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Auteur Kristen LYALL |
Documents disponibles écrits par cet auteur (26)
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What are quantitative traits and how can they be used in autism research? / Kristen LYALL in Autism Research, 16-7 (July 2023)
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Titre : What are quantitative traits and how can they be used in autism research? Type de document : Texte imprimé et/ou numérique Auteurs : Kristen LYALL, Auteur Article en page(s) : p.1289-1298 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Quantitative traits are measurable characteristics distributed along a continuous scale thought to relate to underlying biology. There is growing interest in the use of quantitative traits in behavioral and psychiatric research, particularly in research on conditions diagnosed based on reports of behaviors, including autism. This brief commentary describes quantitative traits, including defining what they are, how we can measure them, and key considerations for their use in autism research. Examples of measures include behavioral report scales like the Social Responsiveness Scale and Broader Autism Phenotype Questionnaire, as well as biological measurements, like certain neuroimaging metrics; such measures can capture quantitative traits or constructs like the broader autism phenotype, social communication, and social cognition. Quantitative trait measures align with the Research Domain Criteria (RDoC) approach and can be used in autism research to help gain a better understanding of causal pathways and biological processes. They can also be used to aid identification of genetic and environmental factors involved in such pathways, and thereby lead to an understanding of influences on traits across the entire population. Finally, in some cases, they may be used to gauge treatment response, and assist screening and clinical characterization of phenotype. In addition, practical benefits of quantitative trait measures include improved statistical power relative to categorical classifications and (for some measures) efficiency. Ultimately, research across autism fields may benefit from incorporating quantitative trait measures as a complement to categorical diagnosis to advance understanding of autism and neurodevelopment. En ligne : https://doi.org/10.1002/aur.2937 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510
in Autism Research > 16-7 (July 2023) . - p.1289-1298[article] What are quantitative traits and how can they be used in autism research? [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur . - p.1289-1298.
Langues : Anglais (eng)
in Autism Research > 16-7 (July 2023) . - p.1289-1298
Index. décimale : PER Périodiques Résumé : Abstract Quantitative traits are measurable characteristics distributed along a continuous scale thought to relate to underlying biology. There is growing interest in the use of quantitative traits in behavioral and psychiatric research, particularly in research on conditions diagnosed based on reports of behaviors, including autism. This brief commentary describes quantitative traits, including defining what they are, how we can measure them, and key considerations for their use in autism research. Examples of measures include behavioral report scales like the Social Responsiveness Scale and Broader Autism Phenotype Questionnaire, as well as biological measurements, like certain neuroimaging metrics; such measures can capture quantitative traits or constructs like the broader autism phenotype, social communication, and social cognition. Quantitative trait measures align with the Research Domain Criteria (RDoC) approach and can be used in autism research to help gain a better understanding of causal pathways and biological processes. They can also be used to aid identification of genetic and environmental factors involved in such pathways, and thereby lead to an understanding of influences on traits across the entire population. Finally, in some cases, they may be used to gauge treatment response, and assist screening and clinical characterization of phenotype. In addition, practical benefits of quantitative trait measures include improved statistical power relative to categorical classifications and (for some measures) efficiency. Ultimately, research across autism fields may benefit from incorporating quantitative trait measures as a complement to categorical diagnosis to advance understanding of autism and neurodevelopment. En ligne : https://doi.org/10.1002/aur.2937 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 Women's posttraumatic stress symptoms and autism spectrum disorder in their children / Andrea L. ROBERTS in Research in Autism Spectrum Disorders, 8-6 (June 2014)
[article]
Titre : Women's posttraumatic stress symptoms and autism spectrum disorder in their children Type de document : Texte imprimé et/ou numérique Auteurs : Andrea L. ROBERTS, Auteur ; Karestan C. KOENEN, Auteur ; Kristen LYALL, Auteur ; Alberto ASCHERIO, Auteur ; Marc G. WEISSKOPF, Auteur Article en page(s) : p.608-616 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Posttraumatic stress disorder Gestational effects Index. décimale : PER Périodiques Résumé : Maternal posttraumatic stress disorder (PTSD) may be associated with autism spectrum disorder (ASD) in offspring through multiple pathways: maternal stress may affect the fetus; ASD in children may increase risk of PTSD in mothers; and the two disorders may share genetic risk. Understanding whether maternal PTSD is associated with child's ASD is important for clinicians treating children with ASD, as PTSD in parents is associated with poorer family functioning. We examined the association of maternal PTSD with offspring ASD in a large US cohort (N ASD cases = 413, N controls = 42,868). Mother's PTSD symptoms were strongly associated with child's ASD (RR 4–5 PTSD symptoms = 1.98, 95% CI = 1.39, 2.81; RR 6–7 symptoms = 2.89, 95% CI = 2.00, 4.18). Clinicians treating persons with ASD should be aware of elevated risk of PTSD in the mother. Genetic studies should investigate PTSD risk alleles in relation to ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.02.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232
in Research in Autism Spectrum Disorders > 8-6 (June 2014) . - p.608-616[article] Women's posttraumatic stress symptoms and autism spectrum disorder in their children [Texte imprimé et/ou numérique] / Andrea L. ROBERTS, Auteur ; Karestan C. KOENEN, Auteur ; Kristen LYALL, Auteur ; Alberto ASCHERIO, Auteur ; Marc G. WEISSKOPF, Auteur . - p.608-616.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-6 (June 2014) . - p.608-616
Mots-clés : Autism spectrum disorder Posttraumatic stress disorder Gestational effects Index. décimale : PER Périodiques Résumé : Maternal posttraumatic stress disorder (PTSD) may be associated with autism spectrum disorder (ASD) in offspring through multiple pathways: maternal stress may affect the fetus; ASD in children may increase risk of PTSD in mothers; and the two disorders may share genetic risk. Understanding whether maternal PTSD is associated with child's ASD is important for clinicians treating children with ASD, as PTSD in parents is associated with poorer family functioning. We examined the association of maternal PTSD with offspring ASD in a large US cohort (N ASD cases = 413, N controls = 42,868). Mother's PTSD symptoms were strongly associated with child's ASD (RR 4–5 PTSD symptoms = 1.98, 95% CI = 1.39, 2.81; RR 6–7 symptoms = 2.89, 95% CI = 2.00, 4.18). Clinicians treating persons with ASD should be aware of elevated risk of PTSD in the mother. Genetic studies should investigate PTSD risk alleles in relation to ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.02.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232