Autism and Cortical Thickness Deviation From Neurotypical Controls: Evidence for a Spatial Association With Serotonin Receptors / Livio TARCHI in Autism Research, 19-6 (June 2026)  

Public ISBD [article]  inAutism Research > 19-6 (June 2026) . - p.e70243 Titre : Autism and Cortical Thickness Deviation From Neurotypical Controls: Evidence for a Spatial Association With Serotonin Receptors Type de document : texte imprimé Auteurs : Livio TARCHI, Auteur ; Arne DOOSE, Auteur ; Julius HENNIG, Auteur ; Fabio BERNARDONI, Auteur ; Joseph A. KING, Auteur ; Tiziana PISANO, Auteur ; Giovanni CASTELLINI, Auteur ; Valdo RICCA, Auteur ; Inge KAMP-BECKER, Auteur ; Stefan EHRLICH, Auteur Article en page(s) : p.e70243 Langues : Anglais (eng) Mots-clés : autism  mental health  neurodevelopment  neurotransmitter receptors  structural neuroimaging Index. décimale : PER Périodiques Résumé : ABSTRACT Cortical thickness (CT) differences between autistic individuals (AI) and neurotypical controls have been consistently reported, yet the neurochemical mechanisms underlying these differences remain insufficiently understood. Neurotransmitter receptor systems exhibit distinct spatial distributions across the cortex and influence synaptic maturation, plasticity, and cortical organization. Consequently, mapping CT deviations onto these receptor density gradients provides a biologically informed framework for investigating the potential underlying neurochemical architectures of observed structural patterns in autism. A total of 1035 structural MRIs (AI n?=?505, neurotypical controls n?=?530) were included from Autism Brain Imaging Data Exchange (ABIDE). Group contrasts and individual-level deviations from age-predicted CT patterns were computed. These spatial patterns were correlated with neurotransmitter receptors cortical density distributions (D1, D2, 5HT1a, 5HT2a, 5HT4, 5HT6, mGluR5) from previous PET studies. Widespread vertex-wise deviations in CT were observed in AI in comparison to neurotypical controls. At the group level, CT differences were spatially aligned with the cortical density of serotonin receptors (5HT1a: r?=?0.22, FDR-p?=?0.032; 5HT4: r?=?0.21, FDR-p?=?0.032). At the individual level, greater deviations from predicted CT, if mapped onto specific neurotransmitter receptor density gradients, correlated with greater difficulties in the social and communication domains. The findings provide novel evidence that serotonin receptors may play a role in shaping cortical structural brain differences between AI and neurotypical controls. The link between CT differences and spatial distributions of the serotoninergic system offers a translational perspective for future targeted support strategies focused on serotonergic pathways. En ligne : https://doi.org/10.1002/aur.70243 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Autism and Cortical Thickness Deviation From Neurotypical Controls: Evidence for a Spatial Association With Serotonin Receptors [texte imprimé] / Livio TARCHI, Auteur ; Arne DOOSE, Auteur ; Julius HENNIG, Auteur ; Fabio BERNARDONI, Auteur ; Joseph A. KING, Auteur ; Tiziana PISANO, Auteur ; Giovanni CASTELLINI, Auteur ; Valdo RICCA, Auteur ; Inge KAMP-BECKER, Auteur ; Stefan EHRLICH, Auteur . - p.e70243. Langues : Anglais (eng) in Autism Research > 19-6 (June 2026) . - p.e70243 Mots-clés : autism  mental health  neurodevelopment  neurotransmitter receptors  structural neuroimaging Index. décimale : PER Périodiques Résumé : ABSTRACT Cortical thickness (CT) differences between autistic individuals (AI) and neurotypical controls have been consistently reported, yet the neurochemical mechanisms underlying these differences remain insufficiently understood. Neurotransmitter receptor systems exhibit distinct spatial distributions across the cortex and influence synaptic maturation, plasticity, and cortical organization. Consequently, mapping CT deviations onto these receptor density gradients provides a biologically informed framework for investigating the potential underlying neurochemical architectures of observed structural patterns in autism. A total of 1035 structural MRIs (AI n?=?505, neurotypical controls n?=?530) were included from Autism Brain Imaging Data Exchange (ABIDE). Group contrasts and individual-level deviations from age-predicted CT patterns were computed. These spatial patterns were correlated with neurotransmitter receptors cortical density distributions (D1, D2, 5HT1a, 5HT2a, 5HT4, 5HT6, mGluR5) from previous PET studies. Widespread vertex-wise deviations in CT were observed in AI in comparison to neurotypical controls. At the group level, CT differences were spatially aligned with the cortical density of serotonin receptors (5HT1a: r?=?0.22, FDR-p?=?0.032; 5HT4: r?=?0.21, FDR-p?=?0.032). At the individual level, greater deviations from predicted CT, if mapped onto specific neurotransmitter receptor density gradients, correlated with greater difficulties in the social and communication domains. The findings provide novel evidence that serotonin receptors may play a role in shaping cortical structural brain differences between AI and neurotypical controls. The link between CT differences and spatial distributions of the serotoninergic system offers a translational perspective for future targeted support strategies focused on serotonergic pathways. En ligne : https://doi.org/10.1002/aur.70243 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

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