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Auteur Tim MCQUEENY |
Documents disponibles écrits par cet auteur (1)
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Depressive symptoms in adolescents: associations with white matter volume and marijuana use / Krista LISDAHL MEDINA in Journal of Child Psychology and Psychiatry, 48-6 (June 2007)
[article]
Titre : Depressive symptoms in adolescents: associations with white matter volume and marijuana use Type de document : Texte imprimé et/ou numérique Auteurs : Krista LISDAHL MEDINA, Auteur ; Bonnie J. NAGEL, Auteur ; Ann PARK, Auteur ; Tim MCQUEENY, Auteur ; Susan F. TAPERT, Auteur Année de publication : 2007 Article en page(s) : p.592–600 Langues : Anglais (eng) Mots-clés : Adolescence depression cannabis marijuana-abuse neuroimaging MRI brain-imaging white-matter hippocampus Index. décimale : PER Périodiques Résumé : Depressed mood has been associated with decreased white matter and reduced hippocampal volumes. However, the relationship between brain structure and mood may be unique among adolescents who use marijuana heavily. The goal of this study was to examine the relationship between white matter and hippocampal volumes and depressive symptoms among adolescent marijuana users and controls.
Methods: Data were collected from marijuana users (n = 16) and demographically similar controls (n = 16) aged 16–18. Extensive exclusionary criteria included psychiatric and neurologic disorders, including major depression. Substance use, mood, and anatomical measures were collected after 28 days of monitored abstinence.
Results: Marijuana (MJ) users demonstrated more depressive symptoms than controls (p < .05). MJ use (β = .42, p < .005) and smaller white matter volume (β = −.34, p < .03) each predicted higher levels of depressive symptoms on the Hamilton Depression Rating Scale. MJ use interacted with white matter volume (β = −.55, p < .03) in predicting depression scores on the Beck Depression Inventory: among MJ users, but not controls, white matter volume was negatively associated with depressive symptoms.
Conclusions: Marijuana use and white matter volume were additive and interactive in predicting depressive symptoms among adolescents. Subtle neurodevelopmental white matter abnormalities may disrupt the connections between areas involved in mood regulation.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01728.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=103
in Journal of Child Psychology and Psychiatry > 48-6 (June 2007) . - p.592–600[article] Depressive symptoms in adolescents: associations with white matter volume and marijuana use [Texte imprimé et/ou numérique] / Krista LISDAHL MEDINA, Auteur ; Bonnie J. NAGEL, Auteur ; Ann PARK, Auteur ; Tim MCQUEENY, Auteur ; Susan F. TAPERT, Auteur . - 2007 . - p.592–600.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 48-6 (June 2007) . - p.592–600
Mots-clés : Adolescence depression cannabis marijuana-abuse neuroimaging MRI brain-imaging white-matter hippocampus Index. décimale : PER Périodiques Résumé : Depressed mood has been associated with decreased white matter and reduced hippocampal volumes. However, the relationship between brain structure and mood may be unique among adolescents who use marijuana heavily. The goal of this study was to examine the relationship between white matter and hippocampal volumes and depressive symptoms among adolescent marijuana users and controls.
Methods: Data were collected from marijuana users (n = 16) and demographically similar controls (n = 16) aged 16–18. Extensive exclusionary criteria included psychiatric and neurologic disorders, including major depression. Substance use, mood, and anatomical measures were collected after 28 days of monitored abstinence.
Results: Marijuana (MJ) users demonstrated more depressive symptoms than controls (p < .05). MJ use (β = .42, p < .005) and smaller white matter volume (β = −.34, p < .03) each predicted higher levels of depressive symptoms on the Hamilton Depression Rating Scale. MJ use interacted with white matter volume (β = −.55, p < .03) in predicting depression scores on the Beck Depression Inventory: among MJ users, but not controls, white matter volume was negatively associated with depressive symptoms.
Conclusions: Marijuana use and white matter volume were additive and interactive in predicting depressive symptoms among adolescents. Subtle neurodevelopmental white matter abnormalities may disrupt the connections between areas involved in mood regulation.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01728.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=103