Night-to-Night Changes in REM Sleep Are Associated With Symptom Severity in Children With Autism Spectrum Disorder: A Two-Night Home Polysomnography Study / Jian JIAO in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70322 Titre : Night-to-Night Changes in REM Sleep Are Associated With Symptom Severity in Children With Autism Spectrum Disorder: A Two-Night Home Polysomnography Study Type de document : texte imprimé Auteurs : Jian JIAO, Auteur ; Hang ZHANG, Auteur ; Xia YANG, Auteur ; Lu TAN, Auteur ; Taomei LI, Auteur ; Xiangdong TANG, Auteur Article en page(s) : p. e70322 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  night-to-night variability  polysomnography  REM sleep  symptom severity Index. décimale : PER Périodiques Résumé : ABSTRACT Sleep disturbances are highly prevalent in autism spectrum disorder (ASD), yet conventional single-night polysomnography (PSG) provides limited insight into dynamic sleep regulatory processes. Using the Synaptic Homeostasis Hypothesis as a conceptual framework, we quantified night-to-night changes (?; Night 2???Night 1) in sleep architecture across two consecutive nights of home-based PSG and examined their association with ASD symptom severity. Seventy-nine children with ASD, stratified into mild ASD (M-ASD, n?=?35) and moderate-to-severe ASD (MS-ASD, n?=?44) subgroups using the Childhood Autism Rating Scale, and 30 typically developing controls (TDC) participated. Overall sleep-continuity changes were broadly comparable between ASD and TDC groups. However, sleep-architecture ? measures showed a severity-related pattern: the M-ASD subgroup exhibited an overnight increase in rapid eye movement sleep percentage (?REM%?=?+2.6%, p?=?0.002), whereas the MS-ASD subgroup showed no significant change (?REM%?=??0.1%, p?=?0.922). An adjusted pairwise comparison indicated a greater ?REM% increase in M-ASD than in MS-ASD (adjusted mean difference?=?3.4%, 95% CI: 1.2 to 5.6; Bonferroni-corrected p?=?0.009). A similar exploratory difference was observed for NREM1%. ?REM% was modestly and negatively associated with ASD symptom severity in correlation analysis (??=??0.234, p?=?0.038) and age- and gender-adjusted regression analysis (??=??0.286, p?=?0.016). Sensitivity analyses showed broadly consistent patterns, although severity-stratified overall effects were attenuated after FDR correction. These findings support further investigation of PSG-derived dynamic sleep measures as hypothesis-generating correlates of clinical heterogeneity in ASD. En ligne : https://doi.org/10.1002/aur.70322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Night-to-Night Changes in REM Sleep Are Associated With Symptom Severity in Children With Autism Spectrum Disorder: A Two-Night Home Polysomnography Study [texte imprimé] / Jian JIAO, Auteur ; Hang ZHANG, Auteur ; Xia YANG, Auteur ; Lu TAN, Auteur ; Taomei LI, Auteur ; Xiangdong TANG, Auteur . - p. e70322. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70322 Mots-clés : autism spectrum disorder  night-to-night variability  polysomnography  REM sleep  symptom severity Index. décimale : PER Périodiques Résumé : ABSTRACT Sleep disturbances are highly prevalent in autism spectrum disorder (ASD), yet conventional single-night polysomnography (PSG) provides limited insight into dynamic sleep regulatory processes. Using the Synaptic Homeostasis Hypothesis as a conceptual framework, we quantified night-to-night changes (?; Night 2???Night 1) in sleep architecture across two consecutive nights of home-based PSG and examined their association with ASD symptom severity. Seventy-nine children with ASD, stratified into mild ASD (M-ASD, n?=?35) and moderate-to-severe ASD (MS-ASD, n?=?44) subgroups using the Childhood Autism Rating Scale, and 30 typically developing controls (TDC) participated. Overall sleep-continuity changes were broadly comparable between ASD and TDC groups. However, sleep-architecture ? measures showed a severity-related pattern: the M-ASD subgroup exhibited an overnight increase in rapid eye movement sleep percentage (?REM%?=?+2.6%, p?=?0.002), whereas the MS-ASD subgroup showed no significant change (?REM%?=??0.1%, p?=?0.922). An adjusted pairwise comparison indicated a greater ?REM% increase in M-ASD than in MS-ASD (adjusted mean difference?=?3.4%, 95% CI: 1.2 to 5.6; Bonferroni-corrected p?=?0.009). A similar exploratory difference was observed for NREM1%. ?REM% was modestly and negatively associated with ASD symptom severity in correlation analysis (??=??0.234, p?=?0.038) and age- and gender-adjusted regression analysis (??=??0.286, p?=?0.016). Sensitivity analyses showed broadly consistent patterns, although severity-stratified overall effects were attenuated after FDR correction. These findings support further investigation of PSG-derived dynamic sleep measures as hypothesis-generating correlates of clinical heterogeneity in ASD. En ligne : https://doi.org/10.1002/aur.70322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

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