, the associations did not remain in the conditional logistic regression of discordant sibling pairs (aORs 0.92 [95% CI 0.61?1.37] and 1.02 [95% CI 0.79?1.33]). Regardless of SRI exposure, children with high levels of anxious behaviors at kindergarten were more likely to receive anxiety and/or depression diagnostic codes later on (SRI exposed: aOR 1.59 [95% CI 1.24?2.06]; SRI unexposed: aOR 1.64 [95% CI 1.51?1.77]). Conclusions The associations of prenatal SRI exposure with increased internalizing behaviors at kindergarten and into adolescence are likely due to shared genetics or environmental factors. Findings also suggested kindergarten as a time for targeted interventions to address developmental vulnerabilities and prevent later development of anxiety and/or depression. En ligne : https://doi.org/10.1111/jcpp.70056 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580

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