Childhood onset schizophrenia: cortical brain abnormalities as young adults / Deanna GREENSTEIN in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1003–1012 Titre : Childhood onset schizophrenia: cortical brain abnormalities as young adults Type de document : Texte imprimé et/ou numérique Auteurs : Deanna GREENSTEIN, Auteur ; Liv S. CLASEN, Auteur ; Jay N. GIEDD, Auteur ; Jason LERCH, Auteur ; Philip SHAW, Auteur ; Peter GOCHMAN, Auteur ; Judith RAPOPORT, Auteur ; Nitin GOGTAY, Auteur Année de publication : 2007 Article en page(s) : p.1003–1012 Langues : Anglais (eng) Mots-clés : Childhood-onset-schizophrenia MRI cortical-thickness development neurodevelopment schizophrenia Index. décimale : PER Périodiques Résumé : Background: Childhood onset schizophrenia (COS) is a rare but severe form of the adult onset disorder. While structural brain imaging studies show robust, widespread, and progressive gray matter loss in COS during adolescence, there have been no longitudinal studies of sufficient duration to examine comparability with the more common adult onset illness. Methods: Neuro-anatomic magnetic resonance scans were obtained prospectively from ages 7 through 26 in 70 children diagnosed with COS and age and sex matched healthy controls. Cortical thickness was measured at 40,962 points across the cerebral hemispheres using a novel, fully automated, validated method. Patterns of patient–control differences in cortical development were compared over a 19-year period. Results: Throughout the age range, the COS group had significantly smaller mean cortical thickness compared to controls. However, the COS brain developmental trajectory appeared to normalize in posterior (parietal) regions, and remained divergent in the anterior regions (frontal and temporal) regions, and the pattern of loss became more like that seen in adults. Conclusions: Cortical thickness loss in COS appears to localize with age to prefrontal and temporal regions that are seen for both medication naïve and medicated adult onset patients. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01658.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=790 [article] Childhood onset schizophrenia: cortical brain abnormalities as young adults [Texte imprimé et/ou numérique] / Deanna GREENSTEIN, Auteur ; Liv S. CLASEN, Auteur ; Jay N. GIEDD, Auteur ; Jason LERCH, Auteur ; Philip SHAW, Auteur ; Peter GOCHMAN, Auteur ; Judith RAPOPORT, Auteur ; Nitin GOGTAY, Auteur . - 2007 . - p.1003–1012. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1003–1012 Mots-clés : Childhood-onset-schizophrenia MRI cortical-thickness development neurodevelopment schizophrenia Index. décimale : PER Périodiques Résumé : Background: Childhood onset schizophrenia (COS) is a rare but severe form of the adult onset disorder. While structural brain imaging studies show robust, widespread, and progressive gray matter loss in COS during adolescence, there have been no longitudinal studies of sufficient duration to examine comparability with the more common adult onset illness. Methods: Neuro-anatomic magnetic resonance scans were obtained prospectively from ages 7 through 26 in 70 children diagnosed with COS and age and sex matched healthy controls. Cortical thickness was measured at 40,962 points across the cerebral hemispheres using a novel, fully automated, validated method. Patterns of patient–control differences in cortical development were compared over a 19-year period. Results: Throughout the age range, the COS group had significantly smaller mean cortical thickness compared to controls. However, the COS brain developmental trajectory appeared to normalize in posterior (parietal) regions, and remained divergent in the anterior regions (frontal and temporal) regions, and the pattern of loss became more like that seen in adults. Conclusions: Cortical thickness loss in COS appears to localize with age to prefrontal and temporal regions that are seen for both medication naïve and medicated adult onset patients. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01658.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=790

Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness / Nitin GOGTAY in Journal of Child Psychology and Psychiatry, 48-9 (September 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-9 (September 2007) . - p.852–862 Titre : Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness Type de document : Texte imprimé et/ou numérique Auteurs : Nitin GOGTAY, Auteur ; Liv S. CLASEN, Auteur ; Paul M. THOMPSON, Auteur ; Arthur W. TOGA, Auteur ; Tom F. III NUGENT, Auteur ; David JUNG, Auteur ; Wendy SHARP, Auteur ; Marge LENANE, Auteur ; Kiralee M. HAYASHI, Auteur ; David H. HERMAN, Auteur ; Anna ORDONEZ, Auteur ; Ellen LEIBENLUFT, Auteur ; Judith RAPOPORT, Auteur ; Deanna GREENSTEIN, Auteur ; Jay N. GIEDD, Auteur ; Catherine VAITUZIS, Auteur Année de publication : 2007 Article en page(s) : p.852–862 Langues : Anglais (eng) Mots-clés : Pediatric bipolar MRI mapping gray matter Index. décimale : PER Périodiques Résumé : Background: There are, to date, no pre-post onset longitudinal imaging studies of bipolar disorder at any age. We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset. Method: We contrast this pattern with that observed in a matched group of healthy children as well as in a matched group of 8 children with ‘atypical psychosis’ who had similar initial presentation marked by mood dysregulation and transient psychosis (labeled as ‘multi-dimensionally impaired’ (MDI)) as in the bipolar group, but have not, to date, developed bipolar illness. Results: Dynamic maps, reconstructed by applying novel cortical pattern matching algorithms, for the children who became bipolar I showed subtle, regionally specific, bilaterally asymmetrical cortical changes. Cortical GM increased over the left temporal cortex and decreased bilaterally in the anterior (and sub genual) cingulate cortex. This was seen most strikingly after the illness onset, and showed a pattern distinct from that seen in childhood onset schizophrenia. The bipolar neurodevelopmental trajectory was generally shared by the children who remained with MDI diagnosis without converting to bipolar I, suggesting that this pattern of cortical development may reflect affective dysregulation (lability) in general. Conclusions: These dynamic trajectories of cortical development may explain age-related disparate findings from cross-sectional studies of bipolar illness, and suggest the importance of mood disordered non-bipolar control group in future studies. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01747.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness [Texte imprimé et/ou numérique] / Nitin GOGTAY, Auteur ; Liv S. CLASEN, Auteur ; Paul M. THOMPSON, Auteur ; Arthur W. TOGA, Auteur ; Tom F. III NUGENT, Auteur ; David JUNG, Auteur ; Wendy SHARP, Auteur ; Marge LENANE, Auteur ; Kiralee M. HAYASHI, Auteur ; David H. HERMAN, Auteur ; Anna ORDONEZ, Auteur ; Ellen LEIBENLUFT, Auteur ; Judith RAPOPORT, Auteur ; Deanna GREENSTEIN, Auteur ; Jay N. GIEDD, Auteur ; Catherine VAITUZIS, Auteur . - 2007 . - p.852–862. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-9 (September 2007) . - p.852–862 Mots-clés : Pediatric bipolar MRI mapping gray matter Index. décimale : PER Périodiques Résumé : Background: There are, to date, no pre-post onset longitudinal imaging studies of bipolar disorder at any age. We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset. Method: We contrast this pattern with that observed in a matched group of healthy children as well as in a matched group of 8 children with ‘atypical psychosis’ who had similar initial presentation marked by mood dysregulation and transient psychosis (labeled as ‘multi-dimensionally impaired’ (MDI)) as in the bipolar group, but have not, to date, developed bipolar illness. Results: Dynamic maps, reconstructed by applying novel cortical pattern matching algorithms, for the children who became bipolar I showed subtle, regionally specific, bilaterally asymmetrical cortical changes. Cortical GM increased over the left temporal cortex and decreased bilaterally in the anterior (and sub genual) cingulate cortex. This was seen most strikingly after the illness onset, and showed a pattern distinct from that seen in childhood onset schizophrenia. The bipolar neurodevelopmental trajectory was generally shared by the children who remained with MDI diagnosis without converting to bipolar I, suggesting that this pattern of cortical development may reflect affective dysregulation (lability) in general. Conclusions: These dynamic trajectories of cortical development may explain age-related disparate findings from cross-sectional studies of bipolar illness, and suggest the importance of mood disordered non-bipolar control group in future studies. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01747.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

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